Masaaki Ito

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. ncbi request reprint Myosin phosphatase: structure, regulation and function
    Masaaki Ito
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan
    Mol Cell Biochem 259:197-209. 2004
  2. doi request reprint Hypertension impairs myocardial blood perfusion reserve in subjects without regional myocardial ischemia
    Hiroshi Nakajima
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Hypertens Res 33:1144-9. 2010
  3. ncbi request reprint Effects of human atrial natriuretic peptide on cardiac function and hemodynamics in patients with high plasma BNP levels
    Kazuki Nakajima
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu 514 0823, Japan
    Int J Cardiol 104:332-7. 2005
  4. doi request reprint Exaggerated hypertensive response to exercise in patients with diastolic heart failure
    Shinya Kato
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Hypertens Res 31:679-84. 2008
  5. doi request reprint Hemodynamic characteristics of patients with diastolic heart failure and hypertension
    Naoki Fujimoto
    Department of Cardiology, Mie University Graduate School of Medicine, 2 175 Edobashi, Tsu, Japan
    Hypertens Res 31:1727-35. 2008
  6. doi request reprint Prognostic value of unrecognised myocardial infarction detected by late gadolinium-enhanced MRI in diabetic patients with normal global and regional left ventricular systolic function
    Yeonyee E Yoon
    Department of Radiology, Mie University Hospital, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Eur Radiol 23:2101-8. 2013
  7. doi request reprint Ventricular function and dyssynchrony quantified by speckle-tracking echocardiography in patients with acute and chronic right ventricular pressure overload
    Kazuhide Ichikawa
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan
    J Am Soc Echocardiogr 26:483-92. 2013
  8. doi request reprint Conventional therapy with an ACE inhibitor diminishes left ventricular dyssynchrony during the progression of heart failure
    Tairo Kurita
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Int J Cardiol 140:48-54. 2010
  9. doi request reprint Left ventricular contraction-relaxation coupling in normal, hypertrophic, and failing myocardium quantified by speckle-tracking global strain and strain rate imaging
    Takeshi Takamura
    Mie University Graduate School of Medicine, Tsu, Japan
    J Am Soc Echocardiogr 23:747-54. 2010
  10. doi request reprint Role of radial strain and displacement imaging to quantify wall motion dyssynchrony in patients with left ventricular mechanical dyssynchrony and chronic right ventricular pressure overload
    Kaoru Dohi
    Mie University Graduate School of Medicine, Tsu, Japan
    Am J Cardiol 101:1206-12. 2008

Detail Information

Publications107 found, 100 shown here

  1. ncbi request reprint Myosin phosphatase: structure, regulation and function
    Masaaki Ito
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan
    Mol Cell Biochem 259:197-209. 2004
    ..The critical role of RhoA/Rho-kinase signaling in various systems is discussed, in particular those vascular smooth muscle disorders involving hypercontractility...
  2. doi request reprint Hypertension impairs myocardial blood perfusion reserve in subjects without regional myocardial ischemia
    Hiroshi Nakajima
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Hypertens Res 33:1144-9. 2010
    ..007, β=-0.248) and hematocrit (P=ns) after adjusting age and gender. Hypertension is the most important effector of MPR in subjects without myocardial ischemia...
  3. ncbi request reprint Effects of human atrial natriuretic peptide on cardiac function and hemodynamics in patients with high plasma BNP levels
    Kazuki Nakajima
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu 514 0823, Japan
    Int J Cardiol 104:332-7. 2005
    ..Thus, ANP infusion may improve LV diastolic function even in patients with moderate heart failure and high plasma BNP levels...
  4. doi request reprint Exaggerated hypertensive response to exercise in patients with diastolic heart failure
    Shinya Kato
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Hypertens Res 31:679-84. 2008
    ..In patients with DHF, systolic blood pressure markedly increased during exercise, and this was accompanied by impaired exercise tolerance and a decreased QOL, both of which were partly suppressed by blocking angiotensin II...
  5. doi request reprint Hemodynamic characteristics of patients with diastolic heart failure and hypertension
    Naoki Fujimoto
    Department of Cardiology, Mie University Graduate School of Medicine, 2 175 Edobashi, Tsu, Japan
    Hypertens Res 31:1727-35. 2008
    ..Changing the loading condition by nitroglycerin improved LV systolic and diastolic function in hypertensive DHF patients...
  6. doi request reprint Prognostic value of unrecognised myocardial infarction detected by late gadolinium-enhanced MRI in diabetic patients with normal global and regional left ventricular systolic function
    Yeonyee E Yoon
    Department of Radiology, Mie University Hospital, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Eur Radiol 23:2101-8. 2013
    ....
  7. doi request reprint Ventricular function and dyssynchrony quantified by speckle-tracking echocardiography in patients with acute and chronic right ventricular pressure overload
    Kazuhide Ichikawa
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan
    J Am Soc Echocardiogr 26:483-92. 2013
    ....
  8. doi request reprint Conventional therapy with an ACE inhibitor diminishes left ventricular dyssynchrony during the progression of heart failure
    Tairo Kurita
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Int J Cardiol 140:48-54. 2010
    ..We hypothesized that an angiotensin converting enzyme (ACE) inhibitor would prevent LV dyssynchrony during the progression of pacing-induced HF through its beneficial effects on hemodynamic change and myocardial fibrosis...
