Katsuya Shiraki

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. ncbi request reprint Clinical utility of transarterial infusion chemotherapy using cisplatin-lipiodol emulsion for unresectable hepatocellular carcinoma
    Tetsuya Beppu
    Department of Gastroenterology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Anticancer Res 32:4923-30. 2012
  2. pmc Impact of chronic kidney disease on the presence and severity of aortic stenosis in patients at high risk for coronary artery disease
    Chiaki Masuda
    Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Japan
    Cardiovasc Ultrasound 9:31. 2011
  3. ncbi request reprint Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Mol Med 12:705-8. 2003
  4. ncbi request reprint Cellular apoptosis susceptibility protein and proliferation in human hepatocellular carcinoma
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Int J Mol Med 18:77-81. 2006
  5. ncbi request reprint CD40 expression in HCV-associated chronic liver diseases
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Int J Mol Med 18:559-63. 2006
  6. ncbi request reprint Detection of precore-mutant hepatitis B virus genome in patients with acute and fulminant hepatitis using mutation site-specific assay (MSSA)
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Tsu 514 8507, Japan
    Hepatogastroenterology 49:1352-6. 2002
  7. ncbi request reprint Expression of TNF-related apoptosis-inducing ligand in human hepatocellular carcinoma
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Oncol 26:1273-81. 2005
  8. ncbi request reprint Hepatic intravascular large B cell lymphoma
    Katsuya Shiraki
    Department of Gastroenterology, Mie University School of Medicine, Tsu
    Intern Med 46:1761-2. 2007
  9. doi request reprint Images in clinical medicine. Sclerosing peritonitis
    Katsuya Shiraki
    Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    N Engl J Med 359:293. 2008
  10. ncbi request reprint Different effects of bile acids, ursodeoxycholic acid and deoxycholic acid, on cell growth and cell death in human colonic adenocarcinoma cells
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Int J Mol Med 16:729-33. 2005

Collaborators

Detail Information

Publications85

  1. ncbi request reprint Clinical utility of transarterial infusion chemotherapy using cisplatin-lipiodol emulsion for unresectable hepatocellular carcinoma
    Tetsuya Beppu
    Department of Gastroenterology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Anticancer Res 32:4923-30. 2012
    ..We evaluated the clinical efficacy of transarterial infusion chemotherapy using a cisplatin-lipiodol emulsion for unresectable hepatocellular carcinoma (HCC)...
  2. pmc Impact of chronic kidney disease on the presence and severity of aortic stenosis in patients at high risk for coronary artery disease
    Chiaki Masuda
    Department of Molecular and Laboratory Medicine, Mie University Graduate School of Medicine, Japan
    Cardiovasc Ultrasound 9:31. 2011
    ..We evaluated the impact of chronic kidney disease (CKD) on the presence and severity of aortic stenosis (AS) in patients at high risk for coronary artery disease (CAD)...
  3. ncbi request reprint Overexpression of X-linked inhibitor of apoptosis in human hepatocellular carcinoma
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Mol Med 12:705-8. 2003
    ..These results indicated that XIAP is a principal inhibitor of apoptosis overexpressed in human HCCs and that XIAP may be a potential target for gene therapy of human HCCs...
  4. ncbi request reprint Cellular apoptosis susceptibility protein and proliferation in human hepatocellular carcinoma
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Int J Mol Med 18:77-81. 2006
    ..CAS may be associated with cell proliferation rather than apoptosis, and further, CAS might play an important role in the development of human HCCs...
  5. ncbi request reprint CD40 expression in HCV-associated chronic liver diseases
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Int J Mol Med 18:559-63. 2006
    ..These results suggest that hepatocyte over-expression of CD40 might play an important role in regulating hepatocyte survival and death in HCV-associated chronic liver diseases...
  6. ncbi request reprint Detection of precore-mutant hepatitis B virus genome in patients with acute and fulminant hepatitis using mutation site-specific assay (MSSA)
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Tsu 514 8507, Japan
    Hepatogastroenterology 49:1352-6. 2002
    ..In this study, we analyzed the occurrence of precore mutants in patients with acute and fulminant hepatitis B using new simple rapid and sensitive MSSA (mutation site-specific assay) and evaluated this method for predicting prognosis...
  7. ncbi request reprint Expression of TNF-related apoptosis-inducing ligand in human hepatocellular carcinoma
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Oncol 26:1273-81. 2005
    ....
