S Kawanishi

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. ncbi request reprint Site-specific oxidation at GG and GGG sequences in double-stranded DNA by benzoyl peroxide as a tumor promoter
    S Kawanishi
    Department of Hygiene, Mie University School of Medicine, Japan
    Biochemistry 38:16733-9. 1999
  2. ncbi request reprint Evaluation for safety of antioxidant chemopreventive agents
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie, 514 8507, Japan
    Antioxid Redox Signal 7:1728-39. 2005
  3. ncbi request reprint Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Biol Chem 387:365-72. 2006
  4. ncbi request reprint Mechanism of telomere shortening by oxidative stress
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Ann N Y Acad Sci 1019:278-84. 2004
  5. pmc Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides
    Shosuke Kawanishi
    Department of Hygiene, Mie University School of Medicine, Mie 514 8507, Japan
    Environ Health Perspect 110:789-91. 2002
  6. ncbi request reprint Amplification of anticancer drug-induced DNA damage and apoptosis by DNA-binding compounds
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Curr Med Chem Anticancer Agents 4:415-9. 2004
  7. ncbi request reprint The role of metals in site-specific DNA damage with reference to carcinogenesis
    Shosuke Kawanishi
    Department of Hygiene, Mie University School of Medicine, Edobashi, Tsu, Japan
    Free Radic Biol Med 32:822-32. 2002
  8. ncbi request reprint Mechanism of DNA damage induced by bromate differs from general types of oxidative stress
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Toxicology 221:172-8. 2006
  9. ncbi request reprint Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging
    S Kawanishi
    Department of Hygiene, Mie University School of Medicine, 514 8507, Mie, Japan
    Mutat Res 488:65-76. 2001
  10. ncbi request reprint Oxidative DNA damage in cultured cells and rat lungs by carcinogenic nickel compounds
    S Kawanishi
    Department of Hygiene, Mie University School of Medicine, Mie, Japan
    Free Radic Biol Med 31:108-16. 2001

Collaborators

Detail Information

Publications83

  1. ncbi request reprint Site-specific oxidation at GG and GGG sequences in double-stranded DNA by benzoyl peroxide as a tumor promoter
    S Kawanishi
    Department of Hygiene, Mie University School of Medicine, Japan
    Biochemistry 38:16733-9. 1999
    ....
  2. ncbi request reprint Evaluation for safety of antioxidant chemopreventive agents
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie, 514 8507, Japan
    Antioxid Redox Signal 7:1728-39. 2005
    ..Therefore, further studies on safety should be required when antioxidants are used for cancer prevention...
  3. ncbi request reprint Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Biol Chem 387:365-72. 2006
    ..On the basis of our results, we propose that 8-nitroguanine is a promising biomarker to evaluate the potential risk of inflammation-mediated carcinogenesis...
  4. ncbi request reprint Mechanism of telomere shortening by oxidative stress
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Ann N Y Acad Sci 1019:278-84. 2004
    ..It is concluded that the formation of 8-oxodG at the GGG triplet in telomere sequence induced by oxidative stress could participate in acceleration of telomere shortening...
  5. pmc Distinct mechanisms of oxidative DNA damage induced by carcinogenic nickel subsulfide and nickel oxides
    Shosuke Kawanishi
    Department of Hygiene, Mie University School of Medicine, Mie 514 8507, Japan
    Environ Health Perspect 110:789-91. 2002
    ..The other mechanism is indirect oxidative DNA damage due to inflammation. This double mechanism for DNA damage may explain the relatively high carcinogenic risk associated with Ni(3)S(2)...
  6. ncbi request reprint Amplification of anticancer drug-induced DNA damage and apoptosis by DNA-binding compounds
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Curr Med Chem Anticancer Agents 4:415-9. 2004
    ..The study on amplifiers of anticancer agents shows a novel approach to the potentially effective anticancer therapy...
  7. ncbi request reprint The role of metals in site-specific DNA damage with reference to carcinogenesis
    Shosuke Kawanishi
    Department of Hygiene, Mie University School of Medicine, Edobashi, Tsu, Japan
    Free Radic Biol Med 32:822-32. 2002
    ..Metabolites of certain carcinogens efficiently caused oxidative DNA damage by forming NADH-dependent redox cycles. These findings suggest that metal-mediated oxidative DNA damage plays important roles in chemical carcinogenesis...
