Susumu Saigusa

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. doi request reprint Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Ann Surg Oncol 16:3488-98. 2009
  2. doi request reprint Inhibition of HGF/cMET expression prevents distant recurrence of rectal cancer after preoperative chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Int J Oncol 40:583-91. 2012
  3. doi request reprint Decreased expression of DUSP4 is associated with liver and lung metastases in colorectal cancer
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Med Oncol 30:620. 2013
  4. doi request reprint Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Cancer Res Clin Oncol 139:131-8. 2013
  5. doi request reprint Clinical significance of LGR5 and CD44 expression in locally advanced rectal cancer after preoperative chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Oncol 41:1643-52. 2012
  6. doi request reprint Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Oncol Rep 28:855-61. 2012
  7. doi request reprint Prognostic significance of glucose transporter-1 (GLUT1) gene expression in rectal cancer after preoperative chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 42:460-9. 2012
  8. doi request reprint Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Oncol Rep 26:1069-74. 2011
  9. doi request reprint Cancer-associated fibroblasts correlate with poor prognosis in rectal cancer after chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie, Japan
    Int J Oncol 38:655-63. 2011
  10. ncbi request reprint Immunohistochemical features of CD133 expression: association with resistance to chemoradiotherapy in rectal cancer
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Oncol Rep 24:345-50. 2010

Collaborators

Detail Information

Publications38

  1. doi request reprint Correlation of CD133, OCT4, and SOX2 in rectal cancer and their association with distant recurrence after chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Ann Surg Oncol 16:3488-98. 2009
    ..We investigated the role of three stem cell markers (CD133, OCT4, and SOX2) in rectal cancer and evaluated the association between these gene levels and clinical outcome in rectal cancer patients with preoperative CRT...
  2. doi request reprint Inhibition of HGF/cMET expression prevents distant recurrence of rectal cancer after preoperative chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Int J Oncol 40:583-91. 2012
    ....
  3. doi request reprint Decreased expression of DUSP4 is associated with liver and lung metastases in colorectal cancer
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Med Oncol 30:620. 2013
    ..In conclusion, DUSP4 expression in colorectal cancer was negatively correlated with factors reflecting tumor progression, including distant metastases. Our data suggest that DUSP4 may act as a tumor suppressor in colorectal cancer...
  4. doi request reprint Significant correlation between LKB1 and LGR5 gene expression and the association with poor recurrence-free survival in rectal cancer after preoperative chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Cancer Res Clin Oncol 139:131-8. 2013
    ..The aim of the present study was to investigate whether the gene expression levels of LKB1 and LGR5 correlated with clinical outcome in patients with locally advanced rectal cancer treated with preoperative chemoradiotherapy (CRT)...
  5. doi request reprint Clinical significance of LGR5 and CD44 expression in locally advanced rectal cancer after preoperative chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Oncol 41:1643-52. 2012
    ..In conclusion, LGR5 and CD44 expression may be coordinately associated with tumor relapse in locally advanced rectal cancer after preoperative CRT...
  6. doi request reprint Gene expression profiles of tumor regression grade in locally advanced rectal cancer after neoadjuvant chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Oncol Rep 28:855-61. 2012
    ..The results of this study suggest that TRG may reflect characteristics, such as proliferative activity, stemness potency and resistance to hypoxia, of residual cancer cells following pre-operative CRT...
  7. doi request reprint Prognostic significance of glucose transporter-1 (GLUT1) gene expression in rectal cancer after preoperative chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Surg Today 42:460-9. 2012
    ..We wondered whether GLUT1 expression was associated with the clinical outcome in rectal cancer after preoperative chemoradiotherapy (CRT), and whether glycolysis inhibition could represent a novel anticancer treatment...
