Takeshi Shimizu

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. ncbi request reprint In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells
    Takeshi Shimizu
    Department of Otorhinolaryngology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514, Japan
    Am J Respir Crit Care Med 168:581-7. 2003
  2. doi request reprint Role of platelet-derived growth factor in airway remodeling in rhinosinusitis
    Hideaki Kouzaki
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Rhinol Allergy 23:273-80. 2009
  3. ncbi request reprint A mechanism of antigen-induced mucus production in nasal epithelium of sensitized rats. A comparison with lipopolysaccharide-induced mucus production
    T Shimizu
    Department of Otorhinolaryngology, Mie University School of Medicine, Mie, Japan
    Am J Respir Crit Care Med 161:1648-54. 2000
  4. ncbi request reprint Osteoma of the malleus: a case report and literature review
    Takeshi Shimizu
    Department of Otorhinolaryngology, Mie University School of Medicine, Japan
    Am J Otolaryngol 24:239-41. 2003
  5. ncbi request reprint Differential properties of mucous glycoproteins in rat nasal epithelium. A comparison between allergic inflammation and lipopolysaccharide stimulation
    T Shimizu
    Department of Otorhinolaryngology, Mie University School of Medicine, Mie 514, Japan
    Am J Respir Crit Care Med 164:1077-82. 2001
  6. ncbi request reprint EP4 agonist inhibits lipopolysaccharide-induced mucus secretion in airway epithelial cells
    Reiko Hattori
    Department of Otorhinolaryngology Head and Neck Surgery, Mie University School of Medicine, Tsu, Japan
    Ann Otol Rhinol Laryngol 117:51-8. 2008
  7. doi request reprint Role of thrombin in chronic rhinosinusitis-associated tissue remodeling
    Shino Shimizu
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Rhinol Allergy 25:7-11. 2011
  8. ncbi request reprint A mechanism of antigen-induced goblet cell degranulation in the nasal epithelium of sensitized rats
    Takeshi Shimizu
    Department of Otorhinolaryngology, Mie University School of Medicine, Japan
    J Allergy Clin Immunol 112:119-25. 2003
  9. ncbi request reprint Pro-resolution mediator lipoxin A4 and its receptor in upper airway inflammation
    Shino Shimizu
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan
    Ann Otol Rhinol Laryngol 122:683-9. 2013
  10. pmc Azithromycin inhibits mucus hypersecretion from airway epithelial cells
    Takeshi Shimizu
    Department of Otorhinolaryngology, Shiga University of Medical Science, Seta, Tsukinowa, Otsu, Shiga 520 2192, Japan
    Mediators Inflamm 2012:265714. 2012

Collaborators

Detail Information

Publications45

  1. ncbi request reprint In vivo and in vitro effects of macrolide antibiotics on mucus secretion in airway epithelial cells
    Takeshi Shimizu
    Department of Otorhinolaryngology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514, Japan
    Am J Respir Crit Care Med 168:581-7. 2003
    ....
  2. doi request reprint Role of platelet-derived growth factor in airway remodeling in rhinosinusitis
    Hideaki Kouzaki
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Rhinol Allergy 23:273-80. 2009
    ..The purpose of this study was to elucidate the role of platelet-derived growth factor (PDGF) in the pathogenesis of rhinosinusitis...
  3. ncbi request reprint A mechanism of antigen-induced mucus production in nasal epithelium of sensitized rats. A comparison with lipopolysaccharide-induced mucus production
    T Shimizu
    Department of Otorhinolaryngology, Mie University School of Medicine, Mie, Japan
    Am J Respir Crit Care Med 161:1648-54. 2000
    ..These results indicate that neutrophil and cyclooxygenase products are important in LPS-induced mucus production, and there are different mechanisms of mucus production between allergic inflammation and LPS stimulation...
  4. ncbi request reprint Osteoma of the malleus: a case report and literature review
    Takeshi Shimizu
    Department of Otorhinolaryngology, Mie University School of Medicine, Japan
    Am J Otolaryngol 24:239-41. 2003
  5. ncbi request reprint Differential properties of mucous glycoproteins in rat nasal epithelium. A comparison between allergic inflammation and lipopolysaccharide stimulation
    T Shimizu
    Department of Otorhinolaryngology, Mie University School of Medicine, Mie 514, Japan
    Am J Respir Crit Care Med 164:1077-82. 2001
    ..05). These results indicate that mucin mRNA expression (for peptide backbone) increases similarly after LPS instillation or OVA challenge; however, carbohydrate compositions of newly produced mucin are different between the two groups...