  8. ncbi request reprint Mechanism of DNA damage induced by bromate differs from general types of oxidative stress
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Toxicology 221:172-8. 2006
    ..Therefore, mechanism of bromate-induced oxidative DNA damage is different from general types of oxidative stress such as *OH...
  9. ncbi request reprint Mechanism of guanine-specific DNA damage by oxidative stress and its role in carcinogenesis and aging
    S Kawanishi
    Department of Hygiene, Mie University School of Medicine, 514 8507, Mie, Japan
    Mutat Res 488:65-76. 2001
    ..Here we discuss the mechanisms of sequence-specific DNA damage in relation to carcinogenesis and aging...
  10. ncbi request reprint Oxidative DNA damage in cultured cells and rat lungs by carcinogenic nickel compounds
    S Kawanishi
    Department of Hygiene, Mie University School of Medicine, Mie, Japan
    Free Radic Biol Med 31:108-16. 2001
    ..This double action may explain relatively high carcinogenic risk of Ni(3)S(2)...
  11. ncbi request reprint Amplification of pepleomycin-mediated DNA cleavage and apoptosis by unfused aromatic cations
    S Kawanishi
    Department of Hygiene, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Biochemistry 39:13210-5. 2000
    ..The present study on amplifiers of anticancer agents shows a novel approach to the potentially effective anticancer therapy...
  12. ncbi request reprint Requirement of glutathione and cysteine in guanine-specific oxidation of DNA by carcinogenic potassium bromate
    M Murata
    Department of Hygiene, Mie University School of Medicine, Tsu, Mie, Japan
    Chem Res Toxicol 14:678-85. 2001
    ....
  13. ncbi request reprint Oxidative DNA damage induced by a metabolite of carcinogenic o-anisidine: enhancement of DNA damage and alteration in its sequence specificity by superoxide dismutase
    Y Ohkuma
    Department of Hygiene, Mie University School of Medicine, Tsu, Japan
    Arch Biochem Biophys 389:49-56. 2001
    ..We consider that SOD may increase the frequency of mutations due to DNA damage induced by o-aminophenol and thus increase its carcinogenic potential...
  14. ncbi request reprint Mechanism of metal-mediated DNA damage induced by metabolites of carcinogenic 2-nitropropane
    K Sakano
    Department of Hygiene, Mie University School of Medicine, 2-174 Edobashi, Tsu, 514-8507, Mie, Japan
    Mutat Res 479:101-11. 2001
    ..Formation of 8-oxodG by IPHA or HAS increased in the presence of metal ions. This study suggests that metal-mediated DNA damage caused by 2-NP metabolites plays an important role in the mutagenicity and the carcinogenicity of 2-NP...
  15. ncbi request reprint Mechanism of oxidative DNA damage induced by carcinogenic 4-aminobiphenyl
    M Murata
    Department of Hygiene, Mie University School of Medicine, Tsu, Mie, Japan
    Free Radic Biol Med 30:765-73. 2001
    ..We conclude that, in addition to DNA adduct formation, oxidative DNA damage may play an important role in the carcinogenic process of 4-ABP...
  16. ncbi request reprint Catechol estrogens induce oxidative DNA damage and estradiol enhances cell proliferation
    Y Hiraku
    Department of Hygiene, Mie University School of Medicine, Mie, Japan
    Int J Cancer 92:333-7. 2001
    ....
  17. ncbi request reprint Oxidative DNA damage induced by an N-hydroxy metabolite of carcinogenic 4-dimethylaminoazobenzene
    S Ohnishi
    Department of Hygiene, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Jpn J Cancer Res 92:23-9. 2001
    ..The main reactive species are probably DNA-copper-hydroperoxo complexes. We conclude that oxidative DNA damage may play an important role in the carcinogenic processes of DAB, in addition to DNA adduct formation...
  18. doi request reprint Comparison of hepatic oxidative DNA damage in patients with chronic hepatitis B and C
    N Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Mie, Japan
    J Viral Hepat 15:498-507. 2008
    ....
