Yoshiji Yamada

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. ncbi request reprint Assessment of the genetic component of hypertension
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan
    Am J Hypertens 19:1158-65. 2006
  2. ncbi request reprint Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors
    Kohta Nishihama
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie, Japan
    Int J Mol Med 19:129-41. 2007
  3. ncbi request reprint Genetic risk for restenosis after coronary stenting
    Mitsutoshi Oguri
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, 5 161 Maehata, Tajimi, Gifu 507 8522, Japan
    Atherosclerosis 194:e172-8. 2007
  4. pmc Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat
    Jie Chang
    Graduate School of Regional Innovation Studies, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Nutr Metab (Lond) 9:87. 2012
  5. doi request reprint Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    J Med Genet 50:410-8. 2013
  6. ncbi request reprint Genetic risk for coronary artery disease in individuals with or without type 2 diabetes
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Mol Genet Metab 81:282-90. 2004
  7. doi request reprint Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations
    Yoshiji Yamada
    Life Science Research Center, Mie University, Tsu, Japan
    Atherosclerosis 215:145-52. 2011
  8. ncbi request reprint Association of gene polymorphisms with blood pressure and the prevalence of hypertension in community-dwelling Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 19:675-83. 2007
  9. ncbi request reprint Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1515 Kamihama, Tsu, 514 8507 Mie, Japan
    J Mol Med (Berl) 83:50-7. 2005
  10. ncbi request reprint Association of polymorphisms in CYP17A1, MTP, and VLDLR with bone mineral density in community-dwelling Japanese women and men
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1515 Kamihama, Tsu, Mie 514 8507, Japan
    Genomics 86:76-85. 2005

Collaborators

Detail Information

Publications98

  1. ncbi request reprint Assessment of the genetic component of hypertension
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan
    Am J Hypertens 19:1158-65. 2006
    ..We have now performed a large-scale association study to identify gene polymorphisms for reliable assessment of the genetic component of hypertension...
  2. ncbi request reprint Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors
    Kohta Nishihama
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie, Japan
    Int J Mol Med 19:129-41. 2007
    ..Stratification of subjects on the basis of such risk factors may thus be important in order to achieve personalized prevention of MI with the use of genetic information...
  3. ncbi request reprint Genetic risk for restenosis after coronary stenting
    Mitsutoshi Oguri
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, 5 161 Maehata, Tajimi, Gifu 507 8522, Japan
    Atherosclerosis 194:e172-8. 2007
    ..The purpose of the present study was to identify gene polymorphisms that confer susceptibility to restenosis after bare-metal stenting of coronary arteries, and thereby to predict the genetic risk for this condition...
  4. pmc Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat
    Jie Chang
    Graduate School of Regional Innovation Studies, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Nutr Metab (Lond) 9:87. 2012
    ..abstract:..
  5. doi request reprint Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    J Med Genet 50:410-8. 2013
    ..We performed a GWAS to identify genetic variants that confer susceptibility to CKD in Japanese individuals...
  6. ncbi request reprint Genetic risk for coronary artery disease in individuals with or without type 2 diabetes
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Japan
    Mol Genet Metab 81:282-90. 2004
    ..Genotyping of these polymorphisms may prove informative for assessment of the genetic risk for CAD in the absence or presence of type 2 diabetes...
  7. doi request reprint Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations
    Yoshiji Yamada
    Life Science Research Center, Mie University, Tsu, Japan
    Atherosclerosis 215:145-52. 2011
    ..We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations...
  8. ncbi request reprint Association of gene polymorphisms with blood pressure and the prevalence of hypertension in community-dwelling Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 19:675-83. 2007
    ..These results suggest that polymorphisms of QPCT and CYP11B2 are determinants of BP and the development of hypertension in Japanese men...
  9. ncbi request reprint Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1515 Kamihama, Tsu, 514 8507 Mie, Japan
    J Mol Med (Berl) 83:50-7. 2005
    ..These results suggest that AR is a susceptibility gene for reduced BMD in premenopausal Japanese women, and that KL is a susceptibility gene for reduced BMD in all women...
