Yusuke Hiraku

Summary

Affiliation: Mie University
Country: Japan

Publications

  1. ncbi request reprint Metal-mediated oxidative DNA damage induced by methylene blue
    Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan Electronic address
    Biochim Biophys Acta 1840:2776-82. 2014
  2. doi request reprint The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis
    Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Ann N Y Acad Sci 1203:15-22. 2010
  3. ncbi request reprint Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide
    Hideki Mizutani
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Life Sci 76:1439-53. 2005
  4. ncbi request reprint Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: a model of inflammation-mediated carcinogenesis
    Somchai Pinlaor
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Nitric Oxide 11:175-83. 2004
  5. ncbi request reprint Mechanism of UVA-dependent DNA damage induced by an antitumor drug dacarbazine in relation to its photogenotoxicity
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Tsu, Mie 514 8507, Japan
    Pharm Res 25:598-604. 2008
  6. ncbi request reprint Amplification of C1027-induced DNA cleavage and apoptosis by a quinacrine-netropsin hybrid molecule in tumor cell lines
    Takuya Iwamoto
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Arch Biochem Biophys 434:232-40. 2005
  7. ncbi request reprint Oxidative DNA damage induced by benz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone
    Kazuharu Seike
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Chem Res Toxicol 16:1470-6. 2003
  8. ncbi request reprint Metabolic activation of carcinogenic ethylbenzene leads to oxidative DNA damage
    Kaoru Midorikawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Chem Biol Interact 150:271-81. 2004
  9. pmc Guanine-specific DNA damage induced by gamma-irradiated histone
    Ayako Furukawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Biochem J 388:813-8. 2005
  10. ncbi request reprint Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle
    Katsuhisa Sakano
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 5148507, Japan
    Biochem Pharmacol 68:1869-78. 2004

Collaborators

Detail Information

Publications54

  1. ncbi request reprint Metal-mediated oxidative DNA damage induced by methylene blue
    Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan Electronic address
    Biochim Biophys Acta 1840:2776-82. 2014
    ..This finding raises a possibility that MB induces carcinogenicity in these organs via light-independent mechanisms, although MB is known to cause light-dependent DNA damage...
  2. doi request reprint The role of iNOS-mediated DNA damage in infection- and asbestos-induced carcinogenesis
    Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Ann N Y Acad Sci 1203:15-22. 2010
    ..On the basis of these findings, we have proposed that 8-nitroguanine could be a potential biomarker to evaluate the risk of inflammation-related carcinogenesis...
  3. ncbi request reprint Mechanism of apoptosis induced by doxorubicin through the generation of hydrogen peroxide
    Hideki Mizutani
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Life Sci 76:1439-53. 2005
    ..This oxidative DNA damage causes indirect H(2)O(2) generation through PARP and NAD(P)H oxidase activation, leading to the Delta Psi m increase and subsequent caspase-3 activation in DOX-induced apoptosis...
  4. ncbi request reprint Mechanism of NO-mediated oxidative and nitrative DNA damage in hamsters infected with Opisthorchis viverrini: a model of inflammation-mediated carcinogenesis
    Somchai Pinlaor
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Nitric Oxide 11:175-83. 2004
    ..In conclusion, nitrative and oxidative DNA damage via iNOS expression in hamsters infected with OV may participate in CHCA carcinogenesis...
  5. ncbi request reprint Mechanism of UVA-dependent DNA damage induced by an antitumor drug dacarbazine in relation to its photogenotoxicity
    Takuya Iwamoto
    Department of Pharmacy, Mie University Hospital, Tsu, Mie 514 8507, Japan
    Pharm Res 25:598-604. 2008
    ..It has been reported that dacarbazine (DTIC) is photogenotoxic. The purpose of this study is to clarify the mechanism of photogenotoxicity induced by DTIC...
