Noboru Motohashi

Summary

Affiliation: Meiji Pharmaceutical University
Country: Japan

Publications

  1. ncbi Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines
    Yoshiaki Akatsu
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 26:1917-23. 2006
  2. ncbi Application of phenothiazine derivatives and other compounds for the determination of metals in various samples
    Jaldappa Seetharamappa
    Department of Studies in Chemistry, Karnatak Univerisity, Dharwad 580 003, Karnataka State, India
    Curr Drug Targets 7:1107-21. 2006
  3. ncbi Diclofenac in the management of E. coli urinary tract infections
    Kaushiki Mazumdar
    Division of Microbiology, Institute of Genetic Engineering, Kalyani University, Calcutta 700 128, India
    In Vivo 20:613-9. 2006
  4. ncbi Relationship between radical intensity and biological activity of cacao husk extracts
    N Motohashi
    Meiji Pharmaceutical University, Tokyo, Japan
    Anticancer Res 19:1125-9. 1999
  5. ncbi Antimicrobial activity of N-acylphenothiazines and their influence on lipid model membranes and erythrocyte membranes
    Noboru Motohashi
    Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Arzneimittelforschung 53:590-9. 2003
  6. ncbi Cytotoxic and multidrug resistance reversal activity of a vegetable, 'Anastasia Red', a variety of sweet pepper
    Noboru Motohashi
    Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Phytother Res 17:348-52. 2003
  7. ncbi Biological activity of barbados cherry (acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions
    Noboru Motohashi
    Meiji Pharmaceutical University, Noshio, Kiyose, Tokyo, Japan
    Phytother Res 18:212-23. 2004
  8. ncbi Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts
    Noboru Motohashi
    Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose shi, Tokyo 204 8588, Japan
    J Ethnopharmacol 81:357-64. 2002
  9. ncbi Synthesis and biological activity of N-acylphenothiazines
    N Motohashi
    Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose shi, Tokyo, Japan
    Int J Antimicrob Agents 14:203-7. 2000
  10. ncbi Biological activity of a fruit vegetable, "Anastasia green", a species of sweet pepper
    N Motohashi
    Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose shi, Tokyo 204 8588, Japan
    In Vivo 15:437-42. 2001

Collaborators

Detail Information

Publications66

  1. ncbi Apoptosis-inducing activity of trihaloacetylazulenes against human oral tumor cell lines
    Yoshiaki Akatsu
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 26:1917-23. 2006
    ..None of the 26 compounds showed anti-HIV activity. These results suggest [5b] and [11b] as possible candidates for future cancer chemotherapy...
  2. ncbi Application of phenothiazine derivatives and other compounds for the determination of metals in various samples
    Jaldappa Seetharamappa
    Department of Studies in Chemistry, Karnatak Univerisity, Dharwad 580 003, Karnataka State, India
    Curr Drug Targets 7:1107-21. 2006
    ..In addition, some extractive spectrophotometric methods based on the formation of ion-association complexes (extractable into organic solvents) and gravimetric methods have been discussed...
  3. ncbi Diclofenac in the management of E. coli urinary tract infections
    Kaushiki Mazumdar
    Division of Microbiology, Institute of Genetic Engineering, Kalyani University, Calcutta 700 128, India
    In Vivo 20:613-9. 2006
    ..All the isolates were sensitive to diclofenac, with MIC values ranging from 5-50 microg/mL. The MIC90 value of the drug was 25 microg/mL. Therefore, it may be suggested that diclofenac has the capacity to treat UTI caused by E. coli...
  4. ncbi Relationship between radical intensity and biological activity of cacao husk extracts
    N Motohashi
    Meiji Pharmaceutical University, Tokyo, Japan
    Anticancer Res 19:1125-9. 1999
    ..However, their cytotoxic activity against human leukemic and carcinoma cell lines is not always correlated with their radical intensity. Water-soluble and lipophilic compounds might induce cytotoxic activity by different mechanisms...
