Toshio Tanaka

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. ncbi Pharmacogenomics and therapeutic target validation in cerebral vasospasm
    T Tanaka
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, Tsu, Japan
    J Cardiovasc Pharmacol 36:S1-4. 2000
  2. ncbi [Pharmacogenomics of cardiovascular pharmacology]
    Toshio Tanaka
    Nihon Yakurigaku Zasshi 128:130-2. 2006
  3. ncbi Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models
    Toshio Tanaka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Japan
    J Pharmacol Sci 107:8-14. 2008
  4. pmc In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish
    Kohei Watanabe
    Corporate R and D Headquarters, Canon Inc Tokyo, Ohta ku, Japan
    BMC Neurosci 13:101. 2012
  5. pmc Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish
    Takahiro Hasumura
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Nutr Metab (Lond) 9:73. 2012
  6. pmc Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model
    Toshiyuki Tainaka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan
    Nutr Metab (Lond) 8:88. 2011
  7. doi Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation
    Zhipeng Wang
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Gene 446:18-27. 2009
  8. ncbi Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4
    Yoshiyuki Ito
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University, Tsu, Japan
    BMB Rep 41:139-45. 2008
  9. pmc Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity
    Takehiko Oka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    BMC Physiol 10:21. 2010
  10. doi Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm
    Yasuhito Shimada
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Eur J Pharmacol 620:16-20. 2009

Collaborators

  • Liqing Zang
  • Takehiko Oka
  • Takeshi Miyazaki
  • Yoshiyuki Ito
  • Kohei Watanabe
  • Toru Maruyama
  • Akira Mizoguchi
  • Shinichi Meguro
  • Y Nishimura
  • Takashi Inoue
  • Yuichi Sugiyama
  • Zhipeng Wang
  • Gozoh Tsujimoto
  • Hirohisa Saito
  • Yasuhito Shimada
  • Junya Kuroyanagi
  • Beibei Zhang
  • Noriko Umemoto
  • Taichi Shintou
  • Michiko Ariyoshi
  • Tsuyoshi Nomoto
  • Minoru Hirano
  • Norihiro Nishimura
  • Shota Sasagawa
  • Miko Kawabata
  • Mari Kawai
  • Junsuke Arimitsu
  • Masanori Hiramitsu
  • Kenichiro Yata
  • Takahiro Hasumura
  • Toshiyuki Tainaka
  • Yukiho Imai
  • Shinji Higa
  • Atsushi Ogata
  • Yoshihito Shima
  • Toru Hirano
  • Tomoki Yamadori
  • Hiroshi Tsunoda
  • Ichiro Kawase
  • Michio Ogasawara
  • Tetsuo Kiso
  • Hirofumi Nikaido
  • Junko Koiwa
  • Tomokazu Hirota
  • Soichiro Murakami
  • Koki Kawaguchi
  • Reiko Kawase
  • Mizuki Yuge
  • Masayuki Miyabe
  • Hidekazu Tomimoto
  • Norihiro Suzuki
  • Masaaki Hayashi
  • Yutaka Tomita
  • Yoshiko Matsumoto
  • Akira Akasawa
  • Takao Katagiri
  • Tadahilo Oshida
  • Yuji Sugita
  • Masahiro Hamada
  • Miyuki Unekawa
  • Yukiko Yamanaka
  • Saki Ito
  • Zi Zhang
  • Yuuki Nakamura
  • Seiya Kishi
  • Kana Okamori
  • Yoshinori Takema
  • Michiru Maruta
  • Tomoharu Ohkawara
  • Keisuke Hagihara
  • Yusuke Kuwahara
  • Tetsuji Naka
  • Tomoharu Ohgawara
  • Keisuke Hagiwara
  • Yusuke Kuwabara
  • Sumihare Noji
  • Nori Satoh
  • Minoru Fujimoto
  • Makoto Taniguchi
  • Xu Ping
  • Takaaki Kirino
  • Ken ichi Fujita
  • Tomoko Kashiwabara
  • Shigemichi Gunji
  • Akiko Nakada
  • Takeshi Nagasu
  • Kenji Matsumoto
  • Ning Lu Yoshida
  • Kyo ichi Nishio
  • Masaya Obayashi

Detail Information

Publications44

  1. ncbi Pharmacogenomics and therapeutic target validation in cerebral vasospasm
    T Tanaka
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, Tsu, Japan
    J Cardiovasc Pharmacol 36:S1-4. 2000
    ....