  19. ncbi request reprint Site specificity and mechanism of oxidative DNA damage induced by carcinogenic catechol
    S Oikawa
    Department of Hygiene, Mie University School of Medicine, Mie 514-8507, Japan
    Carcinogenesis 22:1239-45. 2001
    ..Therefore, we conclude that oxidative DNA damage by catechol through the generation of H2O2 plays an important role in the carcinogenic process of catechol and benzene...
  20. ncbi request reprint Site-specific DNA damage at the GGG sequence by UVA involves acceleration of telomere shortening
    S Oikawa
    Department of Hygiene, Mie University School of Medicine, Mie 514-8507, Japan
    Biochemistry 40:4763-8. 2001
    ..It is concluded that the site-specific damage in telomere sequence induced by UVA irradiation may participate in the increase of telomere shortening rate...
  21. ncbi request reprint Protective effect of phytic acid on oxidative DNA damage with reference to cancer chemoprevention
    K Midorikawa
    Department of Hygiene, Mie University School of Medicine, Mie, 514-8507, Japan
    Biochem Biophys Res Commun 288:552-7. 2001
    ..We conclude that phytic acid acts as an antioxidant to inhibit the generation of reactive oxygen species from H2O2 by chelating metals, resulting in chemoprevention of cancer...
  22. ncbi request reprint Oxidative DNA damage by an N-hydroxy metabolite of the mutagenic compound formed from norharman and aniline
    S Ohnishi
    Department of Hygiene, Mie University School of Medicine, 2-174 Edobashi, Tsu, 514-8507, Mie, Japan
    Mutat Res 494:63-72. 2001
    ..We conclude that oxidative DNA damage, in addition to DNA adduct formation, may play an important role in the expression of genotoxicity of APNH...
  23. ncbi request reprint Acrylonitrile enhances H2O2-mediated DNA damage via nitrogen-centered radical formation
    M Murata
    Department of Hygiene, Mie University School of Medicine, Tsu, Mie 514-8507, Japan
    Chem Res Toxicol 14:1421-7. 2001
    ..It is considered that ACN enhances H2O2-mediated DNA damage via nitrogen-centered radical formation. We will discuss the mechanism of the enhancing effect on oxidative DNA damage in relation to expression of ACN carcinogenicity...
  24. ncbi request reprint Amplification of bleomycin-induced DNA cleavage at cytosine residues 3' to GGG sequences by pyrrole triamide
    Y Hiraku
    Department of Hygiene, Mie University School of Medicine, Tsu, 514 8507, Mie, Japan
    Biochem Pharmacol 61:351-6. 2001
    ..The present study on amplifiers of antitumor drugs would appear to offer a novel approach to the establishment of more effective chemotherapy...
  25. ncbi request reprint Superoxide dismutases enhance H2O2-induced DNA damage and alter its site specificity
    K Midorikawa
    Department of Hygiene, Mie University School of Medicine, 514-8507, Mie, Japan
    FEBS Lett 495:187-90. 2001
    ..SODs also enhanced the formation of 8-oxo-7,8-dihydro-2'-deoxyguanosine by H2O2 and Cu(II). We conclude that SODs may increase carcinogenic risks, e.g. of tumors in Down syndrome...
  26. ncbi request reprint Sequence-specific DNA damage induced by carcinogenic danthron and anthraquinone in the presence of Cu(II), cytochrome P450 reductase and NADPH
    Y Ohkuma
    Department of Hygiene, Mie University School of Medicine, Tsu, Mie, Japan
    Free Radic Res 34:595-604. 2001
    ..We conclude that oxidative DNA damage by danthron and anthraquinone seems to be relevant for the expression of their carcinogenicity...
  27. ncbi request reprint Hydroxyurea induces site-specific DNA damage via formation of hydrogen peroxide and nitric oxide
    K Sakano
    Department of Hygiene, Mie University School of Medicine, Tsu, Mie 514-8507
    Jpn J Cancer Res 92:1166-74. 2001
    ..Therefore, it is considered that DNA damage by hydroxyurea participates in not only anti-cancer activity, but also carcinogenesis...
