Tomoki Nakamura

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. ncbi request reprint A new limb salvage surgery in cases of high-grade soft tissue sarcoma using photodynamic surgery, followed by photo- and radiodynamic therapy with acridine orange
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Postgraduate School of Medicine, Tsu City, Japan
    J Surg Oncol 97:523-8. 2008
  2. ncbi request reprint Determination of the LD50 of acridine orange via intravenous administration in mice in preparation for clinical application to cancer therapy
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan
    In Vivo 28:523-7. 2014
  3. ncbi request reprint Role of High-sensitivity C-reactive Protein in the Differentiation of Benign and Malignant Soft Tissue Tumors
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu City, Mie 514 8507, Japan
    Anticancer Res 34:933-6. 2014
  4. ncbi request reprint The relationship between pretreatment anaemia and survival in patients with adult soft tissue sarcoma
    Tomoki Nakamura
    Department of Oncology Orthopaedic Surgery, The Royal Orthopaedic Hospital, Bristol Road South, Northfield, Birmingham, B31 2AP, UK
    J Orthop Sci 18:987-93. 2013
  5. doi request reprint Outcome of soft-tissue sarcoma patients who were alive and event-free more than five years after initial treatment
    T Nakamura
    The Royal Orthopaedic Hospital, Oncology Service, Bristol Road South, Birmingham, UK
    Bone Joint J 95:1139-43. 2013
  6. doi request reprint The prognostic value of the serum level of C-reactive protein for the survival of patients with a primary sarcoma of bone
    T Nakamura
    The Royal Orthopaedic Hospital, Oncology Service, Bristol Road South, Northfield, Birmingham B31 2AP, UK
    Bone Joint J 95:411-8. 2013
  7. doi request reprint Foreign-body granulomas in the trunk and extremities may simulate malignant soft-tissue tumors: report of three cases
    T Nakamura
    Department of Orthopedic Surgery, Mie University Faculty of Medicine, Tsu, Mie, Japan
    Acta Radiol 49:80-3. 2008
  8. doi request reprint Prosthetic limb salvage surgery for bone and soft tissue tumors around the knee
    Rui Niimi
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Oncol Rep 28:1984-90. 2012
  9. pmc Can a less radical surgery using photodynamic therapy with acridine orange be equal to a wide-margin resection?
    Takao Matsubara
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu City, Mie 514 8507, Japan
    Clin Orthop Relat Res 471:792-802. 2013
  10. doi request reprint Clinical significance of pretreatment serum C-reactive protein level in soft tissue sarcoma
    Tomoki Nakamura
    Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu City, Japan
    Cancer 118:1055-61. 2012

Collaborators

Detail Information

Publications39

  1. ncbi request reprint A new limb salvage surgery in cases of high-grade soft tissue sarcoma using photodynamic surgery, followed by photo- and radiodynamic therapy with acridine orange
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Postgraduate School of Medicine, Tsu City, Japan
    J Surg Oncol 97:523-8. 2008
    ....
  2. ncbi request reprint Determination of the LD50 of acridine orange via intravenous administration in mice in preparation for clinical application to cancer therapy
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie, Japan
    In Vivo 28:523-7. 2014
    ..We undertook studies to determine the lethal dose 50 (LD50) of acridine orange (AO) using mice in order to confirm the safety of intravenous administration of AO...
  3. ncbi request reprint Role of High-sensitivity C-reactive Protein in the Differentiation of Benign and Malignant Soft Tissue Tumors
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu City, Mie 514 8507, Japan
    Anticancer Res 34:933-6. 2014
    ..3%, respectively, for identifying. The current analyses showed that an elevated hs-CRP level is associated with the presence of STS and may, therefore, be used as an additional marker for the differential diagnosis of soft tissue tumors. ..
  4. ncbi request reprint The relationship between pretreatment anaemia and survival in patients with adult soft tissue sarcoma
    Tomoki Nakamura
    Department of Oncology Orthopaedic Surgery, The Royal Orthopaedic Hospital, Bristol Road South, Northfield, Birmingham, B31 2AP, UK
    J Orthop Sci 18:987-93. 2013
    ..The aim of this study was to elucidate the relationship between anaemia and clinical outcome and to determine whether pretreatment anaemia predicted disease-specific survival in patients with adult soft tissue sarcoma...
  5. doi request reprint Outcome of soft-tissue sarcoma patients who were alive and event-free more than five years after initial treatment
    T Nakamura
    The Royal Orthopaedic Hospital, Oncology Service, Bristol Road South, Birmingham, UK
    Bone Joint J 95:1139-43. 2013
    ..7 to 61.7), respectively, with a median survival time of 46 months. Patients with soft-tissue sarcoma, especially if large, require long-term follow-up, especially as they have moderate potential to have their disease controlled...