  2. ncbi [Pharmacogenomics of cardiovascular pharmacology]
    Toshio Tanaka
    Nihon Yakurigaku Zasshi 128:130-2. 2006
  3. ncbi Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models
    Toshio Tanaka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Japan
    J Pharmacol Sci 107:8-14. 2008
    ..These results suggest that pharmacogenomic network analysis has the potential to bridge the gap between in vitro and in vivo studies and could define strategies for identifying novel drug targets in various cardiovascular diseases...
  4. pmc In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish
    Kohei Watanabe
    Corporate R and D Headquarters, Canon Inc Tokyo, Ohta ku, Japan
    BMC Neurosci 13:101. 2012
    ..Simple and reliable in vivo assays are necessary to identify compounds that can easily cross the BBB and BRB...
  5. pmc Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish
    Takahiro Hasumura
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Nutr Metab (Lond) 9:73. 2012
    ..abstract:..
  6. pmc Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model
    Toshiyuki Tainaka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan
    Nutr Metab (Lond) 8:88. 2011
    ..abstract:..
  7. doi Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation
    Zhipeng Wang
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Gene 446:18-27. 2009
    ..Our data suggest that adrb2a may regulate pigmentation, partly by modulating F1F0-ATPase...
  8. ncbi Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4
    Yoshiyuki Ito
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University, Tsu, Japan
    BMB Rep 41:139-45. 2008
    ..These results reveal that cell proliferation via CysLT2 signaling was mediated by Gi/o signaling but independent of calcium mobilization...
  9. pmc Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity
    Takehiko Oka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    BMC Physiol 10:21. 2010
    ..The purpose of this study was to establish a zebrafish model of diet-induced obesity (DIO)...
  10. doi Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm
    Yasuhito Shimada
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Eur J Pharmacol 620:16-20. 2009
    ....
  11. doi In Vivo Detection of Mitochondrial Dysfunction Induced by Clinical Drugs and Disease-Associated Genes Using a Novel Dye ZMJ214 in Zebrafish
    Shota Sasagawa
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharamacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    ACS Chem Biol 11:381-8. 2016
    ..These results suggest that ZMJ214 can be a useful tool to identify chemicals and genes that cause mitochondrial dysfunction in vivo. ..
  12. pmc Fluorescent-based methods for gene knockdown and functional cardiac imaging in zebrafish
    Noriko Umemoto
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Mol Biotechnol 55:131-42. 2013
    ..Our combinatorial approach can be applied for analyzing the molecular function of any protein associated with human cardiac diseases...
  13. doi In vivo selective imaging and inhibition of leukemia stem-like cells using the fluorescent carbocyanine derivative, DiOC5(3)
    Beibei Zhang
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Biomaterials 52:14-25. 2015
    ..In summary, DiOC5(3) is a new type of anti-LSC compound available for diagnostic imaging and therapeutics that has the advantage of being a single fluorescent chemical. ..
  14. ncbi [Genomic drug discovery of vascular remodeling]
    Toshio Tanaka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Division of Genomics and Regenerative Medicine, Mie University Graduate School of Medicine
    Nihon Rinsho 64:576-82. 2006
  15. pmc Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis
    Masanori Hiramitsu
    1 Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan 2 Central Laboratory, Pokka Sapporo Food and Beverage Ltd, Aichi, Japan 3
    Sci Rep 4:3708. 2014
    ..In summary, dietary eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis...
  16. doi Zebrafish xenotransplantation model for cancer stem-like cell study and high-throughput screening of inhibitors
    Beibei Zhang
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan
    Tumour Biol 35:11861-9. 2014
    ..In summary, these zebrafish xenotransplantation models devote a good platform for the CSC mechanism investigation and anti-CSC inhibitor screening. ..
  17. ncbi Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression
    Minoru Hirano
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu Mei 514 8507, Japan
    Biochem Biophys Res Commun 351:185-91. 2006
    ..We first report the novel negative feedback model of cAMP signaling through GPRC5A gene expression. This evidence explains one of the mechanisms of the GPRC5A-regulated cell growth in some cancer cell lines...
  18. pmc In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives
    Kohei Watanabe
    Department of Molecular and Cellular Pharmacology, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    BMC Neurosci 11:116. 2010
    ..However, these fluorescent molecules also localize to the interstitial fluid and stain whole larvae...
  19. pmc A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening
    Yasuhito Shimada
    Department of Molecular and Cellular Pharmacology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    PLoS ONE 7:e52549. 2012
    ..In conclusion, we have developed an assay that uses zebrafish, which can be applied to high-throughput screening and target gene discovery for appetite suppressants and enhancers...
  20. doi Zinc finger MYND-type containing 8 promotes tumour angiogenesis via induction of vascular endothelial growth factor-A expression
    Junya Kuroyanagi
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    FEBS Lett 588:3409-16. 2014
    ..Integrated analysis of human and zebrafish transcriptomes, which identified ZMYND8, might be a powerful strategy to determine also other molecular targets for inhibiting prostate cancer progression. ..