  28. pmc Hepatic oxidative DNA damage is associated with increased risk for hepatocellular carcinoma in chronic hepatitis C
    H Tanaka
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Sciences, Mie University Graduate School of Medicine, Mie, Japan
    Br J Cancer 98:580-6. 2008
    ..The strong correlation between hepatic DNA damage and iron overload suggests that the iron content may be a strong mediator of oxidative stress and iron reduction may reduce HCC incidence in patients with chronic hepatitis C...
  29. ncbi request reprint Radical production and DNA damage induced by carcinogenic 4-hydrazinobenzoic acid, an ingredient of mushroom Agaricus bisporus
    Shinji Oikawa
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Japan
    Free Radic Res 40:31-9. 2006
    ..This study suggests that both oxidative DNA damage and DNA adduct formation play important roles in the expression of carcinogenesis of 4-hydrazinobenzoic acid...
  30. ncbi request reprint Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage
    Katsuhisa Sakano
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Free Radic Biol Med 39:1041-9. 2005
    ..Our results raise the possibility that procyanidin B2 exerts both antioxidant and pro-oxidant properties by interacting with H2O2 and metal ions...
  31. ncbi request reprint Accumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C
    Shinichiro Horiike
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    J Hepatol 43:403-10. 2005
    ....
  32. ncbi request reprint Guanine-specific DNA damage photosensitized by the dihydroxo(tetraphenylporphyrinato)antimony(V) complex
    Kazutaka Hirakawa
    Division of Applied Science and Basic Engineering, Faculty of Engineering, Shizuoka University, Johoku 3 5 1, Hamamatsu, Shizuoka 432 8561, Japan
    J Photochem Photobiol B 82:37-44. 2006
    ..A similar mechanism can damage other biomacromolecules, such as protein and the phospholipid membrane. The damage to biomacromolecules via these mechanisms may participate in the phototoxicity of SbTPP...
  33. ncbi request reprint Histone peptide AKRHRK enhances H(2)O(2)-induced DNA damage and alters its site specificity
    Kaoru Midorikawa
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Biochem Biophys Res Commun 333:1073-7. 2005
    ..It is noteworthy that the histone H4 peptide with specific sequence AKRHRK can cause DNA damage rather than protection under metal-overloaded condition...
  34. ncbi request reprint Inducible nitric oxide synthase-dependent DNA damage in mouse model of inflammatory bowel disease
    Xiaohui Ding
    Department of Anatomy, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Cancer Sci 96:157-63. 2005
    ..These results indicate that nitrative DNA damage, as well as oxidative DNA damage, is induced in colon epithelial cells of the IBD mouse model followed by proliferation of these cells, which may contribute to colon carcinogenesis...
  35. pmc Guanine-specific DNA damage induced by gamma-irradiated histone
    Ayako Furukawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Biochem J 388:813-8. 2005
    ..It is concluded that histone protein-hydroperoxides can induce guanine-specific DNA damage, which may contribute to gamma-irradiation-induced carcinogenesis...
  36. ncbi request reprint Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide
    Hideki Mizutani
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Life Sci 76:1439-53. 2005
    ..This oxidative DNA damage causes indirect H(2)O(2) generation through PARP and NAD(P)H oxidase activation, leading to the Delta Psi m increase and subsequent caspase-3 activation in DOX-induced apoptosis...
  37. ncbi request reprint Chemopreventive action of xanthone derivatives on photosensitized DNA damage
    Kazutaka Hirakawa
    Division of Applied Science and Basic Engineering, Faculty of Engineering, Shizuoka University, Johoku, Hamamatsu, Shizuoka, Japan
    Photochem Photobiol 81:314-9. 2005
    ..In conclusion, XAN derivatives, especially GEN, may act as novel chemopreventive agents by the quenching mechanism of an excited photosensitizer...
  38. ncbi request reprint Amplification of C1027-induced DNA cleavage and apoptosis by a quinacrine-netropsin hybrid molecule in tumor cell lines
    Takuya Iwamoto
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Arch Biochem Biophys 434:232-40. 2005
    ..These results suggest that QN enhances C1027-induced antitumor effect via DNA cleavage and apoptosis. The present study shows a novel approach to the potentially effective anticancer therapy...
  39. ncbi request reprint Oxidative DNA damage induced by carcinogenic dinitropyrenes in the presence of P450 reductase
    Mariko Murata
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Chem Res Toxicol 17:1750-6. 2004
    ..We conclude that oxidative DNA damage in addition to DNA adduct formation may play important roles in the carcinogenesis of DNPs via their metabolites...
