Affiliation: Mitsubishi Kagaku Institute of Life Sciences
- Spherical aggregates of beta-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3betaMinako Hoshi
Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
Proc Natl Acad Sci U S A 100:6370-5. 2003..Here we describe the identification and characterization of ASPD and discuss its possible role in the neurodegeneration in Alzheimer's disease...
- [Amylospheroid and the 'morphometabolism' disease (conformational disease)]Minako Hoshi
Tanpakushitsu Kakusan Koso 49:1098-100. 2004
- [Morphology and neurotoxicity of newly identified spherical beta-amyloid aggregates, 'amylospheroid', aiming at elucidation of the neurodegenerative cascades in Alzheimer's disease]Minako Hoshi
Unit of Neurodegenerative Disease, Mitsubishi Kagaku Institute of Life Sciences, 11 Minamiooya, Machida, Tokyo 194 8511, Japan
Seikagaku 76:631-9. 2004
- Isolation and characterization of patient-derived, toxic, high mass amyloid beta-protein (Abeta) assembly from Alzheimer disease brainsAkihiko Noguchi
Mitsubishi Kagaku Institute of Life Sciences, Tokyo 194 8511, Japan
J Biol Chem 284:32895-905. 2009..Thus, our findings indicate that native ASPDs with a distinct toxic surface induce neuronal loss through a different mechanism from other Abeta assemblies...
- Two distinct amyloid beta-protein (Abeta) assembly pathways leading to oligomers and fibrils identified by combined fluorescence correlation spectroscopy, morphology, and toxicity analysesSatoko Matsumura
Mitsubishi Kagaku Institute of Life Sciences, Tokyo, Japan
J Biol Chem 286:11555-62. 2011..These differences in the assembly pathways clearly indicated that ASPDs are not fibril precursors. The method we have developed should facilitate identifying Aβ assembly steps at which inhibition may be beneficial...