  5. ncbi Antimicrobial activity of N-acylphenothiazines and their influence on lipid model membranes and erythrocyte membranes
    Noboru Motohashi
    Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Arzneimittelforschung 53:590-9. 2003
    ..Above results show that phenothiazine maleates were generally more effective than other phenothiazines used in this study...
  6. ncbi Cytotoxic and multidrug resistance reversal activity of a vegetable, 'Anastasia Red', a variety of sweet pepper
    Noboru Motohashi
    Meiji Pharmaceutical University, Kiyose, Tokyo, Japan
    Phytother Res 17:348-52. 2003
    ..Thus, this study suggests the effective and selective antitumor potential of 'Anastasia Red' of sweet pepper for further phytochemical and biological investigation...
  7. ncbi Biological activity of barbados cherry (acerola fruits, fruit of Malpighia emarginata DC) extracts and fractions
    Noboru Motohashi
    Meiji Pharmaceutical University, Noshio, Kiyose, Tokyo, Japan
    Phytother Res 18:212-23. 2004
    ..The tumor specific cytotoxic activity and MDR reversal activity of barbados cherry may suggest its possible application for cancer therapy...
  8. ncbi Cancer prevention and therapy with kiwifruit in Chinese folklore medicine: a study of kiwifruit extracts
    Noboru Motohashi
    Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose shi, Tokyo 204 8588, Japan
    J Ethnopharmacol 81:357-64. 2002
    ..All fractions were inactive against Helicobacter pylori. These results demonstrate that gold kiwifruit extracts contain valuable, various bioactive materials, which can be separated with each other...
  9. ncbi Synthesis and biological activity of N-acylphenothiazines
    N Motohashi
    Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose shi, Tokyo, Japan
    Int J Antimicrob Agents 14:203-7. 2000
    ..It suggested that the radical-mediated-mechanisms has not involved in the induction of cytotoxic activity by lipophilic compounds, such as N-acylphenothiazines...
  10. ncbi Biological activity of a fruit vegetable, "Anastasia green", a species of sweet pepper
    N Motohashi
    Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose shi, Tokyo 204 8588, Japan
    In Vivo 15:437-42. 2001
    ..All extracts and fractions showed no anti-human immunodeficiency virus (HIV) nor anti-Helicobacter pylori activity. These data suggest the medicinal importance of an Anastasia Green extract...
  11. ncbi Chemical structure and tumor type specificity of "half-mustard type" phenothiazines
    N Motohashi
    Department of Medicinal Chemistry, Meiji Pharmaceutical University, Tokyo, Japan
    Anticancer Res 19:1859-64. 1999
    ..These data suggest the "cancer-type-specific" antitumor action of "half-mustard type" phenothiazines...
  12. ncbi Cytotoxic potential of phenothiazines
    Noboru Motohashi
    Meiji Pharmaceutical University, 2 522 1 Noshio, Kiyose shi, Tokyo 204 8588, Japan
    Curr Drug Targets 7:1055-66. 2006
    ....
  13. ncbi Coumarin derivatives with tumor-specific cytotoxicity and multidrug resistance reversal activity
    Masami Kawase
    Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
    In Vivo 19:705-11. 2005
    ..A deeper understanding of the relationship between their structures and their potency will contribute to the design of optimal agents...
  14. ncbi In vitro and in vivo antimycobacterial activity of an antihypertensive agent methyl-L-DOPA
    Noton Kumar Dutta
    Division of Microbiology, Department of Pharmaceutical Technology, Jadavpur University, Calcutta, 700 032, India
    In Vivo 19:539-45. 2005
    ..tuberculosis H37Rv102. According to the chi2 test, the in vivo data were highly significant (p<0.01)...
  15. ncbi Human sarcoma cell lines MES-SA and MES-SA/Dx5 as a model for multidrug resistance modulators screening
    Olga Wesolowska
    Department of Biophysics, Wroclaw Medical University, 50 368 Wroclaw, Poland
    Anticancer Res 25:383-9. 2005
    ..We conclude that the MES-SA and MES-SA/Dx5 cell line pair constitute a good model for MDR modulators study...
