Research Topics
Species | T MamiyaSummaryAffiliation: Meijo University Country: Japan Publications
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Publications
Memory impairment induced by chronic intracerebroventricular infusion of beta-amyloid (1-40) involves downregulation of protein kinase CAna Olariu
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, Japan
Brain Res 957:278-86. 2002..Our data indicate that chronic accumulation of beta-amyloid (1-40) into the rat brain reduced activation of PKC, effect that would substantially contribute to the memory deficit found in these animals...
Effects of anticholinergic drugs selective for muscarinic receptor subtypes on prepulse inhibition in miceMakoto Ukai
Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya 468 8503, Japan
Eur J Pharmacol 492:183-7. 2004..c.v.) but not 4-DAMP (10 and 30 microg/mouse, i.c.v.) produced a significant increase in startle amplitude. These results suggest that the blockade of muscarinic M(3) and M(4) receptors leads to the disruption of prepulse inhibition...
Effects of pre-germinated brown rice on depression-like behavior in miceTakayoshi Mamiya
Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku ku, Nagoya 468 8503, Japan
Pharmacol Biochem Behav 86:62-7. 2007..These results suggest that the increase of 5-HT levels in the mouse frontal cortex contributes to the antidepressant-like effects of PGBR pellets...
Effects of soybean food pellets on m-CPP-induced anxiety model of miceTakayoshi Mamiya
Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan
Biol Pharm Bull 29:1498-500. 2006..On the other hand, we could not observe the m-CPP-induced anxiety-like behavior in mice fed soybean pellets in this test. These results suggest that soybean pellets may attenuate anxiety-like behavior in mice...
Intake of fermented soybean (natto) increased locomotor activity in miceTakayoshi Mamiya
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University Japan
Biol Pharm Bull 30:845-6. 2007..The results suggest that the enhanced locomotor activity induced by continuous intake of natto granules in mice is sensitive to haloperidol...
Ferulic acid attenuated cognitive deficits and increase in carbonyl proteins induced by buthionine-sulfoximine in miceTakayoshi Mamiya
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, 150 Yagotoyama, Tempaku ku, Nagoya 468 8503, Japan
Neurosci Lett 430:115-8. 2008..These findings suggest that pretreatment with FA may attenuate the memory deficits and increase the carbonyl protein levels induced by BSO in mice...
[Gly(14)]-Humanin improved the learning and memory impairment induced by scopolamine in vivoT Mamiya
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University, 150, Yagotoyama, Tempaku ku, Nagoya 468 8503, Japan
Br J Pharmacol 134:1597-9. 2001..These results suggest that (I) [Gly(14)]-humanin is a beneficial drug for the impairment of learning and memory and (II) it modulates the learning and memory function mediated via cholinergic systems in mice...
Morphine tolerance and dependence in the nociceptin receptor knockout miceT Mamiya
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
J Neural Transm 108:1349-61. 2001..Furthermore, it is demonstrated that morphine withdrawal syndrome excepting jumping can be induced by naloxone benzoylhydrazone without any changes in the cyclic AMP levels in the thalamus...
Silibinin attenuates amyloid beta(25-35) peptide-induced memory impairments: implication of inducible nitric-oxide synthase and tumor necrosis factor-alpha in miceP Lu
Department of Chemical Pharmacology, Meijo University, Nagoya, Japan
J Pharmacol Exp Ther 331:319-26. 2009..These findings suggest that silibinin (i) attenuates memory impairment through amelioration of oxidative stress and inflammatory response induced by Abeta(25-35) and (ii) may be a potential candidate for an AD medication...
Effects of sigma receptor agonists on the impairment of spontaneous alternation behavior and decrease of cyclic GMP level induced by nitric oxide synthase inhibitors in miceT Mamiya
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, 466 8560, Nagoya, Japan
Neuropharmacology 39:2391-8. 2000..Further, the ameliorating effects of (+) SKF 10,047 on the impairment of spontaneous alternation behavior may be mediated through activation of guanylate cyclase, but not nitric oxide synthase in the hippocampus of mice...
Silibinin prevents amyloid beta peptide-induced memory impairment and oxidative stress in miceP Lu
Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, 150 Yagotoyama, Tempaku ku, Nagoya, Japan
Br J Pharmacol 157:1270-7. 2009..In the present study, we examined the effect of silibinin on the memory impairment and accumulation of oxidative stress induced by Abeta(25-35) in mice...
