Research Topics
| Satoshi MishimaSummaryCountry: Japan Publications
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Detail Information
Publications
Royal jelly has estrogenic effects in vitro and in vivoSatoshi Mishima
Nagaragawa Research Center, API Co, Ltd, 692 3 Nagara, Gifu 502 0071, Japan
J Ethnopharmacol 101:215-20. 2005..c.) restored it in uterus but not in brain. These findings provide evidence that RJ has estrogenic activities through interaction with estrogen receptors followed by endogenous gene expressions...
Vaticanol C, a resveratrol tetramer, activates PPARalpha and PPARbeta/delta in vitro and in vivoTomoko Tsukamoto
Department of Food Science and Nutrition, Nara Women s University, Nara, 630 8506, Japan
Nutr Metab (Lond) 7:46. 2010..We previously demonstrated that resveratrol protects brain against ischemic stroke in mice through a PPARalpha-dependent mechanism. Here we report the different effects of the oligomers of resveratrol...
Bee products prevent VEGF-induced angiogenesis in human umbilical vein endothelial cellsHiroshi Izuta
Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu 502 8585, Japan
BMC Complement Altern Med 9:45. 2009..The aim of this study was to investigate the anti-angiogenic effects of bee products using human umbilical vein endothelial cells (HUVECs)...
Comparison of bee products based on assays of antioxidant capacitiesYoshimi Nakajima
Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 5 6 1 Mitahora Higashi, Gifu, Japan
BMC Complement Altern Med 9:4. 2009..We compared antioxidant effects among water and ethanol extracts of Brazilian green propolis (WEP or EEP), its main constituents, water-soluble royal jelly (RJ), and an ethanol extract of bee pollen...
Identification of caffeoylquinic acid derivatives from Brazilian propolis as constituents involved in induction of granulocytic differentiation of HL-60 cellsSatoshi Mishima
Nagaragawa Research Center, API Co, Ltd, 692-3 Nagara, Gifu 502-0071, Japan
Bioorg Med Chem 13:5814-8. 2005..This is the first report demonstrating that the caffeoylquinic acid derivatives induce granulocytic differentiation of HL-60 cells...
Royal jelly stimulates bone formation: physiologic and nutrigenomic studies with mice and cell linesYukio Narita
Nagaragawa Research Center, API Co, Ltd, Japan
Biosci Biotechnol Biochem 70:2508-14. 2006..These data suggest that RJ as a whole or some of its individual components stimulates production of type I collagen and other activities for bone formation through action on osteoblasts...
Estrogenic activities of Fatty acids and a sterol isolated from royal jellyKazu Michi Suzuki
Nagaragawa Research Center, API Co, Ltd, 692 3 Nagara, Gifu 502 0071 and Graduate School of Pharmaceutical Sciences, Kumamoto University, 5 1 Oe honmachi, Kumamoto 862 0973, Japan
Evid Based Complement Alternat Med 5:295-302. 2008..These findings provide evidence that these compounds contribute to the estrogenic effect of RJ...
Effects of long-term administration of royal jelly on pituitary weight and gene expression in middle-aged female ratsYukio Narita
Nagaragawa Research Center, API Co, Ltd, Nagara, Gifu, Japan
Biosci Biotechnol Biochem 73:431-3. 2009..RJ tended to down-regulate prolactin mRNA and up-regulated thyroid-stimulating hormone beta mRNA in the pituitary. This suggests that RJ compensates for age-associated decline in pituitary functions...
Antihypertensive effects of Brazilian propolis: identification of caffeoylquinic acids as constituents involved in the hypotension in spontaneously hypertensive ratsSatoshi Mishima
Nagaragawa Research Center, API Co, Ltd; 692-3 Yamasaki, Nagara, Gifu 502-0071, Japan
Biol Pharm Bull 28:1909-14. 2005..These results suggest that 25% ethanol extract of propolis is useful for prevention and treatment of hypertension...
Royal jelly facilitates restoration of the cognitive ability in trimethyltin-intoxicated miceNoriko Hattori
Nagaragawa Research Center, API Co, Ltd, Nagara, Gifu 502 0071, Japan
Evid Based Complement Alternat Med 2011:165968. 2011....
Effects of propolis on cell growth and gene expression in HL-60 cellsSatoshi Mishima
Nagaragawa Research Center, API Co. Ltd, 692-3 Nagara, Gifu 502-0071, Japan
J Ethnopharmacol 99:5-11. 2005..Propolis-induced growth inhibition in HL-60 cells was, at least in part, due to differentiation with gene expression profiles, which are similar to those induced by all-trans retinoic acid...