  8. ncbi request reprint Hepatic intravascular large B cell lymphoma
    Katsuya Shiraki
    Department of Gastroenterology, Mie University School of Medicine, Tsu
    Intern Med 46:1761-2. 2007
  9. doi request reprint Images in clinical medicine. Sclerosing peritonitis
    Katsuya Shiraki
    Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    N Engl J Med 359:293. 2008
  10. ncbi request reprint Different effects of bile acids, ursodeoxycholic acid and deoxycholic acid, on cell growth and cell death in human colonic adenocarcinoma cells
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Int J Mol Med 16:729-33. 2005
    ..Bile acids play an important role in regulating cell survival and cell death in colon adenocarcinoma cells...
  11. ncbi request reprint Targeting of X-linked inhibitor of apoptosis protein or survivin by short interfering RNAs sensitize hepatoma cells to TNF-related apoptosis-inducing ligand- and chemotherapeutic agent-induced cell death
    Yumi Yamaguchi
    First Department of Internal Medicine, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Oncol Rep 14:1311-6. 2005
    ..In particular, the XIAP may be a potential target to increase therapeutic sensitivity...
  12. ncbi request reprint Functional cell surface expression of toll-like receptor 9 promotes cell proliferation and survival in human hepatocellular carcinomas
    Junichiro Tanaka
    Department of Gastroenterology, Mie Graduate University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Oncol 37:805-14. 2010
    ..In conclusion, our results indicate that functional cell surface expression of TLR9 in human HCC may play an important role in tumorigenesis and cancer progression...
  13. ncbi request reprint Involvement of tumor necrosis factor-related apoptosis-inducing ligand and tumor necrosis factor-related apoptosis-inducing ligand receptors in viral hepatic diseases
    Yukiko Saitou
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Hum Pathol 36:1066-73. 2005
    ..Transforming growth factor-beta1 also enhanced TRAIL expression in HepG2 cells. These results indicate that TRAIL/TRAIL-R apoptotic pathways play important roles in the hepatic cell death during viral infection...
  14. ncbi request reprint Cellular FLICE/caspase-8-inhibitory protein as a principal regulator of cell death and survival in human hepatocellular carcinoma
    Hiroshi Okano
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan
    Lab Invest 83:1033-43. 2003
    ..These results suggest that cFLIP plays an important role in cell survival not simply by inhibiting death-receptor-mediated apoptosis but also by regulating NF-kappaB activation in human HCCs...
  15. ncbi request reprint 15-deoxy-delta-12-14-PGJ2 regulates apoptosis induction and nuclear factor-kappaB activation via a peroxisome proliferator-activated receptor-gamma-independent mechanism in hepatocellular carcinoma
    Hiroshi Okano
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Lab Invest 83:1529-39. 2003
    ....
  16. ncbi request reprint COX-2 inhibitors sensitize human hepatocellular carcinoma cells to TRAIL-induced apoptosis
    Yutaka Yamanaka
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Mol Med 18:41-7. 2006
    ..These results demonstrate that COX-2 inhibitors can induce apoptosis and augment TRAIL sensitivity by up-regulation of TRAIL receptors and down-regulation of both survivin and AKT signaling...
  17. ncbi request reprint Functional expression of TWEAK in human colonic adenocarcinoma cells
    Tomoyuki Kawakita
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Eobashi, Tsu, Mie, Japan
    Int J Oncol 26:87-93. 2005
    ..Thus, functional expression of TWEAK from human colonic adenocarcinoma cells may contribute to neovascularization...
  18. ncbi request reprint Fas stimulation activates NF-kappaB in SK-Hep1 hepatocellular carcinoma cells
    Hiroshi Okano
    First Department of Internal Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Oncol Rep 10:1145-8. 2003
    ..SK-Hep1 cell lines receiving Fas stimulation had increased viability, but the extent of cell proliferation was not dose-dependent. The observation suggests that Fas stimulation may contribute to HCC cell survival or proliferation...
  19. ncbi request reprint Functional expression of a proliferation-related ligand in hepatocellular carcinoma and its implications for neovascularization
    Hiroshi Okano
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    World J Gastroenterol 11:4650-4. 2005
    ..To detect the expression of a proliferation-related ligand on human hepatocellular carcinoma (HCC) cell lines (SK-Hep1, HLE and HepG2) and in culture medium...