  40. ncbi request reprint The mechanism of guanine specific photooxidation in the presence of berberine and palmatine: activation of photosensitized singlet oxygen generation through DNA-binding interaction
    Kazutaka Hirakawa
    Division of Applied Science and Basic Engineering, Faculty of Engineering, Shizuoka University, Johoku 3 5 1, Hamamatsu, Shizuoka 432 8561, Japan
    Chem Res Toxicol 18:1545-52. 2005
    ..The present study suggests that berberine and palmatine can act as functional photosensitizers enabling a switch in phototoxicity via 1O2 formation by the interaction with DNA...
  41. ncbi request reprint Critical role of hydrogen peroxide in the differential susceptibility of Th1 and Th2 cells to tributyltin-induced apoptosis
    Saeko Tada-Oikawa
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi, Tsu, Mie 514 8507, Japan
    Biochem Pharmacol 75:552-61. 2008
    ..These results suggest that TBT selectively induces apoptosis via generation of H(2)O(2) in Th1 cells because of their low GSH levels, which may contribute to the Th2 predominance induced by TBT...
  42. ncbi request reprint Mechanism of UVA-dependent DNA damage induced by an antitumor drug dacarbazine in relation to its photogenotoxicity
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Tsu, Mie 514 8507, Japan
    Pharm Res 25:598-604. 2008
    ..It has been reported that dacarbazine (DTIC) is photogenotoxic. The purpose of this study is to clarify the mechanism of photogenotoxicity induced by DTIC...
  43. ncbi request reprint Photosensitized DNA damage induced by NADH: site specificity and mechanism
    Kimiko Ito
    Department of Life Science, Tsu City College, Tsu, Mie 514 0112, Japan
    Free Radic Res 41:461-8. 2007
    ..These results imply that NADH may participate as an endogenous photosensitizer in UVA carcinogenesis via H(2)O(2) generation, producing metal-mediated mutagenic lesions such as 8-oxodG...
  44. ncbi request reprint Hepatic oxidative DNA damage correlates with iron overload in chronic hepatitis C patients
    Naoki Fujita
    Department of Gastroenterology and Hepatology, Division of Clinical Medicine and Biomedical Science, Institute of Medical Science, Mie University Graduate School of Medicine, Mie, Japan
    Free Radic Biol Med 42:353-62. 2007
    ....
  45. ncbi request reprint Mechanism of oxidative DNA damage induced by capsaicin, a principal ingredient of hot chili pepper
    Shinji Oikawa
    Mie University Graduate School of Medicine, Department of Environmental and Molecular Medicine, Mie, Japan
    Free Radic Res 40:966-73. 2006
    ..Therefore, we conclude that Cu(II)-mediated oxidative DNA damage by CYP-treated capsaicin seems to be relevant for the expression of its carcinogenicity...
  46. ncbi request reprint Photosensitized DNA damage and its protection via a novel mechanism
    Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Photochem Photobiol 83:205-12. 2007
    ..It is thus considered that naturally occurring quenchers including xanthone derivatives may act as novel chemopreventive agents against photocarcinogenesis...
  47. ncbi request reprint Mechanism for manganese enhancement of dopamine-induced oxidative DNA damage and neuronal cell death
    Shinji Oikawa
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Free Radic Biol Med 41:748-56. 2006
    ..Therefore, it is concluded that oxidative DNA damage induced by dopamine in the presence of Mn(II), NADH, and Cu(II) is possibly linked to the degeneration of dopaminergic neurons...
  48. ncbi request reprint Oxidative DNA damage induced by hair dye components ortho-phenylenediamines and the enhancement by superoxide dismutase
    Mariko Murata
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Mutat Res 607:184-91. 2006
    ..These results suggest that carcinogenicity of ortho-phenylenediamines is associated with ability to cause oxidative DNA damage rather than bacterial mutagenicity...
  49. ncbi request reprint Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Antioxid Redox Signal 8:1047-58. 2006
    ..Interestingly, 8-nitroguanine was formed at the sites of carcinogenesis regardless of etiology. Therefore, 8-nitroguanine could be used as a potential biomarker to evaluate the risk of inflammation- related carcinogenesis...
