Kazuhiro Umeyama

Summary

Affiliation: Meiji University
Country: Japan

Publications

  1. doi request reprint Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs
    Kazuhiro Umeyama
    BIOS Research Laboratory Inc, Hiratsuka, Kanagawa 254 0031, Japan
    Transgenic Res 18:697-706. 2009
  2. ncbi request reprint The production of a diabetic mouse using constructs encoding porcine insulin promoter-driven mutant human hepatocyte nuclear factor-1alpha
    Masahito Watanabe
    BIOS Research Laboratory Inc, Hiratsuka, Japan
    J Reprod Dev 53:189-200. 2007

Collaborators

  • Masahito Watanabe
  • Hiroshi Nagashima
  • Hiro Omi Kawano
  • Keizaburo Miki
  • Naoko Izuno

Detail Information

Publications2

  1. doi request reprint Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs
    Kazuhiro Umeyama
    BIOS Research Laboratory Inc, Hiratsuka, Kanagawa 254 0031, Japan
    Transgenic Res 18:697-706. 2009
    ..Histochemical analysis of pancreas tissue from the cloned pigs showed small and irregularly formed Langerhans Islets, in which poor insulin secretion was detected...
  2. ncbi request reprint The production of a diabetic mouse using constructs encoding porcine insulin promoter-driven mutant human hepatocyte nuclear factor-1alpha
    Masahito Watanabe
    BIOS Research Laboratory Inc, Hiratsuka, Japan
    J Reprod Dev 53:189-200. 2007
    ..These results indicate that HNF1alphaP291 expression driven by the porcine insulin promoter, together with the cytomegalovirus enhancer, induces a diabetic phenotype in transgenic mice...