- Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigsKazuhiro Umeyama
BIOS Research Laboratory Inc, Hiratsuka, Kanagawa 254 0031, Japan
Transgenic Res 18:697-706. 2009..Histochemical analysis of pancreas tissue from the cloned pigs showed small and irregularly formed Langerhans Islets, in which poor insulin secretion was detected...
- The production of a diabetic mouse using constructs encoding porcine insulin promoter-driven mutant human hepatocyte nuclear factor-1alphaMasahito Watanabe
BIOS Research Laboratory Inc, Hiratsuka, Japan
J Reprod Dev 53:189-200. 2007..These results indicate that HNF1alphaP291 expression driven by the porcine insulin promoter, together with the cytomegalovirus enhancer, induces a diabetic phenotype in transgenic mice...