  8. doi request reprint Podoplanin and SOX2 expression in esophageal squamous cell carcinoma after neoadjuvant chemo-radiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Oncol Rep 26:1069-74. 2011
    ..05). In conclusion, the expression levels of podoplanin and SOX2 expression may be useful prognostic markers for ESCC treated with neoadjuvant CRT...
  9. doi request reprint Cancer-associated fibroblasts correlate with poor prognosis in rectal cancer after chemoradiotherapy
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie, Japan
    Int J Oncol 38:655-63. 2011
    ..In conclusion, FAP-α and SDF-1 expression was shown to be involved in tumor re-growth and recurrence in rectal cancer patients treated with pre-operative CRT...
  10. ncbi request reprint Immunohistochemical features of CD133 expression: association with resistance to chemoradiotherapy in rectal cancer
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Oncol Rep 24:345-50. 2010
    ..Further studies clarifying the role of CD133 in tumor re-growth and resistance to conventional CRT in colorectal cancer may assist the development of future cancer therapeutics...
  11. doi request reprint Stromal CXCR4 and CXCL12 expression is associated with distant recurrence and poor prognosis in rectal cancer after chemoradiotherapy
    Susumu Saigusa
    Division of Reparative Medicine, Institute of Life Sciences, Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Ann Surg Oncol 17:2051-8. 2010
    ..It has been reported that expression of CXCR4 and its ligand CXCL12 are associated with migration, invasion, and proliferation of colorectal cancer...
  12. doi request reprint Clinical significance of CD133 and hypoxia inducible factor-1α gene expression in rectal cancer after preoperative chemoradiotherapy
    S Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, Japan
    Clin Oncol (R Coll Radiol) 23:323-32. 2011
    ..Therefore, we investigated the correlation between the expression of CD133 and hypoxia inducible factor-1α (HIF-1α), and their association with clinical outcome...
  13. ncbi request reprint Elevated CD133, but not VEGF or EGFR, as a predictive marker of distant recurrence after preoperative chemoradiotherapy in rectal cancer
    Hiromi Yasuda
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Oncol Rep 22:709-17. 2009
    ..Elevated CD133, but not VEGF or EGFR, on FFPE specimens may be a predictive marker of distant recurrence and poor survival after preoperative CRT in rectal cancer...
  14. doi request reprint CXCL5, a promoter of cell proliferation, migration and invasion, is a novel serum prognostic marker in patients with colorectal cancer
    Mikio Kawamura
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan
    Eur J Cancer 48:2244-51. 2012
    ..Serum CXCL5 levels in patients with colorectal cancer (CRC) were assessed to evaluate correlation with clinicopathologic features and prognosis. The effects of CXCL5 on CRC cells were also investigated in vitro...
  15. doi request reprint Co-expression of hepatocyte growth factor and c-Met predicts peritoneal dissemination established by autocrine hepatocyte growth factor/c-Met signaling in gastric cancer
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie, Japan
    Int J Cancer 130:2912-21. 2012
    ..Blockade of the autocrine HGF/c-Met pathway could be clinically useful for the treatment of peritoneal dissemination in gastric cancer...
  16. doi request reprint TS and DPD mRNA levels on formalin-fixed paraffin-embedded specimens as predictors for distant recurrence of rectal cancer treated with preoperative chemoradiotherapy
    Koji Tanaka
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Mie, Japan
    J Surg Oncol 105:529-34. 2012
    ..This study aimed to investigate mRNA level of 5-FU metabolizing enzymes in post-treatment specimens and to evaluate their predictive value of distant recurrence after CRT...
  17. ncbi request reprint C-reactive protein as predictor of recurrence in patients with rectal cancer undergoing chemoradiotherapy followed by surgery
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Graduate School of Medicine, Mie University, Mie 514 8507, Japan
    Anticancer Res 33:5065-74. 2013
    ..The clinical significance of the systemic inflammatory response (SIR) in patients with rectal cancer undergoing neoadjuvant chemoradiotherapy (CRT), to the best of our knowledge, has not been thus far investigated...