  6. ncbi request reprint EP4 agonist inhibits lipopolysaccharide-induced mucus secretion in airway epithelial cells
    Reiko Hattori
    Department of Otorhinolaryngology Head and Neck Surgery, Mie University School of Medicine, Tsu, Japan
    Ann Otol Rhinol Laryngol 117:51-8. 2008
    ..We examined the in vivo effects of agonists for prostaglandin E2 receptors (EP1, EP2, EP3, and EP4) on mucus hypersecretion. We also examined the in vitro effects of EP agonists on airway epithelial cells...
  7. doi request reprint Role of thrombin in chronic rhinosinusitis-associated tissue remodeling
    Shino Shimizu
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Rhinol Allergy 25:7-11. 2011
    ..The role of thrombin in chronic nasal inflammation-associated tissue remodeling still has not been appraised. This study was conducted to elucidate the role of thrombin in the pathogenesis of CRS...
  8. ncbi request reprint A mechanism of antigen-induced goblet cell degranulation in the nasal epithelium of sensitized rats
    Takeshi Shimizu
    Department of Otorhinolaryngology, Mie University School of Medicine, Japan
    J Allergy Clin Immunol 112:119-25. 2003
    ..A variety of allergic mediators and inflammatory cells are capable of stimulating goblet cell degranulation (epithelial mucus secretion); however, little is known about the mechanism by which antigen induces mucus hypersecretion...
  9. ncbi request reprint Pro-resolution mediator lipoxin A4 and its receptor in upper airway inflammation
    Shino Shimizu
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan
    Ann Otol Rhinol Laryngol 122:683-9. 2013
    ..Lipoxin A4, an endogenous lipid mediator, is a potential pro-resolution mediator that could attenuate inflammation. This study was conducted to elucidate the role of lipoxin A4 in upper airway inflammation...
  10. pmc Azithromycin inhibits mucus hypersecretion from airway epithelial cells
    Takeshi Shimizu
    Department of Otorhinolaryngology, Shiga University of Medical Science, Seta, Tsukinowa, Otsu, Shiga 520 2192, Japan
    Mediators Inflamm 2012:265714. 2012
    ....
  11. doi request reprint Expression and localization of aquaporin 1, 2, 3, 4, and 5 in human nasal mucosa
    Satoshi Seno
    Department of Otorhinolaryngology, Shiga University of Medical Science, Japan
    Am J Rhinol Allergy 26:167-71. 2012
    ..Aquaporins (AQPs) are water-specific membrane channel proteins that regulate water homeostasis for cells and organisms. The purpose of this study was to elucidate the role of AQPs 1, 2, 3, 4, and 5 in normal and diseased human nasal mucosa...
  12. ncbi request reprint Prostaglandin E2 receptor EP2, EP3, and EP4 agonists inhibit antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats
    Reiko Hattori
    Department of Otorhinolaryngology Head and Neck Surgery, Mie University School of Medicine, Tsu, Japan
    Ann Otol Rhinol Laryngol 118:536-41. 2009
    ..To elucidate the functions of the PGE2 receptors (EP1, EP2, EP3, and EP4) in allergic inflammation, we examined the in vivo effects of EP agonists on mucus hypersecretion and eosinophil infiltration in rat nasal epithelium...
  13. doi request reprint Effects of clarithromycin and dexamethasone on mucus production in isografted rat trachea
    Masako Kitano
    Department of Otorhinolaryngology Head and Neck Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    Pharmacology 87:56-62. 2011
    ..The purpose of this study was to develop an animal model for the study of mucus overproduction and to assess the effect of a 14-membered macrolide antibiotic and a glucocorticoid on lipopolysaccharide (LPS)-induced mucus production...
  14. ncbi request reprint The effect of heparin on antigen-induced mucus hypersecretion in the nasal epithelium of sensitized rats
    Takao Ogawa
    Department of Otorhinolaryngology, Shiga University of Medical Science, Shiga, Japan
    Allergol Int 62:77-83. 2013
    ..To elucidate the effects of heparin on allergic inflammation, we examined the in vivo effects of heparin on antigen-induced mucus hypersecretion and infiltration of eosinophils and neutrophils in the nasal epithelium of sensitized rats...