  6. ncbi request reprint Amplification of C1027-induced DNA cleavage and apoptosis by a quinacrine-netropsin hybrid molecule in tumor cell lines
    Takuya Iwamoto
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Arch Biochem Biophys 434:232-40. 2005
    ..These results suggest that QN enhances C1027-induced antitumor effect via DNA cleavage and apoptosis. The present study shows a novel approach to the potentially effective anticancer therapy...
  7. ncbi request reprint Oxidative DNA damage induced by benz[a]anthracene metabolites via redox cycles of quinone and unique non-quinone
    Kazuharu Seike
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Chem Res Toxicol 16:1470-6. 2003
    ..In conclusion, oxidative DNA damage induced by BA-3,4-dihydrodiol not only via quinone-type redox cycle but also via a new type of redox cycle participates in the expression of carcinogenicity of BA and BA-3,4-dihydrodiol...
  8. ncbi request reprint Metabolic activation of carcinogenic ethylbenzene leads to oxidative DNA damage
    Kaoru Midorikawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Chem Biol Interact 150:271-81. 2004
    ..In conclusion, these active dihydroxylated metabolites would be involved in the mechanism of carcinogenesis by ethylbenzene...
  9. pmc Guanine-specific DNA damage induced by gamma-irradiated histone
    Ayako Furukawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Biochem J 388:813-8. 2005
    ..It is concluded that histone protein-hydroperoxides can induce guanine-specific DNA damage, which may contribute to gamma-irradiation-induced carcinogenesis...
  10. ncbi request reprint Oxidative DNA damage induced by a melatonin metabolite, 6-hydroxymelatonin, via a unique non-o-quinone type of redox cycle
    Katsuhisa Sakano
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 5148507, Japan
    Biochem Pharmacol 68:1869-78. 2004
    ..Therefore, it is concluded that melatonin may exhibit carcinogenic potential through oxidative DNA damage by its metabolite...
  11. ncbi request reprint Procyanidin B2 has anti- and pro-oxidant effects on metal-mediated DNA damage
    Katsuhisa Sakano
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Free Radic Biol Med 39:1041-9. 2005
    ..Our results raise the possibility that procyanidin B2 exerts both antioxidant and pro-oxidant properties by interacting with H2O2 and metal ions...
  12. ncbi request reprint Photosensitized DNA damage induced by NADH: site specificity and mechanism
    Kimiko Ito
    Department of Life Science, Tsu City College, Tsu, Mie 514 0112, Japan
    Free Radic Res 41:461-8. 2007
    ..These results imply that NADH may participate as an endogenous photosensitizer in UVA carcinogenesis via H(2)O(2) generation, producing metal-mediated mutagenic lesions such as 8-oxodG...
  13. ncbi request reprint Oxidative and nitrative DNA damage in animals and patients with inflammatory diseases in relation to inflammation-related carcinogenesis
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Biol Chem 387:365-72. 2006
    ..On the basis of our results, we propose that 8-nitroguanine is a promising biomarker to evaluate the potential risk of inflammation-mediated carcinogenesis...
  14. ncbi request reprint 8-Nitroguanine as a potential biomarker for progression of malignant fibrous histiocytoma, a model of inflammation-related cancer
    Yoko Hoki
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Oncol Rep 18:1165-9. 2007
    ..In conclusion, 8-nitroguanine is an excellent candidate prognostic and predictive biomarker together with HIF-1alpha in inflammation-related tumor progression...
  15. ncbi request reprint Photosensitized DNA damage and its protection via a novel mechanism
    Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Photochem Photobiol 83:205-12. 2007
    ..It is thus considered that naturally occurring quenchers including xanthone derivatives may act as novel chemopreventive agents against photocarcinogenesis...
  16. ncbi request reprint Oxidative and nitrative DNA damage as biomarker for carcinogenesis with special reference to inflammation
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie, Japan
    Antioxid Redox Signal 8:1047-58. 2006
    ..Interestingly, 8-nitroguanine was formed at the sites of carcinogenesis regardless of etiology. Therefore, 8-nitroguanine could be used as a potential biomarker to evaluate the risk of inflammation- related carcinogenesis...