  9. doi request reprint Left ventricular contraction-relaxation coupling in normal, hypertrophic, and failing myocardium quantified by speckle-tracking global strain and strain rate imaging
    Takeshi Takamura
    Mie University Graduate School of Medicine, Tsu, Japan
    J Am Soc Echocardiogr 23:747-54. 2010
    ..The aim of this study was to noninvasively quantify global left ventricular (LV) contraction and relaxation, and to investigate their relationship in normal, hypertrophic, and failing myocardium...
  10. doi request reprint Role of radial strain and displacement imaging to quantify wall motion dyssynchrony in patients with left ventricular mechanical dyssynchrony and chronic right ventricular pressure overload
    Kaoru Dohi
    Mie University Graduate School of Medicine, Tsu, Japan
    Am J Cardiol 101:1206-12. 2008
    ....
  11. ncbi request reprint Force- and relaxation-frequency relations in patients with diastolic heart failure
    Takashi Yamanaka
    The First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Am Heart J 152:966.e1-7. 2006
    ..However, the force- and relaxation-frequency relation and LV-arterial coupling in patients with diastolic heart failure (DHF) has not been fully investigated...
  12. ncbi request reprint Impaired myocardial perfusion reserve in patients with fatty liver disease assessed by quantitative myocardial perfusion magnetic resonance imaging
    Shiro Nakamori
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Circ J 76:2234-40. 2012
    ..The purpose of this study was to determine whether the presence of fatty liver is associated with an alteration in myocardial perfusion reserve (MPR)...
  13. ncbi request reprint Change in filling pattern with preload reduction reflects left ventricular relaxation
    Masaki Tanabe
    First Department of Internal Medicine, Mie University School of Medicine, Mie, Japan
    Int J Cardiol 98:67-72. 2005
    ..Accordingly, we hypothesized that the left ventricular filling pattern with preload reduction can be used to estimate left ventricular relaxation in patients with preserved systolic function...
  14. ncbi request reprint RhoA activation in vascular smooth muscle cells from stroke-prone spontaneously hypertensive rats
    Nobuyuki Moriki
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Hypertens Res 27:263-70. 2004
    ..These results suggest that the possible mechanisms underlying RhoA activation in VSMC from SHRSP are autocrine/paracrine regulation by Ang II and/or cGKIalpha downregulation...
  15. ncbi request reprint Characterization and function of MYPT2, a target subunit of myosin phosphatase in heart
    Ryuji Okamoto
    Department of Cardiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Cell Signal 18:1408-16. 2006
    ..Similarity of the two MYPT isoforms suggests common enzymatic mechanisms and regulation. Cardiac myosin is a substrate for the MYPT2 holoenzyme, but the Z-line location raises the possibility of other substrates...
  16. doi request reprint Patients with a hypertensive response to exercise have impaired left ventricular diastolic function
    Takeshi Takamura
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Hypertens Res 31:257-63. 2008
    ..0+/-1.9 cm/s, respectively, p<0.05). In conclusion, irrespective of the presence of resting hypertension, patients with hypertensive response to exercise had impaired LV longitudinal diastolic function and exercise intolerance...
  17. doi request reprint Des-γ-carboxy prothrombin ratio measured by P-11 and P-16 antibodies is a novel biomarker for hepatocellular carcinoma
    Masahiko Tameda
    Department of Molecular and Laboratory Medicine, Mie University School of Medicine, Tsu, Japan
    Cancer Sci 104:725-31. 2013
    ..Patients with HCC had higher NX-PVKA ratios compared to patients with LC taking warfarin (P = 0.063). These results suggest that, when used in combination with DCP, the NX-PVKA ratio is a promising novel marker for the detection of HCC...
  18. doi request reprint Prognostic value of coronary magnetic resonance angiography for prediction of cardiac events in patients with suspected coronary artery disease
    Yeonyee E Yoon
    Department of Radiology, Mie University Hospital, Tsu, Mie, Japan
    J Am Coll Cardiol 60:2316-22. 2012
    ..This study sought to determine whether whole-heart coronary magnetic resonance angiography (CMRA) can predict cardiac events in patients with suspected coronary artery disease...
  19. ncbi request reprint Correlation between late gadolinium enhancement and diastolic function in hypertrophic cardiomyopathy assessed by magnetic resonance imaging
    Munenobu Motoyasu
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Circ J 72:378-83. 2008
    ..The purpose of this study was to determine the relationship between the extent of myocardial fibrosis demonstrated by late gadolinium-enhanced MRI and diastolic dysfunction...
  20. doi request reprint Reversible right ventricular regional non-uniformity quantified by speckle-tracking strain imaging in patients with acute pulmonary thromboembolism
    Emiyo Sugiura
    Mie University Graduate School of Medicine, Tsu, Japan
    J Am Soc Echocardiogr 22:1353-9. 2009
    ....
  21. doi request reprint Improving drug adherence using fixed combinations caused beneficial treatment outcomes and decreased health-care costs in patients with hypertension
    Naoto Kumagai
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Clin Exp Hypertens 35:355-60. 2013
    ..136 ± 11/77 ± 9 mm Hg, P < .01) accompanied with increasing drug adherence. After lowering BP by fixed-dose combinations, the costs for medications decreased by 31% over the 3 months. ..