  20. ncbi request reprint Functional expression of tumor necrosis factor-related apoptosis-inducing ligand in human colonic adenocarcinoma cells
    Hidekazu Inoue
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan
    Lab Invest 82:1111-9. 2002
    ....
  21. ncbi request reprint The cyclin-dependent kinase inhibitor flavopiridol sensitizes human hepatocellular carcinoma cells to TRAIL-induced apoptosis
    Kazumi Miyashita
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Mol Med 18:249-56. 2006
    ..Thus, combining flavopiridol with a TRAIL agonist may prove to be an effective new strategy for treatment of HCC...
  22. ncbi request reprint Hepatocellular carcinoma presenting with obstructive jaundice: a clinicopathological study of eight cases
    Kazumoto Murata
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Hepatogastroenterology 50:2057-60. 2003
    ..The aim of this study is to evaluate characteristics of icteric hepatocellular carcinoma for early diagnosis...
  23. ncbi request reprint Adenoviral-mediated transfer of p53 gene enhances TRAIL-induced apoptosis in human hepatocellular carcinoma cells
    Hidekazu Inoue
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Mol Med 14:271-5. 2004
    ..Thus, death of HCC cells due to combined p53 gene transduction and exogenous TRAIL may be due to down regulation of FLIP or XIAP...
  24. ncbi request reprint Augmentation of tumor necrosis factor family-induced apoptosis by E3330 in human hepatocellular carcinoma cell lines via inhibition of NF kappa B
    Yukiko Saitou
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    World J Gastroenterol 11:6258-61. 2005
    ..To investigate the reduction of cell viability in human hepatocellular carcinoma (HCC) cell lines induced by inhibition of nuclear factor kappa B (NF kappa B)...
  25. ncbi request reprint Functional expression of TWEAK in human hepatocellular carcinoma: possible implication in cell proliferation and tumor angiogenesis
    Tomoyuki Kawakita
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Biochem Biophys Res Commun 318:726-33. 2004
    ..In conclusion, these results indicate that TWEAK might play a critical role in HCC cellular proliferation using both autocrine and paracrine mechanisms, and modulate tumor-related angiogenesis...
  26. doi request reprint Early-stage hepatocellular carcinoma: radiofrequency ablation combined with chemoembolization versus hepatectomy
    Koichiro Yamakado
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Radiology 247:260-6. 2008
    ..To retrospectively evaluate the long-term results of radiofrequency (RF) ablation combined with chemoembolization (combination therapy) as compared with hepatectomy for the treatment of early-stage hepatocellular carcinoma (HCC)...
  27. ncbi request reprint Jak inhibitor induces S phase cell-cycle arrest and augments TRAIL-induced apoptosis in human hepatocellular carcinoma cells
    Hiroyuki Fuke
    Department of Gastroenterology, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Biochem Biophys Res Commun 363:738-44. 2007
    ..Our study suggests that the Jak-STAT pathway plays an important role in cell-cycle progression and resistance to apoptosis. Inhibition of the Jak-STAT pathway may thus be a therapeutic target for HCC...
  28. ncbi request reprint Peroxisome proliferator-activated receptor gamma augments tumor necrosis factor family-induced apoptosis in hepatocellular carcinoma
    Hiroshi Okano
    First Department of Internal Medicine, Mie University School of Medicine, Tsu 514 8507, Japan
    Anticancer Drugs 13:59-65. 2002
    ..However, 15d-PGJ2 facilitated Fas-mediated HCC apoptosis that could not be induced by Fas alone. These results suggest that PPARgamma can augment TNF-family-induced apoptosis...
  29. ncbi request reprint Expression of CD34-positive sinusoidal endothelial cells in patients with HBV-associated chronic liver diseases
    Shigeru Ohmori
    First Department of Internal Medicine, Mie University School of Medicine, Tsu 514 8507, Mie, Japan
    Int J Mol Med 14:179-84. 2004
    ..689; P = 0.033). We conclude that CD34-positive endothelial cells in patients with HBV-associated chronic liver diseases might play a role in hepatocarcinogenesis...
  30. ncbi request reprint A new prognostic scoring system involving des-gamma-carboxy prothrombin as a useful marker for predicting prognosis in patients with hepatocellular carcinoma
    Tomoyuki Kawakita
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Oncol 23:1115-20. 2003
    ..In conclusion, the described scoring system provides more accurate prognostic information than the CLIP scoring system. It may help physicians decide more appropriate clinical and therapeutic management...
