Sahoko Ichihara

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. pmc The pathological roles of environmental and redox stresses in cardiovascular diseases
    Sahoko Ichihara
    Graduate School of Regional Innovation Studies, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Environ Health Prev Med 18:177-84. 2013
  2. pmc Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat
    Jie Chang
    Graduate School of Regional Innovation Studies, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Nutr Metab (Lond) 9:87. 2012
  3. ncbi request reprint A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Arterioscler Thromb Vasc Biol 27:1297-304. 2007
  4. ncbi request reprint Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan
    Biochem Biophys Res Commun 350:105-13. 2006
  5. ncbi request reprint Genetic factors for human obesity
    S Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie, Japan
    Cell Mol Life Sci 65:1086-98. 2008
  6. doi request reprint Association of a polymorphism of ABCB1 with obesity in Japanese individuals
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Genomics 91:512-6. 2008
  7. ncbi request reprint Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Biochem Biophys Res Commun 359:27-33. 2007
  8. pmc Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurimamachiya cho, Tsu, Mie 514 8507, Japan
    Biochem Biophys Res Commun 381:44-9. 2009
  9. doi request reprint Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Arterioscler Thromb Vasc Biol 30:1553-61. 2010
  10. ncbi request reprint Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors
    Sahoko Ichihara
    Department of Cardiovascular Genome Science, Nagoya University School of Medicine, Japan
    J Mol Cell Cardiol 41:318-29. 2006

Collaborators

Detail Information

Publications56

  1. pmc The pathological roles of environmental and redox stresses in cardiovascular diseases
    Sahoko Ichihara
    Graduate School of Regional Innovation Studies, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Environ Health Prev Med 18:177-84. 2013
    ..The roles of these transcription factors, AHR and Nrf2 in angiogenesis are also discussed in this review...
  2. pmc Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat
    Jie Chang
    Graduate School of Regional Innovation Studies, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Nutr Metab (Lond) 9:87. 2012
    ..abstract:..
  3. ncbi request reprint A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Arterioscler Thromb Vasc Biol 27:1297-304. 2007
    ..We have investigated the interaction between AHR and hypoxia signaling pathways in regulation of angiogenesis with the use of a surgical model of ischemia...
  4. ncbi request reprint Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan
    Biochem Biophys Res Commun 350:105-13. 2006
    ..Attenuation of the development of cardiac dysfunction by bisoprolol may thus result in part from normalization of the associated increases in the levels of oxidative stress and pro-inflammatory cytokines in the left ventricle...
  5. ncbi request reprint Genetic factors for human obesity
    S Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie, Japan
    Cell Mol Life Sci 65:1086-98. 2008
    ..Identification of the underlying genetic causes of obesity will likely provide a basis both for the development of new therapeutic agents and for the personalized prevention of this condition...
  6. doi request reprint Association of a polymorphism of ABCB1 with obesity in Japanese individuals
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Genomics 91:512-6. 2008
    ..Our results suggest that the ABCB1 genotype may prove informative for assessment of genetic risk for obesity in Japanese individuals...
  7. ncbi request reprint Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Biochem Biophys Res Commun 359:27-33. 2007
    ..These results suggest that fenofibrate and PEG-SOD prevented cardiac dysfunction induced by DOX through normalization of oxidative stress and redox-regulated NF-kappaB signaling...
  8. pmc Inhibition of ischemia-induced angiogenesis by benzo[a]pyrene in a manner dependent on the aryl hydrocarbon receptor
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurimamachiya cho, Tsu, Mie 514 8507, Japan
    Biochem Biophys Res Commun 381:44-9. 2009
    ....
  9. doi request reprint Ablation of the transcription factor Nrf2 promotes ischemia-induced neovascularization by enhancing the inflammatory response
    Sahoko Ichihara
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurimamachiya cho, Tsu 514 8507, Japan
    Arterioscler Thromb Vasc Biol 30:1553-61. 2010
    ..To investigate the potential role of nuclear factor-erythroid 2-related factor 2 (Nrf2) in neovascularization with a murine surgical model of ischemia...
  10. ncbi request reprint Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors
    Sahoko Ichihara
    Department of Cardiovascular Genome Science, Nagoya University School of Medicine, Japan
    J Mol Cell Cardiol 41:318-29. 2006
    ..These effects were associated with inhibition of the inflammatory response and of activation of redox-regulated transcription factors in the left ventricle...
