Meiji Seika Kaisha

Summary

Organization: Meiji Seika Kaisha
Country: Japan

Top Publications

  1. doi Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain
    Makoto Ishikawa
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    J Med Chem 53:6445-56. 2010
  2. ncbi Phenylimidazole derivatives as new inhibitors of bacterial enoyl-ACP reductase FabK
    Hideo Kitagawa
    Medicinal Chemistry Research Laboratories, Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, Yokohama, Japan
    Bioorg Med Chem Lett 17:4982-6. 2007
  3. ncbi The selective serotonin reuptake inhibitor fluvoxamine suppresses post-feeding hyperactivity induced by food restriction in rats
    Fumikazu Yokoyama
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Pharmacol Biochem Behav 87:98-103. 2007
  4. ncbi Discovery of 4-Pyridone derivatives as specific inhibitors of enoyl-acyl carrier protein reductase (FabI) with antibacterial activity against Staphylococcus aureus
    Sho Takahata
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Yokohama, Japan
    J Antibiot (Tokyo) 60:123-8. 2007
  5. ncbi Identification of marker genes for intestinal immunomodulating effect of a fructooligosaccharide by DNA microarray analysis
    Tomoyuki Fukasawa
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    J Agric Food Chem 55:3174-9. 2007
  6. ncbi Direct evidence that stimulation of neuropeptide Y Y5 receptor activates hypothalamo-pituitary-adrenal axis in conscious rats via both corticotropin-releasing factor- and arginine vasopressin-dependent pathway
    Nobukazu Kakui
    Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, 760 Moro oka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Endocrinology 148:2854-62. 2007
  7. pmc In vitro activities of oral cephem and telithromycin against clinical isolates of major respiratory pathogens in Japan
    Atsuyuki Shimizu
    Pharmaceutical Research Center, Meiji Seika Kaisha, Kanagawa, Japan
    J Korean Med Sci 22:20-5. 2007
  8. ncbi A new class of anti-MRSA and anti-VRE agents: preparation and antibacterial activities of indole-containing compounds
    Yasuo Yamamoto
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Bioorg Med Chem Lett 17:1626-8. 2007
  9. pmc Increase in terminal restriction fragments of Bacteroidetes-derived 16S rRNA genes after administration of short-chain fructooligosaccharides
    Yusuke Nakanishi
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Appl Environ Microbiol 72:6271-6. 2006
  10. pmc Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae
    Sho Takahata
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Antimicrob Agents Chemother 50:3638-45. 2006