  15. doi request reprint Heparin inhibits mucus hypersecretion in airway epithelial cells
    Takao Ogawa
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Japan
    Am J Rhinol Allergy 25:69-74. 2011
    ..We also examined the in vitro effects of heparin on mucin production and IL-8 secretion from cultured human airway epithelial cells...
  16. doi request reprint Differential properties of mucous glycoproteins produced by allergic inflammation and lipopolysaccharide stimulation in rat nasal epithelium
    Takeshi Shimizu
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Adv Otorhinolaryngol 72:107-9. 2011
    ..These results indicate that mucin mRNA expression increases similarly after LPS instillation or OVA challenge, however, carbohydrate compositions of newly produced mucin are different between the two groups...
  17. doi request reprint Successful treatment of rhino-orbital mucormycosis by a new combination therapy with liposomal amphotericin B and micafungin
    Takao Ogawa
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Auris Nasus Larynx 39:224-8. 2012
    ..The early diagnosis, surgical debridement and a new combination therapy with liposomal amphotericin B and micafungin were effective. This new combination antifungal therapy will be useful for the treatment of mucormycosis...
  18. ncbi request reprint Endoscopic sinus surgery for the odontogenic maxillary cysts
    Satoshi Seno
    Department of Otorhinolaryngology, Shiga University of Medical Science, Setatsukinowa, Otsu, Shiga, Japan
    Rhinology 47:305-9. 2009
    ..To evaluate the effectiveness and usefulness of transnasal endoscopic surgery for the treatment of odontogenic maxillary cysts...
  19. ncbi request reprint Eosinophil-epithelial cell interactions stimulate the production of MUC5AC mucin and profibrotic cytokines involved in airway tissue remodeling
    Shino Shimizu
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Rhinol Allergy 28:103-9. 2014
    ....
  20. doi request reprint True aneurysm of the facial artery
    Eriko Hoshi
    Department of Otorhinolaryngology, Shiga University of Medical Science, Seta Tsukinowa, Otsu, Shiga 520 2192, Japan
    Auris Nasus Larynx 37:656-8. 2010
    ..The postoperative course was uneventful, and no recurrence has been noted in more than 1-year follow-up...
  21. ncbi request reprint Activated protein C inhibits the expression of platelet-derived growth factor in the lung
    Shino Shimizu
    Department of Molecular Pathobiology, Mie University School of Medicine, Tsu City, Japan
    Am J Respir Crit Care Med 167:1416-26. 2003
    ..In brief, this study describes a novel biological function of activated protein C that may further explain its inhibitory activity on lung inflammation and fibrosis...
  22. ncbi request reprint Pendred's syndrome with goiter and enlarged vestibular aqueducts diagnosed by PDS gene mutation
    Hajime Ishinaga
    Department of Otorhinolaryngology, Mie University School of Medicine, 2 174, Tsu, Mie 514 8507 Japan
    Head Neck 24:710-3. 2002
    ..Recent advances in molecular biology revealed the gene responsible for PS (PDS) and provided an important aid for the diagnosis of this condition...
  23. ncbi request reprint Valproic acid promotes neural regeneration of olfactory epithelium in adult mice after methimazole-induced damage
    Takao Ogawa
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Rhinol Allergy 28:95-9. 2014
    ..To elucidate the effects of VPA on regeneration of olfactory sensory neurons, we examined the in vivo effects of oral VPA administration on recovery from methimazole-induced degeneration of olfactory neuroepithelium in mice...
  24. doi request reprint Role of the coagulation system in allergic inflammation in the upper airways
    Shino Shimizu
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Clin Immunol 129:365-71. 2008
    ..The results of this study suggest that activation of the coagulation system occurs during the allergic response and that thrombin plays a crucial role in the regulation of mucin production in the upper airways...
  25. doi request reprint Endoscopic ligation of the sphenopalatine artery and the maxillary artery for the treatment of intractable posterior epistaxis
    Satoshi Seno
    Department of Otorhinolaryngology, Shiga University of Medical Science, Otsu, Shiga, Japan
    Am J Rhinol Allergy 23:197-9. 2009
    ..This investigation evaluates the effectiveness and complications of endoscopic ligation of the sphenopalatine or maxillary artery for the treatment of intractable posterior epistaxis...