  11. ncbi request reprint Association of genetic variants with atherothrombotic cerebral infarction in Japanese individuals with metabolic syndrome
    Yoshiji Yamada
    FAHA, Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Mie 514 8507, Japan
    Int J Mol Med 21:801-8. 2008
    ..Genotypes for these polymorphisms, especially for the 2445G-->A (Ala54Thr) polymorphism of FABP2, may prove informative for the prediction of genetic risk for atherothrombotic cerebral infarction among such individuals...
  12. ncbi request reprint Attenuation of ventricular hypertrophy and fibrosis in rats by pitavastatin: potential role of the RhoA-extracellular signal-regulated kinase-serum response factor signalling pathway
    Masako Saka
    Department of Cardiovascular Genome Science, Nagoya University School of Medicine, Nagoya, Japan
    Clin Exp Pharmacol Physiol 33:1164-71. 2006
    ....
  13. doi request reprint Genetic factors for ischemic and hemorrhagic stroke in Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    Stroke 39:2211-8. 2008
    ..We performed an association study to identify gene polymorphisms that confer susceptibility to atherothrombotic cerebral infarction, intracerebral hemorrhage, or subarachnoid hemorrhage...
  14. ncbi request reprint Association of gene polymorphisms with myocardial infarction in individuals with or without conventional coronary risk factors
    Kohta Nishihama
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie, Japan
    Int J Mol Med 19:129-41. 2007
    ..Stratification of subjects on the basis of such risk factors may thus be important in order to achieve personalized prevention of MI with the use of genetic information...
  15. ncbi request reprint Association of polymorphisms of ABCA1 and ROS1 with hypertension in Japanese individuals
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 21:83-9. 2008
    ..Determination of genotypes for ABCA1 and ROS1 may thus prove informative for the prediction of the genetic risk for hypertension...
  16. ncbi request reprint Association of a polymorphism of CYP3A4 with type 2 diabetes mellitus
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Int J Mol Med 20:703-7. 2007
    ..Genotyping for CYP3A4 may thus prove informative for assessment of the genetic risk for type 2 diabetes mellitus...
  17. ncbi request reprint Assessment of genetic risk for myocardial infarction
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Thromb Haemost 96:220-7. 2006
    ..Determination of the combined genotype for these genes may contribute to primary, personalized prevention of this condition...
  18. ncbi request reprint Nicorandil promotes myocardial capillary and arteriolar growth in the failing heart of Dahl salt-sensitive hypertensive rats
    Jinglan Xu
    Department of Cardiovascular Genome Science, Nagoya University School of Medicine, Nagoya 466 8550, Japan
    Hypertension 46:719-24. 2005
    ..Nicorandil may prove beneficial for the treatment of hypertensive heart failure as well as of ischemic heart disease...
  19. ncbi request reprint Gender differences in the association of gene polymorphisms with type 2 diabetes mellitus
    Sachiyo Yamaguchi
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 19:631-7. 2007
    ..Genotyping of these polymorphisms may prove informative for assessment of the genetic component of type 2 diabetes mellitus for men and women separately...
  20. ncbi request reprint Pitavastatin improves cardiac function and survival in association with suppression of the myocardial endothelin system in a rat model of hypertensive heart failure
    Masako Saka
    Department of Cardiovascular Genome Science, Nagoya University School of Medicine, Japan
    J Cardiovasc Pharmacol 47:770-9. 2006
    ..Both early and late pitavastatin treatment thus improved cardiac function and survival, with modulation of extracellular matrix remodeling and endothelin-1 signaling possibly contributing to these beneficial effects...
  21. ncbi request reprint Assessment of genetic factors for type 2 diabetes mellitus
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 18:299-308. 2006
    ..Genotype for F3 may prove reliable for assessment of genetic factors for type 2 diabetes mellitus. Determination of the genotype for this gene may contribute to personalized prevention of this condition...
  22. ncbi request reprint Genetic risk for atherothrombotic cerebral infarction in individuals stratified by sex or conventional risk factors for atherosclerosis
    Sachiyo Yamaguchi
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 18:871-83. 2006
    ..Stratification of subjects on the basis of sex or conventional risk factors for atherosclerosis may therefore be important in order to achieve the personalized prevention of ACI with the use of genetic information...