  6. doi request reprint The prognostic value of the serum level of C-reactive protein for the survival of patients with a primary sarcoma of bone
    T Nakamura
    The Royal Orthopaedic Hospital, Oncology Service, Bristol Road South, Northfield, Birmingham B31 2AP, UK
    Bone Joint J 95:411-8. 2013
    ..We recommend that CRP levels are measured routinely in patients with a suspected sarcoma of bone as a further prognostic indicator of survival...
  7. doi request reprint Foreign-body granulomas in the trunk and extremities may simulate malignant soft-tissue tumors: report of three cases
    T Nakamura
    Department of Orthopedic Surgery, Mie University Faculty of Medicine, Tsu, Mie, Japan
    Acta Radiol 49:80-3. 2008
    ..A palpable tumor adjacent to a previous surgery scar is therefore a warning that it might represent a granuloma, in spite of various image findings...
  8. doi request reprint Prosthetic limb salvage surgery for bone and soft tissue tumors around the knee
    Rui Niimi
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Oncol Rep 28:1984-90. 2012
    ..Limb salvage surgery is considered to be an effective treatment option. However, the high complication rate is a major concern for prosthetic replacement. Future improvements of prostheses are very important...
  9. pmc Can a less radical surgery using photodynamic therapy with acridine orange be equal to a wide-margin resection?
    Takao Matsubara
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu City, Mie 514 8507, Japan
    Clin Orthop Relat Res 471:792-802. 2013
    ..However, whether this less radical surgical approach increases or decreases survival or whether it increases the risk of local recurrence remains uncertain...
  10. doi request reprint Clinical significance of pretreatment serum C-reactive protein level in soft tissue sarcoma
    Tomoki Nakamura
    Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu City, Japan
    Cancer 118:1055-61. 2012
    ..The aim of this study was to determine whether circulating C-reactive protein (CRP) levels before treatment predict the overall survival and disease-free survival in soft tissue sarcoma patients...
  11. doi request reprint Clinical significance of radiofrequency ablation and metastasectomy in elderly patients with lung metastases from musculoskeletal sarcomas
    Tomoki Nakamura
    Department of Orthopedic Surgery, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu City, Mie 514 8507, Japan
    J Cancer Res Ther 9:219-23. 2013
    ....
  12. doi request reprint Clinical outcomes of minimally invasive surgery using acridine orange for musculoskeletal sarcomas around the forearm, compared with conventional limb salvage surgery after wide resection
    Takao Matsubara
    Department of Orthopaedic Surgery, Mie Postgraduate School of Medicine, Tsu City, Mie Prefecture, Japan
    J Surg Oncol 102:271-5. 2010
    ....
  13. ncbi request reprint Acridine orange inhibits pulmonary metastasis of mouse osteosarcoma
    Haruhiko Satonaka
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
    Anticancer Res 31:4163-8. 2011
    ....
  14. ncbi request reprint Methylene blue in place of acridine orange as a photosensitizer in photodynamic therapy of osteosarcoma
    Takao Matsubara
    Department of Orthopaedic Surgery, Mie Postgraduate School of Medicine, Tsu, Japan
    In Vivo 22:297-303. 2008
    ..In vivo studies showed that MB did not specifically accumulate in mouse osteosarcoma tissue and that it did not inhibit tumor growth. MB is not a better photosensitizer than AO in PDS, PDT and RDT for osteosarcoma...
  15. ncbi request reprint A new therapeutic modality involving acridine orange excitation by photon energy used during reduction surgery for rhabdomyosarcomas
    Takao Matsubara
    Department of Orthopaedic Surgery, Mie Postgraduate School of Medicine, Mie Prefecture 514 8507, Japan
    Oncol Rep 21:89-94. 2009
    ..Based on these results, AO-PDS, PDT and RDT can be used to preserve excellent limb function in patients with rhabdomyosarcoma involving major nerves and vessels or bones...
  16. ncbi request reprint Flash wave light strongly enhanced the cytocidal effect of photodynamic therapy with acridine orange on a mouse osteosarcoma cell line
    Haruhiko Satonaka
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, Japan
    Anticancer Res 27:3339-44. 2007
    ..We therefore concluded that FWL is more useful for AO-PDT than CWL in terms of saving on the excitation time and of obtaining good efficacy of destruction of the residual tumor in the treatment of musculoskeletal sarcomas...
