Toshio Tanaka

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. ncbi request reprint Pharmacogenomics and therapeutic target validation in cerebral vasospasm
    T Tanaka
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, Tsu, Japan
    J Cardiovasc Pharmacol 36:S1-4. 2000
  2. ncbi request reprint [Pharmacogenomics of cardiovascular pharmacology]
    Toshio Tanaka
    Nihon Yakurigaku Zasshi 128:130-2. 2006
  3. ncbi request reprint Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models
    Toshio Tanaka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Japan
    J Pharmacol Sci 107:8-14. 2008
  4. pmc Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis
    Masanori Hiramitsu
    1 Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan 2 Central Laboratory, Pokka Sapporo Food and Beverage Ltd, Aichi, Japan 3
    Sci Rep 4:3708. 2014
  5. pmc Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation
    Beibei Zhang
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Edobashi, Tsu, Mie, Japan
    PLoS ONE 9:e85439. 2014
  6. pmc A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening
    Yasuhito Shimada
    Department of Molecular and Cellular Pharmacology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    PLoS ONE 7:e52549. 2012
  7. pmc In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish
    Kohei Watanabe
    Corporate R and D Headquarters, Canon Inc Tokyo, Ohta ku, Japan
    BMC Neurosci 13:101. 2012
  8. pmc Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish
    Takahiro Hasumura
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Nutr Metab (Lond) 9:73. 2012
  9. pmc Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model
    Toshiyuki Tainaka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan
    Nutr Metab (Lond) 8:88. 2011
  10. doi request reprint Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation
    Zhipeng Wang
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Gene 446:18-27. 2009

Collaborators

  • Liqing Zang
  • Takehiko Oka
  • Yoshiyuki Ito
  • Kohei Watanabe
  • Takeshi Miyazaki
  • Y Nishimura
  • Shinichi Meguro
  • Takashi Inoue
  • Yuichi Sugiyama
  • Zhipeng Wang
  • Gozoh Tsujimoto
  • Hirohisa Saito
  • Yasuhito Shimada
  • Junya Kuroyanagi
  • Minoru Hirano
  • Noriko Umemoto
  • Norihiro Nishimura
  • Mari Kawai
  • Junsuke Arimitsu
  • Masanori Hiramitsu
  • Beibei Zhang
  • Takahiro Hasumura
  • Toshiyuki Tainaka
  • Yukiho Imai
  • Ichiro Kawase
  • Tomoki Yamadori
  • Hiroshi Tsunoda
  • Toru Hirano
  • Shinji Higa
  • Yoshihito Shima
  • Atsushi Ogata
  • Michio Ogasawara
  • Hirofumi Nikaido
  • Tetsuo Kiso
  • Masaaki Hayashi
  • Masahiro Hamada
  • Yuji Sugita
  • Yoshiko Matsumoto
  • Akira Akasawa
  • Tadahilo Oshida
  • Takao Katagiri
  • Saki Ito
  • Seiya Kishi
  • Zi Zhang
  • Kana Okamori
  • Yukiko Yamanaka
  • Yuuki Nakamura
  • Yoshinori Takema
  • Tomoharu Ohkawara
  • Keisuke Hagihara
  • Yusuke Kuwahara
  • Michiru Maruta
  • Nori Satoh
  • Minoru Fujimoto
  • Sumihare Noji
  • Yusuke Kuwabara
  • Keisuke Hagiwara
  • Tetsuji Naka
  • Tomoharu Ohgawara
  • Makoto Taniguchi
  • Ken ichi Fujita
  • Takaaki Kirino
  • Xu Ping
  • Tomoko Kashiwabara
  • Toshio Katsunuma
  • Kyo ichi Nishio
  • Takeshi Nagasu
  • Matsumi Doe
  • Akiko Nakada
  • Kenji Matsumoto
  • Naoko Nagata
  • Yoshinosuke Usuki
  • Izumi Obayashi
  • Ryoichi Hashida
  • Takaaki Hama
  • Kaoru Ogawa
  • Shigemichi Gunji
  • Masaya Obayashi
  • Ning Lu Yoshida
  • Keiko Matsui

Detail Information

Publications34

  1. ncbi request reprint Pharmacogenomics and therapeutic target validation in cerebral vasospasm
    T Tanaka
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, Tsu, Japan
    J Cardiovasc Pharmacol 36:S1-4. 2000
    ....
