N Osakabe

Summary

Affiliation: Meiji Seika Kaisha
Country: Japan

Publications

  1. ncbi request reprint Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice
    Naomi Osakabe
    Functional Foods Research and Development Laboratory, Meiji Seika Kaisha Ltd, Chiyoda Sakado, Japan
    Free Radic Biol Med 33:798-806. 2002
  2. ncbi request reprint Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro
    Naomi Osakabe
    Functional Foods Research and Development Laboratory, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Exp Biol Med (Maywood) 227:51-6. 2002
  3. ncbi request reprint Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model
    Naomi Osakabe
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Carcinogenesis 25:549-57. 2004
  4. ncbi request reprint Daily cocoa intake reduces the susceptibility of low-density lipoprotein to oxidation as demonstrated in healthy human volunteers
    N Osakabe
    Functional Food Research and Development Laboratory, Meiji Seika Kaisha Ltd, Chiyoda Sakado, Japan
    Free Radic Res 34:93-9. 2001
  5. ncbi request reprint Analyses of polyphenols in cacao liquor, cocoa, and chocolate by normal-phase and reversed-phase HPLC
    M Natsume
    Functional Foods R and D Laboratory, Meiji Seika Kaisha Ltd, Saitama, Japan
    Biosci Biotechnol Biochem 64:2581-7. 2000
  6. ncbi request reprint Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers
    S Baba
    Funtional Foods R and D Labs, Meiji Seika Kaisha Ltd, Saitama, Japan
    Free Radic Res 33:635-41. 2000
  7. ncbi request reprint Cocoa powder enhances the level of antioxidative activity in rat plasma
    S Baba
    Functional Foods R and D Laboratories, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Br J Nutr 84:673-80. 2000
  8. ncbi request reprint Anticlastogenic activity of cacao: inhibitory effect of cacao liquor polyphenols against mitomycin C-induced DNA damage
    M Yamagishi
    Food Research Development Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1, Chiyoda, Sakado shi, 350 0289, Saitama, Japan
    Food Chem Toxicol 39:1279-83. 2001
  9. ncbi request reprint Cacao liquor proanthocyanidins inhibit lung injury induced by diesel exhaust particles
    A Yasuda
    Food and Health Laboratories, Meiji Seika Kaisha, Ltd, Sakado, Saitama, Japan
    Int J Immunopathol Pharmacol 21:279-88. 2008
  10. ncbi request reprint Effects of polyphenol substances derived from Theobroma cacao on gastric mucosal lesion induced by ethanol
    N Osakabe
    Functional Food Research and Development Laboratories, Meiji Seika Kaisha, Ltd, Saitama, Japan
    Biosci Biotechnol Biochem 62:1535-8. 1998