  17. doi request reprint Oncolytic virotherapy for human bone and soft tissue sarcomas using live attenuated poliovirus
    Satoru Atsumi
    Department of Orthopedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Int J Oncol 41:893-902. 2012
    ..These results suggest that oncolytic therapy using a LAPV may represent a new option for the treatment of bone and soft tissue sarcomas...
  18. doi request reprint Clinical impact of the tumor volume doubling time on sarcoma patients with lung metastases
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Clin Exp Metastasis 28:819-25. 2011
    ..The patients with lung metastasis that have a longer VDT should therefore be considered for aggressive treatment even if the lesions are multiple and/or bilateral...
  19. pmc The adverse effect of an unplanned surgical excision of foot soft tissue sarcoma
    Akinobu Nishimura
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu City, Mie 514 8507, Japan
    World J Surg Oncol 9:160. 2011
    ..Malignant soft tissue tumors of the foot are extremely rare and thus can be prematurely excised without appropriate preoperative evaluation. The present study compares adverse effects between unplanned and planned surgical excisions...
  20. doi request reprint The combined use of the neutrophil-lymphocyte ratio and C-reactive protein level as prognostic predictors in adult patients with soft tissue sarcoma
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    J Surg Oncol 108:481-5. 2013
    ....
  21. ncbi request reprint [Outcome for pulmonary metastases from malignant osteogenic and soft tissue sarcomas]
    Hironori Tempaku
    Department of Thoracic and Cardiovascular Surgery, Mie University School of Medicine, Tsu, Japan
    Kyobu Geka 66:311-4. 2013
    ..These results might suggest that the hybrid therapy of operation and radiofrequency ablation improves the prognosis of patients with pulmonary metastases from malignant osteogenic and soft tissue sarcomas...
  22. doi request reprint The symptom-to-diagnosis delay in soft tissue sarcoma influence the overall survival and the development of distant metastasis
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
    J Surg Oncol 104:771-5. 2011
    ..The purpose of this study is to investigate whether symptom-treatment delay are associated with the presence of metastasis at diagnosis, overall survival and distant metastasis-free survival in primary soft tissue sarcomas...
  23. doi request reprint Management of small pulmonary nodules in patients with sarcoma
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu City, Mie, 514 8507, Japan
    Clin Exp Metastasis 26:713-8. 2009
    ..If the nodule remains < or = 5 mm in size for more than 6 months, the nodule will be a benign lesion. On the contrary, if the nodule becomes larger than 5 mm within 6 months, a surgical excision of the nodules is recommended...
  24. doi request reprint A novel hyperthermia treatment for bone metastases using magnetic materials
    Akihiko Matsumine
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Int J Clin Oncol 16:101-8. 2011
    ..The purpose of this review is to summarize the latest studies on hyperthermic treatment in the field of musculoskeletal tumors, and to introduce the treatment strategy employing our novel hyperthermia approach...
  25. ncbi request reprint The expression of hDlg as a biomarker of the outcome in malignant fibrous histiocytomas
    Rui Niimi
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Oncol Rep 23:631-8. 2010
    ..0214; log-rank test). This is the first report to demonstrate that a reduced expression of hDlg protein is an independent negative prognostic factor for MFH...
  26. doi request reprint The value of C-reactive protein and comorbidity in predicting survival of patients with high grade soft tissue sarcoma
    Tomoki Nakamura
    Oncology Service, The Royal Orthopaedic Hospital, Birmingham, UK
    Eur J Cancer 49:377-85. 2013
    ..The aim of this study was to determine whether C-reactive protein (CRP) levels or patient's comorbidity before treatment predicted the overall disease-specific survival and local tumour control in high grade soft tissue sarcoma patients...
  27. pmc The clinical outcomes of extracorporeal irradiated and re-implanted cemented autologous bone graft of femoral diaphysis after tumour resection
    Tomoki Nakamura
    Oncology Service, The Royal Orthopaedic Hospital, Bristol Road South, Birmingham, B31 2AP, UK
    Int Orthop 37:647-51. 2013
    ..We report the outcome of intercalary resection of the femoral diaphysis and extracorporeal irradiated autologous bone graft reconstruction, without the use of vascularized fibular graft...
  28. doi request reprint Lung radiofrequency ablation in patients with pulmonary metastases from musculoskeletal sarcomas [corrected]
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu City, Mie, Japan
    Cancer 115:3774-81. 2009
    ..The authors retrospectively evaluated the impact of lung radiofrequency (RF) ablation on survival in patients with lung metastases from musculoskeletal sarcomas...