  23. ncbi request reprint Prediction of genetic risk for metabolic syndrome
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    Atherosclerosis 191:298-304. 2007
    ..The aim of the study was to identify gene polymorphisms that confer susceptibility to metabolic syndrome in order to allow reliable assessment of genetic risk for this condition...
  24. ncbi request reprint Assessment of the genetic component of hypertension
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Japan
    Am J Hypertens 19:1158-65. 2006
    ..We have now performed a large-scale association study to identify gene polymorphisms for reliable assessment of the genetic component of hypertension...
  25. ncbi request reprint Prediction of genetic risk for dyslipidemia
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie 514 8507, Japan
    Genomics 90:551-8. 2007
    ....
  26. ncbi request reprint Genetic factors for obesity
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Mie 514 8507, Japan
    Int J Mol Med 18:843-51. 2006
    ..Genotypes for ACE, GCK, and ESR1 may prove reliable for the assessment of genetic factors for obesity. Determination of the combined genotypes for these genes may contribute to the personalized prevention of this condition...
  27. ncbi request reprint Genetic risk for ischemic and hemorrhagic stroke
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    Arterioscler Thromb Vasc Biol 26:1920-5. 2006
    ..We performed an association study to identify gene polymorphisms for assessing the genetic risk of ischemic or hemorrhagic stroke...
  28. ncbi request reprint Pravastatin increases survival and suppresses an increase in myocardial matrix metalloproteinase activity in a rat model of heart failure
    Sahoko Ichihara
    Department of Cardiovascular Genome Science, Nagoya University School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Cardiovasc Res 69:726-35. 2006
    ..We have now investigated the role of MMPs and their tissue inhibitors (TIMPs) in the transition from compensated left ventricular (LV) hypertrophy to heart failure as well as the effects of pravastatin on this transition in a rat model...
  29. ncbi request reprint Overexpression of calmodulin induces cardiac hypertrophy by a calcineurin-dependent pathway
    Koji Obata
    Department of Cardiovascular Genome Science, Nagoya University School of Medicine, Nagoya, Japan
    Biochem Biophys Res Commun 338:1299-305. 2005
    ..Activation of a calcineurin-dependent pathway thus contributes to the development of cardiac hypertrophy induced by CaM overexpression in the heart...
  30. doi request reprint Identification of chromosome 3q28 and ALPK1 as susceptibility loci for chronic kidney disease in Japanese individuals by a genome-wide association study
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie 514 8507, Japan
    J Med Genet 50:410-8. 2013
    ..We performed a GWAS to identify genetic variants that confer susceptibility to CKD in Japanese individuals...
  31. doi request reprint Association of a polymorphism of BTN2A1 with myocardial infarction in East Asian populations
    Yoshiji Yamada
    Life Science Research Center, Mie University, Tsu, Japan
    Atherosclerosis 215:145-52. 2011
    ..We have performed a genome-wide association study (GWAS) to identify genetic variants that confer susceptibility to myocardial infarction (MI) in Japanese and Korean populations...
  32. ncbi request reprint Proinflammatory gene polymorphisms and ischemic stroke
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, Tsu, Mie, Japan
    Curr Pharm Des 14:3590-600. 2008
    ..Such studies may provide insight into the function of implicated genes as well as into the role of genetic factors in the development of ischemic stroke...
  33. doi request reprint Serial changes in adipocytokines and cardiac function in a rat model of the metabolic syndrome
    Takanori Yamaguchi
    Department of Human Functional Genomics, Life Science Research Center, Tsu, Japan
    Clin Exp Pharmacol Physiol 40:443-8. 2013
    ..Using echocardiography, we demonstrated reduced systolic function in 32-week-old SHR/cp. Changes in myocardial cytokine concentrations could be involved in worsening of cardiac function in our animal model of metabolic syndrome. ..
  34. pmc Molecular genetics of myocardial infarction
    Yoshiji Yamada
    Department of Human Functional Genomics, Life Science Research Center, Mie University, 1577 Kurima machiya, Tsu, Mie, 514 8507, Japan
    Genomic Med 2:7-22. 2008
    ..3 by genome-wide scans. Such studies may provide insight into the function of implicated genes as well as into the role of genetic factors in the development of CHD and MI...
  35. ncbi request reprint AT1 receptor blockade reduces cardiac calcineurin activity in hypertensive rats
    Kohzo Nagata
    Department of Clinical Pathophysiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Hypertension 40:168-74. 2002
    ..Calcineurin may be downstream from TGF-beta1 in AT1 receptor-mediated angiotensin II signaling in vivo...
