Affiliation: Meiji Seika Kaisha
Yamada M, Watanabe T, Baba N, Takeuchi Y, Ohsawa F, Gomi S. Crystal structures of biapenem and tebipenem complexed with penicillin-binding proteins 2X and 1A from Streptococcus pneumoniae. Antimicrob Agents Chemother. 2008;52:2053-60 pubmed publisher
..These results suggest that interactions between the C-2 side chains of carbapenems and the conserved Trp and Thr residues in PBPs play important roles in the binding of carbapenems to PBPs. ..
Yamada M, Watanabe T, Miyara T, Baba N, Saito J, Takeuchi Y, et al
. Crystal structure of cefditoren complexed with Streptococcus pneumoniae penicillin-binding protein 2X: structural basis for its high antimicrobial activity. Antimicrob Agents Chemother. 2007;51:3902-7 pubmed
..These features likely play a role in the high level of activity of cefditoren against S. pneumoniae. ..
Yamada M, Watanabe T, Baba N, Miyara T, Saito J, Takeuchi Y. Crystallization and preliminary crystallographic analysis of the transpeptidase domain of penicillin-binding protein 2B from Streptococcus pneumoniae. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2008;64:284-8 pubmed publisher
..39, c = 143.27 A. Diffraction data were collected to 2.4 A resolution using the BL32B2 beamline at SPring-8. The asymmetric unit contains one protein molecule and 63.7% solvent. ..