  18. doi request reprint Smad interacting protein 1 (SIP1) is associated with peritoneal carcinomatosis in intestinal type gastric cancer
    Yoshinaga Okugawa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Clin Exp Metastasis 30:417-29. 2013
    ..SIP1 appears to play an important role in progression to peritoneal carcinomatosis and may be a therapeutic target for patients with intestinal type gastric cancer...
  19. ncbi request reprint Microdissection is essential for gene expression analysis of irradiated rectal cancer tissues
    Yasuhiro Inoue
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Oncol Rep 22:901-6. 2009
    ....
  20. doi request reprint Increased expression of Slug and Vimentin as novel predictive biomarkers for lymph node metastasis and poor prognosis in colorectal cancer
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie 514 8507, Japan and
    Carcinogenesis 34:2548-57. 2013
    ..Our data provide novel evidence for the biological and clinical significance of Slug and Vimentin expression as potential predictive biomarkers for identifying patients with lymph node metastasis or poor prognosis in CRC. ..
  21. doi request reprint Soluble CXCL16 in preoperative serum is a novel prognostic marker and predicts recurrence of liver metastases in colorectal cancer patients
    Kohei Matsushita
    Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Ann Surg Oncol 19:S518-27. 2012
    ..This study was designed to identify novel and reliable serum prognostic markers in patients with colorectal cancer (CRC)...
  22. doi request reprint Clinical significance of Zinc finger E-box Binding homeobox 1 (ZEB1) in human gastric cancer
    Yoshinaga Okugawa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
    J Surg Oncol 106:280-5. 2012
    ..The aim of this study is to clarify the clinical significance of ZEB1 expression in gastric cancer patients...
  23. doi request reprint High TrkB expression levels are associated with poor prognosis and EMT induction in colorectal cancer cells
    Hiroyuki Fujikawa
    Division of Reparative Medicine, Department of Gastrointestinal and Pediatric Surgery, Institute of Life Sciences, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    J Gastroenterol 47:775-84. 2012
    ..This study investigates whether TrkB expression is associated with the clinical outcome of colorectal cancer (CRC) patients and whether TrkB induces EMT in CRC cells...
  24. doi request reprint In vivo real-time imaging of chemotherapy response on the liver metastatic tumor microenvironment using multiphoton microscopy
    Koji Tanaka
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Oncol Rep 28:1822-30. 2012
    ..Time-series intravital TPLSM imaging on the metastatic tumor xenografts may be useful for screening and evaluating new chemotherapeutics with less interindividual variability...
  25. doi request reprint Clinical significance of serum soluble E-cadherin in colorectal carcinoma
    Yoshinaga Okugawa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Japan
    J Surg Res 175:e67-73. 2012
    ..However, the prognostic value of serum sE-cadherin level has not been demonstrated in colorectal cancer...
  26. doi request reprint Low NDRG1 mRNA expression predicts a poor prognosis in neuroblastoma patients
    Kohei Matsushita
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, Japan
    Pediatr Surg Int 29:363-8. 2013
    ..However, NDRG1's function in malignant tumors has not been fully determined. Therefore, we investigated the association of NDRG1 expression with clinical outcomes in neuroblastoma (NB) patients...
  27. ncbi request reprint Correlation of MACC1 and MET expression in rectal cancer after neoadjuvant chemoradiotherapy
    Mikio Kawamura
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie, Japan
    Anticancer Res 32:1527-31. 2012
    ..In this study, we demonstrated the correlation and the clinical significance of MACC1 and MET expression in rectal cancer patients treated with chemoradiotherapy (CRT) followed by surgery...
  28. doi request reprint DPEP1, expressed in the early stages of colon carcinogenesis, affects cancer cell invasiveness
    Yuji Toiyama
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Gastroenterol 46:153-63. 2011
    ..We investigated changes in the gene expression profile in colon cancer in order to identify gene markers that may be useful in the management of this disease...