  36. ncbi request reprint Effect of nicorandil on left ventricular end-diastolic pressure during exercise in patients with hypertrophic cardiomyopathy
    Hideo Izawa
    Department of Cardiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Eur Heart J 24:1340-8. 2003
    ..The effects of nicorandil on left ventricular end-diastolic pressure during exercise were examined in patients with this condition...
  37. pmc Increased expression of plasminogen activator inhibitor-1 in cardiomyocytes contributes to cardiac fibrosis after myocardial infarction
    Kyosuke Takeshita
    Department of Cardiology, Nagoya University Graduate School of Medicine, Showa, Japan
    Am J Pathol 164:449-56. 2004
    ....
  38. doi request reprint Xanthine oxidase inhibition improves left ventricular dysfunction in dilated cardiomyopathic hamsters
    Keiko Hayashi
    Department of Pathophysiology Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Card Fail 14:238-44. 2008
    ..We tested whether xanthine oxidase (XO) inhibition could decrease myocardial oxidative stress and attenuate left ventricular (LV) remodeling and dysfunction in the TO-2 hamster model of dilated cardiomyopathy...
  39. ncbi request reprint Serial alterations of beta-adrenergic signaling in dilated cardiomyopathic hamsters: possible role of myocardial oxidative stress
    Takao Nishizawa
    Department of Cardiovascular Genetics, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Circ J 68:1051-60. 2004
    ..The relationship between enhanced myocardial oxidative stress and impaired beta-adrenergic signaling remains to be characterized during the development of dilated cardiomyopathy...
  40. ncbi request reprint Differential cardiovascular effects of endotoxin derived from Escherichia coli or Pseudomonas aeruginosa
    Aya Matsushita
    Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University, Japan
    Exp Anim 56:339-48. 2007
    ..These differential responses may be attributable in part to the difference in the associated increases in the plasma concentration of TNF-alpha. The cardiovascular effects of LPS thus depend on the causative organisms...
  41. ncbi request reprint Sex differences in the relationships between electrocardiographic abnormalities and the extent of left ventricular hypertrophy by echocardiography
    Hikari Ochi
    Department of Pathophysiological Laboratory Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Ann Noninvasive Electrocardiol 11:222-9. 2006
    ..Furthermore, the diagnostic accuracy of abnormalities in ST-T patterns for LVH is known to be uncertain, especially in women. We examined the relationship between electrocardiographic abnormalities and the extent of LVH...
  42. ncbi request reprint Discrimination of nonobstructive hypertrophic cardiomyopathy from hypertensive left ventricular hypertrophy on the basis of strain rate imaging by tissue Doppler ultrasonography
    Tomoko S Kato
    Department of Clinical Pathophysiology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Circulation 110:3808-14. 2004
    ..We investigated whether strain rate (SR) imaging derived from tissue Doppler imaging (TDI) is able to discriminate HCM from H-LVH...
  43. ncbi request reprint Prognostic value of mechanical efficiency in ambulatory patients with idiopathic dilated cardiomyopathy in sinus rhythm
    Il Sung Kim
    Cardiovascular Division, Department of Clinical Pathophysiology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Am Coll Cardiol 39:1264-8. 2002
    ....
  44. ncbi request reprint Biphasic relaxation-frequency relations in patients with effort angina pectoris: a new marker of myocardial demand ischemia
    Hisashi Umeda
    Department of Organ Regulation and Internal Medicine, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    Am Heart J 146:75-83. 2003
    ..Relaxation-frequency relations (RFR) during demand ischemia have not been fully examined in patients with effort angina pectoris (AP). We sought to clarify the effects of pacing and exercise on RFR in patients with AP...
  45. ncbi request reprint [Point of contact between internal medicine and emergency medicine (discussion)]
    Shingo Hori
    Nihon Naika Gakkai Zasshi 95:2510-30. 2006
  46. ncbi request reprint Myocardial velocity gradient as a noninvasively determined index of left ventricular diastolic dysfunction in patients with hypertrophic cardiomyopathy
    Tomoko Kato
    Cardiovascular Division, Department of Clinical Pathophysiology, Nagoya University, Graduate School of Medicine, Nagoya, Japan
    J Am Coll Cardiol 42:278-85. 2003
    ..We investigated the utility of the peak negative myocardial velocity gradient (MVG) derived from tissue Doppler imaging (TDI) for evaluation of diastolic dysfunction in patients with hypertrophic cardiomyopathy (HCM)...
