Yoshiji Yamada

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. request reprint
    Yamada Y, Matsuo H, Segawa T, Watanabe S, Kato K, Hibino T, et al. Assessment of the genetic component of hypertension. Am J Hypertens. 2006;19:1158-65 pubmed
    ..Determination of the combined genotypes for these genes may contribute to personalized prevention of this condition. ..
  2. Yokoyama Y, Mise N, Suzuki Y, Tada Oikawa S, Izuoka K, Zhang L, et al. MicroRNAs as Potential Mediators for Cigarette Smoking Induced Atherosclerosis. Int J Mol Sci. 2018;19: pubmed publisher
    ..Our findings provide evidence for miRNAs as potential mediators of inflammation and atherosclerosis induced by CS. ..
  3. request reprint
    Yamada Y, Kato K, Hibino T, Yokoi K, Matsuo H, Segawa T, et al. Prediction of genetic risk for metabolic syndrome. Atherosclerosis. 2007;191:298-304 pubmed
    ..Genotype for APOA5 may prove reliable for assessment of genetic risk for metabolic syndrome. ..
  4. Tada Oikawa S, Ichihara G, Fukatsu H, Shimanuki Y, Tanaka N, Watanabe E, et al. Titanium Dioxide Particle Type and Concentration Influence the Inflammatory Response in Caco-2 Cells. Int J Mol Sci. 2016;17:576 pubmed publisher
    ..Further studies are required to determine the in vivo relevance of these findings to avoid the hazards of ingested particles. ..
  5. Yoshida T, Kato K, Oguri M, Horibe H, Kawamiya T, Yokoi K, et al. Association of polymorphisms of BTN2A1 and ILF3 with myocardial infarction in Japanese individuals with different lipid profiles. Mol Med Rep. 2011;4:511-8 pubmed publisher
    ..Stratification of subjects according to lipid profiles may thus be useful for the personalized prevention of MI based on genetic information. ..
  6. request reprint
    Yamada Y, Matsuo H, Watanabe S, Kato K, Yajima K, Hibino T, et al. Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus. Int J Mol Med. 2007;20:703-7 pubmed
    ..Genotyping for CYP3A4 may thus prove informative for assessment of the genetic risk for type 2 diabetes mellitus. ..
  7. Yamada Y, Nishida T, Ichihara S, Sawabe M, Fuku N, Nishigaki Y, et al. Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations. Atherosclerosis. 2011;215:145-52 pubmed publisher
    ..However, the association of neither rs6929846 nor rs2569512 with MI was replicated in the Korean population. BTN2A1 may be a susceptibility gene for MI in Japanese individuals. ..
  8. Yamada Y, Metoki N, Yoshida H, Satoh K, Kato K, Hibino T, et al. Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals. Stroke. 2008;39:2211-8 pubmed publisher
    ..We performed an association study to identify gene polymorphisms that confer susceptibility to atherothrombotic cerebral infarction, intracerebral hemorrhage, or subarachnoid hemorrhage...
  9. request reprint
    Yamada Y, Kato K, Oguri M, Fujimaki T, Yokoi K, Matsuo H, et al. Genetic risk for myocardial infarction determined by polymorphisms of candidate genes in a Japanese population. J Med Genet. 2008;45:216-21 pubmed
    ..Although several environmental factors influence the development of myocardial infarction (MI), genetic factors have been shown to contribute to individual susceptibility to this condition...