  50. ncbi request reprint Mechanism of DNA damage and apoptosis induced by tetrahydropapaveroline, a metabolite of dopamine
    Hatasu Kobayashi
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Japan
    Neurochem Res 31:523-32. 2006
    ..This study demonstrated that THP-induced apoptosis via reactive oxygen species generated from reaction of H(2)O(2) and metals plays an important role in cytotoxicity of L-DOPA...
  51. ncbi request reprint Endocrine disruptors that deplete glutathione levels in APC promote Th2 polarization in mice leading to the exacerbation of airway inflammation
    Takuma Kato
    Department of Bioregulation, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Eur J Immunol 36:1199-209. 2006
    ....
  52. ncbi request reprint Carcinogenic 3-nitrobenzanthrone induces oxidative damage to isolated and cellular DNA
    Mariko Murata
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Free Radic Biol Med 40:1242-9. 2006
    ..We conclude that oxidative DNA damage may play an important role in the carcinogenic process of 3-NBA in addition to previously reported DNA adduct formation...
  53. doi request reprint Mechanism of metal-mediated DNA damage and apoptosis induced by 6-hydroxydopamine in neuroblastoma SH-SY5Y cells
    Hatasu Kobayashi
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Free Radic Res 42:651-60. 2008
    ..This study suggests that copper, as well as iron, may play an important role in 6-OHDA-induced neuronal cell death...
  54. ncbi request reprint Copper-mediated oxidative DNA damage induced by eugenol: possible involvement of O-demethylation
    Katsuhisa Sakano
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Mutat Res 565:35-44. 2004
    ..Therefore, it is concluded that eugenol may express carcinogenicity through oxidative DNA damage by its metabolite...
  55. ncbi request reprint Oxidative damage to cellular and isolated DNA by homocysteine: implications for carcinogenesis
    Shinji Oikawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Oncogene 22:3530-8. 2003
    ..These results indicated that the metal-dependent DNA damage through H(2)O(2) is likely to be a more relevant mechanism for homocysteine carcinogenicity...
  56. ncbi request reprint DNA damage by ethylbenzenehydroperoxide formed from carcinogenic ethylbenzene by sunlight irradiation
    Chitose Toda
    Faculty of Pharmacy, Meijo University, Nagoya 468 8503, Japan
    Biochem Biophys Res Commun 304:638-42. 2003
    ..These results indicate a novel pathway that oxidative DNA damage induced by the peroxide and H(2)O(2) derived from sunlight-irradiated ethylbenzene may lead to expression of the carcinogenicity...
  57. ncbi request reprint Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals
    Kazutaka Hirakawa
    Radioisotope Center, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Mutat Res 536:91-101. 2003
    ..In addition, semicarbazide-derived free radicals participate in DNA damage. DNA damage induced by these reactive species may be relevant to the carcinogenicity of semicarbazide...
  58. ncbi request reprint Sequence-specific DNA damage induced by ultraviolet A-irradiated folic acid via its photolysis product
    Kazutaka Hirakawa
    Radioisotope Center, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Arch Biochem Biophys 410:261-8. 2003
    ..Excess intake of folic acid supplements may increase a risk of skin cancer by solar ultraviolet light...
  59. ncbi request reprint Photohydrolysis of methotrexate produces pteridine, which induces poly-G-specific DNA damage through photoinduced electron transfer
    Kazutaka Hirakawa
    Radioisotope Center, Mie University School of Medicine, Edobashi, Tsu, Mie, Japan
    Photochem Photobiol 76:467-72. 2002
    ....
  60. ncbi request reprint Oxidative DNA damage by a common metabolite of carcinogenic nitrofluorene and N-acetylaminofluorene
    Mariko Murata
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie, Japan
    Int J Cancer 102:311-7. 2002
    ..We conclude that oxidative DNA damage may play an important role in the carcinogenic process of NF and AAF in addition to previously reported DNA adduct formation...
  61. ncbi request reprint Metal-mediated DNA damage induced by curcumin in the presence of human cytochrome P450 isozymes
    Katsuhisa Sakano
    Department of Hygiene, Mie University School of Medicine, Mie 514 8507, Japan
    Arch Biochem Biophys 405:223-30. 2002
    ..Therefore, it is concluded that curcumin may exhibit carcinogenic potential through oxidative DNA damage by its metabolite...