  47. ncbi request reprint Progressive development of pulmonary hypertension leading to right ventricular hypertrophy assessed by echocardiography in rats
    Yosuke Kato
    School of Health Sciences, Nagoya University, 1 1 20 Daiko Minami, Higashi ku, Nagoya 461 8673, Japan
    Exp Anim 52:285-94. 2003
    ..In conclusion, the progressive development of pulmonary hypertension leading to RV hypertrophy can be evaluated appropriately by echocardiography including PA flow Doppler indices in rats...
  48. ncbi request reprint Growth hormone-releasing peptide can improve left ventricular dysfunction and attenuate dilation in dilated cardiomyopathic hamsters
    Mitsunori Iwase
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 1 20 Daiko Minami, Higashi, Nagoya 461 8673, Japan
    Cardiovasc Res 61:30-8. 2004
    ..We sought to compare the effects of GHRP and GH on progressive left ventricular (LV) dysfunction in the TO-2 hamster model of dilated cardiomyopathy...
  49. ncbi request reprint Effect of centrifuge-induced artificial gravity and ergometric exercise on cardiovascular deconditioning, myatrophy, and osteoporosis induced by a -6 degrees head-down bedrest
    Satoshi Iwase
    Dept Physiol II, Aichi Med Univ, Aichi, Japan
    J Gravit Physiol 11:P243-4. 2004
    ..The combination of high/low G-load with low/high intensity exercise will determine the optimal protocol for prevention of cardiovascular deconditioning, myatrophy, and osteoporosis...
  50. ncbi request reprint Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through activation of mitochondrial ATP-sensitive potassium channels and a nitrate-like effect
    Kohzo Nagata
    Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    J Mol Cell Cardiol 35:1505-12. 2003
    ..Nicorandil inhibits oxidative stress-induced apoptosis in cardiac myocytes through a nitric oxide/cGMP-dependent mechanism as well as by activating mitochondrial K(ATP) channels...
  51. ncbi request reprint A sensitive colorimetric assay for polyamines in erythrocytes using oat seedling polyamine oxidase
    Kenji Takagi
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 1 20 Daikominami, Nagoya 461 8673, Higashi, Japan
    Clin Chim Acta 340:219-27. 2004
    ..The method is based on the unique substrate specificity of OSPO, which is active toward Spd and Spm, but not toward diamines such as Put and cadaverine and monoamines such as histamine...
  52. ncbi request reprint Cardiac 123I-MIBG reflects left ventricular functional reserve in patients with nonobstructive hypertrophic cardiomyopathy
    Satoshi Isobe
    Department of Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya, Aichi 466 8550, Japan
    J Nucl Med 46:909-16. 2005
    ....
  53. ncbi request reprint Endotoxin from various gram-negative bacteria has differential effects on function of hepatic cytochrome P450 and drug transporters
    Jun Ueyama
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 1 20 Daikominami, Higashi ku, Nagoya 461 8673, Japan
    Eur J Pharmacol 510:127-34. 2005
    ..Endotoxin appears to regulate coordinately CYP3A2, CYP2C11 and P-glycoprotein, but not Mrp2...
  54. ncbi request reprint Effect of pioglitazone on endotoxin-induced decreases in hepatic drug-metabolizing enzyme activity and expression of CYP3A2 and CYP2C11
    Jun Ueyama
    Department of Medical Technology, Nagoya University School of Health Sciences, 1 1 20 Daikominami, Higashi ku, Nagoya 461 8673, Japan
    Eur J Pharmacol 498:257-65. 2004
    ....
  55. ncbi request reprint Acceleration with exercise during head-down bed rest preserves upright exercise responses
    Keisho Katayama
    Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya 464 8601, Japan
    Aviat Space Environ Med 75:1029-35. 2004
    ..e., prolonged head-down bed rest (HDBR), on respiratory and cardiovascular responses to upright exercise...
  56. ncbi request reprint Differential myolysis of myocardium and skeletal muscle in hamsters with dilated cardiomyopathy: beneficial protective effect of diltiazem
    Yosuke Kato
    Pathophysiological Laboratory Sciences, Graduate School of Medicine, Nagoya University, Nagoya, Japan
    Circ J 70:1497-502. 2006
    ....