Detail Information

Publications32

  1. ncbi request reprint Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice
    Naomi Osakabe
    Functional Foods Research and Development Laboratory, Meiji Seika Kaisha Ltd, Chiyoda Sakado, Japan
    Free Radic Biol Med 33:798-806. 2002
    ..These results suggest that the liver protection of RA is due to the scavenging or reducing activities-superoxide or peroxynitirite rather than to inhibition of TNF-alpha production...
  2. ncbi request reprint Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro
    Naomi Osakabe
    Functional Foods Research and Development Laboratory, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Exp Biol Med (Maywood) 227:51-6. 2002
    ..It is suggested that these compounds contribute to the activity of cacao products to protect LDL from oxidation...
  3. ncbi request reprint Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model
    Naomi Osakabe
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Carcinogenesis 25:549-57. 2004
    ..Thus, we conclude that part of the anticarcinogenic effects of P.frutescens extract is due to RA via two independent mechanisms: inhibition of the inflammatory response and scavenging of reactive oxygen radicals...
  4. ncbi request reprint Daily cocoa intake reduces the susceptibility of low-density lipoprotein to oxidation as demonstrated in healthy human volunteers
    N Osakabe
    Functional Food Research and Development Laboratory, Meiji Seika Kaisha Ltd, Chiyoda Sakado, Japan
    Free Radic Res 34:93-9. 2001
    ..In conclusion, the antioxidants in cocoa powder might be absorbed and increase the resistance of human LDL to oxidation...
  5. ncbi request reprint Analyses of polyphenols in cacao liquor, cocoa, and chocolate by normal-phase and reversed-phase HPLC
    M Natsume
    Functional Foods R and D Laboratory, Meiji Seika Kaisha Ltd, Saitama, Japan
    Biosci Biotechnol Biochem 64:2581-7. 2000
    ....
  6. ncbi request reprint Bioavailability of (-)-epicatechin upon intake of chocolate and cocoa in human volunteers
    S Baba
    Funtional Foods R and D Labs, Meiji Seika Kaisha Ltd, Saitama, Japan
    Free Radic Res 33:635-41. 2000
    ..8+/-5.3%'; and 25.3+/-8.1% of total EC intake. EC in chocolate and cocoa was partly absorbed and was found to be present as a component of various conjugates in plasma, and these were rapidly excreted in urine...
  7. ncbi request reprint Cocoa powder enhances the level of antioxidative activity in rat plasma
    S Baba
    Functional Foods R and D Laboratories, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Br J Nutr 84:673-80. 2000
    ....
  8. ncbi request reprint Anticlastogenic activity of cacao: inhibitory effect of cacao liquor polyphenols against mitomycin C-induced DNA damage
    M Yamagishi
    Food Research Development Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1, Chiyoda, Sakado shi, 350 0289, Saitama, Japan
    Food Chem Toxicol 39:1279-83. 2001
    ..These findings suggest that cacao liquor polyphenols are effective in preventing DNA damage, and one of the mechanisms of action might involve scavenging of active oxygen radicals generated in reactions initiated by MMC...
  9. ncbi request reprint Cacao liquor proanthocyanidins inhibit lung injury induced by diesel exhaust particles
    A Yasuda
    Food and Health Laboratories, Meiji Seika Kaisha, Ltd, Sakado, Saitama, Japan
    Int J Immunopathol Pharmacol 21:279-88. 2008
    ..These results suggest that CPs inhibit DEP-induced lung injury by reducing oxidative stress, in association with a reduction in the expression of adhesion molecules...
  10. ncbi request reprint Effects of polyphenol substances derived from Theobroma cacao on gastric mucosal lesion induced by ethanol
    N Osakabe
    Functional Food Research and Development Laboratories, Meiji Seika Kaisha, Ltd, Saitama, Japan
    Biosci Biotechnol Biochem 62:1535-8. 1998
    ..According to an in vitro study, CWSP directly reducted XOD but not MPO. These results suggest that the antiulcer mechanism of CWSP was not only radical scavenging but also modulation of leukocyte function...
  11. ncbi request reprint Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats
    S Baba
    Functional Foods Research and Development Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    J Agric Food Chem 49:6050-6. 2001
    ....
  12. ncbi request reprint In vivo comparison of the bioavailability of (+)-catechin, (-)-epicatechin and their mixture in orally administered rats
    S Baba
    Functional Foods R and D Laboratories, Meiji Seika Kaisha, Ltd, Sakado 350 0289, Japan
    J Nutr 131:2885-91. 2001
    ....
  13. ncbi request reprint Rosmarinic acid in perilla extract inhibits allergic inflammation induced by mite allergen, in a mouse model
    C Sanbongi
    Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Sakado, Saitama, Japan
    Clin Exp Allergy 34:971-7. 2004
    ..Perilla and its constituent rosmarinic acid have been suggested to have anti-allergic activity. However, few studies have examined the effects on allergic asthma...
  14. ncbi request reprint In vitro antioxidative activity of (-)-epicatechin glucuronide metabolites present in human and rat plasma
    Midori Natsume
    Healthcare R and D Laboratories, Meiji Seika Kaisha Ltd, Sakado shi, Saitama 350 0289, Japan
    Free Radic Res 38:1341-8. 2004
    ..In contrast, the other metabolites had light antioxidative activities over the range of physiological concentrations found in plasma...
  15. ncbi request reprint Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits
    Tohru Kurosawa
    Toxicology Laboratory, Pharmaceutical Development Department, Meiji Seika Kaisha Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Atherosclerosis 179:237-46. 2005
    ..Therefore, CLP suppressed the generation of atherosclerosis, and its antioxidative effect appeared to have an important role in its anti-atherosclerotic activity...
  16. ncbi request reprint Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats
    Seigo Baba
    Nutritional Science Center, Health Laboratory, Meiji Seika Kaisha, Ltd, Sakado shi, Saitama, Japan
    Free Radic Biol Med 33:142-8. 2002
    ..Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions...
  17. ncbi request reprint Pulmonary exposure to diesel exhaust particles enhances fatty change of the liver in obese diabetic mice
    Makoto Tomaru
    Gerodontology, Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Int J Mol Med 19:17-22. 2007
    ..These results suggest that pulmonary exposure to DEP, PM, enhances steatosis in the liver of obese diabetic subjects possibly via enhanced oxidative stress...