  2. ncbi request reprint [Pharmacogenomics of cardiovascular pharmacology]
    Toshio Tanaka
    Nihon Yakurigaku Zasshi 128:130-2. 2006
  3. ncbi request reprint Pharmacogenomics of cardiovascular pharmacology: pharmacogenomic network of cardiovascular disease models
    Toshio Tanaka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Japan
    J Pharmacol Sci 107:8-14. 2008
    ..These results suggest that pharmacogenomic network analysis has the potential to bridge the gap between in vitro and in vivo studies and could define strategies for identifying novel drug targets in various cardiovascular diseases...
  4. pmc Eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis
    Masanori Hiramitsu
    1 Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan 2 Central Laboratory, Pokka Sapporo Food and Beverage Ltd, Aichi, Japan 3
    Sci Rep 4:3708. 2014
    ..In summary, dietary eriocitrin ameliorates diet-induced hepatic steatosis with activation of mitochondrial biogenesis...
  5. pmc Quantitative phenotyping-based in vivo chemical screening in a zebrafish model of leukemia stem cell xenotransplantation
    Beibei Zhang
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Edobashi, Tsu, Mie, Japan
    PLoS ONE 9:e85439. 2014
    ..Our approach offers a simple, rapid, and reliable in vivo screening system that facilitates the phenotype-driven discovery of drugs effective in suppressing LSCs. ..
  6. pmc A high-throughput fluorescence-based assay system for appetite-regulating gene and drug screening
    Yasuhito Shimada
    Department of Molecular and Cellular Pharmacology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    PLoS ONE 7:e52549. 2012
    ..In conclusion, we have developed an assay that uses zebrafish, which can be applied to high-throughput screening and target gene discovery for appetite suppressants and enhancers...
  7. pmc In vivo assessment of the permeability of the blood-brain barrier and blood-retinal barrier to fluorescent indoline derivatives in zebrafish
    Kohei Watanabe
    Corporate R and D Headquarters, Canon Inc Tokyo, Ohta ku, Japan
    BMC Neurosci 13:101. 2012
    ..Simple and reliable in vivo assays are necessary to identify compounds that can easily cross the BBB and BRB...
  8. pmc Green tea extract suppresses adiposity and affects the expression of lipid metabolism genes in diet-induced obese zebrafish
    Takahiro Hasumura
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Nutr Metab (Lond) 9:73. 2012
    ..abstract:..
  9. pmc Transcriptome analysis of anti-fatty liver action by Campari tomato using a zebrafish diet-induced obesity model
    Toshiyuki Tainaka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Mie, Japan
    Nutr Metab (Lond) 8:88. 2011
    ..abstract:..
  10. doi request reprint Zebrafish beta-adrenergic receptor mRNA expression and control of pigmentation
    Zhipeng Wang
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Gene 446:18-27. 2009
    ..Our data suggest that adrb2a may regulate pigmentation, partly by modulating F1F0-ATPase...
  11. ncbi request reprint Guinea pig cysteinyl leukotriene receptor 2 (gpCysLT2) mediates cell proliferation and intracellular calcium mobilization by LTC4 and LTD4
    Yoshiyuki Ito
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University, Tsu, Japan
    BMB Rep 41:139-45. 2008
    ..These results reveal that cell proliferation via CysLT2 signaling was mediated by Gi/o signaling but independent of calcium mobilization...
  12. pmc Diet-induced obesity in zebrafish shares common pathophysiological pathways with mammalian obesity
    Takehiko Oka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    BMC Physiol 10:21. 2010
    ..The purpose of this study was to establish a zebrafish model of diet-induced obesity (DIO)...
