Takuya Iwamoto

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. ncbi request reprint Clinical application of drug delivery systems in cancer chemotherapy: review of the efficacy and side effects of approved drugs
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University, Tsu, Mie 514 8507, Japan
    Biol Pharm Bull 36:715-8. 2013
  2. ncbi request reprint Evaluation of basophil CD203c as a predictor of carboplatin-related hypersensitivity reaction in patients with gynecologic cancer
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, and Department of Otorhinolaryngology Head and Neck Surgery, Mie University, Graduate School of Medicine, Mie, Japan
    Biol Pharm Bull 35:1487-95. 2012
  3. ncbi request reprint Clinical efficacy of therapeutic drug monitoring in patients receiving vancomycin
    Takuya Iwamoto
    Department of Hospital Pharmacy, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Biol Pharm Bull 26:876-9. 2003
  4. ncbi request reprint [Pharmacokinetic and molecular biological approaches to achieve the safety and effective management of drug therapies]
    Takuya Iwamoto
    Department of Hospital Pharmacy, Mie University School of Medicine, Department of Clinical Pharmacy and Biopharmaceutics, Mie University Graduate School of Medicine, Japan
    Yakugaku Zasshi 127:1077-80. 2007
  5. ncbi request reprint Clinical evaluation of plasma free phenytoin measurement and factors influencing its protein binding
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Tsu, Mie 514 8507, Japan
    Biopharm Drug Dispos 27:77-84. 2006
  6. ncbi request reprint Factors influencing the overestimation of plasma vancomycin concentrations measured by the Abbott TDx technique
    Takuya Iwamoto
    Department of Hospital Pharmacy, Mie University School of Medicine, Mie 514 8507, Japan
    Ther Drug Monit 27:58-62. 2005
  7. ncbi request reprint Steroid-induced diabetes mellitus and related risk factors in patients with neurologic diseases
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Tsu, Mie, Japan
    Pharmacotherapy 24:508-14. 2004
  8. ncbi request reprint [Successful treatment by tacrolimus in two patients with Osserman's grade III intractable myasthenia gravis and elderly IIb]
    Takuya Iwamoto
    Department of Hospital Pharmacy, Mie University School of Medicine, Tsu City, Japan
    Yakugaku Zasshi 124:237-41. 2004
  9. ncbi request reprint Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients
    Yuichi Muraki
    Department of Pharmacy, Mie University Hospital, 2 174 Edobachi, Tsu, Mie, Japan
    Ann Transplant 16:55-62. 2011
  10. ncbi request reprint Mechanism of UVA-dependent DNA damage induced by an antitumor drug dacarbazine in relation to its photogenotoxicity
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Tsu, Mie 514 8507, Japan
    Pharm Res 25:598-604. 2008