  26. ncbi request reprint Malignant external otitis: treatment with prolonged usage of antibiotics and Burow's solution
    Takeshi Shimizu
    Department of Otorhinolaryngology, Shiga University of Medical Science and Mie University School of Medicine, Tsukinowa, Seta, Otsu, Shiga 520 2192, Japan
    Auris Nasus Larynx 32:403-6. 2005
    ..No recurrence has been noted after 4-week additional treatment with intravenous carbapenems followed by 3-week treatment with Burow's solution as ear drops...
  27. ncbi request reprint Effect of nitric oxide synthase inhibitor on increase in nasal mucosal blood flow induced by sensory and parasympathetic nerve stimulation in rats
    Fumio Ogawa
    Department of Otorhinolaryngology, Shiga University of Medical Science, Shiga, Japan
    Ann Otol Rhinol Laryngol 119:424-30. 2010
    ..The aim of the present study was to evaluate the effect of electrical stimulation of both sensory and parasympathetic nerves innervating the nasal mucosal arteries on NBF in rats...
  28. ncbi request reprint Mucociliary transport function and damage of ciliated epithelium
    Tian qun Yang
    Department of Otorhinolaryngology, Mie University School of Medicine, Tsu, Japan
    Am J Rhinol 16:215-9. 2002
    ..Moreover, MTR of L-mucus was decreased with increasing the degree of epithelial damage. This study indicates that the degree of loss of cilia is an important factor of mucociliarn deceleration...
  29. ncbi request reprint [Therapeutic results of respiratory disturbance during sleep in children]
    Masayoshi Kobayashi
    Department of Otorhinolaryngology, Mie University School of Medicine, Tsu
    Nihon Jibiinkoka Gakkai Kaiho 106:815-22. 2003
    ..In conclusion, surgical treatment for children's respiratory disturbance during sleep is effective and involves a low rate of symptom recurrence...
  30. doi request reprint A new modification of uvulopalatopharyngoplasty for the treatment of obstructive sleep apnea syndrome
    Ichiro Komada
    Department of Otorhinolaryngology, Shiga Hospital of Social Insurance, 16 1 Fujimidai Otsu, Shiga 520 0846, Japan
    Auris Nasus Larynx 39:84-9. 2012
    ..To evaluate objective and subjective improvement after applying a new surgical technique, two-piece palatopharyngoplasty (Two-P4), to the treatment of obstructive sleep apnea syndrome (OSAS)...
  31. ncbi request reprint High-pressure grease injury of the face
    Hajime Ishinaga
    Department of Otorhinolaryngology, Mie University School of Medicine, Japan
    Am J Otolaryngol 25:278-81. 2004
    ..CT and magnetic resonance imaging were useful to diagnose the remaining grease, and the remnant of the grease was completely removed by the Weber-Fergusson incision approach...
  32. ncbi request reprint Lipoblastoma of the neck: a case report and literature review
    Mayuko Sakaida
    Department of Otorhinolaryngology, Mie University School of Medicine, Japan
    Am J Otolaryngol 25:266-9. 2004
    ..The postoperative course was uneventful, and no recurrence of tumor has been noted in more than 2 years follow-up...
  33. ncbi request reprint [Effect of azithromycin on mucus secretion from nasal epithelium]
    Takeshi Shimizu
    Jpn J Antibiot 56:25-8. 2003
  34. ncbi request reprint Nanogel DDS enables sustained release of IL-12 for tumor immunotherapy
    Takeshi Shimizu
    Department of Surgery, Kyoto Prefectural University of Medicine, Kamikyo, Kyoto 602 8566, Japan
    Biochem Biophys Res Commun 367:330-5. 2008
    ..The present study proposes a novel therapeutic intervention technology, taking advantage of slow and sustained release of bioactive cytokines from the self-assembling biocompatible nanoparticles...