  29. ncbi request reprint [Topic of minimally invasive surgery for connective and soft tissue neoplasms]
    Akihiko Matsumine
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine
    Gan To Kagaku Ryoho 35:421-423. 2008
  30. doi request reprint Novel p53 splicing site mutation in Li-Fraumeni-like syndrome with osteosarcoma
    Naoto Sakurai
    Departments of Pediatrics and Developmental Science Orthopaedic Surgery, Mie University Graduate School of Medicine Division of Personalized Medicine, Mie University Hospital, Tsu, Mie, Japan
    Pediatr Int 55:107-11. 2013
    ..This case provides interesting insight into the phenotype-genotype correlation in LFL syndrome with a TP53 splicing mutation...
  31. doi request reprint Epithelioid hemangioendothelioma after radiotherapy for congenital hemangioma: a case report
    Rui Niimi
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu City, Mie, Japan
    Med Oncol 27:130-3. 2010
    ..Although malignant change in a benign vascular tumor is extremely rare, irradiation can induce malignant transformation of a hemangioma...
  32. ncbi request reprint Case report: recurrence of soft tissue MFH in bone due to minute intravenous tumor emboli detected by MRI
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Faculty of Medicine, Tsu City, Edobashi 514 8507, Mie Prefecture, Japan
    Oncol Rep 10:1957-60. 2003
    ..As at the time of writing, our patient remains alive and disease-free, with no evidence of any local recurrence or distant metastasis after wide tumor resection for the recurrent tumor...
  33. ncbi request reprint Malignant melanoma with a rhabdoid phenotype exhibiting numerous solid tumor masses: a case report
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Postgraduate School of Medicine, Mie University Postgraduate School of Medicine, Mie 514 8507, Japan
    Oncol Rep 21:887-91. 2009
    ..In addition, the positive expression of BAF47 was also recognized. These findings lead to the conclusion that this quite unique aggressive soft tissue tumor should therefore be diagnosed as malignant melanoma with a rhabdoid phenotype...
  34. pmc Clinical outcomes of Kyocera Modular Limb Salvage system after resection of bone sarcoma of the distal part of the femur: the Japanese Musculoskeletal Oncology Group study
    Tomoki Nakamura
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    Int Orthop 38:825-30. 2014
    ..The purpose of this study is to evaluate the clinical outcomes of treatment using this system following tumour resection of primary bone sarcoma of the distal femur...
  35. doi request reprint A tumor endoprosthesis is useful in elderly rheumatoid arthritis patient with acute intercondylar fracture of the distal femur
    Hiroki Wakabayashi
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu Mie 514 8507, Japan
    Rheumatol Int 32:1411-3. 2012
    ..A tumor prosthesis appears to be a viable treatment option for intercondylar femoral fractures in elderly patients. It is well tolerated and permits early ambulation and return to activities of daily living...
  36. ncbi request reprint Pelvic recurrence after Miles' operation for anastomotic recurrence in a patient with stage I rectal cancer invading the proper muscle layer: Case report
    Tatsuhiko Hoshikawa
    Department of Surgery, Tokai University Hachioji Hospital, Hachioji, Tokyo 192 0032, Japan
    Oncol Rep 17:743-6. 2007
    ..Further studies are required to examine the relationship between local recurrence and extranodal ONCs in patients with primary rectal cancer...
  37. ncbi request reprint Estimation of the time of pulmonary metastasis in colorectal cancer patients with isolated synchronous liver metastasis
    Sotaro Sadahiro
    Department of Surgery, Tokai University, Bohseidai Isehara, Kanagawa 259 1193, Japan
    Jpn J Clin Oncol 35:18-22. 2005
    ..The aim of this study was to estimate the time when pulmonary metastases began to grow in colorectal cancer (CRC) patients with isolated synchronous liver metastasis based on the tumor doubling time (DT)...
  38. ncbi request reprint Recurrence patterns after curative resection of colorectal cancer in patients followed for a minimum of ten years
    Sotaro Sadahiro
    Department of Surgery, Tokai University School of Medicine, Bohseidai, Isehara, Kanagawa, 259 1193, Japan
    Hepatogastroenterology 50:1362-6. 2003
    ..To investigate the recurrence patterns and interval from initial surgery in patients with curatively resected colorectal cancer followed for a minimum of 10 years...
  39. ncbi request reprint The stability of dihydropyrimidine dehydrogenase activity in colorectal cancer tissue after resection
    Sotaro Sadahiro
    Department of Surgery, Tokai University School of Medicine, Bohseidai, Isehara shi, Kanagawa 259 1193, Japan
    Oncol Rep 10:867-9. 2003
    ..496). Based on these results, it appears possible to make comparative assessments of DPD activity in colorectal cancer tissue without strictly stipulating the time between resection and freezing...