  31. ncbi request reprint Long-term follow-up of chronic hepatitis C in Japan
    Hiroshi Okano
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Hepatogastroenterology 49:1632-5. 2002
    ..Chronic hepatitis C which exhibits a varied natural course, is becoming a major problem worldwide...
  32. doi request reprint Prospective study on the outcome of patients with hepatocellular carcinoma registered for living donor liver transplantation: how long can they wait?
    Shugo Mizuno
    Department of Transplantation and Hepatobiliary Pancreatic Surgery, School of Medicine, Mie University, Tsu, Mie, Japan
    Transplantation 89:650-4. 2010
    ..9, 12.2, and 3.5 months, respectively. CONCLUSIONS.: LDLT is acceptable for the patients who gave up the conventional treatment. Approximately 12 months remain for the LDLT candidates with HCC to decide to undergo it...
  33. ncbi request reprint Long-term follow-up of patients with liver cirrhosis after endoscopic esophageal varices ligation therapy: comparison with ethanol injection therapy
    Hiroshi Okano
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Hepatogastroenterology 50:2013-6. 2003
    ..Esophageal variceal hemorrhage is the most dreaded complication of liver disease. Prevention or emergency therapy of bleeding is important...
  34. ncbi request reprint Over-expression of Smac promotes TRAIL-induced cell death in human hepatocellular carcinoma
    Hiroshi Okano
    First Department of Internal Medicine, Mie University School of Medicine, Tsu 514 8507, Japan
    Int J Mol Med 12:25-8. 2003
    ..With over-expression of Smac in HCC cells, TRAIL induced by 10% HCC cell death. The role of Smac in apoptosis signaling pathway in HCC cells warrants further study...
  35. ncbi request reprint Adenovirus-mediated transfection of caspase-8 sensitizes hepatocellular carcinoma to TRAIL- and chemotherapeutic agent-induced cell death
    Yumi Yamaguchi
    First Department of Internal Medicine, Mie University School of Medicine, Edobashi, 2 174, Tsu, Mie 514 8507, Japan
    Biochim Biophys Acta 1763:844-53. 2006
    ....
  36. doi request reprint Survival with up to 10-year follow-up after combination therapy of chemoembolization and radiofrequency ablation for the treatment of hepatocellular carcinoma: single-center experience
    Masashi Fujimori
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Vasc Interv Radiol 24:655-66. 2013
    ..To report 10-year outcomes of treating hepatocellular carcinomas (HCCs) by combination therapy of chemoembolization and radiofrequency (RF) ablation...
  37. ncbi request reprint Risk factors for the recurrence of hepatocellular carcinoma after radiofrequency ablation of hepatocellular carcinoma in patients with hepatitis C
    Yutaka Yamanaka
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan
    World J Gastroenterol 11:2174-8. 2005
    ..To analyze the risk factors of hepatocellular carcinoma (HCC) recurrence after radiofrequency ablation (RFA) treatment with HCV-associated hepatitis...
  38. ncbi request reprint Macrocytic anemia during low-dose cisplatin and 5-Fluorouracil through implanted infusion port for unresectable hepatobilliary malignancies
    Norihiko Yamamoto
    First Department of Internal Medicine, Mie University School of Medicine, Japan
    Anticancer Res 25:1243-6. 2005
    ..The cumulative appearance rate of anemia was 19% at 12 weeks and 51% at 18 weeks. The Child-Pugh score or Japanese integrated staging (JIS) score were significantly higher in the "anemia" group than that in the "no anemia" group...
  39. doi request reprint Subphrenic versus nonsubphrenic hepatocellular carcinoma: combined therapy with chemoembolization and radiofrequency ablation
    Koichiro Yamakado
    Department of Radiology, Mie University School of Medicine, Japan
    AJR Am J Roentgenol 194:530-5. 2010
    ....
  40. ncbi request reprint Dual topology of functional Toll-like receptor 3 expression in human hepatocellular carcinoma: differential signaling mechanisms of TLR3-induced NF-kappaB activation and apoptosis
    Kentaro Yoneda
    Department of Gastroenterology, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Oncol 33:929-36. 2008
    ..Endogenously expressed TLR3 may provide new clinical prospects for TLR3 agonists as cytotoxic agents in HCC...
