Affiliation: Mie University
Wu W, Ichihara G, Hashimoto N, Hasegawa Y, Hayashi Y, Tada Oikawa S, et al
. Synergistic effect of bolus exposure to zinc oxide nanoparticles on bleomycin-induced secretion of pro-fibrotic cytokines without lasting fibrotic changes in murine lungs. Int J Mol Sci. 2014;16:660-76 pubmed publisher
..The present study demonstrated the synergistic effect of pulmonary exposure to ZnO nanoparticles and subcutaneous infusion of BLM on the secretion of pro-fibrotic cytokines in the lungs. ..
Ichihara S. The pathological roles of environmental and redox stresses in cardiovascular diseases. Environ Health Prev Med. 2013;18:177-84 pubmed publisher
..The roles of these transcription factors, AHR and Nrf2 in angiogenesis are also discussed in this review. ..
Tada Oikawa S, Ichihara G, Fukatsu H, Shimanuki Y, Tanaka N, Watanabe E, et al
. Titanium Dioxide Particle Type and Concentration Influence the Inflammatory Response in Caco-2 Cells. Int J Mol Sci. 2016;17:576 pubmed publisher
..Further studies are required to determine the in vivo relevance of these findings to avoid the hazards of ingested particles. ..
Suzuki Y, Tada Oikawa S, Hayashi Y, Izuoka K, Kataoka M, Ichikawa S, et al
. Single- and double-walled carbon nanotubes enhance atherosclerogenesis by promoting monocyte adhesion to endothelial cells and endothelial progenitor cell dysfunction. Part Fibre Toxicol. 2016;13:54 pubmed
..The results suggested that SWCNTs and DWCNTs enhanced atherosclerogenesis by promoting monocyte adhesion to endothelial cells and inducing EPC dysfunction. ..
Ichihara S, Yamada Y, Ichihara G, Nakajima T, Li P, Kondo T, et al
. A role for the aryl hydrocarbon receptor in regulation of ischemia-induced angiogenesis. Arterioscler Thromb Vasc Biol. 2007;27:1297-304 pubmed
..This effect was likely attributable in part to the associated enhancement of ischemia-induced VEGF expression, which in turn may be caused by an increased abundance and activity of the HIF-1alpha-ARNT heterodimer. ..
Ichihara S, Obata K, Yamada Y, Nagata K, Noda A, Ichihara G, et al
. Attenuation of cardiac dysfunction by a PPAR-alpha agonist is associated with down-regulation of redox-regulated transcription factors. J Mol Cell Cardiol. 2006;41:318-29 pubmed
..These effects were associated with inhibition of the inflammatory response and of activation of redox-regulated transcription factors in the left ventricle...
Ichihara S, Yamada Y, Ichihara G, Kanazawa H, Hashimoto K, Kato Y, et al
. Attenuation of oxidative stress and cardiac dysfunction by bisoprolol in an animal model of dilated cardiomyopathy. Biochem Biophys Res Commun. 2006;350:105-13 pubmed
..Attenuation of the development of cardiac dysfunction by bisoprolol may thus result in part from normalization of the associated increases in the levels of oxidative stress and pro-inflammatory cytokines in the left ventricle...
Ichihara S, Yamada Y, Kawai Y, Osawa T, Furuhashi K, Duan Z, et al
. Roles of oxidative stress and Akt signaling in doxorubicin cardiotoxicity. Biochem Biophys Res Commun. 2007;359:27-33 pubmed
..These results suggest that fenofibrate and PEG-SOD prevented cardiac dysfunction induced by DOX through normalization of oxidative stress and redox-regulated NF-kappaB signaling. ..
Ichihara S, Yamada Y, Kato K, Hibino T, Yokoi K, Matsuo H, et al
. Association of a polymorphism of ABCB1 with obesity in Japanese individuals. Genomics. 2008;91:512-6 pubmed publisher
..Our results suggest that the ABCB1 genotype may prove informative for assessment of genetic risk for obesity in Japanese individuals. ..