  10. ncbi request reprint Association of polymorphisms in CYP17A1, MTP, and VLDLR with bone mineral density in community-dwelling Japanese women and men
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1515 Kamihama, Tsu, Mie 514 8507, Japan
    Genomics 86:76-85. 2005
    ..These results suggest that CYP17A1 and MTP are susceptibility loci for increased BMD in postmenopausal and premenopausal Japanese women, respectively, and that VLDLR constitutes such a locus in Japanese men...
  11. ncbi request reprint Genetic factors for obesity
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 18:843-51. 2006
    ..Genotypes for ACE, GCK, and ESR1 may prove reliable for the assessment of genetic factors for obesity. Determination of the combined genotypes for these genes may contribute to the personalized prevention of this condition...
  12. ncbi request reprint Identification of genetic factors and development of genetic risk diagnosis systems for cardiovascular diseases and stroke
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Kurima Machiya, Tsu, Japan
    Circ J 70:1240-8. 2006
    ..More recently, a large genetic epidemiological study was performed to identify additional gene polymorphisms that confer susceptibility to cardiovascular diseases, stroke, and other complex diseases...
  13. ncbi request reprint Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 17:83-8. 2006
    ..040) in postmenopausal women, with the TT genotype protecting against this condition. These results suggest that MTP genotype is a determinant of blood pressure in Japanese women...
  14. ncbi request reprint Genetic risk for ischemic and hemorrhagic stroke
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    Arterioscler Thromb Vasc Biol 26:1920-5. 2006
    ..We performed an association study to identify gene polymorphisms for assessing the genetic risk of ischemic or hemorrhagic stroke...
  15. ncbi request reprint Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 18:119-27. 2006
    ..This polymorphism of PLIN was not associated with BMD in all women. These results suggest that FOXC2 is a susceptibility locus for reduced BMD in Japanese men and women, and that PLIN constitutes such a locus in Japanese men...
  16. ncbi request reprint Prediction of genetic risk for metabolic syndrome
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    Atherosclerosis 191:298-304. 2007
    ..The aim of the study was to identify gene polymorphisms that confer susceptibility to metabolic syndrome in order to allow reliable assessment of genetic risk for this condition...
  17. ncbi request reprint Assessment of genetic factors for type 2 diabetes mellitus
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 18:299-308. 2006
    ..Genotype for F3 may prove reliable for assessment of genetic factors for type 2 diabetes mellitus. Determination of the genotype for this gene may contribute to personalized prevention of this condition...
  18. ncbi request reprint Catalytic inactivation of human phospholipase D2 by a naturally occurring Gly901Asp mutation
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan
    Arch Med Res 37:696-9. 2006
    ..In the present study, we have examined the possible functional relevance of other naturally occurring polymorphisms (or mutations) of the human PLD2 gene that result in amino acid substitutions...
  19. ncbi request reprint Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie, Japan
    Int J Mol Med 19:791-801. 2007
    ..The polymorphisms of ICAM1 and CNR2 may confer susceptibility to postmenopausal osteoporosis in women, and that of GJA4 to osteoporosis in men...
  20. doi request reprint Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Mol Med Rep 4:511-8. 2011
    ..Stratification of subjects according to lipid profiles may thus be useful for the personalized prevention of MI based on genetic information...
  21. doi request reprint Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Atherosclerosis 207:144-9. 2009
    ..We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to ischemic stroke...
  22. pmc Molecular genetics of myocardial infarction
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie, 514 8507, Japan
    Genomic Med 2:7-22. 2008
    ..3 by genome-wide scans. Such studies may provide insight into the function of implicated genes as well as into the role of genetic factors in the development of CHD and MI...
  23. ncbi request reprint Proinflammatory gene polymorphisms and ischemic stroke
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie, Japan
    Curr Pharm Des 14:3590-600. 2008
    ..Such studies may provide insight into the function of implicated genes as well as into the role of genetic factors in the development of ischemic stroke...
  24. ncbi request reprint Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    Stroke 39:2211-8. 2008
    ..We performed an association study to identify gene polymorphisms that confer susceptibility to atherothrombotic cerebral infarction, intracerebral hemorrhage, or subarachnoid hemorrhage...