  13. ncbi request reprint [Genomic drug discovery of vascular remodeling]
    Toshio Tanaka
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Division of Genomics and Regenerative Medicine, Mie University Graduate School of Medicine
    Nihon Rinsho 64:576-82. 2006
  14. doi request reprint Synergistic induction of heme oxygenase-1 by nicaraven after subarachnoid hemorrhage to prevent delayed cerebral vasospasm
    Yasuhito Shimada
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Eur J Pharmacol 620:16-20. 2009
    ....
  15. pmc Fluorescent-based methods for gene knockdown and functional cardiac imaging in zebrafish
    Noriko Umemoto
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Mol Biotechnol 55:131-42. 2013
    ..Our combinatorial approach can be applied for analyzing the molecular function of any protein associated with human cardiac diseases...
  16. pmc In vivo imaging of zebrafish retinal cells using fluorescent coumarin derivatives
    Kohei Watanabe
    Department of Molecular and Cellular Pharmacology, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    BMC Neurosci 11:116. 2010
    ..However, these fluorescent molecules also localize to the interstitial fluid and stain whole larvae...
  17. ncbi request reprint Potential role for heat shock protein 72 in antagonizing cerebral vasospasm after rat subarachnoid hemorrhage
    Hirofumi Nikaido
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, Tsu, Mie, Japan
    Circulation 110:1839-46. 2004
    ..We therefore elucidated the role of the HSP72 gene in cerebral vasospasm in a rat experimental SAH model...
  18. ncbi request reprint Novel reciprocal regulation of cAMP signaling and apoptosis by orphan G-protein-coupled receptor GPRC5A gene expression
    Minoru Hirano
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu Mei 514 8507, Japan
    Biochem Biophys Res Commun 351:185-91. 2006
    ..We first report the novel negative feedback model of cAMP signaling through GPRC5A gene expression. This evidence explains one of the mechanisms of the GPRC5A-regulated cell growth in some cancer cell lines...
  19. pmc Identification of a novel indoline derivative for in vivo fluorescent imaging of blood-brain barrier disruption in animal models
    Yuhei Nishimura
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    ACS Chem Neurosci 4:1183-93. 2013
    ..The strategy used in this study can also be applied to diversity-oriented libraries to identify novel fluorescent tracers that may be superior to ZMB741. ..
  20. ncbi request reprint A novel, reliable method for repeated blood collection from aquarium fish
    Liqing Zang
    Department of Translational Medical Science, Mie University, Tsu, Japan
    Zebrafish 10:425-32. 2013
    ....
  21. ncbi request reprint [Pharmacogenomics: the frontiers of genome medicine]
    Toshio Tanaka
    Molecular and Cellular Pharmacology, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Nihon Yakurigaku Zasshi 120:141-8. 2002
    ..Pharmacogenomics and pharmainformatics enable us to move quickly and efficiently from targets to appropriate medicines...
  22. ncbi request reprint [Pharmacoinformatics and pharmacogenomics]
    Toshio Tanaka
    Nihon Yakurigaku Zasshi 126:113-6. 2005
  23. ncbi request reprint [Pharmacogenomics and pharmainformatics]
    Toshio Tanaka
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine
    Nihon Rinsho 60:39-50. 2002
    ..1) J Clin Invest 104: 59-66, 1999. (2) J Biol Chem 276: 19921-19928, 2001. (3) J Cardiovasc Pharm 36: S1-S4, 2000...
  24. doi request reprint A novel protocol for the oral administration of test chemicals to adult zebrafish
    Liqing Zang
    Department of Translational Medical Science, Graduate School of Medicine, Mie University, Mie 514 8507, Japan
    Zebrafish 8:203-10. 2011
    ....
  25. ncbi request reprint Zebrafish-based systems pharmacology of cancer metastasis
    Yasuhito Shimada
    Department of Molecular and Cellular Pharmacology, Pharmacogenomics and Pharmacoinformatics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Methods Mol Biol 1165:223-38. 2014
    ..In the current chapter, we describe the methods for human cancer cell xenotransplantation into zebrafish, phenotypic image analysis, and transcriptome analysis using deep sequencing. ..