  22. doi request reprint Quantification of myocardial blood flow using model based analysis of first-pass perfusion MRI: extraction fraction of Gd-DTPA varies with myocardial blood flow in human myocardium
    Masaki Ishida
    Department of Radiology, Mie University Hospital, Tsu, Mie, Japan
    Magn Reson Med 66:1391-9. 2011
    ..14 × MBF + 0.56)/MBF). The current results indicate that MBF can be accurately quantified by Patlak plot method of first-pass myocardial perfusion MRI by performing a correction of extraction fraction...
  23. ncbi request reprint Rho/Rho-kinase pathway contributes to C-reactive protein-induced plasminogen activator inhibitor-1 expression in endothelial cells
    Tetsuya Nakakuki
    Department of Cardiology, Mie University Graduate School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    Arterioscler Thromb Vasc Biol 25:2088-93. 2005
    ..However, its molecular mechanism has not been fully investigated. We examined the involvement of Rho/Rho-kinase signaling in CRP-induced plasminogen activator inhibitor-1 (PAI-1) expression in bovine aortic endothelial cells (BAECs)...
  24. ncbi request reprint Assessment of left ventricular systolic function in patients with chronic atrial fibrillation and dilated cardiomyopathy using the ratio of preceding to prepreceding R-R intervals
    Masaki Tanabe
    The First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Int J Cardiol 108:197-201. 2006
    ....
  25. ncbi request reprint High glucose induces plasminogen activator inhibitor-1 expression through Rho/Rho-kinase-mediated NF-kappaB activation in bovine aortic endothelial cells
    Hitoshi Iwasaki
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Atherosclerosis 196:22-8. 2008
    ..Inhibition of Rho/Rho-kinase signaling might be a novel target for diabetes and metabolic syndrome...
  26. doi request reprint Role of haemodialytic therapy on left ventricular mechanical dyssynchrony in patients with end-stage renal disease quantified by speckle-tracking strain imaging
    Tomohiro Murata
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan
    Nephrol Dial Transplant 26:1655-61. 2011
    ..The aims of this study were to characterize and quantify LV function and mechanical dyssynchrony in patients with ESRD, and to elucidate the impact of haemodialytic (HD) therapy on these parameters by speckle-tracking strain imaging...
  27. doi request reprint Diagnostic accuracy of 1.5-T unenhanced whole-heart coronary MR angiography performed with 32-channel cardiac coils: initial single-center experience
    Motonori Nagata
    Department of Radiology and Cardiology, Mie University Hospital, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Radiology 259:384-92. 2011
    ....
  28. doi request reprint Reversible left ventricular regional non-uniformity quantified by speckle-tracking displacement and strain imaging in patients with acute pulmonary embolism
    Takeshi Takamura
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan
    J Am Soc Echocardiogr 24:792-802. 2011
    ....
  29. ncbi request reprint High plasma level of factor VIII: an important risk factor for venous thromboembolism
    Satoshi Ota
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Circ J 75:1472-5. 2011
    ..Elevated levels of factor VIII (FVIII) have been suggested as important for the pathogenesis of venous thromboembolism (VTE). The objective of this study was to explore the association between elevated FVIII level and VTE in Japan...
  30. doi request reprint The long-term effects of splenectomy and subsequent interferon therapy in patients with HCV-related liver cirrhosis
    Yuji Inagaki
    Department of Internal Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Mol Med Rep 9:487-92. 2014
    ..The results of the present study demonstrate that splenectomy followed by interferon therapy could be beneficial in patients with HCV-related LC...
  31. doi request reprint Myocardial perfusion reserve is impaired in patients with chronic obstructive pulmonary disease: a comparison to current smokers
    Shiro Nakamori
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Eur Heart J Cardiovasc Imaging 15:180-8. 2014
    ....
  32. ncbi request reprint Nitroglycerin improves left ventricular relaxation by changing systolic loading sequence in patients with excessive arterial load
    Naoki Fujimoto
    The First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    J Cardiovasc Pharmacol 45:211-6. 2005
    ..Thus, nitroglycerin improved LV relaxation in patients with excessive arterial load partly by changing the systolic loading sequence...
  33. doi request reprint The impact of preprocedural hemoglobin A1c on the efficacy of sirolimus-eluting and paclitaxel-eluting stents
    Toshiki Sawai
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Cardiovasc Interv Ther 27:72-83. 2012
    ..Preprocedural A1c (≥7.0%) was found to be an independent predictor of restenosis in the SES group, but not in the PES group...
  34. doi request reprint Clinical features of patients with left atrial thrombus undergoing anticoagulant therapy
    Shinya Sugiura
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    J Interv Card Electrophysiol 34:59-63. 2012
    ..This study analyzed the clinical features of patients with LA thrombi who received anticoagulant therapy and whether the D-dimer test is useful to exclude LA thrombus...
  35. ncbi request reprint The relationship between aortic augmentation index and pulse wave velocity: an invasive study
    Masato Sakurai
    Department of Cardiology, Mie University of Medicine, Mie, Japan
    J Hypertens 25:391-7. 2007
    ..However, it is not clear whether aortic AI and PWV reflect aortic stiffness in similar ways. We investigated the relationship between aortic AI and PWV by measuring them directly using a catheter technique...