  21. ncbi Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage
    Hirofumi Nikaido
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, Tsu, Mie, Japan
    Circulation 110:1839-46. 2004
    ..We therefore elucidated the role of the HSP72 gene in cerebral vasospasm in a rat experimental SAH model...
  22. pmc Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models
    Yuhei Nishimura
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    ACS Chem Neurosci 4:1183-93. 2013
    ..The strategy used in this study can also be applied to diversity-oriented libraries to identify novel fluorescent tracers that may be superior to ZMB741. ..
  23. doi Novel immunologic tolerance of human cancer cell xenotransplants in zebrafish
    Beibei Zhang
    Department of Molecular and Cellular Pharmacology, Mie University Graduate School of Medicine, Mie, Japan Department of Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan
    Transl Res 170:89-98.e3. 2016
    ..In conclusion, this xenograft method has potential as a platform for zebrafish-based anticancer drug discovery because it can closely mimic human clinical cancers without inducing immune suppression. ..
  24. doi Downregulation of stanniocalcin 1 is responsible for sorafenib-induced cardiotoxicity
    Miko Kawabata
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Department of Clinical Anesthesiology, Department of Systems Pharmacology, Mie University Graduate School of Medicine, Mie 514 8507, Japan, Mie University Medical Zebrafish Research Center, Mie 514 8507, Japan, Department of Bioinformatics, Mie University Life Science Research Center, Mie 514 8507, Japan and Department of Omics Medicine, Mie University Industrial Technology Innovation, Mie 514 8507, Japan Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Department of Clinical Anesthesiology, Department of Systems Pharmacology, Mie University Graduate School of Medicine, Mie 514 8507, Japan, Mie University Medical Zebrafish Research Center, Mie 514 8507, Japan, Department of Bioinformatics, Mie University Life Science Research Center, Mie 514 8507, Japan and Department of Omics Medicine, Mie University Industrial Technology Innovation, Mie 514 8507, Japan
    Toxicol Sci 143:374-84. 2015
    ..We discovered for the first time that STC1 downregulation is responsible for sorafenib-induced cardiotoxicity through activated ROS generation. ..
  25. doi A novel, reliable method for repeated blood collection from aquarium fish
    Liqing Zang
    Department of Translational Medical Science, Mie University, Tsu, Japan
    Zebrafish 10:425-32. 2013
    ....
  26. pmc Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers
    Yuhei Nishimura
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine Tsu, Japan Mie University Medical Zebrafish Research Center Tsu, Japan Department of Systems Pharmacology, Mie University Graduate School of Medicine Tsu, Japan Department of Omics Medicine, Mie University Industrial Technology Innovation Institute Tsu, Japan Department of Bioinformatics, Mie University Life Science Research Center Tsu, Japan
    Front Pharmacol 6:257. 2015
    ....
  27. doi Using zebrafish in systems toxicology for developmental toxicity testing
    Yuhei Nishimura
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie
    Congenit Anom (Kyoto) 56:18-27. 2016
    ..Zebrafish as a systems toxicology model has the potential to elucidate developmental toxicity pathways, and to provide a sound basis for human health risk assessments. ..
  28. pmc Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation
    Beibei Zhang
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Edobashi, Tsu, Mie, Japan
    PLoS ONE 9:e85439. 2014
    ..Our approach offers a simple, rapid, and reliable in vivo screening system that facilitates the phenotype-driven discovery of drugs effective in suppressing LSCs. ..
  29. ncbi [Pharmacogenomics: the frontiers of genome medicine]
    Toshio Tanaka
    Molecular and Cellular Pharmacology, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Nihon Yakurigaku Zasshi 120:141-8. 2002
    ..Pharmacogenomics and pharmainformatics enable us to move quickly and efficiently from targets to appropriate medicines...
  30. ncbi [Pharmacoinformatics and pharmacogenomics]
    Toshio Tanaka
    Nihon Yakurigaku Zasshi 126:113-6. 2005
  31. doi Zebrafish as a systems toxicology model for developmental neurotoxicity testing
    Yuhei Nishimura
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Japan Mie University Medical Zebrafish Research Center, Tsu, Japan Depertment of Systems Pharmacology, Mie University Graduate School of Medicine, Tsu, Japan Department of Omics Medicine, Mie University Industrial Technology Innovation Institute, Tsu, Japan Department of Bioinformatics, Mie University Life Science Research Center, Tsu, Japan
    Congenit Anom (Kyoto) 55:1-16. 2015
    ..Zebrafish may be a systems toxicology model that has the potential to reveal the pathways of developmental neurotoxicity and to provide a sound basis for human risk assessments. ..