Endomorphin-1 improves scopolamine-induced impairment of short-term memory via mu1-opioid receptor in miceM Ukai
Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya 468-8503, Japan
Neuroreport 12:3723-7. 2001..These results suggest that endomorphin-1 improves the disturbance of short-term memory resulting from cholinergic dysfunction through the mediation of mu1-opioid receptors...
Phencyclidine impairs latent learning in mice: interaction between glutamatergic systems and sigma(1) receptorsA Noda
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
Neuropsychopharmacology 24:451-60. 2001..These results suggest that PCP induces an impairment of latent learning, this effect being mediated via glutamatergic systems, and that activation of sigma(1) receptors ameliorates impairment of latent learning induced by PCP...
The long-lasting effects of cross-fostering on the emotional behavior in ICR miceLingling Lu
Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, Japan
Behav Brain Res 198:172-8. 2009..These findings suggested that the early-life stress of cross-fostering induced long-lasting emotional abnormalities, which might be possibly related to alterations of serotonin metabolisms...
Effects of U-50,488H, a kappa-opioid receptor agonist, on the learned helplessness model of depression in miceM Ukai
Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Japan
J Neural Transm 109:1221-5. 2002..This attenuation by U-50,488H was blocked by MR2266 (10 mg/kg/day, s.c.), an opioid receptor antagonist. These results suggest that the kappa-opioid system plays an important role in the learned helplessness depression in mice...
Neuronal mechanism of nociceptin-induced modulation of learning and memory: involvement of N-methyl-D-aspartate receptorsT Mamiya
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
Mol Psychiatry 8:752-65. 2003..These results suggest that nociceptin system negatively modulates learning and memory through the regulation of NMDA receptor function and the expression of N-CAM...
Silibinin attenuates cognitive deficits and decreases of dopamine and serotonin induced by repeated methamphetamine treatmentPing Lu
Department of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, Meijo University, Nagoya 468 8503, Japan
Behav Brain Res 207:387-93. 2010..These results suggest that silibinin may be useful as a pharmacological tool to investigate the mechanisms of METH-induced cognitive impairments...
Effects of L-745,870, a dopamine D4 receptor antagonist, on naloxone-induced morphine dependence in miceT Mamiya
Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya, 468-8503, Japan
Ann N Y Acad Sci 1025:424-9. 2004..Furthermore, dopamine D4 receptor antagonists may be useful drugs for attenuating the expression of morphine dependence...
Effects of pre-germinated brown rice on beta-amyloid protein-induced learning and memory deficits in miceTakayoshi Mamiya
Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, Nagoya, Japan
Biol Pharm Bull 27:1041-5. 2004..These results suggest that polished rice and PGR have facilitating effects on spatial learning. In particular, it is surmised that PGR may prevent Alzheimer's disease associated with Abeta...
Molecular mechanisms in dizocilpine-induced attenuation of development of morphine dependence: an association with cortical Ca2+/calmodulin-dependent signal cascadeMoustafa Mahmoud Hamdy
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
Behav Brain Res 152:263-70. 2004....
The role of nociceptin in cognitionT Nabeshima
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
Brain Res 848:167-73. 1999..In addition, the antagonists for the nociceptin receptor may be worth testing for alleviating memory disorders...
[Behavioral characterization of mouse strains in learning and memory tests]Tsutomu Kameyama
Department of Chemical Pharmacology, Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku-ku, Nagoya 468-8503, Japan
Nihon Shinkei Seishin Yakurigaku Zasshi 25:153-7. 2005..We have to pay attention to the mouse strain to analyze the behavioral changes when we use different strains of mice...
[Possible effects of ingredients in foods on brain function]Takayoshi Mamiya
Nippon Yakurigaku Zasshi 131:244-7. 2008
Irradiation in adulthood as a new model of schizophreniaYasuhide Iwata
Department of Psychiatry and Neurology, Hamamatsu University School of Medicine, Shizuoka, Japan
PLoS ONE 3:e2283. 2008..Epidemiological studies suggest that radiation exposure may be a potential risk factor for schizophrenia in adult humans. Here, we investigated whether adult irradiation in rats caused behavioral abnormalities relevant to schizophrenia...
A neuroactive steroid, dehydroepiandrosterone sulfate, prevents the development of morphine dependence and tolerance via c-fos expression linked to the extracellular signal-regulated protein kinaseXiuhai Ren
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65, Tsuruma-cho, Showa-ku, Nagoya 466-8560, Japan
Behav Brain Res 152:243-50. 2004....
Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicityAkira Nakajima
Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
J Neurosci 24:2212-25. 2004....