  25. ncbi request reprint Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome
    Yoshiji Yamada
    FAHA, Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Mie 514 8507, Japan
    Int J Mol Med 21:801-8. 2008
    ..Genotypes for these polymorphisms, especially for the 2445G-->A (Ala54Thr) polymorphism of FABP2, may prove informative for the prediction of genetic risk for atherothrombotic cerebral infarction among such individuals...
  26. ncbi request reprint Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population
    Y Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    J Med Genet 45:216-21. 2008
    ..Although several environmental factors influence the development of myocardial infarction (MI), genetic factors have been shown to contribute to individual susceptibility to this condition...
  27. ncbi request reprint Prediction of genetic risk for dyslipidemia
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Genomics 90:551-8. 2007
    ....
  28. ncbi request reprint Association of the genetic variants of APOA5 and PRKCH with hypertension in community-dwelling Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Mol Med Report 1:407-14. 2008
    ..These results suggest that the APOA5 and PRKCH polymorphisms are determinants of BP and the development of hypertension in Japanese men and women, respectively...
  29. ncbi request reprint Association of genetic variants of MAOA and SH2B1 with bone mineral density in community-dwelling Japanese women
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Mol Med Report 1:269-74. 2008
    ..These results suggest that MAOA and SH2B1 are determinative loci for bone mass in Japanese women, especially in postmenopausal ones...
  30. ncbi request reprint Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Int J Mol Med 20:703-7. 2007
    ..Genotyping for CYP3A4 may thus prove informative for assessment of the genetic risk for type 2 diabetes mellitus...
  31. ncbi request reprint Genetic risk for metabolic syndrome: examination of candidate gene polymorphisms related to lipid metabolism in Japanese people
    Y Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    J Med Genet 45:22-8. 2008
    ..The aim of this study was to identify genetic polymorphisms that confer susceptibility to metabolic syndrome, to allow prediction of genetic risk for this condition...
  32. doi request reprint Association of polymorphisms of SORBS1, GCK and WISP1 with hypertension in community-dwelling Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie, Japan
    Hypertens Res 32:325-31. 2009
    ..These results suggest that SORBS1 and GCK are susceptibility loci for hypertension in Japanese women and that WISP1 is such a locus in men...
  33. ncbi request reprint Association of a polymorphism of the dopamine receptor D4 gene with bone mineral density in Japanese men
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Gifu, Japan
    J Hum Genet 48:629-33. 2003
    ..For women, there were no differences in BMD among -521C-->T genotypes. These results implicate DRD4 as a candidate locus for reduced BMD in Japanese men...
  34. ncbi request reprint Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 21:83-9. 2008
    ..Determination of genotypes for ABCA1 and ROS1 may thus prove informative for the prediction of the genetic risk for hypertension...
  35. ncbi request reprint Assessment of genetic risk for myocardial infarction
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Thromb Haemost 96:220-7. 2006
    ..Determination of the combined genotype for these genes may contribute to primary, personalized prevention of this condition...
  36. ncbi request reprint Association of genetic variants with chronic kidney disease in Japanese individuals with type 2 diabetes mellitus
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Int J Mol Med 23:529-37. 2009
    ..05) associated with the prevalence of CKD. Our results suggest that ALOX5AP, IRAK1, and FABP2 are susceptibility loci for CKD among Japanese individuals with type 2 diabetes mellitus...
  37. ncbi request reprint Association of gene polymorphisms with myocardial infarction in individuals with different lipid profiles
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan
    Int J Mol Med 20:581-90. 2007
    ..Stratification of subjects according to lipid profiles may thus be important for personalized prevention of MI based on genetic information...
  38. pmc Association of genetic variants with chronic kidney disease in Japanese individuals
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Clin J Am Soc Nephrol 4:883-90. 2009
    ..The purpose of the present study was to identify genetic variants that confer susceptibility to CKD in Japanese individuals...
  39. ncbi request reprint Association of gene polymorphisms with chronic kidney disease in high- or low-risk subjects defined by conventional risk factors
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Int J Mol Med 23:785-92. 2009
    ..Stratification of subjects according to conventional risk factors may thus be important for personalized prevention of CKD based on genetic information...
  40. ncbi request reprint Association of genetic variants with myocardial infarction in Japanese individuals with chronic kidney disease
    Tetsuo Fujimaki
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan
    Thromb Haemost 101:963-8. 2009
    ..Determination of genotype for the 11496G-->A (Arg353Gln) polymorphism of F7 may prove informative for assessment of the genetic risk for MI in individuals with CKD...
