Esteban C Gabazza


Affiliation: Mie University
Country: Japan


  1. Baffour Tonto P, Yasuma T, Kobayashi T, D Alessandro Gabazza C, Toda M, Saiki H, et al. Protein S is Protective in Acute Lung Injury by Inhibiting Cell Apoptosis. Int J Mol Sci. 2019;20: pubmed publisher
    ..The results of this study suggest that human protein S is protective in lipopolysaccharide-induced acute lung injury by inhibiting apoptosis of lung cells. ..
  2. Yasuma T, Kobayashi T, D Alessandro Gabazza C, Fujimoto H, Ito K, Nishii Y, et al. Renal Injury during Long-Term Crizotinib Therapy. Int J Mol Sci. 2018;19: pubmed publisher
    ..In conclusion, this study shows the renal detrimental effects of crizotinib, suggesting the need of careful monitoring of renal function during crizotinib therapy. ..
  3. Roeen Z, Toda M, D Alessandro Gabazza C, Onishi M, Kobayashi T, Yasuma T, et al. Thrombomodulin inhibits the activation of eosinophils and mast cells. Cell Immunol. 2015;293:34-40 pubmed publisher
    ..The results of this study suggest that thrombomodulin may modulate allergic responses by inhibiting the activation of both eosinophils and mast cells. ..
  4. Wu W, Ichihara G, Hashimoto N, Hasegawa Y, Hayashi Y, Tada Oikawa S, et al. Synergistic effect of bolus exposure to zinc oxide nanoparticles on bleomycin-induced secretion of pro-fibrotic cytokines without lasting fibrotic changes in murine lungs. Int J Mol Sci. 2014;16:660-76 pubmed publisher
    ..The present study demonstrated the synergistic effect of pulmonary exposure to ZnO nanoparticles and subcutaneous infusion of BLM on the secretion of pro-fibrotic cytokines in the lungs. ..
  5. Nishihama K, Yasuma T, Yano Y, D Alessandro Gabazza C, Toda M, Hinneh J, et al. Anti-apoptotic activity of human matrix metalloproteinase-2 attenuates diabetes mellitus. Metabolism. 2018;82:88-99 pubmed publisher
    ..Overall, this study demonstrates that increased expression of hMMP2 may attenuate the severity of diabetes by protecting islet β-cells from apoptosis through an integrin-mediated activation of the Akt/BAD pathway. ..
  6. Onishi M, Kobayashi T, D Alessandro Gabazza C, Fujimoto H, Chelakkot Govindalayathil A, Takahashi Y, et al. Mice overexpressing latent matrix metalloproteinase-2 develop lung emphysema after short-term exposure to cigarette smoke extract. Biochem Biophys Res Commun. 2018;497:332-338 pubmed publisher
    ..This novel mouse model will be a very useful tool for evaluating the mechanistic pathways and for development of novel therapies in cigarette smoke-associated lung emphysema. ..
  7. Totoki T, D Alessandro Gabazza C, Toda M, Tonto P, Takeshita A, Yasuma T, et al. Protein S Exacerbates Chronic Liver Injury and Fibrosis. Am J Pathol. 2018;188:1195-1203 pubmed publisher
    ..Human protein S inhibited apoptosis and increased Akt pathway activation in hepatic stellate cells. The antiapoptotic activity of protein S may play a role in chronic liver injury and subsequent liver fibrosis. ..
  8. Yasuma T, Yano Y, D Alessandro Gabazza C, Toda M, Gil Bernabe P, Kobayashi T, et al. Amelioration of Diabetes by Protein S. Diabetes. 2016;65:1940-51 pubmed publisher
    ..This study shows that protein S attenuates diabetes by inhibiting apoptosis of ?-cells and the development of diabetic nephropathy. ..
  9. D Alessandro Gabazza C, Kobayashi T, Boveda Ruiz D, Takagi T, Toda M, Gil Bernabe P, et al. Development and preclinical efficacy of novel transforming growth factor-?1 short interfering RNAs for pulmonary fibrosis. Am J Respir Cell Mol Biol. 2012;46:397-406 pubmed publisher
    ..Mice showed no off-target effects after intratracheal administration of siRNA. These results suggest the applicability of these novel siRNAs as tools for treating pulmonary fibrosis in humans. ..

More Information


  1. Ito K, Hataji O, Kobayashi H, Fujiwara A, Yoshida M, D Alessandro Gabazza C, et al. Sequential Therapy with Crizotinib and Alectinib in ALK-Rearranged Non-Small Cell Lung Cancer-A Multicenter Retrospective Study. J Thorac Oncol. 2017;12:390-396 pubmed publisher
    ..However, large-scale prospective studies are needed to confirm these observations. ..
  2. Kainuma K, Kobayashi T, D Alessandro Gabazza C, Toda M, Yasuma T, Nishihama K, et al. β2 adrenergic agonist suppresses eosinophil-induced epithelial-to-mesenchymal transition of bronchial epithelial cells. Respir Res. 2017;18:79 pubmed publisher
    ..Overall, these observations support the beneficial effect of procaterol on airway remodeling frequently associated with chronic obstructive pulmonary diseases. ..
  3. Fujiwara K, Kobayashi T, Fujimoto H, Nakahara H, D Alessandro Gabazza C, Hinneh J, et al. Inhibition of Cell Apoptosis and Amelioration of Pulmonary Fibrosis by Thrombomodulin. Am J Pathol. 2017;187:2312-2322 pubmed publisher