Collaborators

Detail Information

Publications25

  1. ncbi request reprint Clinical application of drug delivery systems in cancer chemotherapy: review of the efficacy and side effects of approved drugs
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University, Tsu, Mie 514 8507, Japan
    Biol Pharm Bull 36:715-8. 2013
    ..Therefore, medical staff must understand DDS anticancer agents fully, including characteristic side effects, to achieve the desired clinical outcomes...
  2. ncbi request reprint Evaluation of basophil CD203c as a predictor of carboplatin-related hypersensitivity reaction in patients with gynecologic cancer
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, and Department of Otorhinolaryngology Head and Neck Surgery, Mie University, Graduate School of Medicine, Mie, Japan
    Biol Pharm Bull 35:1487-95. 2012
    ..The results suggest that basophil CD203c may be a promising biomarker for the prediction of severe carboplatin-related anaphylaxis...
  3. ncbi request reprint Clinical efficacy of therapeutic drug monitoring in patients receiving vancomycin
    Takuya Iwamoto
    Department of Hospital Pharmacy, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Biol Pharm Bull 26:876-9. 2003
    ..0 g) in Group B. These results indicate that monitoring peak concentration is essential to obtain better clinical effects for VCM therapy, and that the peak concentration above 25 microg/ml is more effective...
  4. ncbi request reprint [Pharmacokinetic and molecular biological approaches to achieve the safety and effective management of drug therapies]
    Takuya Iwamoto
    Department of Hospital Pharmacy, Mie University School of Medicine, Department of Clinical Pharmacy and Biopharmaceutics, Mie University Graduate School of Medicine, Japan
    Yakugaku Zasshi 127:1077-80. 2007
    ..These findings may provide useful information to prevent phototoxicity of drugs and to develop new photodynamic therapies...
  5. ncbi request reprint Clinical evaluation of plasma free phenytoin measurement and factors influencing its protein binding
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Tsu, Mie 514 8507, Japan
    Biopharm Drug Dispos 27:77-84. 2006
    ..It was also found that the free phenytoin fraction was significantly influenced by aging, CLcr and serum albumin levels...
  6. ncbi request reprint Factors influencing the overestimation of plasma vancomycin concentrations measured by the Abbott TDx technique
    Takuya Iwamoto
    Department of Hospital Pharmacy, Mie University School of Medicine, Mie 514 8507, Japan
    Ther Drug Monit 27:58-62. 2005
    ..Thus, VCM postdose samples may provide useful information in cases in which a good clinical outcome has not been obtained using monitoring of the predose concentration alone...
  7. ncbi request reprint Steroid-induced diabetes mellitus and related risk factors in patients with neurologic diseases
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Tsu, Mie, Japan
    Pharmacotherapy 24:508-14. 2004
    ..To determine the frequency of steroid-induced diabetes mellitus (SDM) and the related risk factors in patients with neurologic diseases who receive high doses of steroids...
  8. ncbi request reprint [Successful treatment by tacrolimus in two patients with Osserman's grade III intractable myasthenia gravis and elderly IIb]
    Takuya Iwamoto
    Department of Hospital Pharmacy, Mie University School of Medicine, Tsu City, Japan
    Yakugaku Zasshi 124:237-41. 2004
    ..4 nmol/l during the treatment period. The concentration of tacrolimus in whole blood was 7.0 ng/ml 6 days after the initiation of treatment. These findings suggest that tacrolimus is effective in intractable and elderly MG patients...
  9. ncbi request reprint Impact of CYP3A5 genotype of recipients as well as donors on the tacrolimus pharmacokinetics and infectious complications after living-donor liver transplantation for Japanese adult recipients
    Yuichi Muraki
    Department of Pharmacy, Mie University Hospital, 2 174 Edobachi, Tsu, Mie, Japan
    Ann Transplant 16:55-62. 2011
    ....
  10. ncbi request reprint Mechanism of UVA-dependent DNA damage induced by an antitumor drug dacarbazine in relation to its photogenotoxicity
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Tsu, Mie 514 8507, Japan
    Pharm Res 25:598-604. 2008
    ..It has been reported that dacarbazine (DTIC) is photogenotoxic. The purpose of this study is to clarify the mechanism of photogenotoxicity induced by DTIC...
  11. doi request reprint Hepatic drug interaction between tacrolimus and lansoprazole in a bone marrow transplant patient receiving voriconazole and harboring CYP2C19 and CYP3A5 heterozygous mutations
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Tsu, Japan
    Clin Ther 33:1077-80. 2011
    ..A PubMed search (implemented March 16, 2011) using search terms drug interaction, tacrolimus, and lansoprazole failed to identify drug interactions in CYP3A5 extensive metabolizers and parenterally administered TAC...
  12. doi request reprint Risk factors contributing to the development of carboplatin-related delayed hypersensitivity reactions in Japanese patients with gynecologic cancers
    Hiroko Sugimoto
    Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Cancer Chemother Pharmacol 67:415-9. 2011
    ..However, risk factors for these onsets have not been well described. In this study, we investigated the contribution of the reported risk factors to the onset of CBDCA-related delayed hypersensitivity reactions...
  13. doi request reprint An antioxidant Trolox restores decreased oral absorption of cyclosporine A after liver ischemia-reperfusion through distinct mechanisms between CYP3A and P-glycoprotein in the small intestine