  36. doi request reprint Elevated levels of soluble fibrin in patients with venous thromboembolism
    Akihiro Tsuji
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Int J Hematol 88:448-53. 2008
    ..2 microg/ml, FDP was less than 1.3 microg/ml, and D-dimer was less than 0.5 microg/ml. Our findings suggest that the SF assay is useful for the diagnosis and exclusion of VTE...
  37. doi request reprint Regional myocardial perfusion reserve determined using myocardial perfusion magnetic resonance imaging showed a direct correlation with coronary flow velocity reserve by Doppler flow wire
    Tairo Kurita
    Department of Cardiology, Mie University Hospital, Tsu, Japan
    Eur Heart J 30:444-52. 2009
    ..The purpose of this study was to compare regional MPR determined by myocardial perfusion MRI with coronary flow reserve (CFR) by intracoronary Doppler flow wire...
  38. ncbi request reprint Candesartan prevents myocardial fibrosis during progression of congestive heart failure
    Katsuya Onishi
    Department of Laboratory Medicine, Mie University School of Medicine, Tsu, Japan
    J Cardiovasc Pharmacol 43:860-7. 2004
    ....
  39. doi request reprint Detection of diminished response to cold pressor test in smokers: assessment using phase-contrast cine magnetic resonance imaging of the coronary sinus
    Shingo Kato
    Department of Radiology, Mie University Hospital, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Magn Reson Imaging 32:217-23. 2014
    ....
  40. doi request reprint Prognostic significance of unrecognized myocardial infarction detected with MR imaging in patients with impaired fasting glucose compared with those with diabetes
    Yeonyee E Yoon
    Department of Radiology, Mie University Hospital, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Radiology 262:807-15. 2012
    ....
  41. doi request reprint Elevated Von Willebrand factor propeptide for the diagnosis of thrombotic microangiopathy and for predicting a poor outcome
    Naomi Ito-Habe
    Department of Hematology and Oncology, Mie University Graduate School of Medicine, Mie, Japan
    Int J Hematol 93:47-52. 2011
    ..A ROC analysis indicated that VWFpp and TM were useful markers for the prediction of a poor outcome. These findings suggest that VWFpp is an useful marker for the diagnosis of TMA and for the prediction of poor outcome...
  42. doi request reprint How long is strict bed rest necessary after renal biopsy?
    Eiji Ishikawa
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Clin Exp Nephrol 13:594-7. 2009
    ..No consensus exists on the amount of bed rest required after renal biopsy. Moreover, forced prolonged bed rest can be uncomfortable in patients undergoing renal biopsy...
  43. ncbi request reprint Single beat determination of regional myocardial strain measurements in patients with atrial fibrillation
    Kaoru Yamanaka-Funabiki
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    J Am Soc Echocardiogr 19:1332-7. 2006
    ..99). In conclusion, regional myocardial strain at RR1/RR2 = 1 on the linear regression represents the average value of all recorded cardiac cycles in patients with AF...
  44. ncbi request reprint Effective cardiac resynchronization after Dor procedure and mitral annuloplasty
    Masaki Tanabe
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Can J Cardiol 20:449-51. 2004
    ..The present case demonstrates the efficacy of adding cardiac resynchronization to Dor ventriculoplasty and mitral annuloplasty in a patient with severely impaired left ventricular function and an intraventricular conduction delay...
  45. ncbi request reprint Human β-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression
    Satoko Uraki
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Int J Oncol 45:1059-64. 2014
    ..In conclusion, progression of colon cancer was inhibited by hBD-3 in a paracrine fashion. Therefore, hBD-3 may be a potent new agent for treating colon cancer. ..
  46. doi request reprint Utility of right ventricular Tei-index for assessing disease severity and determining response to treatment in patients with pulmonary arterial hypertension
    Yoshito Ogihara
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    J Cardiol 63:149-53. 2014
    ....
  47. doi request reprint Hemodynamic and pathophysiological characteristics of intradialytic blood pressure elevation in patients with end-stage renal disease
    Kazuki Oosugi
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan
    Hypertens Res 37:158-65. 2014
    ....
  48. pmc Collagen triple helix repeat containing 1 is overexpressed in hepatocellular carcinoma and promotes cell proliferation and motility
    Masahiko Tameda
    First Department of Internal Medicine, Mie University School of Medicine, Tsu 514 8507, Japan
    Int J Oncol 45:541-8. 2014
    ..Moreover, some cases showed strong staining for CTHRC1 in invasive areas of HCC. CTHRC1 has the potential to be a new biomarker for the aggressive HCC, and to be a new therapeutic target in treating HCC. ..
  49. ncbi request reprint Relationship between CYP2C19 loss-of-function polymorphism and platelet reactivities with clopidogrel treatment in Japanese patients undergoing coronary stent implantation
    Tomoyuki Nakata
    Department of Cardiology, Mie University Faculty of Medicine, Tsu, Japan
    Circ J 77:1436-44. 2013
    ..The contribution of these genotypes to platelet reactivity in Japanese patients in a steady state receiving dual antiplatelet therapy after coronary stenting was evaluated...