  41. ncbi request reprint Association of genetic variants with chronic kidney disease in individuals with different lipid profiles
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Int J Mol Med 24:233-46. 2009
    ..Stratification of subjects according to lipid profiles may thus be important for personalized prevention of CKD based on genetic information...
  42. ncbi request reprint Identification of a polymorphism of UCP3 associated with recurrent in-stent restenosis of coronary arteries
    Mitsutoshi Oguri
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan
    Int J Mol Med 20:533-8. 2007
    ..0014, recessive model) affected the prevalence of recurrent in-stent restenosis. Determination of the genotype for UCP3 may thus contribute to assessment of the genetic risk for recurrent in-stent restenosis...
  43. doi request reprint Association of candidate gene polymorphisms with chronic kidney disease in Japanese individuals with hypertension
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Hypertens Res 32:411-8. 2009
    ..Determination of the genotypes for these polymorphisms may prove informative for the assessment of genetic risk for CKD among such individuals...
  44. ncbi request reprint Association of genetic variants with myocardial infarction in Japanese individuals with different lipid profiles
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Int J Mol Med 25:607-16. 2010
    ..Stratification of subjects according to lipid profiles may thus be important for personalized prevention of MI based on genetic information...
  45. ncbi request reprint Association of genetic variants with myocardial infarction in individuals with or without hypertension or diabetes mellitus
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Int J Mol Med 24:701-9. 2009
    ..Stratification of subjects based on hypertension or diabetes mellitus may thus be important in order to achieve personalized prevention of MI with the use of genetic information...
  46. doi request reprint Association of a genetic variant of BTN2A1 with chronic kidney disease in Japanese individuals
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Nephrology (Carlton) 16:642-8. 2011
    ..The purpose of the present study was to examine a possible association of these polymorphisms (rs6929846, rs2569512) with CKD in Japanese individuals...
  47. doi request reprint Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with or without hypertension, diabetes mellitus or chronic kidney disease
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Int J Mol Med 27:745-52. 2011
    ..Stratification of subjects based on hypertension, DM or CKD may thus be informative in order to achieve personalized prevention of MI with the use of genetic information...
  48. doi request reprint Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Arterioscler Thromb Vasc Biol 30:1553-61. 2010
    ..To investigate the potential role of nuclear factor-erythroid 2-related factor 2 (Nrf2) in neovascularization with a murine surgical model of ischemia...
  49. ncbi request reprint Association of genetic variants in SEMA3F, CLEC16A, LAMA3, and PCSK2 with myocardial infarction in Japanese individuals
    Tetsuo Fujimaki
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan
    Atherosclerosis 210:468-73. 2010
    ..The purpose of the present study was to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese individuals...
  50. ncbi request reprint Association of genetic variants with hemorrhagic stroke in Japanese individuals
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Int J Mol Med 25:649-56. 2010
    ....
  51. ncbi request reprint Association of a polymorphism of the apolipoprotein E gene with chronic kidney disease in Japanese individuals with metabolic syndrome
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Genomics 93:221-6. 2009
    ..05) with the prevalence of CKD. Among these polymorphisms, the -219G-->T polymorphism of APOE (rs405509) was most significantly associated with CKD in Japanese individuals with metabolic syndrome...
  52. ncbi request reprint Association of genetic variants with ischemic stroke in Japanese individuals with or without metabolic syndrome
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Int J Mol Med 25:281-6. 2010
    ..Stratification of subjects according to the presence or absence of metabolic syndrome may thus be important for personalized prevention of ischemic stroke based on genetic information...
  53. ncbi request reprint Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus
    Sachiyo Yamaguchi
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 19:631-7. 2007
    ..Genotyping of these polymorphisms may prove informative for assessment of the genetic component of type 2 diabetes mellitus for men and women separately...
  54. ncbi request reprint Assessment of genetic risk factors for thoracic aortic aneurysm in hypertensive patients
    Kimihiko Kato
    Department of Cardiovascular Medicine, Gifu Prefectural Government TAJIMI Hospital, Tajimi, Japan
    Am J Hypertens 21:1023-7. 2008
    ..In addition, evidence suggests that genetic factors play a role in the development of this condition. The purpose of the present study was to identify genetic variants that confer susceptibility to TAA in hypertensive subjects...
