Naoki Saito

Summary

Affiliation: Meiji Pharmaceutical University
Country: Japan

Publications

  1. pmc Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids
    Hiroko Tabunoki
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, 204 8588, Japan
    Cancer Cell Int 12:14. 2012
  2. ncbi request reprint Synthetic approaches toward ecteinascidins. Part 2. Preparation of the ABCDE ring system of ecteinascidins having characteristic substituents in both benzene rings
    Naoki Saito
    Meiji Pharmaceutical University, Kiyose, Japan
    Chem Pharm Bull (Tokyo) 51:821-31. 2003
  3. ncbi request reprint Chemistry of renieramycins. Part 4.synthesis of a simple natural marine product, 6-hydroxy-7-methoxyisoquinolinemethanol
    Naoki Saito
    Meiji Pharmaceutical University, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 52:282-6. 2004
  4. ncbi request reprint [JSPS Asia and Africa scientific platform program development for the medicinal chemistry based on biologically active natural products in the subtropical zone]
    Naoki Saito
    Division of Asia and Africa Center for the Drug Discovery, Meiji Pharmaceutical University, Japan
    Yakugaku Zasshi 129:407-12. 2009
  5. ncbi request reprint Preparation of tricyclic lactam model compounds of renieramycin and saframycin anticancer natural products from common intermediate
    Keiyo Nakai
    Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    Chem Pharm Bull (Tokyo) 61:853-69. 2013
  6. ncbi request reprint Synthesis of renieramycins: construction of the core ring system of cribrostatin 4 through modified Pictet-Spengler cyclization of 3,6-bisarylpiperazine-2,5-dione with diethoxyethyl benzoate
    Masashi Yokoya
    Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 59:787-92. 2011
  7. ncbi request reprint Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide
    Khanit Suwanborirux
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
    J Nat Prod 66:1441-6. 2003
  8. ncbi request reprint Chemistry of renieramycins. Part 5. Structure elucidation of renieramycin-type derivatives O, Q, R, and S from thai marine sponge Xestospongia species pretreated with potassium cyanide
    Surattana Amnuoypol
    Bioactive Marine Natural Products Chemistry Research Unit BMNCU, Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
    J Nat Prod 67:1023-8. 2004
  9. ncbi request reprint Jorunnamycins A-C, new stabilized renieramycin-type bistetrahydroisoquinolines isolated from the Thai nudibranch Jorunna funebris
    Kornvika Charupant
    Bioactive Marine Natural Products Chemistry Research Unit BMNCU, Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
    Chem Pharm Bull (Tokyo) 55:81-6. 2007
  10. ncbi request reprint Chemistry of ecteinascidins. Part 2. Preparation of 6'-O-acyl derivatives of stable ecteinascidin and evaluation of cytotoxicity
    Ploenthip Puthongking
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University Pathumwan, Bangkok 10330, Thailand
    Chem Pharm Bull (Tokyo) 54:1010-6. 2006

Collaborators

  • Khanit Suwanborirux
  • Masashi Yokoya
  • Surattana Amnuoypol
  • Kornvika Charupant
  • Akinori Kubo
  • Keiyo Nakai
  • Hiroko Tabunoki
  • Ploenthip Puthongking
  • Jun ichi Satoh
  • Hiroshi Ito
  • Emi Saito
  • Chamnan Patarapanich
  • Sunibhond Pummangura
  • Chieko Tanaka