  16. ncbi Cytotoxic activity of azulenequinones against human oral tumor cell lines
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 25:305-12. 2005
    ..None of the twenty-seven azulenequinones showed anti-HIV activity. These results suggest [12] and [24] as possible candidates for future cancer chemotherapy...
  17. ncbi Biological activity of carotenoids in red paprika, Valencia orange and Golden delicious apple
    Peter Molnar
    Department of Biochemistry and Medical Chemistry, University of Pecs Medical School, Pecs, H 7601 Hungary
    Phytother Res 19:700-7. 2005
    ..The data suggest the potential importance of carotenoids as possible anti-H. pylori and MDR reversal agents. The active principles in the carotenoid extract might differ, depending upon the types of fruits and vegetables...
  18. ncbi Cytotoxicty and radical modulating activity of isoflavones and isoflavanones from Sophora species
    Yoshiaki Shirataki
    Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan
    Anticancer Res 24:1481-8. 2004
    ..These data suggest that the inhibition of macrophage NO production by these isoflavanones may, at least in part, be explained by their radical scavenging or reduction activity...
  19. ncbi Inhibitory action of a new proton pump inhibitor, trifluoromethyl ketone derivative, against the motility of clarithromycin-susceptible and-resistant Helicobacter pylori
    Gabriella Spengler
    Department of Medical Microbiology and Immunobiology, , Faculty of Medicine, University of Szeged, Szeged, Hungary
    Int J Antimicrob Agents 23:631-3. 2004
    ..Based on the results, it is supposed that TF18 works as an uncoupler similar to the 'clutch' in a biological motor, in which counterclockwise rotation is more sensitive to the effect of TF18 than the clockwise rotation...
  20. ncbi Presence of anionic phospholipids rules the membrane localization of phenothiazine type multidrug resistance modulator
    Olga Wesołowska
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368 Wrocław, Poland
    Biophys Chem 109:399-412. 2004
    ..Behavior of equimolar PC:PS mixtures is similar to pure PS bilayers, while 2:1 or 1:2 (mole:mole) PC:PS mixtures resemble pure PC ones...
  21. ncbi Bioactivities of anastasia black (Russian sweet pepper)
    Yoshiaki Shirataki
    Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan
    Anticancer Res 25:1991-9. 2005
    ..These data suggest that Anastasia Black should be further investigated as a potent supplement for cancer chemotherapy...
  22. ncbi Benzo[a]phenoxazines: a new group of potent P-glycoprotein inhibitors
    Olga Wesolowska
    Department of Biophysics, Wroclaw Medical University, ul Chalubinskiego 10, 50 368 Wroclaw, Poland
    In Vivo 20:109-13. 2006
    ..e. to be new effective MDR modulators. The results allowed us to draw preliminary conclusions about the structural features of benzo[a]phenoxazines which are important for MDR modulation...
  23. ncbi Studies on the antimicrobial potential of the cardiovascular drug lacidipine
    Asish Dasgupta
    Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India
    In Vivo 21:847-50. 2007
    ..typhimurium NCTC 74. According to the chi-square test, the in vivo data were highly significant (p<0.001)...
  24. ncbi Tumor-specificity and type of cell death induced by trihaloacetylazulenes in human tumor cell lines
    Takashi Sekine
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 27:133-43. 2007
    ..These results suggest the diversity of cell death type induced in human tumor cell lines by trihaloacetylazulene derivatives...
  25. ncbi Qualitative analysis of MDR-reversing Anastasia Black (Russian black sweet pepper, Capsicum annuum, Solanaceae) extracts and fractions by HPLC and LC-MS-MS methods
    Zsuzsanna Schelz
    Department of Medical Microbiology and Immunobiology, Faculty of Medicine, University of Szeged, , H-6720 Szeged, Hungary
    In Vivo 20:651-6. 2006
    ..Other lipophilic compounds, most probably carotenoids, present in Russian black sweet pepper may act as inhibitors of MDR reversal...