  50. doi request reprint Quantitative assessment of myocardial strain with displacement encoding with stimulated echoes MRI in patients with coronary artery disease
    Hideki Miyagi
    Department of Radiology, Mie University Hospital, 2 174 Edobashi, Tsu, Mie, 514 8507, Japan
    Int J Cardiovasc Imaging 29:1779-86. 2013
    ..Myocardial strain, especially e2 is useful in detecting altered abnormal systolic contraction in the segments with myocardial scar...
  51. doi request reprint Short-term effects of low-dose tolvaptan on hemodynamic parameters in patients with chronic heart failure
    Kiyotaka Watanabe
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Tsu, Japan
    J Cardiol 60:462-9. 2012
    ..We evaluated the short-term effects of low-dose tolvaptan treatment on hemodynamic parameters in patients with chronic heart failure (HF)...
  52. ncbi request reprint Early results of rheolytic thrombectomy in patients with proximal deep vein thrombosis
    Akihiro Tsuji
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Circ J 75:1742-6. 2011
    ..The utility of rheolytic thrombectomy as a treatment for proximal deep vein thrombosis (DVT) is not well understood...
  53. doi request reprint The association of protein S Tokushima-K196E with a risk of deep vein thrombosis
    Makoto Ikejiri
    Central Laboratory, Mie University Graduate School of Medicine, Tsu, Japan
    Int J Hematol 92:302-5. 2010
    ..There were no significant differences of CYP2C9, VKORC1 or GGCX between the patients with and without DVT. Therefore, PS Tokushima (K196E) is an important genetic risk factor for DVT in the Japanese population...
  54. ncbi request reprint Intravascular hemolysis in aortic stenosis
    Akihiro Tsuji
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu 514 8507
    Intern Med 43:935-8. 2004
    ..3 mg/dl, and hemosiderinuria was evident. We diagnosed intravascular hemolysis related to aortic stenosis. After we performed an aortic valve replacement, fragmentation on the peripheral blood smear dramatically disappeared...
  55. doi request reprint Elevated serum levels of bromine do not always indicate pseudohyperchloremia
    Takayasu Ito
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2 174 Edo Bashi, Tsu, Mie, 514 8507, Japan
    Clin Exp Nephrol 14:431-5. 2010
    ..Hyperchloremia is known to be able to reveal existing bromism, but the fact that bromine (Br(-)) influences chloride (Cl(-)) in assays that use ion electrode machines is not widely known...
  56. doi request reprint Identification of bovine hibernation-specific protein complex and evidence of its regulation in fasting and aging
    Satoshi Fujita
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Biochem 153:453-61. 2013
    ..Interestingly, bovine HP20 was highly expressed in cattle serum after fasting. Native bovine HP20c may be a useful tool for investigating HP function...
  57. doi request reprint Incremental prognostic values of serum tenascin-C levels with blood B-type natriuretic peptide testing at discharge in patients with dilated cardiomyopathy and decompensated heart failure
    Naoki Fujimoto
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    J Card Fail 15:898-905. 2009
    ..This study investigates the predictive value of serum tenascin-C (TN-C), which is observed at the active sites of ongoing tissue remodeling, for cardiac events of patients with dilated cardiomyopathy (DCM)...
  58. ncbi request reprint Incidence and clinical predictors of deep vein thrombosis in patients hospitalized with heart failure in Japan
    Satoshi Ota
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Japan
    Circ J 73:1513-7. 2009
    ..The aim of this study was to clarify the incidence and clinical predictors of deep vein thrombosis (DVT) in patients with congestive heart failure (CHF) in Japan...
  59. ncbi request reprint Alternans decay of postextrasystolic potentiation in human left ventricle
    Masaki Tanabe
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, 514 8507 Japan
    Jpn J Physiol 54:87-91. 2004
    ..These Emax alternans decays resemble those reported in canine LVs. This finding suggests for the first time the applicability of the same organ-level RF assessment method developed for canine hearts to human hearts...
  60. doi request reprint Pacing tachycardia exaggerates left ventricular diastolic dysfunction but not systolic function and regional asynergy or asynchrony in patients with hypertrophic cardiomyopathy
    Toshiaki Tarumi
    Department of Cardiology, Mie University of Medicine, Tsu, Mie, Japan
    Europace 12:1308-15. 2010
    ..We hypothesized that left ventricular (LV) systolic or diastolic dysfunction would be provocated by pacing tachycardia in patients with HCM...
  61. ncbi request reprint A case of primary cardiac lymphoma located in the pericardial effusion
    Tetsuya Nakakuki
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, 514 8507, Mie, Japan
    Heart Vessels 19:199-202. 2004
    ..Systemic chemotherapy with CHOP (cyclophosphamide, farmorubicin, oncovin, and prednisolone) resulted in a complete resolution of the pericardial effusion. She has been in remission 48 months after discontinuation of the chemotherapy...
  62. ncbi request reprint Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle
    Tetsuya Seko
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Circ Res 92:411-8. 2003
    ..These results suggest that independent of the cause of hypertension, a common point in downstream signaling and a critical component of hypertension is activation of RhoA and subsequent activation of Rho-kinase...