Detail Information

Publications11

  1. pmc Molecular network profiling of U373MG human glioblastoma cells following induction of apoptosis by novel marine-derived anti-cancer 1,2,3,4-tetrahydroisoquinoline alkaloids
    Hiroko Tabunoki
    Department of Bioinformatics and Molecular Neuropathology, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, 204 8588, Japan
    Cancer Cell Int 12:14. 2012
    ..abstract:..
  2. ncbi request reprint Synthetic approaches toward ecteinascidins. Part 2. Preparation of the ABCDE ring system of ecteinascidins having characteristic substituents in both benzene rings
    Naoki Saito
    Meiji Pharmaceutical University, Kiyose, Japan
    Chem Pharm Bull (Tokyo) 51:821-31. 2003
    ..A synthesis of an advanced ABCDE ring system (24c) having characteristic substituents in both benzene rings of ecteinascidin marine natural products is described based on our model studies...
  3. ncbi request reprint Chemistry of renieramycins. Part 4.synthesis of a simple natural marine product, 6-hydroxy-7-methoxyisoquinolinemethanol
    Naoki Saito
    Meiji Pharmaceutical University, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 52:282-6. 2004
    ..The former was prepared in ten steps from vanillin (22) in 26% overall yield using an isopropyl for phenol protection...
  4. ncbi request reprint [JSPS Asia and Africa scientific platform program development for the medicinal chemistry based on biologically active natural products in the subtropical zone]
    Naoki Saito
    Division of Asia and Africa Center for the Drug Discovery, Meiji Pharmaceutical University, Japan
    Yakugaku Zasshi 129:407-12. 2009
    ..The JSPS 3rd Medicinal Chemistry Seminar of the Asia/Africa Scientific Platform Program was co-organized with The 2nd International Seminar of MPU-AACDD in Tokyo on January 14-15, 2009...
  5. ncbi request reprint Preparation of tricyclic lactam model compounds of renieramycin and saframycin anticancer natural products from common intermediate
    Keiyo Nakai
    Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo 204 8588, Japan
    Chem Pharm Bull (Tokyo) 61:853-69. 2013
    ..We presented also an unexpected reductive acetylation of the p-quinone to produce the corresponding 3,4-dehydro derivative. ..
  6. ncbi request reprint Synthesis of renieramycins: construction of the core ring system of cribrostatin 4 through modified Pictet-Spengler cyclization of 3,6-bisarylpiperazine-2,5-dione with diethoxyethyl benzoate
    Masashi Yokoya
    Graduate School of Pharmaceutical Sciences, Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose, Tokyo, Japan
    Chem Pharm Bull (Tokyo) 59:787-92. 2011
    ..The key step of this synthesis is the stereoselective cyclization of lactam nitrogen with diethoxyethyl benzoate, followed by the stereoselective hydrogenation to generate ABC ring system 6...
  7. ncbi request reprint Chemistry of renieramycins. Part 3.(1) isolation and structure of stabilized renieramycin type derivatives possessing antitumor activity from Thai sponge Xestospongia species, pretreated with potassium cyanide
    Khanit Suwanborirux
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
    J Nat Prod 66:1441-6. 2003
    ..This strategy is the first example of the gram-scale preparation of this series of compounds and presents a potential solution for increasing the gram-scale supply of novel natural products from marine sources...
  8. ncbi request reprint Chemistry of renieramycins. Part 5. Structure elucidation of renieramycin-type derivatives O, Q, R, and S from thai marine sponge Xestospongia species pretreated with potassium cyanide
    Surattana Amnuoypol
    Bioactive Marine Natural Products Chemistry Research Unit BMNCU, Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
    J Nat Prod 67:1023-8. 2004
    ..Their structures were elucidated by comparison of spectral data with those of recently reported renieramycins M (1m) and N (1n). The results of transformation and cytotoxicity measurements are also described...
  9. ncbi request reprint Jorunnamycins A-C, new stabilized renieramycin-type bistetrahydroisoquinolines isolated from the Thai nudibranch Jorunna funebris
    Kornvika Charupant
    Bioactive Marine Natural Products Chemistry Research Unit BMNCU, Department of Pharmacognosy, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand
    Chem Pharm Bull (Tokyo) 55:81-6. 2007
    ..The results of cytotoxicity studies are also presented...
  10. ncbi request reprint Chemistry of ecteinascidins. Part 2. Preparation of 6'-O-acyl derivatives of stable ecteinascidin and evaluation of cytotoxicity
    Ploenthip Puthongking
    Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Chulalongkorn University Pathumwan, Bangkok 10330, Thailand
    Chem Pharm Bull (Tokyo) 54:1010-6. 2006
    ..Furthermore, we discovered that the N-indole-3-carbonyl derivative of ecteinascidin 770 (22) has higher cytotoxicity than 1b...
  11. ncbi request reprint Ecteinascidins 770 and 786 from the Thai tunicate Ecteinascidia thurstoni
    Khanit Suwanborirux
    Faculty of Pharmaceutical Sciences, Chulalongkorn University, Phyathai Road, Bangkok 10330, Thailand
    J Nat Prod 65:935-7. 2002
    ..Ecteinascidins 770 (1b) and 786 (3b) were isolated from the pretreated Thai tunicate Ecteinascidia thurstoni with potassium cyanide in buffer solution (pH 7). These structures were fully elucidated by extensive 2D NMR analysis...