  62. ncbi request reprint Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage
    Katsuhisa Sakano
    Department of Hygiene, Mie University School of Medicine, Mie, Japan
    Free Radic Biol Med 33:703-14. 2002
    ..It is concluded that urethane may induce carcinogenesis through oxidation and, to a lesser extent, depurination of DNA by its metabolites...
  63. ncbi request reprint Hydroxylation of deoxyguanosine at 5' site of GG and GGG sequences in double-stranded DNA induced by carbamoyl radicals
    Kaoru Midorikawa
    Department of Hygiene, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Free Radic Res 36:667-75. 2002
    ..These results shows that carbamoyl radicals specifically induced hydroxylation of deoxyguanosine at 5' site of GG and GGG sequences in double-stranded DNA...
  64. ncbi request reprint 2,4,6-trinitrotoluene-induced reproductive toxicity via oxidative DNA damage by its metabolite
    Shino Homma-Takeda
    Graduate School Doctoral Program in Medical Sciences, University of Tsukuba, Ibaraki, Japan
    Free Radic Res 36:555-66. 2002
    ..We propose that oxidative DNA damage in the testis plays a role in reproductive toxicity induced by TNT and other nitroaromatic compounds...
  65. ncbi request reprint Oxidative DNA damage induced by a metabolite of 2-naphthylamine, a smoking-related bladder carcinogen
    Shiho Ohnishi
    Department of Hygiene, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Jpn J Cancer Res 93:736-43. 2002
    ..The oxidative DNA damage by these amino-aromatic compounds may participate in smoking-related bladder cancer, in addition to DNA adduct formation...
  66. ncbi request reprint Oxidation of 5'-site guanine at GG and GGG sequences induced by a metabolite of carcinogenic heterocyclic amine PhIP in the presence of Cu(II) and NADH
    Mariko Murata
    Department of Hygiene, Mie University School of Medicine, Tsu, Mie, Japan
    Carcinogenesis 23:855-60. 2002
    ..We conclude that in addition to DNA adduct formation, oxidative DNA damage may be involved in the carcinogenic process of PhIP...
  67. ncbi request reprint DNA damage induced by hypochlorite and hypobromite with reference to inflammation-associated carcinogenesis
    Shiho Ohnishi
    Department of Hygiene, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Cancer Lett 178:37-42. 2002
    ..Endogenous OCl- may play a role in genotoxicity close to the site of inflammation...
  68. ncbi request reprint Oxidative DNA damage induced by photodegradation products of 3(')-azido-3(')-deoxythymidine
    Takuya Iwamoto
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Arch Biochem Biophys 416:155-63. 2003
    ..The basic compound, hydroxylamine, showed similar site specificity. The hydroxylamine derivative produced by photodegradation and/or possible metabolism of AZT induces oxidative DNA damage, which may participate in carcinogenesis...
  69. ncbi request reprint Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450 reductase
    Hideki Mizutani
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Edobashi, Tsu, Mie 514 8507, Japan
    Cancer Sci 94:686-91. 2003
    ..OH. We conclude that DOX may induce carcinostatic and genotoxic effects through oxidation of its p-hydroquinone moiety by metal ion rather than through p-quinone reduction by cytochrome P450 reductase...
  70. ncbi request reprint Metabolic activation of carcinogenic ethylbenzene leads to oxidative DNA damage
    Kaoru Midorikawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Chem Biol Interact 150:271-81. 2004
    ..In conclusion, these active dihydroxylated metabolites would be involved in the mechanism of carcinogenesis by ethylbenzene...
  71. ncbi request reprint Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: a model of inflammation-mediated carcinogenesis
    Somchai Pinlaor
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Nitric Oxide 11:175-83. 2004
    ..In conclusion, nitrative and oxidative DNA damage via iNOS expression in hamsters infected with OV may participate in CHCA carcinogenesis...