  17. doi request reprint The mechanisms of oxidative DNA damage and apoptosis induced by norsalsolinol, an endogenous tetrahydroisoquinoline derivative associated with Parkinson's disease
    Hatasu Kobayashi
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Edobashi 2 174, Tsu, Mie, Japan
    J Neurochem 108:397-407. 2009
    ..In summary, NorSAL-generated ROS induced oxidative DNA damage, which led to caspase-dependent apoptosis in neuronal cells...
  18. ncbi request reprint Mechanism of metal-mediated DNA damage induced by a metabolite of carcinogenic acetamide
    Katsuhisa Sakano
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Edobashi, Tsu, Japan
    Chem Biol Interact 149:52-9. 2004
    ..These results suggest that metal-mediated DNA damage mediated by amidase-catalyzed hydroxylamine generation plays an important role in the carcinogenicity of acetamide...
  19. ncbi request reprint Copper-mediated oxidative DNA damage induced by eugenol: possible involvement of O-demethylation
    Katsuhisa Sakano
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Mutat Res 565:35-44. 2004
    ..Therefore, it is concluded that eugenol may express carcinogenicity through oxidative DNA damage by its metabolite...
  20. ncbi request reprint Accumulation of 8-nitroguanine in human gastric epithelium induced by Helicobacter pylori infection
    Ning Ma
    Department of Anatomy, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Biochem Biophys Res Commun 319:506-10. 2004
    ..pylori infection may lead to gastric carcinoma. 8-Nitroguanine could be not only a promising biomarker for inflammation but also a useful indicator of the risk of gastric cancer development in response to chronic H. pylori infection...
  21. ncbi request reprint Distinct mechanisms of site-specific oxidative DNA damage by doxorubicin in the presence of copper(II) and NADPH-cytochrome P450 reductase
    Hideki Mizutani
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Edobashi, Tsu, Mie 514 8507, Japan
    Cancer Sci 94:686-91. 2003
    ..OH. We conclude that DOX may induce carcinostatic and genotoxic effects through oxidation of its p-hydroquinone moiety by metal ion rather than through p-quinone reduction by cytochrome P450 reductase...
  22. ncbi request reprint Oxidative DNA damage by hyperglycemia-related aldehydes and its marked enhancement by hydrogen peroxide
    Mariko Murata
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174, Edobashi, Tsu, Mie 514 8507, Japan
    FEBS Lett 554:138-42. 2003
    ..We conclude that oxidative DNA damage by hyperglycemia-related aldehydes, especially GA, and marked enhancement of DNA damage by H2O2 may participate in diabetes-associated carcinogenesis...
  23. ncbi request reprint (-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA
    Ayako Furukawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Mie 514 8507, Japan
    Biochem Pharmacol 66:1769-78. 2003
    ..It is concluded that EGCG can induce H(2)O(2) generation and subsequent damage to isolated and cellular DNA, and that oxidative DNA damage may mediate the potential carcinogenicity of EGCG...
  24. ncbi request reprint Mechanism of carcinogenesis induced by a veterinary antimicrobial drug, nitrofurazone, via oxidative DNA damage and cell proliferation
    Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Cancer Lett 215:141-50. 2004
    ..These findings suggest that nitrofurazone metabolites are involved in tumor initiation through oxidative DNA damage and nitrofurazone itself enhances cell proliferation, leading to promotion and/or progression in carcinogenesis...
  25. ncbi request reprint Accumulation of 8-nitroguanine in the liver of patients with chronic hepatitis C
    Shinichiro Horiike
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    J Hepatol 43:403-10. 2005
    ....
  26. ncbi request reprint Molecular mechanisms of DNA damage induced by procarbazine in the presence of Cu(II)
    Kazuhiko Ogawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Mutat Res 539:145-55. 2003
    ..In conclusion, in addition to alkylation, oxidative DNA damage may play important roles in not only antitumor effects but also mutagenesis and carcinogenesis induced by procarbazine...