  41. ncbi request reprint Clinical significance of tumor markers in detection of recurrent hepatocellular carcinoma after radiofrequency ablation
    Tetsuya Beppu
    Department of Gastroenterology, Mie University School of Medicine, Tsu, Mie, Japan
    Int J Mol Med 26:425-33. 2010
    ..All three tumor markers should be routinely measured to detect recurrence during follow-up after RFA. Especially high AFP-L3 levels should be followed closely...
  42. ncbi request reprint Vitamin K analog (compound 5) induces apoptosis in human hepatocellular carcinoma independent of the caspase pathway
    Naoyuki Enokimura
    First Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
    Anticancer Drugs 16:837-44. 2005
    ..These results demonstrate that Cpd 5 induced apoptosis in human HCC cell lines, mainly independently of caspase activities. This may contribute to its highly potent cytotoxicity toward HCC cells...
  43. ncbi request reprint Long-term follow-up of patients with liver cirrhosis after endoscopic ethanol injection sclerotherapy for esophageal varices
    Hiroshi Okano
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Hepatogastroenterology 50:1556-9. 2003
    ..In this study, we evaluated the long-term cumulative survival rate of patients with esophageal varices after treatment with endoscopic ethanol injection sclerotherapy (EIS group) or pharmacological therapy (non-EIS group)...
  44. ncbi request reprint Noninvasive estimation of liver fibrosis and response to interferon therapy by a serum fibrogenesis marker, YKL-40, in patients with HCV-associated liver disease
    Yukiko Saitou
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    World J Gastroenterol 11:476-81. 2005
    ..To evaluate the clinical utility of serum fibrosis markers, including YKL-40, in patients with HCV-associated liver disease...
  45. ncbi request reprint The usefulness of digital subtraction imaging with Levovist in the diagnosis of focal hepatic tumors
    Kouji Yamamoto
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Oncol 22:353-8. 2003
    ....
  46. ncbi request reprint Laparoscopic microwave coagulation therapy for small hepatocellular carcinoma on the liver surface
    Hiroshi Okano
    First Department of Internal Medicine, Mie University School of Medicine, Tsu 514 8507, Japan
    Oncol Rep 9:1001-4. 2002
    ..However, in severe liver dysfunction, the use of LMCT may have a negative influence on patient survival...
  47. ncbi request reprint HBV subtype as a marker of the clinical course of chronic HBV infection in Japanese patients
    Takahisa Sakai
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan
    J Med Virol 68:175-81. 2002
    ..05). The subtypic change and the course of chronic HBV infection had no significant correlation. These results suggest that HBV subtypes are associated with the clinical course of chronic HBV infection...
  48. ncbi request reprint Corona enhancement in ultrasonographical post-vascular phase images with microbubble contrast agent: a novel specific sign for hepatocellular carcinomas
    Kouji Yamamoto
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Oncol Rep 15:785-90. 2006
    ..Corona enhancement may be due to the trapping of contrast agent in the endothelial cells in the surround of HCC nodules and be a novel specific sign for HCC...
  49. ncbi request reprint Expression of survivin during liver regeneration
    Masatoshi Deguchi
    First Department of Internal Medicine, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie, Japan
    Biochem Biophys Res Commun 297:59-64. 2002
    ..These findings suggest that survivin is dramatically expressed in a cell cycle-dependent manner during liver regeneration and provide a new insight into the regulation of cell proliferation and differentiation...
  50. ncbi request reprint Protective role of interleukin-18 against Fas-mediated liver injury
    Norihiko Yamamoto
    Department of Gastroenterology, Mie University Graduate School of Medicine, Tsu City, Mie Prefecture, Japan
    Int J Mol Med 22:43-8. 2008
    ..This observation raises the possibility that IL-18 could be a therapeutic strategy for Fas-mediated liver injury as a negative regulator of XIAP...
  51. ncbi request reprint Radiofrequency ablation combined with chemoembolization for the treatment of hepatocellular carcinomas 5 cm or smaller: risk factors for local tumor progression
    Haruyuki Takaki
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie, Japan
    J Vasc Interv Radiol 18:856-61. 2007
    ..To investigate the risk factors for local tumor progression after radiofrequency (RF) ablation combined with chemoembolization for the treatment of hepatocellular carcinoma (HCC)...