  26. ncbi request reprint Genomic organization, chromosomal localization, and alternative splicing of the human phosphodiesterase 8B gene
    Masaaki Hayashi
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, 2 174 Edobashi, Tsu, 514 8507, Mie, Japan
    Biochem Biophys Res Commun 297:1253-8. 2002
    ..These findings suggest that selective usage of exons produces three different PDE8B variants that exhibit a tissue-specific expression pattern...
  27. ncbi request reprint [Therapeutic gene clusters as drug action mechanisms]
    Toshio Tanaka
    Department of Molecular and Cellular Pharmacology, Mie University School of Medicine, Edobashi, Tsu, Mie, 514 8507, Japan
    Nihon Yakurigaku Zasshi 122:5P-7P. 2003
    ..These techniques provided an excellent strategy for screening and validation of targets...
  28. ncbi request reprint Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis
    Yoshiko Matsumoto
    Genox Research, Inc, Teikyo University Biotech Center, Kawasaki, Kanagawa, Japan
    Int Arch Allergy Immunol 129:327-40. 2002
    ..Analysis of genes that are differentially expressed in patients with atopic dermatitis (AD) and normal individuals will provide important information on the underlying molecular pathogenetic mechanisms of AD...
  29. ncbi request reprint IL-18 gene polymorphisms affect IL-18 production capability by monocytes
    Junsuke Arimitsu
    Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 342:1413-6. 2006
    ..Thus, the genetic capacity to produce more IL-18 in response to stimuli may affect the onset of asthma...
  30. ncbi request reprint Farnesylpyridinium, an analog of isoprenoid farnesol, induces apoptosis but suppresses apoptotic body formation in human promyelocytic leukemia cells
    Masahiro Hamada
    Department of Bio and Geoscience, Graduate School of Science, Osaka City University, 3 3 138 Sugimoto, Sumiyoshi ku, Osaka 558 8585, Japan
    FEBS Lett 514:250-4. 2002
    ..FPy exhibited a cytochalasin-like effect on spatial arrangement of actin filament independent of its apoptosis-inducing activity...
  31. ncbi request reprint Flavonoids and related compounds as anti-allergic substances
    Mari Kawai
    Department of Respiratory Medicine, Allergy and Rheumatic Diseases, Osaka University Medical School, Osaka, Japan
    Allergol Int 56:113-23. 2007
    ..Clinical studies to verify these points are now in progress...
  32. pmc Screening for microtubule-disrupting antifungal agents by using a mitotic-arrest mutant of Aspergillus nidulans and novel action of phenylalanine derivatives accompanying tubulin loss
    Tetsuo Kiso
    Department of Bio and Geoscience, Graduate School of Science, Osaka City University, Sumiyoshi ku, Osaka 558 8585, Japan
    Antimicrob Agents Chemother 48:1739-48. 2004
    ....
  33. ncbi request reprint Cloning and characterization of the highly expressed ETEA gene from blood cells of atopic dermatitis patients
    Yukiho Imai
    Genox Research, Inc, Teikyo University Biotech Center, 907 Nogawa, Miyamae, Kawasaki, 216 0001, Kanagawa, Japan
    Biochem Biophys Res Commun 297:1282-90. 2002
    ..The enhanced expression of ETEA may play a role in the regulating the resistance to apoptosis that is observed in T cells and eosinophils of AD patients...
  34. ncbi request reprint Rapid and stable buffer exchange system using InSitu Chip suitable for multicolor and large-scale whole-mount analyses
    Michio Ogasawara
    Department of Biology, Faculty of Science, Chiba University, Inage Ku, Japan
    Dev Genes Evol 216:100-4. 2006
    ..Using the InSitu Chip, about 1,500 gene expression patterns were stably surveyed in ascidian Ciona intestinalis juveniles...