  55. ncbi request reprint Genetic risk for myocardial infarction in Japanese individuals with or without chronic kidney disease
    Tetsuo Fujimaki
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan
    Int J Mol Med 25:743-9. 2010
    ..CLEC16A and LAMA3 may be susceptibility loci for MI in Japanese individuals without CKD. Determination of genotypes for CLEC16A and LAMA3 may prove informative for assessment of the genetic risk for MI in such individuals...
  56. ncbi request reprint Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis
    Sachiyo Yamaguchi
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 18:871-83. 2006
    ..Stratification of subjects on the basis of sex or conventional risk factors for atherosclerosis may therefore be important in order to achieve the personalized prevention of ACI with the use of genetic information...
  57. doi request reprint Association of a polymorphism of BTN2A1 with hypertension in Japanese individuals
    Hideki Horibe
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Japan
    Am J Hypertens 24:924-9. 2011
    ..We have thus examined the relation of rs6929846 of BTN2A1 to hypertension in Japanese individuals...
  58. pmc Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurimamachiya cho, Tsu, Mie 514 8507, Japan
    Biochem Biophys Res Commun 381:44-9. 2009
    ....
  59. ncbi request reprint Association of a polymorphism of ABCB1 with obesity in Japanese individuals
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Genomics 91:512-6. 2008
    ..Our results suggest that the ABCB1 genotype may prove informative for assessment of genetic risk for obesity in Japanese individuals...
  60. ncbi request reprint Genetic factors for lone atrial fibrillation
    Kimihiko Kato
    Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Gifu 507 8522, Japan
    Int J Mol Med 19:933-9. 2007
    ..Determination of the genotypes for these polymorphisms may thus prove informative for assessment of the genetic component of AF...
  61. ncbi request reprint Association of a polymorphism of the matrix metalloproteinase-9 gene with bone mineral density in Japanese men
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Gifu, Japan
    Metabolism 53:135-7. 2004
    ..No significant differences in BMD among MMP9 genotypes were observed in premenopausal or postmenopausal women. The -1562C-->T polymorphism of MMP9 was thus associated with BMD in Japanese men...
  62. ncbi request reprint Association of gene polymorphisms with chronic kidney disease in Japanese individuals
    Tetsuro Yoshida
    Department of Cardiovascular Medicine, Inabe General Hospital, Inabe, Japan
    Int J Mol Med 24:539-47. 2009
    ..Determination of genotypes for the Cright curved arrow T polymorphism of F10 may prove informative for assessment of genetic risk for CKD in Japanese individuals...
  63. ncbi request reprint Prediction of the risk of myocardial infarction from polymorphisms in candidate genes
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Japan
    N Engl J Med 347:1916-23. 2002
    ....
  64. ncbi request reprint Association of polymorphisms of the osteoprotegerin gene with bone mineral density in Japanese women but not men
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    Mol Genet Metab 80:344-9. 2003
    ..1% for Ward's triangle (P=0.0038). BMD was not associated with the 950T --> C or 245T --> G genotypes in men. The present results implicate the osteoprotegerin gene as a susceptibility locus for reduced BMD in Japanese women...
  65. ncbi request reprint Association of polymorphisms of the estrogen receptor alpha gene with bone mineral density of the femoral neck in elderly Japanese women
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, and Institute of Applied Biochemistry, Mitake, Gifu 505 0116, Japan
    J Mol Med (Berl) 80:452-60. 2002
    ..These results suggest that the estrogen receptor alpha gene is a susceptibility locus for bone mass, especially for the femoral neck, in elderly Japanese women...
  66. ncbi request reprint Association of a -1997G-->T polymorphism of the collagen Ialpha1 gene with bone mineral density in postmenopausal Japanese women
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1515 Kami hama, Tsu, Mie 514 8507, Japan
    Hum Biol 77:27-36. 2005
    ..These results suggest that COL1A1 is a susceptibility locus for reduced BMD in postmenopausal Japanese women...