  52. ncbi request reprint Proteasome inhibition sensitizes hepatocellular carcinoma cells to TRAIL by suppressing caspase inhibitors and AKT pathway
    Tomoko Inoue
    First Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
    Anticancer Drugs 17:261-8. 2006
    ..In conclusion, proteasome inhibitors induced apoptosis and augmented TRAIL sensitivity via both the IAP family and AKT pathways. Thus, combining proteasome inhibitors with a TRAIL agonist may provide a new therapeutic strategy for HCC...
  53. doi request reprint Des-γ-carboxy prothrombin ratio measured by P-11 and P-16 antibodies is a novel biomarker for hepatocellular carcinoma
    Masahiko Tameda
    Department of Molecular and Laboratory Medicine, Mie University School of Medicine, Tsu, Japan
    Cancer Sci 104:725-31. 2013
    ..Patients with HCC had higher NX-PVKA ratios compared to patients with LC taking warfarin (P = 0.063). These results suggest that, when used in combination with DCP, the NX-PVKA ratio is a promising novel marker for the detection of HCC...
  54. ncbi request reprint The usefulness of 1.5 harmonic imaging ultrasonography with Levovist in the diagnosis of focal hepatic tumors
    Kouji Yamamoto
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Oncol 27:989-95. 2005
    ....
  55. ncbi request reprint Use of an interpositional venous graft posterior to the pancreas for LDLT patients with portal vein thrombosis
    Shugo Mizuno
    First Department of Surgery, Mie University School of Medicine, Tsu, Mie, Japan
    Hepatogastroenterology 54:541-4. 2007
    ..This method provided a shorter rout between the donor and recipient portal vein than a jump graft. Our experience suggests that this solution can be helpful in treating portal vein thrombosis...
  56. ncbi request reprint High-molecular intestinal alkaline phosphatase in chronic liver diseases
    Kinue Ooi
    Department of Laboratory Medicine, Mie University School of Medicine, Mie, Japan
    J Clin Lab Anal 21:133-9. 2007
    ..In conclusion, the HIALP-positive rate was particularly high in patients with chronic liver disease, and was related to the pathological progression, which suggests that the method is clinically useful...
  57. ncbi request reprint Up-regulation of IL-18 by interferon alpha-2b/ribavirin combination therapy induces an anti-viral effect in patients with chronic hepatitis C
    Kazumoto Murata
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan
    Hepatogastroenterology 52:547-51. 2005
    ..However, the potential mechanism of ribavirin is not clear...
  58. ncbi request reprint Histone deacetylase inhibitors sensitize human colonic adenocarcinoma cell lines to TNF-related apoptosis inducing ligand-mediated apoptosis
    Hidekazu Inoue
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Int J Mol Med 9:521-5. 2002
    ..HDAI sensitizes human colonic adenocarcinoma cell lines to TRAIL-mediated apoptosis. HDAI may be useful as an adjuvant agent for TRAIL in the treatment of human colonic adenocarcinomas that are resistant to TRAIL...
  59. ncbi request reprint Usefulness of digital subtraction imaging with Levovist in the diagnosis of hepatocellular carcinomas
    Kouji Yamamoto
    First Department of Internal Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Oncol Rep 13:95-9. 2005
    ..8%). DSI demonstrated characteristic findings of HCC enhancement during the early phase, the portal phase and the late phase, permitting classification of HCC to be performed...
  60. ncbi request reprint Hepatocellular carcinoma development in sustained viral responders to interferon therapy in patients with chronic hepatitis C
    Naoyuki Enokimura
    First Department of Internal Medicine, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Anticancer Res 23:593-6. 2003
    ..These results suggest that the prognosis of sustained responders who develop HCC after IFN therapy is not necessarily good, so close follow-up remains necessary, despite their response to IFN therapy...
  61. doi request reprint Sorafenib and TRAIL have synergistic effect on hepatocellular carcinoma
    Keiichiro Nojiri
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Int J Oncol 42:101-8. 2013
    ..Our data showed that in combination TRAIL and sorafenib had a synergistic cytokilling effect on HCC cells and that this effect derived from sorafenib-mediated downregulation of anti-apoptotic proteins...
  62. doi request reprint Radiofrequency ablation combined with chemoembolization: treatment of recurrent hepatocellular carcinomas after hepatectomy
    Haruyuki Takaki
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    AJR Am J Roentgenol 197:488-94. 2011
    ..The purpose of this study is to evaluate the treatment effect and prognostic factors of radiofrequency ablation (RFA) combined with chemoembolization for patients with recurrent hepatocellular carcinomas (HCCs) after hepatectomy...