  27. ncbi request reprint Oxidative DNA damage induced by photodegradation products of 3(')-azido-3(')-deoxythymidine
    Takuya Iwamoto
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Arch Biochem Biophys 416:155-63. 2003
    ..The basic compound, hydroxylamine, showed similar site specificity. The hydroxylamine derivative produced by photodegradation and/or possible metabolism of AZT induces oxidative DNA damage, which may participate in carcinogenesis...
  28. ncbi request reprint 8-Nitroguanine formation in oral leukoplakia, a premalignant lesion
    Ning Ma
    Department of Anatomy, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Nitric Oxide 14:137-43. 2006
    ..These results suggest that iNOS-mediated nitrative stress contributes to development of oral carcinogenesis from leukoplakia through DNA damage as well as oxidative stress...
  29. doi request reprint Reactive nitrogen species-dependent DNA damage in EBV-associated nasopharyngeal carcinoma: the relation to STAT3 activation and EGFR expression
    Ning Ma
    Department of Anatomy, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Int J Cancer 122:2517-25. 2008
    ..These data suggest that nuclear accumulation of EGFR and STAT3 activation by IL-6 play the key role in iNOS expression and resultant DNA damage, leading to EBV-mediated NPC...
  30. doi request reprint Inflammation-related DNA damage and expression of CD133 and Oct3/4 in cholangiocarcinoma patients with poor prognosis
    Raynoo Thanan
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan Department of Biochemistry, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie, 513 8670, Japan
    Free Radic Biol Med 65:1464-72. 2013
    ....
  31. doi request reprint Nitrative DNA damage induced by multi-walled carbon nanotube via endocytosis in human lung epithelial cells
    Feiye Guo
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Toxicol Appl Pharmacol 260:183-92. 2012
    ....
  32. doi request reprint Inflammation-induced protein carbonylation contributes to poor prognosis for cholangiocarcinoma
    Raynoo Thanan
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Free Radic Biol Med 52:1465-72. 2012
    ..1 with antioxidative property and A1AT with protease inhibitory capacity may cause them to become dysfunctional, leading to CCA progression...
  33. ncbi request reprint Inducible nitric oxide synthase-dependent DNA damage in mouse model of inflammatory bowel disease
    Xiaohui Ding
    Department of Anatomy, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Cancer Sci 96:157-63. 2005
    ..These results indicate that nitrative DNA damage, as well as oxidative DNA damage, is induced in colon epithelial cells of the IBD mouse model followed by proliferation of these cells, which may contribute to colon carcinogenesis...
  34. doi request reprint Immunohistochemical analysis of 8-nitroguanine, a nitrative DNA lesion, in relation to inflammation-associated carcinogenesis
    Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie, Japan
    Methods Mol Biol 512:3-13. 2009
    ..In this paper, we describe the procedures of these experiments and the application to clinical specimens and animal tissues...
  35. ncbi request reprint iNOS-dependent DNA damage in patients with malignant fibrous histiocytoma in relation to prognosis
    Yoko Hoki
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514 8507, Japan
    Cancer Sci 98:163-8. 2007
    ..In conclusion, 8-nitroguanine appears to participate in not only the initiation and promotion of MFH, but also in the progression of MFH, and could therefore be used as a promising biomarker to evaluate the prognosis of cancer patients...
  36. ncbi request reprint DNA intrastrand cross-link at the 5'-GA-3' sequence formed by busulfan and its role in the cytotoxic effect
    Takuya Iwamoto
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Cancer Sci 95:454-8. 2004
    ..The mechanism and the role of cross-linking at the 5'-GA-3' sequence are discussed in relation to the cytotoxicity induced by busulfan...