  67. ncbi request reprint Association of polymorphisms of interleukin-6, osteocalcin, and vitamin D receptor genes, alone or in combination, with bone mineral density in community-dwelling Japanese women and men
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology and Institute of Applied Biochemistry, Mitake, Gifu 505 0116, Japan
    J Clin Endocrinol Metab 88:3372-8. 2003
    ..The combined IL-6 and osteocalcin genotypes may prove informative for the assessment of osteoporosis in women...
  68. ncbi request reprint Association of polymorphisms of paraoxonase 1 and 2 genes, alone or in combination, with bone mineral density in community-dwelling Japanese
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, 1 1 Naka fudogaoka, Kakamigahara, Gifu 504 0838, Japan
    J Hum Genet 48:469-75. 2003
    ..None of these three polymorphisms was associated with BMD in premenopausal women or in men. Our results suggest that the paraoxonase 1 and 2 genes are candidate loci for reduced bone mass in postmenopausal Japanese women...
  69. doi request reprint Association of a genetic variant of BTN2A1 with metabolic syndrome in East Asian populations
    Mitsutoshi Oguri
    Department of Cardiology, Japanese Red Cross Nagoya First Hospital, Nagoya, Japan
    J Med Genet 48:787-92. 2011
    ....
  70. ncbi request reprint Association of a polymorphism of the transforming growth factor-beta1 gene with blood pressure in Japanese individuals
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology and Institute of Applied Biochemistry, Yagi Memorial Park, 2193 128 Mitake, Mitake cho, Kani gun, Gifu 505 0116, Japan
    J Hum Genet 47:243-8. 2002
    ..These results suggest that the TGF-beta1 gene at chromosome 19q13.1 may be a candidate susceptibility locus for hypertension in Japanese women...
  71. ncbi request reprint Association of a polymorphism of the phospholipase D2 gene with the prevalence of colorectal cancer
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, 2193 128 Mitake, 505 0116, Gifu, Japan
    J Mol Med (Berl) 81:126-31. 2003
    ..These results suggest that the phospholipase D(2) gene is a susceptibility locus for colorectal cancer in Japanese individuals, although a functional effect of the 1814C-->T (Thr577Ile) polymorphism was not detected...
  72. ncbi request reprint Golden mean to longevity: rareness of mitochondrial cytochrome b variants in centenarians but not in patients with Parkinson's disease
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Gifu, Japan
    J Neurosci Res 70:347-55. 2002
    ..A multiplex detection system for various deleterious variations in combination with genetic tests for longevity-associated genotypes will be necessary to predict longevity or age-related diseases...
  73. ncbi request reprint Repression of E1AF transcriptional activity by sumoylation and PIASy
    Tamotsu Nishida
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu 514 8507, Japan
    Biochem Biophys Res Commun 360:226-32. 2007
    ..Taken together, our results indicate that PIASy negatively regulates E1AF-mediated transcription by both E1AF sumoylation in a dependent and independent fashion...
  74. pmc PIASy controls ubiquitination-dependent proteasomal degradation of Ets-1
    Tamotsu Nishida
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu 514 8507, Japan
    Biochem J 405:481-8. 2007
    ..Our results suggested that PIASy controls Ets-1 function, at least in part, by inhibiting Ets-1 protein turnover via the ubiquitin-proteasome system...
  75. ncbi request reprint Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan
    Biochem Biophys Res Commun 350:105-13. 2006
    ..Attenuation of the development of cardiac dysfunction by bisoprolol may thus result in part from normalization of the associated increases in the levels of oxidative stress and pro-inflammatory cytokines in the left ventricle...
  76. ncbi request reprint Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Biochem Biophys Res Commun 359:27-33. 2007
    ..These results suggest that fenofibrate and PEG-SOD prevented cardiac dysfunction induced by DOX through normalization of oxidative stress and redox-regulated NF-kappaB signaling...
  77. ncbi request reprint SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2 from nucleolar and cytoplasmic nucleophosmin
    Tamotsu Nishida
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu 514 8507, Japan
    Biochem Biophys Res Commun 374:382-7. 2008
    ..Our findings suggest that SMT3IP1-mediated desumoylation might control NPM physiological functions at both the nucleolus and other subcellular compartments...