  26. ncbi Tumor-specificity and type of cell death induced by phenoxazines
    Fumika Suzuki
    Division of Pharmacology, Meikai University School of Dentistry, Sakado, Saitama 350 0283, Japan
    Anticancer Res 27:4233-8. 2007
    ....
  27. ncbi Multidrug resistance reversal by 3-formylchromones in human colon cancer and human mdr1 gene-transfected mouse lymphoma cells
    Zoltán Baráth
    Institute of Medical Microbiology and Immunobiology, Faculty of General Medicine, University of Szeged, Szeged, Hungary
    In Vivo 20:645-9. 2006
    ..The log P values can provide an adequate explanation for the selective cytotoxicity against cancer cells...
  28. ncbi Tumour-specific cytotoxicity and MDR-reversal activity of dihydropyridines
    Helga Engi
    Department of Medical Microbiology and Immunobiology, , University of Szeged, H-6720 Szeged, Hungary
    In Vivo 20:637-43. 2006
    ..There was no clear-cut relationship between the multidrug-resistance activity or cytotoxicity and the chemical structures of the compounds. New ring substituents could prevent the oxidation of the ring of the aromatic compound...
  29. ncbi Luminescence and photophysical properties of benzo[a]phenothiazines--therapeutic, physico-chemical, and analytical applications
    Mame Diabou Gaye-Seye
    ITODYS, , , 1, rue Guy de la Brosse, 75005 Paris, France
    Curr Drug Targets 7:1083-93. 2006
    ..This review article is based on selected literature data published in the last ten years (1993-2004)...
  30. ncbi Synergistic interaction between proton pump inhibitors and resistance modifiers: promoting effects of antibiotics and plasmid curing
    Kristina Wolfart
    Department of Medical Microbiology, University of Szeged, 6720 Szeged, , Hungary
    In Vivo 20:367-72. 2006
    ..coli and that it was this pump which, when inhibited by TF14, allowed more PMZ to reach its plasmid elimination target...
  31. ncbi A study on the perturbation of model lipid membranes by phenoxazines
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, Wrocław, Poland
    Bioorg Med Chem 14:5948-54. 2006
    ..These studies showed also that phenoxazine molecules are located close to the polar/apolar interface of bilayer. The results allow to conclude that phenoxazines rather weakly interact with lipid bilayers...
  32. ncbi Inhibition of P-glycoprotein transport function by N-acylphenothiazines
    Olga Wesolowska
    Department of Biophysics, Wroclaw Medical University, ul Chalubinskiego 10, 50 368 Wroclaw, Poland
    Anticancer Res 22:2863-7. 2002
    ..As a result of the present study a new group of mdr reversal agents was identified...
  33. ncbi Interaction between various resistance modifiers and apoptosis inducer 12H-benzo[alpha]phenothiazine
    Ilona Mucsi
    Department of Medical Microbiology, Faculty of General Medicine, University of Szeged, Hungary
    Anticancer Res 22:2833-6. 2002
    ..The resistance modifier compounds alone also induced apoptosis and it was slightly higher in the parent cells than its MDR1/A gene-transformed subline...
  34. ncbi Interaction between 3,5-diacetyl-1,4-dihydropyridines and ampicillin, and erythromycin on different E. coli strains
    Györgyi Gunics
    Department of Microbiology, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    Int J Antimicrob Agents 20:227-9. 2002
    ..None of the drugs had any effect on a multidrug resistant (MDR) clinical isolate of E. coli Gy-2/Ap(res)Er(res)...
  35. ncbi New phenothiazine-type multidrug resistance modifiers: anti-MDR activity versus membrane perturbing potency
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368, Wrocław, Poland
    Biochem Biophys Res Commun 304:260-5. 2003
    ..It is concluded that the biological and biophysical activity of phenothiazine derivatives depends more on the type of ring substitution than on the nature of the side chain group...
