Machiko Nishio

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. ncbi request reprint Interaction between nucleocapsid protein (NP) and phosphoprotein (P) of human parainfluenza virus type 2: one of the two NP binding sites on P is essential for granule formation
    M Nishio
    Department of Microbiology, Mie University School of Medicine, Tsu Shi, Japan
    J Gen Virol 77:2457-63. 1996
  2. pmc Human parainfluenza virus type 2 L protein regions required for interaction with other viral proteins and mRNA capping
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    J Virol 85:725-32. 2011
  3. pmc Human parainfluenza virus type 2 V protein inhibits genome replication by binding to the L protein: possible role in promoting viral fitness
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    J Virol 82:6130-8. 2008
  4. ncbi request reprint The conserved carboxyl terminus of human parainfluenza virus type 2 V protein plays an important role in virus growth
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie, 514 8507, Japan
    Virology 362:85-98. 2007
  5. pmc Human parainfluenza virus type 4 is incapable of evading the interferon-induced antiviral effect
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu Shi, Mie Prefecture, 514 8507 Japan
    J Virol 79:14756-68. 2005
  6. ncbi request reprint Identification of RNA-binding regions on the P and V proteins of human parainfluenza virus type 2
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Med Microbiol Immunol 195:29-36. 2006
  7. pmc Identification of paramyxovirus V protein residues essential for STAT protein degradation and promotion of virus replication
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, Tsu Shi, Mie Prefecture, Japan
    J Virol 79:8591-601. 2005
  8. ncbi request reprint Mapping of domains on the human parainfluenza type 2 virus P and NP proteins that are involved in the interaction with the L protein
    M Nishio
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu Shi, Mie Ken, 514 8507, Japan
    Virology 273:241-7. 2000
  9. ncbi request reprint Mapping of domains on the human parainfluenza virus type 2 nucleocapsid protein (NP) required for NP-phosphoprotein or NP-NP interaction
    M Nishio
    Department of Microbiology, Mie University School of Medicine, Tsu Shi, Mie Ken, Japan
    J Gen Virol 80:2017-22. 1999
  10. ncbi request reprint Isolation of monoclonal antibodies directed against the V protein of human parainfluenza virus type 2 and localization of the V protein in virus-infected cells
    M Nishio
    Department of Microbiology, Mie University School of Medicine, Japan
    Med Microbiol Immunol 188:79-82. 1999

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Interaction between nucleocapsid protein (NP) and phosphoprotein (P) of human parainfluenza virus type 2: one of the two NP binding sites on P is essential for granule formation
    M Nishio
    Department of Microbiology, Mie University School of Medicine, Tsu Shi, Japan
    J Gen Virol 77:2457-63. 1996
    ..However, cells co-expressing NP and P proteins with C-terminal deletions showed a different immunofluorescence staining pattern (diffuse pattern), indicating that the C-terminal region is required for granule formation...
  2. pmc Human parainfluenza virus type 2 L protein regions required for interaction with other viral proteins and mRNA capping
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    J Virol 85:725-32. 2011
    ..We propose that this conserved region of L also binds GTP (or GDP) to carry out the second step of the unconventional nonsegmented negative-strand virus capping reaction...
  3. pmc Human parainfluenza virus type 2 V protein inhibits genome replication by binding to the L protein: possible role in promoting viral fitness
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    J Virol 82:6130-8. 2008
    ..A possible role for this inhibition of genome replication in promoting viral fitness is discussed...
  4. ncbi request reprint The conserved carboxyl terminus of human parainfluenza virus type 2 V protein plays an important role in virus growth
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie, 514 8507, Japan
    Virology 362:85-98. 2007
    ..Depletion of AIP1/Alix by small interfering RNA suppressed virus growth. These data suggest that the conserved carboxyl terminus of the V protein plays an important role in virus growth...
  5. pmc Human parainfluenza virus type 4 is incapable of evading the interferon-induced antiviral effect
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu Shi, Mie Prefecture, 514 8507 Japan
    J Virol 79:14756-68. 2005
    ..Moreover, we established HeLa cells persistently infected with hPIV4 to make sure of the inability to escape IFN and confirmed that hPIV4 is the only paramyxovirus analyzed to date that can't evade the IFN-induced antiviral responses...
  6. ncbi request reprint Identification of RNA-binding regions on the P and V proteins of human parainfluenza virus type 2
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Med Microbiol Immunol 195:29-36. 2006
    ..Intriguingly, the P and V proteins of hPIV2 can selectively bind to the viral RNA under our experimental conditions...
  7. pmc Identification of paramyxovirus V protein residues essential for STAT protein degradation and promotion of virus replication
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, Tsu Shi, Mie Prefecture, Japan
    J Virol 79:8591-601. 2005
    ..Interestingly, many of the residues that are essential for anti-IFN activity, e.g., the Cys of this cluster and Phe207 within this cluster, as well as the Trp of this motif, are also essential for promoting virus growth...