  37. ncbi request reprint Photohydrolysis of methotrexate produces pteridine, which induces poly-G-specific DNA damage through photoinduced electron transfer
    Kazutaka Hirakawa
    Radioisotope Center, Mie University School of Medicine, Edobashi, Tsu, Mie, Japan
    Photochem Photobiol 76:467-72. 2002
    ....
  38. ncbi request reprint Metabolism of carcinogenic urethane to nitric oxide is involved in oxidative DNA damage
    Katsuhisa Sakano
    Department of Hygiene, Mie University School of Medicine, Mie, Japan
    Free Radic Biol Med 33:703-14. 2002
    ..It is concluded that urethane may induce carcinogenesis through oxidation and, to a lesser extent, depurination of DNA by its metabolites...
  39. ncbi request reprint Mechanism for generation of hydrogen peroxide and change of mitochondrial membrane potential during rotenone-induced apoptosis
    Saeko Tada-Oikawa
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu Shi, Mie, 514 8507, Japan
    Life Sci 73:3277-88. 2003
    ....
  40. pmc Relationships of alpha-SMA-positive fibroblasts and SDF-1-positive tumor cells with neoangiogenesis in nasopharyngeal carcinoma
    Shumin Wang
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan Department of Otolaryngology Head and Neck Surgery, First Affiliated Hospital of Guangxi Medical University, No 22 Shuangyong Road, Nanning 530027, China
    Biomed Res Int 2014:507353. 2014
    ..Our data suggest that CAFs and NPC tumor cells may enhance neoangiogenesis in a VEGF- and SDF-1-dependent manner by recruiting EPCs from the bone marrow into tumor stroma...
  41. doi request reprint Promoter hypermethylation of Ras-related GTPase gene RRAD inactivates a tumor suppressor function in nasopharyngeal carcinoma
    Yingxi Mo
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Japan
    Cancer Lett 323:147-54. 2012
    ..These results indicate that RRAD might act as a functional tumor suppressor and its epigenetic inactivation may play an important role in NPC development...
  42. ncbi request reprint The role of metals in site-specific DNA damage with reference to carcinogenesis
    Shosuke Kawanishi
    Department of Hygiene, Mie University School of Medicine, Edobashi, Tsu, Japan
    Free Radic Biol Med 32:822-32. 2002
    ..Metabolites of certain carcinogens efficiently caused oxidative DNA damage by forming NADH-dependent redox cycles. These findings suggest that metal-mediated oxidative DNA damage plays important roles in chemical carcinogenesis...
  43. doi request reprint Nitrative DNA damage and Oct3/4 expression in urinary bladder cancer with Schistosoma haematobium infection
    Ning Ma
    Faculty of Health Science, Suzuka University of Medical Science, Suzuka, Mie, Japan
    Biochem Biophys Res Commun 414:344-9. 2011
    ..In conclusion, inflammation by S.haematobium infection may increase the number of mutant stem cells, in which iNOS-dependent DNA damage occurs via NF-κB activation, leading to tumor development...
  44. doi request reprint Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett's esophagus by increasing Mn-SOD expression
    Raynoo Thanan
    Faculty of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Mie 513 8670, Japan
    Biochem Biophys Res Commun 421:280-5. 2012
    ..These DNA lesions can be useful biomarkers to predict both the risk of BEA and the efficacy of PPIs treatment to prevent BEA in BE patients...
  45. doi request reprint Proteomic identification of carbonylated proteins in the monkey hippocampus after ischemia-reperfusion
    Shinji Oikawa
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie 514 8507, Japan
    Free Radic Biol Med 46:1472-7. 2009
    ..Therefore, ischemia-reperfusion-induced oxidative damage to these proteins in the CA1 may lead to loss of the neuroprotective function, which contributes to neuronal death...
  46. ncbi request reprint Amplification of anticancer drug-induced DNA damage and apoptosis by DNA-binding compounds
    Shosuke Kawanishi
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Curr Med Chem Anticancer Agents 4:415-9. 2004
    ..The study on amplifiers of anticancer agents shows a novel approach to the potentially effective anticancer therapy...