  63. ncbi request reprint The Günther-Tulip retrievable IVC filter: clinical experience in 118 consecutive patients
    Satoshi Ota
    Department of Cardiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Japan
    Circ J 72:287-92. 2008
    ..The purpose of this study was to assess the use of the Günther Tulip Filter (GTF) for the management of venous thromboembolism (VTE)...
  64. ncbi request reprint The targeted disruption of the MYPT1 gene results in embryonic lethality
    Ryuji Okamoto
    The First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Transgenic Res 14:337-40. 2005
    ..The point of embryonic lethality is before 7.5 dpc. These findings indicate that MYPT1 is essential for mouse embryogenesis...
  65. doi request reprint Unusual glomerulopathy with aggregated subepithelial microspheric particles resembling membranous nephropathy: a variant of glomerulopathy associated with podocytic infolding?
    Shinsuke Nomura
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Mie, 514 8507, Japan
    Clin Exp Nephrol 12:513-7. 2008
    ..J Nephrol 49:61-67, 2007), could not be excluded...
  66. pmc Mycotic aortic aneurysm associated with Legionella anisa
    Masaki Tanabe
    Department of Cardiology, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    J Clin Microbiol 47:2340-3. 2009
    ..This case report is potentially useful for the future diagnosis of intravascular infection...
  67. doi request reprint Cut-off values of D-dimer and soluble fibrin for prediction of deep vein thrombosis after orthopaedic surgery
    Akihiro Sudo
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Japan
    Int J Hematol 89:572-6. 2009
    ..6 microg/ml of SF at day 1 after surgery, or less than 7.0 microg/ml of D-dimer at day 4 excluded DVT. These findings suggest that the D-dimer and SF are useful for the diagnosis and exclusion of DVT after orthopaedic surgery...
  68. ncbi request reprint Addition of angiotensin II receptor antagonist to an ACE inhibitor in heart failure improves cardiovascular function by a bradykinin-mediated mechanism
    Takafumi Koji
    First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    J Cardiovasc Pharmacol 41:632-9. 2003
    ..Thus, endogenous bradykinin partially contributes to the synergistic improvement of cardiovascular function in CHF with additional treatment with ATRA to ACEI...
  69. ncbi request reprint Up-regulation of glypican-3 in human hepatocellular carcinoma
    Masahiro Suzuki
    First Department of Internal Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Anticancer Res 30:5055-61. 2010
    ..To investigate the expression and significance of glypican-3 (GPC3) in human hepatocellular carcinoma (HCC)...
  70. ncbi request reprint Risk factors for nonfatal pulmonary embolism in a Japanese population: A hospital-based case-control study
    Norikazu Yamada
    Department of Cardiology, Mie University Graduate School of Medicine, Japan
    Angiology 61:269-74. 2010
    ..Inherited thrombophilia was found in 14 patients with PE (14%). Risk factors for PE in Japan are comparable in magnitude to those in Western countries; only one third of PE cases had received VTE prophylaxis...
  71. doi request reprint Efficacy of linear block at the left atrial roof in atrial fibrillation
    Michiharu Senga
    Department of Cardiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    J Cardiol 55:322-7. 2010
    ..This study examined the efficacy of additional linear ablation at the left atrial (LA) roof in combination with EEPVI to prevent arrhythmia recurrences...
  72. ncbi request reprint Intraortic pulse pressure is correlated with coronary artery stenosis
    Morihiro Ozaki
    Yokkaichi Social Insurance Hospital, Mie, Japan
    Int Heart J 46:69-78. 2005
    ..0024). The results of the present study indicate that aortic pulse pressure is significantly and independently correlated with angiographically determined coronary artery stenosis...
  73. doi request reprint Relation between signal intensity on T2-weighted MR images and presence of microvascular obstruction in patients with acute myocardial infarction
    Yoko Mikami
    Department of Radiology, Mie University Hospital, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    AJR Am J Roentgenol 193:W321-6. 2009
    ..The purpose of this study was to determine whether detection of myocardial edema with T2-weighted MRI is influenced by the presence of microvascular obstruction...
  74. ncbi request reprint Primary amyloidosis with pulmonary involvement which presented exudative pleural effusion and high fever
    Naoki Fujimoto
    First Department of Internal Medicine, Mie University School of Medicine, Tsu
    Intern Med 42:756-60. 2003
    ..Treatment with melphalan (6 mg) and prednisolone (35 mg) for 4 days every 6 weeks decreased the fever and alleviated his symptoms...
  75. ncbi request reprint Ultrasonography as a predictor of overt bleeding after renal biopsy
    Eiji Ishikawa
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, 2 174 Edo Bashi, Tsu, Mie 514 8507, Japan
    Clin Exp Nephrol 13:325-31. 2009
    ..Renal biopsy is essential for the diagnosis of kidney diseases, but complications, particularly bleeding incidents, remain problematic...
  76. ncbi request reprint Ruptured aneurysm of the sinus of valsalva coexisting with a ventricular septal defect and single coronary artery
    Mie Ishii
    The First Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan
    Circ J 67:470-2. 2003
    ..This rare combination of a ruptured aneurysm of the sinus of Valsalva coexisting with a ventricular septal defect and a single coronary artery has not been reported previously...