  32. ncbi [Pharmacogenomics and pharmainformatics]
    Toshio Tanaka
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine
    Nihon Rinsho 60:39-50. 2002
    ..1) J Clin Invest 104: 59-66, 1999. (2) J Biol Chem 276: 19921-19928, 2001. (3) J Cardiovasc Pharm 36: S1-S4, 2000...
  33. doi A novel protocol for the oral administration of test chemicals to adult zebrafish
    Liqing Zang
    Department of Translational Medical Science, Graduate School of Medicine, Mie University, Mie 514 8507, Japan
    Zebrafish 8:203-10. 2011
    ....
  34. doi In vivo imaging of the mouse neurovascular unit under chronic cerebral hypoperfusion
    Kenichiro Yata
    From the Department of Neurology K Y, H T, Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics Y N, T T, and Department of Neural Regeneration and Cell Communication A M, Mie University Graduate School of Medicine, Tsu, Mie, Japan and Department of Neurology, Keio University School of Medicine, Shinjuku, Tokyo, Japan M U, Y T, N S
    Stroke 45:3698-703. 2014
    ..Therefore, we established an in vivo imaging method and clarified the NVU response to chronic cerebral hypoperfusion...
  35. doi Zebrafish-based systems pharmacology of cancer metastasis
    Yasuhito Shimada
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Methods Mol Biol 1165:223-38. 2014
    ..In the current chapter, we describe the methods for human cancer cell xenotransplantation into zebrafish, phenotypic image analysis, and transcriptome analysis using deep sequencing. ..
  36. ncbi Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene
    Masaaki Hayashi
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, 2 174 Edobashi, Tsu, 514 8507, Mie, Japan
    Biochem Biophys Res Commun 297:1253-8. 2002
    ..These findings suggest that selective usage of exons produces three different PDE8B variants that exhibit a tissue-specific expression pattern...
  37. ncbi [Therapeutic gene clusters as drug action mechanisms]
    Toshio Tanaka
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, Edobashi, Tsu, Mie, 514 8507, Japan
    Nihon Yakurigaku Zasshi 122:5P-7P. 2003
    ..These techniques provided an excellent strategy for screening and validation of targets...
  38. ncbi Flavonoids and related compounds as anti-allergic substances
    Mari Kawai
    Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka, Japan
    Allergol Int 56:113-23. 2007
    ..Clinical studies to verify these points are now in progress...
  39. ncbi IL-18 gene polymorphisms affect IL-18 production capability by monocytes
    Junsuke Arimitsu
    Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 342:1413-6. 2006
    ..Thus, the genetic capacity to produce more IL-18 in response to stimuli may affect the onset of asthma...
  40. ncbi Rapid and stable buffer exchange system using InSitu Chip suitable for multicolor and large-scale whole-mount analyses
    Michio Ogasawara
    Department of Biology, Faculty of Science, Chiba University, Inage Ku, Japan
    Dev Genes Evol 216:100-4. 2006
    ..Using the InSitu Chip, about 1,500 gene expression patterns were stably surveyed in ascidian Ciona intestinalis juveniles...
  41. ncbi Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells
    Masahiro Hamada
    Department of Bio and Geoscience, Graduate School of Science, Osaka City University, 3 3 138 Sugimoto, Sumiyoshi ku, Osaka 558 8585, Japan
    FEBS Lett 514:250-4. 2002
    ..FPy exhibited a cytochalasin-like effect on spatial arrangement of actin filament independent of its apoptosis-inducing activity...
  42. ncbi Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients
    Yukiho Imai
    Genox Research, Inc, Teikyo University Biotech Center, 907 Nogawa, Miyamae, Kawasaki, 216 0001, Kanagawa, Japan
    Biochem Biophys Res Commun 297:1282-90. 2002
    ..The enhanced expression of ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients...
  43. pmc Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss
    Tetsuo Kiso
    Department of Bio and Geoscience, Graduate School of Science, Osaka City University, Sumiyoshi ku, Osaka 558 8585, Japan
    Antimicrob Agents Chemother 48:1739-48. 2004
    ....
  44. ncbi Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis
    Yoshiko Matsumoto
    Genox Research, Inc, Teikyo University Biotech Center, Kawasaki, Kanagawa, Japan
    Int Arch Allergy Immunol 129:327-40. 2002
    ..Analysis of genes that are differentially expressed in patients with atopic dermatitis (AD) and normal individuals will provide important information on the underlying molecular pathogenetic mechanisms of AD...