  47. ncbi request reprint Repeated infection with Opisthorchis viverrini induces accumulation of 8-nitroguanine and 8-oxo-7,8-dihydro-2'-deoxyguanine in the bile duct of hamsters via inducible nitric oxide synthase
    Somchai Pinlaor
    Department of Environmental and Molecular Medicine and Department of Anatomy, Mie University School of Medicine, 2 174 Edobashi, Tsu, Mie 514 8507, Japan
    Carcinogenesis 25:1535-42. 2004
    ....
  48. ncbi request reprint Nitrative and oxidative DNA damage in cervical intraepithelial neoplasia associated with human papilloma virus infection
    Yusuke Hiraku
    Department of Environmental and Molecular Medicine, Mie University Graduate School of Medicine, Mie, Japan
    Cancer Sci 98:964-72. 2007
    ..Thus, 8-nitroguanine is a more suitable and promising biomarker for evaluating the risk of inflammation-mediated cervical carcinogenesis than p16...
  49. ncbi request reprint Site-specific hydroxylation at polyguanosine in double-stranded DNA by nickel(II) in the presence of SH compounds: comparison with singlet oxygen-induced DNA damage
    Shinji Oikawa
    Department of Hygiene, Mie University School of Medicine, Tsu, Mie 514 8507, Japan
    Chem Res Toxicol 15:1017-22. 2002
    ..Endogenous SH compounds, which have similar chemical structures to DTT, would participate in nickel carcinogenesis through causing oxidative DNA damage...
  50. pmc DNA damage and estrogenic activity induced by the environmental pollutant 2-nitrotoluene and its metabolite
    Chigusa Watanabe
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Tsu, Mie, 514 8507, Japan
    Environ Health Prev Med 15:319-26. 2010
    ..The environmental pollutant 2-nitrotoluene (2-NO(2)-T) is carcinogenic and reproductively toxic in animals. In this study, we elucidated the mechanisms of its carcinogenicity and reproductive toxicity...
  51. ncbi request reprint Mechanism of apoptosis induced by a new topoisomerase inhibitor through the generation of hydrogen peroxide
    Hideki Mizutani
    Department of Environmental and Molecular Medicine, Mie University School of Medicine, Edobashi, Tsu, Mie 514 8507, Japan
    J Biol Chem 277:30684-9. 2002
    ..This enzyme mediates O(2)(-)-derived H(2)O(2) generation, followed by the increase in DeltaPsim and subsequent caspase-3 activation, leading to apoptosis...
  52. ncbi request reprint Vacuolar H+-ATPase inhibitor induces apoptosis via lysosomal dysfunction in the human gastric cancer cell line MKN-1
    Shigehito Nakashima
    Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Mie, 514 8507
    J Biochem 134:359-64. 2003
    ..The present study showed that flow cytometric analysis of lysosomal pH can be useful to evaluate lysosomal protease-mediated apoptosis...
  53. ncbi request reprint Determination of intracellular glutathione and thiols by high performance liquid chromatography with a gold electrode at the femtomole level: comparison with a spectroscopic assay
    Yusuke Hiraku
    Department of Hygiene, Mie University, School of Medicine, Tsu, 514 8507, Mie, Japan
    Biochim Biophys Acta 1570:47-52. 2002
    ..On the basis of these results, the advantage of this electrochemical method is extremely sensitive and specific to detect femtomole levels of GSH and other various thiols...
  54. ncbi request reprint Catechol and hydroquinone have different redox properties responsible for their differential DNA-damaging ability
    Kazutaka Hirakawa
    Radioisotope Center, and Department of Hygiene, Mie University School of Medicine, Edobashi 2 174, Tsu, Mie 514 8507, Japan
    Chem Res Toxicol 15:76-82. 2002
    ..These results suggest that the differences in NADH-mediated redox properties of catechol and hydroquinone contribute to their different carcinogenicities...