  78. ncbi request reprint A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Arterioscler Thromb Vasc Biol 27:1297-304. 2007
    ..We have investigated the interaction between AHR and hypoxia signaling pathways in regulation of angiogenesis with the use of a surgical model of ischemia...
  79. ncbi request reprint Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors
    Sahoko Ichihara
    Department of Cardiovascular Genome Science, Nagoya University School of Medicine, Japan
    J Mol Cell Cardiol 41:318-29. 2006
    ..These effects were associated with inhibition of the inflammatory response and of activation of redox-regulated transcription factors in the left ventricle...
  80. doi request reprint The nucleolar SUMO-specific protease SMT3IP1/SENP3 attenuates Mdm2-mediated p53 ubiquitination and degradation
    Tamotsu Nishida
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu 514 8507, Japan
    Biochem Biophys Res Commun 406:285-91. 2011
    ..Interestingly, the desumoylation activity of SMT3IP1 was not necessary for p53 stabilization. These results suggest that SMT3IP1 is a new regulator of the p53-Mdm2 pathway...
  81. ncbi request reprint Association of a polymorphism of the matrix metalloproteinase-1 gene with bone mineral density
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Yagi Memorial Park, Mitake, Gifu 505 0116, Japan
    Matrix Biol 21:389-92. 2002
    ..Men did not exhibit any significant differences in BMD among MMP-1 genotypes. The MMP-1 gene may thus be a susceptibility locus for reduced BMD at the distal radius in postmenopausal women...
  82. ncbi request reprint Association of a polymorphism of the CC chemokine receptor-2 gene with bone mineral density
    Yoshiji Yamada
    Department of Gene Therapy, Gifu International Institute of Biotechnology and Institute of Applied Biochemistry, Mitake, Gifu, 505 0116, Japan
    Genomics 80:8-12. 2002
    ..These results suggest that CCR2 may be a new candidate for a susceptibility locus for bone mass in middle-aged men and postmenopausal women...
  83. pmc Mitochondrial genome variation in eastern Asia and the peopling of Japan
    Masashi Tanaka
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Kakamigahara, Gifu 504 0838, Japan
    Genome Res 14:1832-50. 2004
    ..All the theories that have been proposed up to now to explain the peopling of Japan seem insufficient to accommodate fully this complex picture...
  84. ncbi request reprint Reduction in the extent of atherosclerosis in apolipoprotein E-deficient mice induced by electroporation-mediated transfer of the human plasma platelet-activating factor acetylhydrolase gene into skeletal muscle
    Makoto Hase
    Department of Gene Therapy, Gifu International Institute of Biotechnology, Mitake, Japan
    Prostaglandins Other Lipid Mediat 70:107-18. 2002
    ..These results suggest that the electrotransfer of the plasma PAF-AH gene to skeletal muscle reduces the extent of atherosclerosis in apoE(-/-) mice...
  85. ncbi request reprint Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure
    Sahoko Ichihara
    Department of Cardiovascular Genome Science, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cardiovasc Res 69:726-35. 2006
    ..We have now investigated the role of MMPs and their tissue inhibitors (TIMPs) in the transition from compensated left ventricular (LV) hypertrophy to heart failure as well as the effects of pravastatin on this transition in a rat model...
  86. ncbi request reprint AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats
    Kohzo Nagata
    Department of Clinical Pathophysiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hypertension 40:168-74. 2002
    ..Calcineurin may be downstream from TGF-beta1 in AT1 receptor-mediated angiotensin II signaling in vivo...
  87. ncbi request reprint Meta-analysis of the association of 4 angiotensinogen polymorphisms with essential hypertension: a role beyond M235T?
    Tiago Veiga Pereira
    Heart Institute InCor, Faculty of Pharmaceutical Sciences, University of Sao Paulo Medical School, Sao Paulo, Brazil
    Hypertension 51:778-83. 2008
    ....
  88. ncbi request reprint Three endothelial nitric oxide (NOS3) gene polymorphisms in hypertensive and normotensive individuals: meta-analysis of 53 studies reveals evidence of publication bias
    Tiago V Pereira
    Heart Institute InCor, Sao Paulo University Medical School, University of Sao Paulo, Brazil
    J Hypertens 25:1763-74. 2007
    ..To explore this hypothesis further, we performed a meta-analysis and re-evaluated the relationship between the three most widely studied NOS3 polymorphisms and hypertension status and blood pressure levels...