  35. ncbi request reprint [A case report of Douglas abscess due to diverticulitis of the sigmoid colon associated with liver abscess]
    Takeshi Shimizu
    Department of Internal Medicine, Tomishiro Chuou Hospital
    Nihon Shokakibyo Gakkai Zasshi 101:281-7. 2004
  36. ncbi request reprint Chemical modification of reveromycin A and its biological activities
    Takeshi Shimizu
    Synthetic Organic Chemistry Laboratory, RIKEN The Institute of Physical and Chemical Research, Wako, Saitama, Japan
    Bioorg Med Chem Lett 12:3363-6. 2002
    ..The C5 hydroxyl group and C24 carboxyl group are particularly important for these activities...
  37. ncbi request reprint [Effect of EM703, a new macrolide derivative, on mucus secretion from the airway epithelial cells]
    Reiko Hattori
    Jpn J Antibiot 57:123-5. 2004
  38. ncbi request reprint [Endoscopic resection of benign and malignant tumors in the nasal cavity and paranasal sinus]
    Mikio Suzuki
    Division of Otolaryngology, Fukuoka Kinen Hospital, Fukuoka
    Nihon Jibiinkoka Gakkai Kaiho 108:724-33. 2005
    ..Endoscopic removal of malignant lesions remains controversial because of the small number of patients and short postoperative observation...
  39. ncbi request reprint Immunohistochemical and ultrastructural abnormalities in muscle from a patient with sensorineural hearing loss related to a 1555 A-to-G mitochondrial mutation
    Hideaki Kouzaki
    Department of Otolaryngology, Shiga University of Medical Science, Tsukinowa cho, Seta, Otsu 520 2192, Japan
    J Clin Neurosci 14:603-7. 2007
    ..These findings suggest that mitochondrial dysfunction from the A1555G mutation extends beyond the inner ear...
  40. ncbi request reprint Receptor affinity, stability and binding mode of Shiga toxins are determinants of toxicity
    Takeshi Shimizu
    Department of Molecular Infectiology, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Microb Pathog 43:88-95. 2007
    ..These results indicated that the receptor affinity, stability and binding mode of Shiga toxins might be important determinants for toxicity in mice...
  41. ncbi request reprint Interaction between the homeodomain protein HOXC13 and ETS family transcription factor PU.1 and its implication in the differentiation of murine erythroleukemia cells
    Toshiyuki Yamada
    Department of Biochemistry and Genome Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan
    Exp Cell Res 314:847-58. 2008
    ..It was, thus, suggested that although HOXC13 negatively regulates the differentiation of MEL cells into erythroid cells, it antagonizes PU.1 possibly by down-regulation of PU.1 protein in the presence of a differentiation stimulus...
  42. ncbi request reprint Protection of mice from Shiga toxin-2 toxemia by mucosal vaccine of Shiga toxin 2B-His with Escherichia coli enterotoxin
    Takao Tsuji
    Department of Microbiology, Fujita Health University, School of Medicine, Toyoake, Aichi, Japan
    Vaccine 26:469-76. 2008
    ..As His-tagged Stx2B showed five or three polymers in gel filtration chromatography, His-tagged Stx2B forms smaller tertiary structure than the native one and is effective for preventing Stx2 toxemia as a nasal vaccine...
  43. ncbi request reprint Synthesis and biological activities of reveromycin A and spirofungin A derivatives
    Takeshi Shimizu
    Synthetic Organic Chemistry Laboratory, RIKEN The Institute of Physical and Chemical Research, Wako, Saitama 351 0198, Japan
    Bioorg Med Chem Lett 18:3756-60. 2008
    ..It was found that 2,3-dihydroreveromycin A is the promising derivative of reveromycin A based on the activity and stability...
  44. ncbi request reprint [Clinical effectiveness of coblation-assisted inferior turbinoplasty]
    Teppei Tani
    Department of Otorhinolaryngology, Shiga University of Medical Science
    Arerugi 57:1053-60. 2008
    ..Coblation-assisted inferior turbinoplasty has recently been reported. The aim of this study was to evaluate the effectiveness of coblation-assisted inferior turbinoplasty, compared with laser surgery...
  45. ncbi request reprint Effective antibiotic treatment of methicillin-resistant Staphylococcus aureus-associated glomerulonephritis
    Yasushi Nagaba
    Department of Internal Medicine, Kitasato University School of Medicine, 1 15 1 Kitasato, Sagamihara City, Kanagawa 228 8555, Japan
    Nephron 92:297-303. 2002
    ..The purpose of this study is to elucidate the clinicopathological features and the responsiveness to treatment of the disease...