  63. ncbi request reprint Pneumothorax after diagnostic laparoscopy
    Katsuya Shiraki
    First Department of Internal Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Hepatogastroenterology 49:1033-5. 2002
    ..The clinical condition of the patients improved rapidly because of the easy diffusion of the gas used in laparoscopy. Diagnostic laparoscopists should be aware of this complication and treat ventilatory problems...
  64. doi request reprint Radiofrequency ablation combined with chemoembolization for the treatment of hepatocellular carcinomas larger than 5 cm
    Haruyuki Takaki
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Vasc Interv Radiol 20:217-24. 2009
    ..To evaluate survival, recurrence-free survival, technical success, technique effectiveness, and safety of radiofrequency (RF) ablation combined with chemoembolization in patients with hepatocellular carcinomas (HCCs) larger than 5 cm...
  65. ncbi request reprint Transcatheter arterial embolization and extrabeam radiation therapy for subcutaneous seeding of hepatocellular carcinoma by percutaneous ethanol injection
    Takenari Yamanaka
    First Department of Internal Medicine, Mie University School of Medicine, Edobashi, 2 174, Tsu, 514 8507, Japan
    Hepatogastroenterology 49:1656-8. 2002
    ..The patient is currently doing well without further recurrence of hepatocellular carcinoma and without enlargement of the subcutaneous tumor after extrabeam radiation therapy and transcatheter arterial embolization...
  66. ncbi request reprint Cardiac metastases of gallbladder carcinoma
    Tomoko Inoue
    Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    World J Gastroenterol 11:2048-9. 2005
    ..This report describes the case of a 68-year-old woman diagnosed with advanced gallbladder cancer, whose autopsy revealed multiple metastases, including cardiac metastases...
  67. ncbi request reprint Low-dose chemotherapy of cisplatin and 5-fluorouracil or doxorubicin via implanted fusion port for unresectable hepatocellular carcinoma
    Kazumoto Murata
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Anticancer Res 23:1719-22. 2003
    ..However, the regimens for this therapy are still controversial. Among these regimens, cisplatinum (CDDP) + 5-fluorouracil (5-FU) or epirubicin have been reported to have favorable effects...
  68. ncbi request reprint Up-regulation of glypican-3 in human hepatocellular carcinoma
    Masahiro Suzuki
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Anticancer Res 30:5055-61. 2010
    ..To investigate the expression and significance of glypican-3 (GPC3) in human hepatocellular carcinoma (HCC)...
  69. ncbi request reprint Multimodality therapy using brachytherapy for caval tumor of hepatocellular carcinoma
    Noriko Ii
    Department of Radiology, Faculty of Medicine, Mie University, Mie, Japan
    Hepatogastroenterology 54:1522-5. 2007
    ..This pilot study was conducted to evaluate the feasibility, safety, and clinical efficacy of multimodality therapy using endovascular brachytherapy with iridium-192 for caval tumor...
  70. ncbi request reprint High expression of p21WAF1/CIP1 is correlated with human hepatocellular carcinoma in patients with hepatitis C virus-associated chronic liver diseases
    Hidetaka Wagayama
    First Department of Internal Medicine, Mie University School of Medicine, Tsu 514 8507, Japan
    Hum Pathol 33:429-34. 2002
    ..These results suggested that p21 is up-regulated by the stress of inflammation and fibrosis in HCV-associated chronic liver diseases and that high p21 expression might be related to hepatocarcinogenesis in cirrhotic patients...
  71. ncbi request reprint Radiofrequency ablation combined with chemoembolization in hepatocellular carcinoma: treatment response based on tumor size and morphology
    Koichiro Yamakado
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8067, Japan
    J Vasc Interv Radiol 13:1225-32. 2002
    ..To evaluate local therapeutic efficacy of radiofrequency (RF) ablation after chemoembolization for hepatocellular carcinoma (HCC) based on tumor size and morphology...
  72. ncbi request reprint Combination therapy with radiofrequency ablation and transcatheter chemoembolization for the treatment of hepatocellular carcinoma: Short-term recurrences and survival
    Koichiro Yamakado
    Department of Radiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8067, Japan
    Oncol Rep 11:105-9. 2004
    ..This combined therapy showed good early therapeutic effects on treated lesions and survival. Tumor number and maximum tumor size are important factors for early intrahepatic recurrence...