  8. ncbi request reprint Mapping of domains on the human parainfluenza type 2 virus P and NP proteins that are involved in the interaction with the L protein
    M Nishio
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu Shi, Mie Ken, 514 8507, Japan
    Virology 273:241-7. 2000
    ....
  9. ncbi request reprint Mapping of domains on the human parainfluenza virus type 2 nucleocapsid protein (NP) required for NP-phosphoprotein or NP-NP interaction
    M Nishio
    Department of Microbiology, Mie University School of Medicine, Tsu Shi, Mie Ken, Japan
    J Gen Virol 80:2017-22. 1999
    ....
  10. ncbi request reprint Isolation of monoclonal antibodies directed against the V protein of human parainfluenza virus type 2 and localization of the V protein in virus-infected cells
    M Nishio
    Department of Microbiology, Mie University School of Medicine, Japan
    Med Microbiol Immunol 188:79-82. 1999
    ..The P and NP proteins were organized in numerous granules in the cytoplasm of hPIV-2 infected cells. In contrast, the V protein showed diffuse nuclear and cytoplasm distributions...
  11. ncbi request reprint Human parainfluenza virus type 2 phosphoprotein: mapping of monoclonal antibody epitopes and location of the multimerization domain
    M Nishio
    Department of Microbiology, Mie University School of Medicine, Japan
    J Gen Virol 78:1303-8. 1997
    ..The oligomer was shown to be a homotrimer by chemical cross-linking experiments...
  12. ncbi request reprint Cytological properties of stromal cells derived from giant cell tumor of bone (GCTSC) which can induce osteoclast formation of human blood monocytes without cell to cell contact
    Makoto Nishimura
    Department of Microbiology, Mie University School of Medicine, Tsu Shi, Mie Prefecture 514 8507, Japan
    J Orthop Res 23:979-87. 2005
    ..Some lines of GCTSC expressed alkaline phosphatase, osteocalcin and Cbfa1, suggesting that GCTSC are intimately related to osteoblastic lineage...
  13. ncbi request reprint Identification of amino acids essential for the human parainfluenza type 2 virus V protein to lower the intracellular levels of the STAT2
    Yuji Kozuka
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu Shi, Mie Prefecture 514 8507, Japan
    Virology 317:208-19. 2003
    ..On the other hand, HeLa/SV41V, HeLa/S216D, and HeLa1217R cells are resistant to both IFNs. Intriguingly, HeLa/A105E and HeLa/H108P cells were found to be sensitive to IFN-gamma...
  14. ncbi request reprint Failure of multinucleated giant cell formation in k562 cells infected with newcastle disease virus and human parainfluenza type 2 virus
    Izumi Yamakawa
    Department of Microbiology, Mie University Graduate School of Medicine, Japan
    Microbiol Immunol 51:601-8. 2007
    ..An unknown regulatory mechanism of virus-induced cell fusion may function on the cell surface of K562 cells...
  15. ncbi request reprint The properties of recombinant Sendai virus having the P gene of Sendai virus pi strain derived from BHK cells persistently infected with Sendai virus
    Machiko Nishio
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174, Edobashi, 514 8507 Tsu Shi, Mie Prefecture, Japan
    Med Microbiol Immunol 195:151-8. 2006
    ..The specific amino acid substitutions unique to the SeVpi are 18. Information about the complete genome sequences of SeVpi strain is important to totally understand the persistent infection and lower pathogenicity of SeV...
  16. pmc Identification of domains on the fusion (F) protein trimer that influence the hemagglutinin-neuraminidase specificity of the f protein in mediating cell-cell fusion
    Masato Tsurudome
    Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Virol 85:3153-61. 2011
    ....
  17. ncbi request reprint Recombinant Sendai viruses with L1618V mutation in their L polymerase protein establish persistent infection, but not temperature sensitivity
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, Mie Prefecture 514 8507, Japan
    Virology 329:289-301. 2004
    ..Three amino acid substitutions are also found in the Ppi protein, but rSeV(Ppi) does not show these phenotypes...
  18. pmc Effects of hemagglutinin-neuraminidase protein mutations on cell-cell fusion mediated by human parainfluenza type 2 virus
    Masato Tsurudome
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507 Japan
    J Virol 82:8283-95. 2008
    ..Notably, the limited cell-cell fusion by H-83/186 virus was greatly promoted by lysophosphatidic acid, a stimulator of the Ras and Rho family GTPases...
  19. ncbi request reprint A mutant fusion (F) protein of simian virus 5 induces hemagglutinin-neuraminidase-independent syncytium formation despite the internalization of the F protein
    Masato Tsurudome
    Department of Microbiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Virology 347:11-27. 2006
    ..Intriguingly, it disappeared from the cell surface due to its internalization, while inducing extensive syncytium formation. These results indicate that L22P may display an internalization signal during the course of fusion induction...