  36. ncbi Neither lipophilicity nor membrane-perturbing potency of phenothiazine maleates correlate with the ability to inhibit P-glycoprotein transport activity
    Andrzej B Hendrich
    Department of Biophysics Wrocław Medical University ul Chalubinskiego 10 50 368 Wrocław, Poland
    Mol Membr Biol 20:53-60. 2003
    ..No clear relation was found between effects exerted by phenothiazine maleates on model membranes and their ability to modulate P-glycoprotein transport activity...
  37. ncbi The alterations of lipid bilayer fluidity induced by newly synthesized phenothiazine derivative
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368, Wrocław, Poland
    Biophys Chem 98:275-85. 2002
    ..This structure is less co-operative than an unperturbed bilayer, but locally the mobility of lipid molecules is decreased...
  38. ncbi Biological activity of persimmon (Diospyros kaki) peel extracts
    Masami Kawase
    Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan
    Phytother Res 17:495-500. 2003
    ..These results indicate the therapeutic value of persimmon peel extracts as potential antitumor and MDR-reversing agents...
  39. ncbi Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by Barbados cherry, a fruit of Malpighia emarginata DC
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama 350-0295, Japan
    Anticancer Res 23:3237-41. 2003
    ..These data suggest that the inhibitory effect on NO production by Barbados cherry extracts is partly due to the inhibition of iNOS expression, and scavenging of O2- and NO radicals...
  40. ncbi New multidrug resistance reversal agents
    Masami Kawase
    Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan
    Curr Drug Targets 4:31-43. 2003
    ..The use of MDR modulators is a promising approach to overcome the undesired MDR phenotype. The more effective MDR modulators are urgently needed for clinical use. This review focuses on literatures published in 1998-2001...
  41. ncbi Cytotoxic activity of azulenes against human oral tumor cell lines
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama, 350 0295, Japan
    Anticancer Res 23:4747-55. 2003
    ..These data suggest that a radical-mediated oxidation mechanism may not be involved in the apoptosis induction by methyl 7-isopropyl-2-methoxyazulene-1-carboxylate [24]...
  42. ncbi Studies on the antibacterial potentiality of isoflavones
    Sujata G Dastidar
    Department of Pharmaceutical Technology, Jadavpur University, Calcutta 700 032, India
    Int J Antimicrob Agents 23:99-102. 2004
    ..At concentrations of 30 and 60 microg/mouse these compounds offered significant protection to mice challenged with 50 median lethal dose (MLD) of a virulent strain of Salmonella Typhimurium...
  43. ncbi 3,5-dibenzoyl-1,4-dihydropyridines: synthesis and MDR reversal in tumor cells
    Masami Kawase
    Faculty of Pharmaceutical Sciences, Josai University, 350 0295, Saitama, Japan
    Bioorg Med Chem 10:1051-5. 2002
    ..These data suggest that 3,5-dibenzoyl-4-(3-chlorophenyl)-1,4-dihydro-2,6-dimethylpyridine (12) can be recommended as a new drug candidate for MDR cancer treatment...
  44. ncbi Cell death-inducing activity of opiates in human oral tumor cell lines
    Masami Kawase
    Faculty of Pharmaceutical Sciences, Josai University, Sakado, Saitama, Japan
    Anticancer Res 22:211-4. 2002
    ..These data suggest that codeinone induces cytotoxicity in oral tumor cell lines, possibly by a Michael-like addition of a protein SH or of an amino group to the bouble bond of codeinone...
  45. ncbi Differential interaction of Sophora isoflavonoids with lipid bilayers
    Andrzej Boguslaw Hendrich
    Department of Biophysics, Wroclaw Medical University, ul Chalubinskiego 10, 50 368, Wroclaw, Poland
    Eur J Pharm Sci 16:201-8. 2002
    ..Comparing our results with biological tests it seems that interactions with the hydrophobic core of membranes are responsible for the activity of the studied isoflavones...
  46. ncbi Quantitative structure-cytotoxicity relationship analysis of phenoxazine derivatives by semiempirical molecular-orbital method
    Mariko Ishihara
    Division of Basic Chemistry, Department of Oral Biology and Tissue Engineering, Meikai University School of Dentistry, Sakado, Saitama 350 0283, Japan
    Anticancer Res 27:4053-7. 2007
    ..27). These data suggest that appropriate chemical descriptors should be selected to estimate the cytotoxicity of phenoxazines, depending on the target cells...