    Kenji Ikemura
    Department of Clinical Pharmacy and Biopharmaceutics, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Eur J Pharmacol 690:192-201. 2012
    ....
  14. ncbi request reprint Amplification of C1027-induced DNA cleavage and apoptosis by a quinacrine-netropsin hybrid molecule in tumor cell lines
    Takuya Iwamoto
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Arch Biochem Biophys 434:232-40. 2005
    ..These results suggest that QN enhances C1027-induced antitumor effect via DNA cleavage and apoptosis. The present study shows a novel approach to the potentially effective anticancer therapy...
  15. ncbi request reprint The impact of total bilirubin on plasma micafungin levels in living-donor liver transplantation recipients with severe liver dysfunction
    Yuichi Muraki
    Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University, Japan
    Biol Pharm Bull 32:750-4. 2009
    ..These results provide helpful advice about MCFG administration for the treatment of fungal infections in LDLT patients with fluctuating liver function...
  16. ncbi request reprint Elevated systemic elimination of cimetidine in rats with acute biliary obstruction: the role of renal organic cation transporter OCT2
    Tomohiko Kurata
    Department of Clinical Pharmacy and Biopharmaceutics, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Drug Metab Pharmacokinet 25:328-34. 2010
    ..These results demonstrate that the renal tubular secretion of cimetidine was increased by acute cholestasis, and this increase was attributable to elevated expression levels of rOCT2 but not of rMATE1 in the rat...
  17. doi request reprint Decreased oral absorption of cyclosporine A after liver ischemia-reperfusion injury in rats: the contribution of CYP3A and P-glycoprotein to the first-pass metabolism in intestinal epithelial cells
    Kenji Ikemura
    Department of Clinical Pharmacy and Biopharmaceutics, Mie University Graduate School of Medicine, Mie, Japan
    J Pharmacol Exp Ther 328:249-55. 2009
    ..The present findings provide useful information for the etiology of liver I/R injury and appropriate use of CsA after liver transplantation...
  18. ncbi request reprint [Risk factor for residual deep vein thrombosis after fondaparinux administration in patients with postoperative replacement arthroplasty]
    Tomoyuki Enokiya
    Department of Pharmacy, Mie University Hospital, Tsu, Japan
    Yakugaku Zasshi 132:683-7. 2012
    ..5, 95% confidential interval 2.0-295.4, p=0.02). These findings should provide useful information for understanding the interindividual difference of the efficacy of FPX after TKA or THA...
  19. ncbi request reprint Involvement of specific transport system on uptake of lactone form of SN-38 in human intestinal epithelial cell line Caco-2
    Yusuke Ueno
    Department of Clinical Pharmacy and Biopharmaceutics, Graduate School of Medicine, Mie University, Edobashi, Tsu, Mie 514 8507, Japan
    Biol Pharm Bull 35:54-8. 2012
    ..These results suggest that apical uptake of SN-38 by Caco-2 is dominantly performed as a lactone form through a specific transporter, which is competitively inhibited by baicalin...
  20. ncbi request reprint Comparison of cyclosporine concentrations in renal transplant recipients using ACMIA and mFPIA methods
    Yoshiyuki Kagawa
    Department of Hospital Pharmacy, Mie University School of Medicine, 2 174 Edobashi, Tsu City, Mie 514 8507, Japan
    Clin Biochem 37:1016-21. 2004
    ....
  21. ncbi request reprint Risk factors contributing to the development of hypocalcemia after zoledronic acid administration in patients with bone metastases of solid tumor
    Miho Hanamura
    Department of Pharmacy, Mie University Hospital, Faculty of Medicine, Mie University, USA
    Biol Pharm Bull 33:721-4. 2010
    ..These findings should provide useful information regarding the monitoring of serum calcium concentration in cancer patients receiving ZDA...
  22. doi request reprint Drug interaction between itraconazole and bortezomib: exacerbation of peripheral neuropathy and thrombocytopenia induced by bortezomib
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Tsu, Mie, Japan
    Pharmacotherapy 30:661-5. 2010
    ....
  23. doi request reprint Altered functions and expressions of drug transporters in liver, kidney and intestine in disorders of local and remote organs: possible role of oxidative stress in the pathogenesis
    Kenji Ikemura
    Mie University Graduate School of Medicine, Department of Clinical Pharmacy and Biopharmaceutics, Tsu, Mie 514 8507, Japan
    Expert Opin Drug Metab Toxicol 5:907-20. 2009
    ..These procedures of drugs in diseases of these organs, mediated by drug transporters, often fluctuate and thereby cause inter- and intra-individual pharmacokinetic variability...
  24. ncbi request reprint Comparative evaluation of digoxin concentrations determined by three assay systems: TDx, IMx and OPUS
    Yoshiyuki Kagawa
    Department of Hospital Pharmacy, Mie University School of Medicine, Edobashi 2 174, Tsu City, Mie 514 8507, Japan
    Biopharm Drug Dispos 25:21-6. 2004
    ..These results suggest that OPUS has a higher specificity for measuring the plasma digoxin concentrations compared with TDx or IMx...
  25. ncbi request reprint DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect
    Takuya Iwamoto
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Cancer Sci 95:454-8. 2004
    ..The mechanism and the role of cross-linking at the 5'-GA-3' sequence are discussed in relation to the cytotoxicity induced by busulfan...