  77. pmc Irradiation prolongs survival of Alport mice
    Kan Katayama
    Department of Cardiology and Nephrology, Mie University Graduate School of Medicine, Mie, 21 153 Noda, Tsu, Mie, 514 0826, Japan
    J Am Soc Nephrol 19:1692-700. 2008
    ..0001). In conclusion, the improved survival observed in Alport mice that received a transplant of wild-type bone marrow might be primarily attributed to as-yet-unidentified effects of irradiation...
  78. ncbi request reprint Impact of heart rate on mechanical dyssynchrony and left ventricular contractility in patients with heart failure and normal QRS duration
    Tairo Kurita
    Department of Cardiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu 514 8507, Japan
    Eur J Heart Fail 9:637-43. 2007
    ..We hypothesized that mechanical dyssynchrony may be augmented at increased heart rates in patients with HF and normal QRS duration...
  79. ncbi request reprint Differential association and localization of myosin phosphatase subunits during agonist-induced signal transduction in smooth muscle
    Heung Mook Shin
    Boston Biomedical Research Institute, Watertown, Mass 02472, USA
    Circ Res 90:546-53. 2002
    ..The phosphorylation and membrane translocation of the targeting subunit are inhibited by a ROK inhibitor. This dissociation of subunits may provide a mechanism for the decreased phosphatase activity of phosphorylated myosin phosphatase...
  80. ncbi request reprint Combined angiotensin receptor blocker and ACE inhibitor on myocardial fibrosis and left ventricular stiffness in dogs with heart failure
    Kaoru Funabiki
    Dept of Laboratory Medicine, Mie Univ School of Medicine, 2 174 Edobashi, Tsu 514 8507, Japan
    Am J Physiol Heart Circ Physiol 287:H2487-92. 2004
    ..Thus ARB + ACEI prevents myocardial fibrosis and decreases LV stiffness during the progression of CHF compared with ARB or ACEI alone...
  81. ncbi request reprint Involvement of rho-kinase in agonists-induced contractions of arteriosclerotic human arteries
    Tadashi Kandabashi
    Department of Cardiovascular Medicine, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 22:243-8. 2002
    ....
  82. pmc Integrin-linked kinase phosphorylates the myosin phosphatase target subunit at the inhibitory site in platelet cytoskeleton
    Eniko Kiss
    Department of Medical Chemistry, University of Debrecen, Medical and Health Science Center, H 4026 Debrecen, Bem tér 18 B, Hungary
    Biochem J 365:79-87. 2002
    ..The above results raise the potential for regulation of MP activity in platelet cytoskeleton by ILK and suggest an alternative to the Rho-linked pathway...
  83. ncbi request reprint NKG2D ligation without T cell receptor engagement triggers both cytotoxicity and cytokine production in dendritic epidermal T cells
    Ayano Nitahara
    Division of Dermatology, Graduate School of Medical and Dental Sciences, Niigata University, 1 757 Asahimachi dori, Niigata 9512 8510, Japan
    J Invest Dermatol 126:1052-8. 2006
    ..These findings demonstrate that DETCs constitutively express NKG2D that acts as a primary activating receptor, and indicate its important role in cutaneous immune surveillance...
  84. ncbi request reprint Cholesterol crystal embolization (CCE) after cardiac catheterization: a case report and a review of 36 cases in the Japanese literature
    Kaoru Funabiki
    Division of Internal Medicine, Ise General Hospital, Ise, Japan
    Jpn Heart J 44:767-74. 2003
    ..Cilostazol and intravenous heparin improved the symptoms and decreased the creatinine level. We retrospectively studied the clinical features of 36 cases registered with a diagnosis of CCE in the Japanese literature...
  85. ncbi request reprint Identification of Tau and MAP2 as novel substrates of Rho-kinase and myosin phosphatase
    Mutsuki Amano
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Aichi, Japan
    J Neurochem 87:780-90. 2003
    ..Thus, it is likely that the Rho-kinase/MBS pathway regulates not only the actin-myosin system but also microtubule dynamics...
  86. ncbi request reprint Involvement of Src family protein tyrosine kinases in Ca(2+) sensitization of coronary artery contraction mediated by a sphingosylphosphorylcholine-Rho-kinase pathway
    Fumiaki Nakao
    Department of Cardiovascular Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Circ Res 91:953-60. 2002
    ..Translocation and activation of SrcPTKs, including Fyn, play an important role in Ca(2+) sensitization of VSM contractions mediated by a SPC-Rho-kinase pathway...
  87. ncbi request reprint Role of protein phosphatase type 1 in contractile functions: myosin phosphatase
    David J Hartshorne
    Muscle Biology Group, University of Arizona, Tucson, Arizona 85721, USA
    J Biol Chem 279:37211-4. 2004
  88. ncbi request reprint Expression and chain assembly of human laminin-332 in an insect cell-free translation system
    Hoang Phuong Phan
    Graduate School of Bioagricultural Sciences, Nagoya University, Furo cho, Nagoya, Japan
    Biosci Biotechnol Biochem 72:1847-52. 2008
    ..We suggest that the cell-free translation system is a valid system with which to study the mechanisms underlying laminin chain assembly...
  89. ncbi request reprint Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension
    Ken Ishikura
    Department of Cardiology, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu 514 8507, Japan
    Circ J 70:174-8. 2006
    ..Rho-kinase is involved in the pathophysiology of several diseases underlying smooth muscle hypercontraction, so the purpose of this study was to investigate the efficacy of fasudil, a Rho-kinase inhibitor, in patients with PAH...