  47. ncbi A new phenothiazine derivative alters the fluidity and thermotropic behaviour of phosphatidylcholine model membranes
    Olga Wesołowska
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, Wrocław, 50 368 Poland
    Cell Mol Biol Lett 7:303. 2002
  48. ncbi Effects of isoflavones from Sophora species on the growth and activation of a mouse macrophage-like cell line
    Miyuki Tashiro
    Department of Dental Pharmacology, Meikai University School of Dentistry, Sakado, Saitama, Japan
    Anticancer Res 22:2185-91. 2002
    ..These data suggest that the inhibiton of LPS action by isoflavones may be coupled with their cytotoxic activity...
  49. ncbi Lipid membrane perturbation caused by some isoflavones and phenothiazines, and the activity of these compounds as inhibitors of multidrug resistance
    Krystyna Michalak
    Department of Biophysics, , , Poland
    Cell Mol Biol Lett 7:293. 2002
  50. ncbi Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by trihaloacetylazulene derivatives
    Juri Takahashi
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 28:171-8. 2008
    ....
  51. ncbi Relationship between electronic structure and cytotoxic activity of azulenequinones and trihaloacetylazulenes
    Teruo Kurihara
    Department of Chemistry, Faculty of Science, Josai University, Sakado, Saitama, Japan
    In Vivo 21:715-20. 2007
    ..The cytotoxic activity of trihaloacetylazulenes was correlated to DeltaDeltaH(f) LUMO energy and mu(ESP-W). QSAR may be applicable to predict the cytotoxicity of azulenequinones and trihaloacetylazulenes...
  52. ncbi Inhibition of NO production in LPS-stimulated mouse macrophage-like cells by trihaloacetylazulenes
    Nobuharu Ohshima
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 26:2921-7. 2006
    ..The present study showed the inhibitory effects of trifluoroacetylazulenes and trichloroacetylazulenes on NO production by activated macrophages...
  53. ncbi Resveratrol oligomers are potent MRP1 transport inhibitors
    Malgorzata Bobrowska-Hägerstrand
    Department of Biology, Abo Akademi University, FIN 20520 Abo Turku, Finland
    Anticancer Res 26:2081-4. 2006
    ..Knowledge of the structure-activity relationships of multidrug resistance protein 1 (MRP1, ABCC1) inhibitors may aid in developing potent inhibitors that can be used to circumvent MRP1-mediated multidrug resistance...
  54. ncbi Cytotoxic activity of tropolones against human oral tumor cell lines
    Hidetsugu Wakabayashi
    Faculty of Science, Josai University, Sakado, Saitama, 350 0295, Japan
    Anticancer Res 23:4757-63. 2003
    ..These data suggest that 5-aminotropolone may induce cytotoxicity by radical-mediated redox reaction...
  55. ncbi Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by tropolones
    Keiko Yokoyama
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 24:3917-22. 2004
    ..These data suggested that the inhibitory effect of [21] on NO production might be generated via the inhibition of iNOS expression, rather than a radical-mediated mechanism...
  56. ncbi Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by azulenes
    Kana Hashiba
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 24:3939-44. 2004
    ..These data suggest that the inhibitory effect of [11] may be produced via a mechanism other than iNOS induction and a radical-mediated mechanism...
  57. ncbi 3,5-Dibenzoyl-4-(3-phenoxyphenyl)-1,4-dihydro-2,6-dimethylpyridine (DP7) as a new multidrug resistance reverting agent devoid of effects on vascular smooth muscle contractility
    Simona Saponara
    Istituto di Scienze Farmacologiche, , Via A. Moro 2, 53100 Siena, Italy
    Br J Pharmacol 141:415-22. 2004
    ..In conclusion, DP7 may represent a lead compound for the development of potent dihydropyridine MDR chemosensitizers devoid of vascular effects.British Journal of Pharmacology (2004) 141, 415-422. doi:10.1038/sj.bjp.0705635..