  18. ncbi request reprint Continuous intake of polyphenolic compounds containing cocoa powder reduces LDL oxidative susceptibility and has beneficial effects on plasma HDL-cholesterol concentrations in humans
    Seigo Baba
    Food and Health R and D Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan
    Am J Clin Nutr 85:709-17. 2007
    ..Cocoa powder is rich in polyphenols such as catechins and procyanidins and has been shown in various models to inhibit LDL oxidation and atherogenesis...
  19. ncbi request reprint Dietary supplementation with cacao liquor proanthocyanidins prevents elevation of blood glucose levels in diabetic obese mice
    Makoto Tomaru
    Gerodontology, Department of Gerodontology, Division of Gerontology and Gerodontology, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan Environmental Health Sciences Division, National Institute for Environmental Studies, Ibaraki, Japan
    Nutrition 23:351-5. 2007
    ..The present study examined whether dietary supplementation with cacao liquor proanthocyanidins (CLPr) could prevent elevation of blood glucose levels in mice with diabetes mellitus and obesity...
  20. ncbi request reprint Plasma LDL and HDL cholesterol and oxidized LDL concentrations are altered in normo- and hypercholesterolemic humans after intake of different levels of cocoa powder
    Seigo Baba
    Food and Health R and D Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan
    J Nutr 137:1436-41. 2007
    ..The results suggest that polyphenolic substances derived from cocoa powder may contribute to a reduction in LDL cholesterol, an elevation in HDL cholesterol, and the suppression of oxidized LDL...
  21. ncbi request reprint Short-term supplementation with plant extracts rich in flavonoids protect nigrostriatal dopaminergic neurons in a rat model of Parkinson's disease
    Krishna P Datla
    Department of Cellular and Molecular Neuroscience, Division of Neuroscience and Mental Health, Faculty of Medicine, Imperial College, Charing Cross Campus, St Dunstan s Road, London W6 8RP, United Kingdom
    J Am Coll Nutr 26:341-9. 2007
    ....
  22. ncbi request reprint Suppressive effect of cocoa powder on atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits
    Tohru Kurosawa
    Toxicology Laboratory, Pharmaceutical Development Department, Meiji Seika Kaisha, Ltd, Kanagawa, Japan
    J Atheroscler Thromb 12:20-8. 2005
    ..We consider that antioxidative activity of polyphenols rich in cocoa powder may be a key factor for the anti-atherosclerotic effect...
  23. ncbi request reprint Anti-inflammatory and anti-allergic effect of rosmarinic acid (RA); inhibition of seasonal allergic rhinoconjunctivitis (SAR) and its mechanism
    Naomi Osakabe
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan co jp
    Biofactors 21:127-31. 2004
    ..In addition, the anti-inflammatory mechanism of RA also estimated in the ear edema models...
  24. ncbi request reprint Absorption, metabolism, degradation and urinary excretion of rosmarinic acid after intake of Perilla frutescens extract in humans
    Seigo Baba
    Nutritional Science Center, Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Sakado shi, Saitama 350 0289, Japan
    Eur J Nutr 44:1-9. 2005
    ..Previous studies have shown RA has antioxidative and anti-inflammatory activity. However, little is known on the absorption, metabolism, degradation and excretion of RA...
  25. ncbi request reprint Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid
    Seigo Baba
    Nutritional Science Center, Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1, Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Life Sci 75:165-78. 2004
    ....
  26. ncbi request reprint Extract of Perilla frutescens enriched for rosmarinic acid, a polyphenolic phytochemical, inhibits seasonal allergic rhinoconjunctivitis in humans
    Hirohisa Takano
    First Department of Medicine, Kyoto Prefectural University of Medicine, Kyoto 602 0841, Japan
    Exp Biol Med (Maywood) 229:247-54. 2004
    ..Use of this alternative treatment for SAR might reduce treatment costs for allergic diseases...
  27. ncbi request reprint Rosmarinic acid inhibits lung injury induced by diesel exhaust particles
    Chiaki Sanbongi
    Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, Saitama, Japan
    Free Radic Biol Med 34:1060-9. 2003
    ..These results suggest that rosmarinic acid inhibits DEP-induced lung injury by the reduction of proinflammatory molecule expression. Antioxidative activities of rosmarinic acid may also contribute to its protective effects...
  28. ncbi request reprint Structures of (-)-epicatechin glucuronide identified from plasma and urine after oral ingestion of (-)-epicatechin: differences between human and rat
    Midori Natsume
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, Saitama, Japan
    Free Radic Biol Med 34:840-9. 2003
    ..The presence of these metabolites in blood and urine suggests that catechins are metabolized and circulated in the body after administration of catechin-containing foods...
  29. ncbi request reprint Chemoprevention of lung carcinogenesis by cacao liquor proanthocyanidins in a male rat multi-organ carcinogenesis model
    Megumi Yamagishi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, Tokyo 158 8501, Japan
    Cancer Lett 191:49-57. 2003
    ..No significant modification in the small intestine, colon or kidney was evident. These results indicate that CLPr exerts chemopreventive effects in the lung without any promoting influence in other major organs...
  30. ncbi request reprint Proanthocyanidin glycosides and related polyphenols from cacao liquor and their antioxidant effects
    Tsutomu Hatano
    Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, 700, Okayama, Japan
    Phytochemistry 59:749-58. 2002
    ..These effects were attributed to the radical-scavenging activity in the peroxidation chain reactions, based on the findings that the cacao polyphenols effectively scavenged the 1,1-diphenyl-2-picrylhydrazyl radical...
  31. ncbi request reprint Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats
    Megumi Yamagishi
    Division of Pathology, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya Ku, 158 8501, Tokyo, Japan
    Cancer Lett 185:123-30. 2002
    ..These results indicate that CLPr inhibit in vitro mutagenicity of PhIP, as well as rat pancreatic carcinogenesis in the initiation stage, but not mammary carcinogenesis induced by PhIP...
  32. ncbi request reprint Ingestion of proanthocyanidins derived from cacao inhibits diabetes-induced cataract formation in rats
    Naomi Osakabe
    Health and Bioscience Laboratory, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Exp Biol Med (Maywood) 229:33-9. 2004
    ..Our findings suggest that CLP inhibits diabetes-induced cataract formation possibly by virtue of its antioxidative activity...