  90. doi request reprint Secreted CXCL1 is a potential mediator and marker of the tumor invasion of bladder cancer
    Hiroaki Kawanishi
    Department of Urology, Graduate School of Medicine, Graduate School of Pharmaceutical Sciences, Kyoto University, Kyoto, Japan
    Clin Cancer Res 14:2579-87. 2008
    ..The purpose of this study was to identify proteins that are potentially involved in the tumor invasion of bladder cancer...
  91. doi request reprint Preoperative diagnosis of lymph node metastases of colorectal cancer by FDG-PET/CT
    Yoshiyuki Tsunoda
    Department of Colorectal and Pelvic Surgery, National Cancer Center Hospital East, 6 5 1 Kashiwa, Chiba 277 8577, Japan
    Jpn J Clin Oncol 38:347-53. 2008
    ..The purpose of this study was to assess the diagnostic value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for lymph node (LN) metastasis of colorectal cancer...
  92. ncbi request reprint Heat shock-induced augmentation of vascular contractility is independent of rho-kinase
    YoungMi Seok
    Department of Pharmacology, Kyungpook National University School of Medicine, Daegu, Republic of Korea
    Clin Exp Pharmacol Physiol 33:264-8. 2006
    ..6. The results of the present study suggest that Rho-kinases are unlikely to be involved in heat shock-induced augmentation of vascular contractility...
  93. ncbi request reprint Urocortin-induced decrease in Ca2+ sensitivity of contraction in mouse tail arteries is attributable to cAMP-dependent dephosphorylation of MYPT1 and activation of myosin light chain phosphatase
    Lubomir T Lubomirov
    Institute of Vegetative Physiology, University of Cologne, Germany
    Circ Res 98:1159-67. 2006
    ....
  94. doi request reprint Diagnosis supporting algorithm for lymph node metastases from colorectal carcinoma on 18F-FDG PET/CT
    Kazumasa Inoue
    Functional Imaging Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Chiba, Japan
    Ann Nucl Med 22:41-8. 2008
    ....
  95. ncbi request reprint Improvement of left ventricular mechanical dyssynchrony associated with restoration of left ventricular function in a patient with fulminant myocarditis and complete left bundle branch block
    Takeshi Takamura
    Int J Cardiol 127:e8-11. 2008
    ....
  96. ncbi request reprint Phosphorylation of Thr695 and Thr850 on the myosin phosphatase target subunit: inhibitory effects and occurrence in A7r5 cells
    Andrea Murányi
    Muscle Biology Group, Department of Nutritional Sciences, University of Arizona, 1177 E 4th Street, Shantz 627, Tucson, AZ 85721 0038, USA
    FEBS Lett 579:6611-5. 2005
    ..Phosphorylation of each site on MYPT1 was detected in A7r5 cells, but Thr850 was preferred by Rho-kinase and Thr695 was phosphorylated by an unidentified kinase(s)...
  97. doi request reprint Improvement of the diagnostic accuracy of lymph node metastases of colorectal cancer in 18F-FDG-PET/CT by optimizing the iteration number for the image reconstruction
    Kazumasa Inoue
    Graduate School of Health Science, Tokyo Metropolitan University, Tokyo, Japan
    Ann Nucl Med 22:465-73. 2008
    ..Improvement in the diagnostic accuracy of lymph node (LN) metastases of colorectal cancer by optimizing the reconstruction parameters was studied, including a phantom study and clinical studies...
  98. ncbi request reprint Regulation of purinergic signaling by prostaglandin E2 in murine macrophages
    Masaaki Ito
    Laboratory of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki shi, Gunma, Japan
    J Pharmacol Sci 107:443-50. 2008
    ..The different inhibitory effects on distinct purinoceptor functions may be related to the anti-inflammatory property of PGE2...
  99. ncbi request reprint Polymorphism within the cyclin D1 gene is associated with an increased risk of carcinoma in situ in patients with superficial bladder cancer
    Masaaki Ito
    Department of Urology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Urology 64:74-8. 2004
    ..To evaluate the prognostic value of CCND1 polymorphism in superficial and invasive transitional cell cancer of the bladder...
  100. ncbi request reprint Interaction of Rho-kinase with myosin II at stress fibres
    Saeko Kawabata
    Department of Cell Pharmacology, Graduate School of Medicine, Nagoya University, Nagoya, Aichi 466 8550, Japan
    Genes Cells 9:653-60. 2004
    ..These results indicate that Rho-kinase is localized at stress fibres through binding of the pleckstrin homology domain to myosin II...
  101. ncbi request reprint Localization of myosin phosphatase target subunit 1 in rat brain and in primary cultures of neuronal cells
    Beata Lontay
    Department of Medical Chemistry, Research Center for Molecular Medicine, Medical and Health Science Center, University of Debrecen, H 4012 Debrecen, Bem tér 18 B, Hungary
    J Comp Neurol 478:72-87. 2004
    ..In conclusion, the widespread cellular and subcellular localization of MYPT1 implies that PP1M may play an important role in the dephosphorylation of key regulatory proteins in neuronal cells...