  58. ncbi Phenothiazines as potent modulators of yeast multidrug resistance
    Marcin Kolaczkowski
    Department of Biophysics, , Chalubinskiego 10, , Poland
    Int J Antimicrob Agents 22:279-83. 2003
    ..They were synergistic with the antifungal ketoconazole at micromolar concentrations. The most active phenothiazines contained the amino group at the end of the alkylene chain substituent...
  59. ncbi Reversal of multidrug resistance in mouse lymphoma cells by phenothiazines
    Joseph Molnar
    Department of Microbiology, Albert Szent Gyorgyi Medical University, Szeged, Hungary
    In Vivo 17:145-9. 2003
    ..Our results demonstrate that MDR can be reversed by interaction of various compounds with Pgp or by modification of the membrane structure around the Pgp...
  60. ncbi Effect of a trifluoromethyl ketone on the motility of proton pump-deleted mutant of Escherichia coli strain and its wild-type
    Annamaria Molnar
    Department of Medical Microbiology, Faculty of General Medicine, University of Szeged, Hungary
    In Vivo 18:505-7. 2004
    ..These data suggest that one of the targets of the antibacterial effect of the trifluoromethyl ketone is the proton pump system...
  61. ncbi Inhibition of LPS-stimulated NO production in mouse macrophage-like cells by azulenequinones
    Masayuki Nishishiro
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 25:4157-63. 2005
    ..These data suggest that the inhibitory effect of NO production by compounds [8, 13] might be generated mostly via the inhibition of iNOS expression, rather than the radical-mediated mechanism...
  62. ncbi Phenothiazine maleates stimulate MRP1 transport activity in human erythrocytes
    Olga Wesołowska
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368 Wrocław, Poland
    Biochim Biophys Acta 1720:52-8. 2005
    ..We conclude that phenothiazine maleates probably exert their stimulatory effect on MRP1 by direct interaction with the protein at the site different from the substrate binding site...
  63. ncbi Relationship between electronic structure and cytotoxic activity of azulenes
    Teruo Kurihara
    Department of Chemistry, Faculty of Science, Josai University, Sakado, Saitama, Japan
    In Vivo 20:385-9. 2006
    ..relationship (QSAR) parameters: deltadeltaHf, HOMO energy and muw Whereas, for the other ten compounds [3-5, 7-8, 10, 15-18], the cytotoxic activity might be related to the three QSAR parameters, deltadeltaHf, LUMO energy and muG..
  64. ncbi Relationship between electronic structure and cytotoxic activity of tropolones
    Teruo Kurihara
    Department of Chemistry, Faculty of Science, Josai University, 1 1 Keyakidai, Sakado, Saitama 350 0295, Japan
    In Vivo 20:391-5. 2006
    ..The results of the present study suggest the applicability of theoretical calculations such as frontier molecular orbital, dipole moments and deltadeltaHf in the prediction of the cytotoxic activity of tropolone derivatives...
  65. ncbi Determination of lipid bilayer/water partition coefficient of new phenothiazines using the second derivative of absorption spectra method
    Andrzej Poła
    Department of Biophysics, Wrocław Medical University, ul Chalubinskiego 10, 50 368 Wroclaw, Poland
    Eur J Pharm Sci 21:421-7. 2004
    ..7-fold when length of the alkyl phenothiazine chain was enhanced by addition of the each next one (-CH(2)) group. Substitution of -H atom by -CF(3) group at position 2 of phenothiazine ring results in 3.5-fold increase in K(p) values...
  66. ncbi Tumor-specific cytotoxicity and type of cell death induced by benzocycloheptoxazines in human tumor cell lines
    Hiromi Murayama
    Faculty of Science, Josai University, Sakado, Saitama, Japan
    Anticancer Res 28:1069-78. 2008
    ..These results indicate the diversity of the type of cell death induced by benzocycloheptoxazine derivatives in human tumor cell lines...