  72. ncbi request reprint Mechanism of carcinogenesis induced by a veterinary antimicrobial drug, nitrofurazone, via oxidative DNA damage and cell proliferation
    Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Cancer Lett 215:141-50. 2004
    ..These findings suggest that nitrofurazone metabolites are involved in tumor initiation through oxidative DNA damage and nitrofurazone itself enhances cell proliferation, leading to promotion and/or progression in carcinogenesis...
  73. ncbi request reprint Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle
    Katsuhisa Sakano
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 5148507, Japan
    Biochem Pharmacol 68:1869-78. 2004
    ..Therefore, it is concluded that melatonin may exhibit carcinogenic potential through oxidative DNA damage by its metabolite...
  74. ncbi request reprint Mechanism of metal-mediated DNA damage induced by a metabolite of carcinogenic acetamide
    Katsuhisa Sakano
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Edobashi, Tsu, Japan
    Chem Biol Interact 149:52-9. 2004
    ..These results suggest that metal-mediated DNA damage mediated by amidase-catalyzed hydroxylamine generation plays an important role in the carcinogenicity of acetamide...
  75. ncbi request reprint Oxidative DNA damage induced by a hydroperoxide derivative of cyclophosphamide
    Mariko Murata
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Free Radic Biol Med 37:793-802. 2004
    ..We conclude that, in addition to DNA cross-linking, oxidative DNA damage through H(2)O(2) generation may participate in the anti-tumor effects of 4-HC...
  76. ncbi request reprint Environmental pollutant tributyltin promotes Th2 polarization and exacerbates airway inflammation
    Takuma Kato
    Department of Bioregulation, Mie University School of Medicine, Tsu, Mie, Japan
    Eur J Immunol 34:1312-21. 2004
    ..Our results highlight the fact that an important environmental pollutant TBT may present significant risk for the induction of allergic diseases via promotion of Th2 polarization...
  77. ncbi request reprint Oxidative DNA damage induced by nitrotyrosine, a biomarker of inflammation
    Mariko Murata
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Edobashi, Tsu, Mie 514 8507, Japan
    Biochem Biophys Res Commun 316:123-8. 2004
    ..We propose the possibility that nitrotyrosine-induced H2O2 formation and DNA damage contribute to inflammation-associated carcinogenesis...
  78. ncbi request reprint Genistein and daidzein induce cell proliferation and their metabolites cause oxidative DNA damage in relation to isoflavone-induced cancer of estrogen-sensitive organs
    Mariko Murata
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Biochemistry 43:2569-77. 2004
    ....
  79. ncbi request reprint Oxidative DNA damage induced by benz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone
    Kazuharu Seike
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Chem Res Toxicol 16:1470-6. 2003
    ..In conclusion, oxidative DNA damage induced by BA-3,4-dihydrodiol not only via quinone-type redox cycle but also via a new type of redox cycle participates in the expression of carcinogenicity of BA and BA-3,4-dihydrodiol...
  80. ncbi request reprint Oxidative DNA damage by hyperglycemia-related aldehydes and its marked enhancement by hydrogen peroxide
    Mariko Murata
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    FEBS Lett 554:138-42. 2003
    ..We conclude that oxidative DNA damage by hyperglycemia-related aldehydes, especially GA, and marked enhancement of DNA damage by H2O2 may participate in diabetes-associated carcinogenesis...
  81. ncbi request reprint Catechins induce oxidative damage to cellular and isolated DNA through the generation of reactive oxygen species
    Shinji Oikawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Free Radic Res 37:881-90. 2003
    ..Therefore, it is reasonably considered that green tea catechins may have the dual function of anticarcinogenic and carcinogenic potentials...
  82. ncbi request reprint (-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA
    Ayako Furukawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Biochem Pharmacol 66:1769-78. 2003
    ..It is concluded that EGCG can induce H(2)O(2) generation and subsequent damage to isolated and cellular DNA, and that oxidative DNA damage may mediate the potential carcinogenicity of EGCG...
  83. ncbi request reprint Double base lesions of DNA by a metabolite of carcinogenic benzo[a]pyrene
    Shiho Ohnishi
    Department of Hygiene, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie, 514 8507, Japan
    Biochem Biophys Res Commun 290:778-82. 2002
    ..We conclude that oxidative DNA damage, especially double base lesions, may participate in the expression of carcinogenicity of BP in addition to DNA adduct formation...