  20. ncbi request reprint The functional interaction between CD98 and CD147 in regulation of virus-induced cell fusion and osteoclast formation
    Kouki Mori
    Department of Microbiology, Mie University School of Medicine, 2 174 Edobashi, Tsu Shi, 514 8507 Mie Prefecture, Japan
    Med Microbiol Immunol 193:155-62. 2004
    ..Ab2 and 3 also suppressed CD98-mediated cell fusion of monocytes. This study indicates the functional interaction between CD98 and CD147 in the regulation of cell fusion...
  21. pmc Early stage of establishment of persistent Sendai virus infection: unstable dynamic phase and then selection of viruses which are tightly cell associated, temperature sensitive, and capable of establishing persistent infection
    Morihiro Ito
    Department of Microbiology, School of Medicine, Mie University, 2 174 Edobashi, Tsu Shi, Mie Prefecture 514 8507, Japan
    J Virol 78:11939-51. 2004
    ..This study shows that there is an unstable dynamic phase at an early stage of the establishment of persistent Sendai virus infection (steady state), and then viruses capable of establishing persistent infection are selected...
  22. ncbi request reprint Characterization of Sendai virus persistently infected L929 cells and Sendai virus pi strain: recombinant Sendai viruses having Mpi protein shows lower cytotoxicity and are incapable of establishing persistent infection
    Machiko Nishio
    Department of Microbiology, Mie University School of Medicine, 2 174, Edobashi, Tsu Shi, Mie Prefecture, 514 8507, Japan
    Virology 314:110-24. 2003
    ..Amino acid 116 of the Mpi protein is related to the nuclear translocation and lower cytopathogenesis, whereas aa183 is involved in the interaction between M protein and viral glycoproteins...
  23. pmc Full conversion of the hemagglutinin-neuraminidase specificity of the parainfluenza virus 5 fusion protein by replacement of 21 amino acids in its head region with those of the simian virus 41 fusion protein
    Masato Tsurudome
    Department of Microbiology and Molecular Genetics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    J Virol 87:8342-50. 2013
    ....
  24. ncbi request reprint Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1
    Morihiro Ito
    Department of Microbiology, Mie University School of Medicine, 2 174 Edobashi, Tsu, Japan
    Int J Biochem Cell Biol 34:1152-63. 2002
    ..This study intends to examine whether these novel transcripts have biological significance through elucidating their genetic aspects and expression profiles in human cells...
  25. ncbi request reprint Human osteosarcoma-derived cell lines produce soluble factor(s) that induces differentiation of blood monocytes to osteoclast-like cells
    Noriki Miyamoto
    Department of Microbiology, Mie University School of Medicine, Tsu, Japan
    Int Immunopharmacol 2:25-38. 2002
    ..9 cells in the presence of OCIF for 14 days, HOS cell-mediated osteoclastogenesis was suppressed, indicating that RANK-RANKL system is involved in the HOS cell-mediated osteoclastogenesis...
  26. doi request reprint Completion of the full-length genome sequence of human parainfluenza virus types 4A and 4B: sequence analysis of the large protein genes and gene start, intergenic and end sequences
    Hiroshi Komada
    Department of Microbiology, Suzuka University of Medical Science Suzuka, Mie, Japan
    Arch Virol 156:161-6. 2011
    ....
  27. ncbi request reprint Possible activation of murine T lymphocyte through CD98 is independent of interleukin 2/interleukin 2 receptor system
    Hiroshi Komada
    Department of Microbiology, Mie University School of Medicine, Mie, Japan
    Biomed Res 27:61-7. 2006
    ..Taken together with these findings, it was speculated that the CD98 system is independent of the IL-2/IL-2R system in murine T lymphocyte activation...
  28. pmc Sendai virus trailer RNA binds TIAR, a cellular protein involved in virus-induced apoptosis
    Frédéric Iseni
    Department of Genetics and Microbiology, University of Geneva School of Medicine CMU, 9 Avenue de Champel, CH 1211 Geneva, Switzerland
    EMBO J 21:5141-50. 2002
    ..In this view, tr RNA is not simply a by-product of abortive genome synthesis, but is also an antigenome transcript that modulates the cellular antiviral response...
  29. ncbi request reprint The carboxyl segment of the mumps virus V protein associates with Stat proteins in vitro via a tryptophan-rich motif
    Machiko Nishio
    Department of Genetics and Microbiology, University of Geneva School of Medicine, CMU, 9 Ave de Champel, CH1211, Geneva, Switzerland
    Virology 300:92-9. 2002
    ..Our results suggest that rubulavirus V proteins may be related to both the C and the V proteins of respiroviruses...
  30. ncbi request reprint Sendai virus, a murine parainfluenza virus type 1, replicates to a level similar to human PIV1 in the upper and lower respiratory tract of African green monkeys and chimpanzees
    Mario H Skiadopoulos
    Respiratory Viruses Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA
    Virology 297:153-60. 2002
    ..Its ability to efficiently replicate in nonhuman primates suggests that MPIV1 lacks a significant host range restriction in primates and could theoretically cause zoonotic disease in humans...