Hiroki Ohara

Summary

Affiliation: Meiji Seika Kaisha
Country: Japan

Publications

  1. doi request reprint Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts
    Hiroki Ohara
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Saitama, Japan
    J Dermatol 37:330-8. 2010
  2. ncbi request reprint Effects of Pro-Hyp, a collagen hydrolysate-derived peptide, on hyaluronic acid synthesis using in vitro cultured synovium cells and oral ingestion of collagen hydrolysates in a guinea pig model of osteoarthritis
    Hiroki Ohara
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, Sakado, Saitama, Japan
    Biosci Biotechnol Biochem 74:2096-9. 2010
  3. doi request reprint Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate
    Satomi Ichikawa
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, Sakado shi, Saitama, Japan
    Int J Food Sci Nutr 61:52-60. 2010
  4. pmc Increase in terminal restriction fragments of Bacteroidetes-derived 16S rRNA genes after administration of short-chain fructooligosaccharides
    Yusuke Nakanishi
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Appl Environ Microbiol 72:6271-6. 2006
  5. ncbi request reprint Identification of marker genes for intestinal immunomodulating effect of a fructooligosaccharide by DNA microarray analysis
    Tomoyuki Fukasawa
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    J Agric Food Chem 55:3174-9. 2007
  6. doi request reprint Collagen hydrolysate intake improves the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice
    Chisato Oba
    Food Science Research Labs, Meiji Co, Ltd, Odawara shi, Kanagawa, Japan
    Photodermatol Photoimmunol Photomed 29:204-11. 2013
  7. ncbi request reprint Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources
    Hiroki Ohara
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1, Chiyoda, Sakado shi, Saitama 350 0289, Japan
    J Agric Food Chem 55:1532-5. 2007

Collaborators

Detail Information

Publications7

  1. doi request reprint Collagen-derived dipeptide, proline-hydroxyproline, stimulates cell proliferation and hyaluronic acid synthesis in cultured human dermal fibroblasts
    Hiroki Ohara
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Saitama, Japan
    J Dermatol 37:330-8. 2010
    ..These results suggest that Pro-Hyp stimulates both cell mitotic activity and hyaluronic acid synthesis, which is mediated by activation of HAS2 transcription...
  2. ncbi request reprint Effects of Pro-Hyp, a collagen hydrolysate-derived peptide, on hyaluronic acid synthesis using in vitro cultured synovium cells and oral ingestion of collagen hydrolysates in a guinea pig model of osteoarthritis
    Hiroki Ohara
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, Sakado, Saitama, Japan
    Biosci Biotechnol Biochem 74:2096-9. 2010
    ..It also reduced the morphological changes associated with osteoarthritic cartilage destruction of the knee joint. The results suggest that collagen hydrolysates have therapeutic potential for treatment of osteoarthritis...
  3. doi request reprint Hydroxyproline-containing dipeptides and tripeptides quantified at high concentration in human blood after oral administration of gelatin hydrolysate
    Satomi Ichikawa
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, Sakado shi, Saitama, Japan
    Int J Food Sci Nutr 61:52-60. 2010
    ..Thus a total of nine Hyp-containing peptides in human plasma were successfully quantified by this approach. The concentration of Hyp-containing peptides is substantially higher than that following oral administration of other peptides...
  4. pmc Increase in terminal restriction fragments of Bacteroidetes-derived 16S rRNA genes after administration of short-chain fructooligosaccharides
    Yusuke Nakanishi
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Appl Environ Microbiol 72:6271-6. 2006
    ..Therefore, the T-RFs derived from Bacteroidetes are good markers of change of murine intestinal microbiota after scFOS administration...
  5. ncbi request reprint Identification of marker genes for intestinal immunomodulating effect of a fructooligosaccharide by DNA microarray analysis
    Tomoyuki Fukasawa
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    J Agric Food Chem 55:3174-9. 2007
    ....
  6. doi request reprint Collagen hydrolysate intake improves the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice
    Chisato Oba
    Food Science Research Labs, Meiji Co, Ltd, Odawara shi, Kanagawa, Japan
    Photodermatol Photoimmunol Photomed 29:204-11. 2013
    ..Here, we investigated the loss of epidermal barrier function and skin elasticity induced by UVB irradiation in hairless mice fed collagen hydrolysate...
  7. ncbi request reprint Comparison of quantity and structures of hydroxyproline-containing peptides in human blood after oral ingestion of gelatin hydrolysates from different sources
    Hiroki Ohara
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1, Chiyoda, Sakado shi, Saitama 350 0289, Japan
    J Agric Food Chem 55:1532-5. 2007
    ..Ala-Hyp-Gly and Ser-Hyp-Gly were detected only with fish scale gelatin hydrolysate. The quantity and structure of Hyp-containing peptides in human blood after oral administration of gelatin hydrolysate depends on the gelatin source...