  89. pmc Mitochondrial haplogroup N9a confers resistance against type 2 diabetes in Asians
    Noriyuki Fuku
    Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan
    Am J Hum Genet 80:407-15. 2007
    ..0002) with an odds ratio of 0.55 (95% confidence interval 0.40-0.75). Even in the modern environment, which is often characterized by satiety and physical inactivity, this haplogroup might confer resistance against T2DM...
  90. ncbi request reprint Prediction of genetic risk for hypertension
    Hideo Izawa
    Cardiovascular Division, Department of Pathophysiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hypertension 41:1035-40. 2003
    ....
  91. ncbi request reprint Genetic risk for restenosis after coronary balloon angioplasty
    Hideki Horibe
    Department of Cardiology, Kosei Hospital, Anjo, Japan
    Atherosclerosis 174:181-7. 2004
    ..Genotyping of these polymorphisms may prove informative for assessment of genetic risk for restenosis after POBA...
  92. ncbi request reprint Genetic risk and gene-environment interaction in coronary artery spasm in Japanese men and women
    Yosuke Murase
    Division of Cardiology, Okazaki City Hospital, Japan
    Eur Heart J 25:970-7. 2004
    ..The aim of the study was to identify genes that confer susceptibility to coronary artery spasm and clarify the interaction between genetic and environmental factors in this condition...
  93. ncbi request reprint Women with mitochondrial haplogroup N9a are protected against metabolic syndrome
    Masashi Tanaka
    Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology Tokyo, 35 2 Sakae cho, Itabashi ku, Tokyo 173 0015, Japan
    Diabetes 56:518-21. 2007
    ..22 (0.06-0.68, P = 0.0129) for G1 and with an OR of 0.32 (0.10-0.96, P = 0.0469) for D5, respectively. These results indicate that mitochondrial haplogroup N9a may be a protective factor against metabolic syndrome in Japanese women...
  94. ncbi request reprint Lack of association of polymorphisms of the lymphotoxin alpha gene with myocardial infarction in Japanese
    Akira Yamada
    Department of Clinical Pathophysiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, 466 8550 Nagoya, Japan
    J Mol Med (Berl) 82:477-83. 2004
    ..The LTA gene thus does not appear to be a susceptibility locus for MI in Japanese men or women, although it might affect susceptibility to type 2 diabetes in Japanese men...
  95. ncbi request reprint Association of a 5178C-->A (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals
    Katsumasa Takagi
    Department of Cardiology, Ogaki Municipal Hospital, Japan
    Atherosclerosis 175:281-6. 2004
    ..These results suggest that the 5178A genotype of mitochondrial ND2 gene polymorphism is protective against MI; and this effect would explain, at least in part, its contribution to longevity...
  96. ncbi request reprint Mitochondrial haplogroup A is a genetic risk factor for atherothrombotic cerebral infarction in Japanese females
    Yutaka Nishigaki
    Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, Tokyo 173 0015, Japan
    Mitochondrion 7:72-9. 2007
    ..Our study shows that haplogroup A confers an increased risk of atherothrombotic cerebral infarction in Japanese females. Validation of our findings will require additional studies with independent subject panels...
  97. ncbi request reprint Mitochondrial haplogroup N9b is protective against myocardial infarction in Japanese males
    Yutaka Nishigaki
    Department of Genomics for Longevity and Health, Tokyo Metropolitan Institute of Gerontology, 35 2 Sakae cho, Itabashi ku, Tokyo, Japan
    Hum Genet 120:827-36. 2007
    ..05). No significant haplogroup-related associations were detected for females. Our data suggest that haplogroup N9b confers resistance against myocardial infarction in Japanese males...
  98. ncbi request reprint Association of gene polymorphisms with coronary artery disease in low- or high-risk subjects defined by conventional risk factors
    Akihiro Hirashiki
    Division of Cardiology, Okazaki City Hospital, Okazaki, Japan
    J Am Coll Cardiol 42:1429-37. 2003
    ..The aim of the study was to identify genes that confer susceptibility to coronary artery disease (CAD) in low- or high-risk men or women separately and thereby to assess the genetic risk of CAD in such individuals...