  73. ncbi request reprint Relative predictive factors for hepatocellular carcinoma after HBeAg seroconversion in HBV infection
    Kazumoto Murata
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi Tsu Mie 514 8507, Japan
    World J Gastroenterol 11:6848-52. 2005
    ..To determine the predictive factors for hepatocellular carcinoma (HCC) development in patients after spontaneous or therapeutic HBeAg seroconversion...
  74. ncbi request reprint Type 1 diabetes mellitus provoked by peginterferon alpha-2b plus ribavirin treatment for chronic hepatitis C
    Junichirou Tanaka
    Department of Gastroenterology, Mie University School of Medicine, Tsu
    Intern Med 47:747-9. 2008
    ....
  75. ncbi request reprint Early graft hemodynamics in living related liver transplantation evaluated by Doppler ultrasonography
    Shigeo Nakanishi
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Mol Med 14:265-9. 2004
    ....
  76. ncbi request reprint Diagnosis of hepatocellular carcinoma using digital subtraction imaging with the contrast agent, Levovist: comparison with helical CT, digital subtraction angiography, and US angiography
    Kouji Yamamoto
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Oncol Rep 9:789-92. 2002
    ..Digital subtraction imaging is useful for evaluating vascularity in HCC when the tumor can be visualized with non-enhanced US angiography...
  77. ncbi request reprint Efficacy of long-term interferon therapy in chronic hepatitis B patients with HBV genotype C
    Takahisa Sakai
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Mol Med 10:201-4. 2002
    ..015) and in the long-term IFN therapy group (p=0.0046). In summary, long-term IFN therapy may be more effective than short-term IFN therapy for patients with chronic HBV genotype C infection...
  78. ncbi request reprint Focal spared area in fatty liver mimicking a tumor
    Katsuhiko Fujikawa
    First Department of Internal Medicine, Mie University School of Medicine 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Hepatogastroenterology 49:1253-4. 2002
    ..A microscopic examination of the specimens from the liver biopsy from the hypoechoic region revealed normal hepatic parenchymal cells, while tissue samples from the surrounding liver had a high fat deposition...
  79. ncbi request reprint Diagnosis of inflammatory pseudotumor of the liver
    Takahisa Sakai
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Int J Mol Med 10:281-5. 2002
    ..It is difficult to diagnose IPT of the liver exclusively with an image examination. Ultrasonography-guided percutaneous liver biopsy should be performed in order to diagnose IPT by histology...
  80. ncbi request reprint Cytoplasmic p21(WAF1/CIP1) expression in human hepatocellular carcinomas
    Katsuya Shiraki
    Liver Int 26:1018-9. 2006
  81. ncbi request reprint Survival rates according to the Cancer of the Liver Italian Program scores of 345 hepatocellular carcinoma patients after multimodality treatments during a 10-year period in a retrospective study
    Kentaro Yamagiwa
    Department of Surgery, Mie Prefectural Shima Hospital, Mie, Japan
    J Gastroenterol Hepatol 23:482-90. 2008
    ..This retrospective cohort study of HCC patients was conducted to assess the efficacy of treatment modalities according to the CLIP score...
  82. ncbi request reprint [Histological findings in the liver in patients with chronic hepatitis C]
    Koujirou Takase
    Kawamura Hospital
    Nihon Rinsho 62:434-8. 2004
  83. ncbi request reprint Expression of survivin in CIN and invasive squamous cell carcinoma of uterine cervix
    Han Seong Kim
    Department of Anatomic Pathology, Inje University Ilsan Paik Hospital, Koyang City, Kyunggi Do, Republic of Korea
    Anticancer Res 22:805-8. 2002
    ..To evaluate the possible role of survivin in tumorigenesis of CIN (cervical intraepithelial neoplasia) and invasive squamous cervical carcinoma of the uterine cervix (SCC), the expression of survivin was studied...
  84. ncbi request reprint Clinical significance of abnormal lipoprotein patterns in liver diseases
    Kinue Ooi
    Department of Laboratory Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Int J Mol Med 15:655-60. 2005
    ..Abnormal LDL, Lp-X, and Lp-Y were often observed in patients with poor outcomes. Lipid analysis in liver diseases by this method showed results reflecting the pathologic conditions and may be clinically useful...
  85. ncbi request reprint Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) during liver regeneration
    Yumi Yamaguchi
    J Hepatol 40:718-9. 2004