  29. doi request reprint Evaluation of CXCL10 as a novel serum marker for predicting liver metastasis and prognosis in colorectal cancer
    Yuji Toiyama
    Department of Gastro intestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Int J Oncol 40:560-6. 2012
    ..Comprehensive analysis using cytokine arrays identified the novel serum prognosis marker CXCL10. Preoperative high serum levels of CXCL10 were associated with poor prognosis and liver metastasis in CRC...
  30. doi request reprint Radiation induces epithelial-mesenchymal transition in colorectal cancer cells
    Aya Kawamoto
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Oncol Rep 27:51-7. 2012
    ..These results indicate that irradiation induces an alteration to a malignant phenotype consistent with EMT in colorectal cancer cells...
  31. doi request reprint Clinical implications of CES2 RNA expression in neuroblastoma
    Keiichi Uchida
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Pediatr Surg 48:502-9. 2013
    ..Human carboxylesterase 2 (CES2) is the key enzyme for metabolic activation of irinotecan (CPT-11). The aim was to evaluate the clinical implications of CES2 RNA expression in neuroblastoma cells...
  32. doi request reprint The prognostic value of KRAS mutations in patients with colorectal cancer
    Yasuhiro Inoue
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Oncol Rep 28:1579-84. 2012
    ..In Japanese CRC patients KRAS p.G13D had prognostic impact on DFS in stage I-III disease, while the prognosis of stage IV patients without anti-EGFR antibody therapy was unaffected by KRAS status...
  33. doi request reprint Loss of the metastasis suppressor gene KiSS1 is associated with lymph node metastasis and poor prognosis in human colorectal cancer
    Yoshinaga Okugawa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Oncol Rep 30:1449-54. 2013
    ..The loss of KiSS1 appears to correlate with the progression of lymph node metastasis. An assessment of KiSS1 expression may assist in the accurate colorectal cancer diagnosis and may contribute to predict clinical outcomes. ..
  34. doi request reprint Leucine-rich repeat-containing G protein-coupled receptor 5 expression in ductular reactions after chemotherapy for metastatic colorectal cancer
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Mie Japan
    Hepatol Res 43:84-90. 2013
    ..Conclusion:  These findings suggest that LGR5 may be involved in maintaining DR in damaged liver...
  35. doi request reprint Glycolysis inhibitors as a potential therapeutic option to treat aggressive neuroblastoma expressing GLUT1
    Kohei Matsushita
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    J Pediatr Surg 47:1323-30. 2012
    ..We also assessed the efficacy of glycolysis inhibition as an anticancer treatment in neuroblastoma cell lines with altered expression of GLUT1...
  36. pmc Late-onset peritoneal recurrence of advanced gastric cancer 20 years after primary resection
    Yoshinaga Okugawa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    World J Surg Oncol 8:104. 2010
    ..In conclusion, we present late onset of peritoneal recurrence of gastric cancer more than 20 years after primary surgery, and speculate on the mechanism of late-onset recurrence in our case...
  37. doi request reprint Single-incision laparoscopic and endoscopic cooperative surgery for gastrointestinal stromal tumor arising from the duodenum
    Masaki Ohi
    Department of Innovative Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    Asian J Endosc Surg 6:307-10. 2013
    ..There were no postoperative complications, including stenosis. Single-incision laparoscopic and endoscopic cooperative surgery can be safely and effectively performed for a duodenal submucosal tumor. ..
  38. doi request reprint Identification of patients with developing ulcerative colitis-associated neoplasia by nitrative DNA damage marker 8-nitroguanin expression in rectal mucosa
    Susumu Saigusa
    Department of Gastrointestinal and Pediatric Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    J Clin Gastroenterol 47:e80-6. 2013
    ..To clarify whether the expression of nitrative and oxidative DNA damage markers in the rectal mucosa of patients with ulcerative colitis (UC) could be used to predict UC-associated neoplasia...