More Information

Publications28

  1. request reprint
    Yamada Y, Ando F, Shimokata H. Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men. Int J Mol Med. 2007;19:791-801 pubmed
    ..The polymorphisms of ICAM1 and CNR2 may confer susceptibility to postmenopausal osteoporosis in women, and that of GJA4 to osteoporosis in men. ..
  2. request reprint
    Yamada Y, Ando F, Niino N, Shimokata H. Association of polymorphisms of the androgen receptor and klotho genes with bone mineral density in Japanese women. J Mol Med (Berl). 2005;83:50-7 pubmed
    ..These results suggest that AR is a susceptibility gene for reduced BMD in premenopausal Japanese women, and that KL is a susceptibility gene for reduced BMD in all women. ..
  3. request reprint
    Yamada Y, Ando F, Shimokata H. Association of polymorphisms in forkhead box C2 and perilipin genes with bone mineral density in community-dwelling Japanese individuals. Int J Mol Med. 2006;18:119-27 pubmed
    ..This polymorphism of PLIN was not associated with BMD in all women. These results suggest that FOXC2 is a susceptibility locus for reduced BMD in Japanese men and women, and that PLIN constitutes such a locus in Japanese men. ..
  4. Nishizawa D, Kasai S, Hasegawa J, Sato N, Yamada H, Tanioka F, et al. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. Mol Brain. 2015;8:50 pubmed publisher
  5. Yamada Y, Nishida T, Ichihara S, Kato K, Fujimaki T, Oguri M, et al. Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study. J Med Genet. 2013;50:410-8 pubmed publisher
    ..Chromosome 3q28 may be a susceptibility locus for CKD in Japanese individuals, and ALPK1 may be a susceptibility gene for CKD in such individuals with diabetes mellitus. ..
  6. Yamada Y, Fuku N, Tanaka M, Aoyagi Y, Sawabe M, Metoki N, et al. Identification of CELSR1 as a susceptibility gene for ischemic stroke in Japanese individuals by a genome-wide association study. Atherosclerosis. 2009;207:144-9 pubmed publisher
    ..CELSR1 is a susceptibility gene for ischemic stroke in Japanese individuals, although the functional relevance of the identified SNPs was not determined. ..
  7. Yamada Y, Ando F, Shimokata H. Association of polymorphisms of SORBS1, GCK and WISP1 with hypertension in community-dwelling Japanese individuals. Hypertens Res. 2009;32:325-31 pubmed publisher
    ..These results suggest that SORBS1 and GCK are susceptibility loci for hypertension in Japanese women and that WISP1 is such a locus in men. ..
  8. request reprint
    Yamada Y, Matsuo H, Warita S, Watanabe S, Kato K, Oguri M, et al. Prediction of genetic risk for dyslipidemia. Genomics. 2007;90:551-8 pubmed
  9. request reprint
    Yamada Y, Ichihara S, Izawa H, Tanaka M, Yokota M. Genetic risk for coronary artery disease in individuals with or without type 2 diabetes. Mol Genet Metab. 2004;81:282-90 pubmed
    ..Genotyping of these polymorphisms may prove informative for assessment of the genetic risk for CAD in the absence or presence of type 2 diabetes. ..
  10. request reprint
    Yamada Y, Matsuo H, Segawa T, Watanabe S, Kato K, Hibino T, et al. Assessment of genetic risk for myocardial infarction. Thromb Haemost. 2006;96:220-7 pubmed
    ..Determination of the combined genotype for these genes may contribute to primary, personalized prevention of this condition. ..
  11. request reprint
    Yamada Y, Banno Y, Yoshida H, Kikuchi R, Akao Y, Murate T, et al. Catalytic inactivation of human phospholipase D2 by a naturally occurring Gly901Asp mutation. Arch Med Res. 2006;37:696-9 pubmed
    ..The G-->A (Gly901Asp) mutation of the human PLD2 gene was found to result in catalytic inactivation of the encoded protein. ..
  12. request reprint
    Yamada Y, Kato K, Yoshida T, Yokoi K, Matsuo H, Watanabe S, et al. Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals. Int J Mol Med. 2008;21:83-9 pubmed
    ..Determination of genotypes for ABCA1 and ROS1 may thus prove informative for the prediction of the genetic risk for hypertension...
  13. request reprint
    Yamada Y, Kato K, Oguri M, Yoshida T, Yokoi K, Watanabe S, et al. Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome. Int J Mol Med. 2008;21:801-8 pubmed
    ..Genotypes for these polymorphisms, especially for the 2445G-->A (Ala54Thr) polymorphism of FABP2, may prove informative for the prediction of genetic risk for atherothrombotic cerebral infarction among such individuals. ..
  14. request reprint
    Yamada Y, Ichihara S, Kato K, Yoshida T, Yokoi K, Matsuo H, et al. Genetic risk for metabolic syndrome: examination of candidate gene polymorphisms related to lipid metabolism in Japanese people. J Med Genet. 2008;45:22-8 pubmed
    ..APOA5, LDLR, CYP3A4 and C1QTNF5 are susceptibility loci for metabolic syndrome in Japanese people. Genotypes for these polymorphisms may prove informative for prediction of genetic risk for metabolic syndrome. ..
  15. request reprint
    Yamada Y, Metoki N, Yoshida H, Satoh K, Ichihara S, Kato K, et al. Genetic risk for ischemic and hemorrhagic stroke. Arterioscler Thromb Vasc Biol. 2006;26:1920-5 pubmed
    ..Validation of our findings will require additional studies with independent subject panels. ..
  16. request reprint
    Yamada Y, Ando F, Shimokata H. Association of a microsomal triglyceride transfer protein gene polymorphism with blood pressure in Japanese women. Int J Mol Med. 2006;17:83-8 pubmed
    ..040) in postmenopausal women, with the TT genotype protecting against this condition. These results suggest that MTP genotype is a determinant of blood pressure in Japanese women. ..
  17. request reprint
    Yamada Y, Ando F, Shimokata H. Association of gene polymorphisms with blood pressure and the prevalence of hypertension in community-dwelling Japanese individuals. Int J Mol Med. 2007;19:675-83 pubmed
    ..These results suggest that polymorphisms of QPCT and CYP11B2 are determinants of BP and the development of hypertension in Japanese men. ..
  18. request reprint
    Yamada Y, Ando F, Shimokata H. Association of polymorphisms in CYP17A1, MTP, and VLDLR with bone mineral density in community-dwelling Japanese women and men. Genomics. 2005;86:76-85 pubmed
    ..These results suggest that CYP17A1 and MTP are susceptibility loci for increased BMD in postmenopausal and premenopausal Japanese women, respectively, and that VLDLR constitutes such a locus in Japanese men. ..
  19. request reprint
    Yamada Y. Identification of genetic factors and development of genetic risk diagnosis systems for cardiovascular diseases and stroke. Circ J. 2006;70:1240-8 pubmed
    ..Identification of gene polymorphisms that confer susceptibility to cardiovascular diseases or stroke and the development of genetic risk diagnosis systems may contribute to the personalized prevention of these conditions. ..