Scientific Experts

Detail Information

Publications62

  1. doi Investigation of the histamine H3 receptor binding site. Design and synthesis of hybrid agonists with a lipophilic side chain
    Makoto Ishikawa
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    J Med Chem 53:6445-56. 2010
    ..These results indicated that 36 served as a useful tool for studies on receptor-agonist interactions and drug design...
  2. ncbi Phenylimidazole derivatives as new inhibitors of bacterial enoyl-ACP reductase FabK
    Hideo Kitagawa
    Medicinal Chemistry Research Laboratories, Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, Yokohama, Japan
    Bioorg Med Chem Lett 17:4982-6. 2007
    ..Through SAR studies of our initial hit compound 2-(1H-benz[d]imidazol-2-ylthio)-N-(6-methoxycarbonylbenzo[d]thiazol-2-yl)acetamide, a series of novel phenylimidazole derivatives were discovered as potent FabK inhibitors...
  3. ncbi The selective serotonin reuptake inhibitor fluvoxamine suppresses post-feeding hyperactivity induced by food restriction in rats
    Fumikazu Yokoyama
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Pharmacol Biochem Behav 87:98-103. 2007
    ..01). These results suggest that repeated treatment with fluvoxamine attenuates the hyperactivity, which is exclusively dependent on the substantial reduction in the SA...
  4. ncbi Discovery of 4-Pyridone derivatives as specific inhibitors of enoyl-acyl carrier protein reductase (FabI) with antibacterial activity against Staphylococcus aureus
    Sho Takahata
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Yokohama, Japan
    J Antibiot (Tokyo) 60:123-8. 2007
    ..aureus. In conclusion, we have identified a novel chemical series, 4-pyridone derivatives, as specific inhibitors of FabI with potent antibacterial activity against S. aureus...
  5. ncbi Identification of marker genes for intestinal immunomodulating effect of a fructooligosaccharide by DNA microarray analysis
    Tomoyuki Fukasawa
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    J Agric Food Chem 55:3174-9. 2007
    ....
  6. ncbi Direct evidence that stimulation of neuropeptide Y Y5 receptor activates hypothalamo-pituitary-adrenal axis in conscious rats via both corticotropin-releasing factor- and arginine vasopressin-dependent pathway
    Nobukazu Kakui
    Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, 760 Moro oka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Endocrinology 148:2854-62. 2007
    ....
  7. pmc In vitro activities of oral cephem and telithromycin against clinical isolates of major respiratory pathogens in Japan
    Atsuyuki Shimizu
    Pharmaceutical Research Center, Meiji Seika Kaisha, Kanagawa, Japan
    J Korean Med Sci 22:20-5. 2007
    ..5 mg/L. These results underline the importance of checking the susceptibility and selecting an appropriate antibiotic against target pathogens...
  8. ncbi A new class of anti-MRSA and anti-VRE agents: preparation and antibacterial activities of indole-containing compounds
    Yasuo Yamamoto
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Bioorg Med Chem Lett 17:1626-8. 2007
    ..A new class of indole-containing compounds were prepared by the use of three component reaction and their in vitro antibacterial activities (MIC) were evaluated against Staphylococcus aureus and Enterococcus faecium including MRSA and VRE...
  9. pmc Increase in terminal restriction fragments of Bacteroidetes-derived 16S rRNA genes after administration of short-chain fructooligosaccharides
    Yusuke Nakanishi
    Food and Health R and D Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Appl Environ Microbiol 72:6271-6. 2006
    ..Therefore, the T-RFs derived from Bacteroidetes are good markers of change of murine intestinal microbiota after scFOS administration...
  10. pmc Amino acid substitutions in mosaic penicillin-binding protein 2 associated with reduced susceptibility to cefixime in clinical isolates of Neisseria gonorrhoeae
    Sho Takahata
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Antimicrob Agents Chemother 50:3638-45. 2006
    ..Therefore, three mutations (G545S, I312M, and V316T) in mosaic PBP2 were identified as the amino acid substitutions responsible for reduced susceptibility to cefixime in N. gonorrhoeae...
  11. ncbi Comparative assessment of distribution of blackcurrant anthocyanins in rabbit and rat ocular tissues
    Hitoshi Matsumoto
    Food and Health R and D Laboratories, Meiji Seika Kaisha Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Exp Eye Res 83:348-56. 2006
    ..Our data show clearly that intact forms of BCAs pass thorough the blood-aqueous barrier and blood-retinal barrier in both rats and rabbits...
  12. ncbi Nonsteroidal progesterone receptor ligands (I): synthesis and SAR of new tetrahydronaphthofuranone derivatives
    Rie Shinei
    Pharmaceutical Research Department, Meiji Seika Kaisha, Ltd, Yokohama 222 8567, Japan
    Bioorg Med Chem 14:4850-61. 2006
    ..Further modification of PF1092C may generate compounds of potential pharmacological interest...
  13. ncbi Pharmacological characterization and feeding-suppressive property of FMS586 [3-(5,6,7,8-tetrahydro-9-isopropyl-carbazol-3-yl)-1-methyl-1-(2-pyridin-4-yl-ethyl)-urea hydrochloride], a novel, selective, and orally active antagonist for neuropeptide Y Y5 rec
    Nobukazu Kakui
    Pharmaceutical Research Department, Meiji Seika Kaisha, Ltd, 760, Moro oka cho, Kohoku Ku, Yokohama 222 8567, Japan
    J Pharmacol Exp Ther 317:562-70. 2006
    ....
  14. ncbi Cloning and characterization of saponin hydrolases from Aspergillus oryzae and Eupenicillium brefeldianum
    Manabu Watanabe
    Microbiological Resources and Technology Laboratories, Meiji Seika Kaisha, Ltd, Kanagawa, Japan
    Biosci Biotechnol Biochem 69:2178-85. 2005
    ..These recombinant enzymes hydrolyzed soyasaponin I to soyasapogenol B and triose, and its substrate specificities for glycosides were similar to that of Sdn1, but the specific activities of these enzymes were lower than that of Sdn1...
  15. pmc Crystal structure of cefditoren complexed with Streptococcus pneumoniae penicillin-binding protein 2X: structural basis for its high antimicrobial activity
    Mototsugu Yamada
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Antimicrob Agents Chemother 51:3902-7. 2007
    ..These features likely play a role in the high level of activity of cefditoren against S. pneumoniae...
  16. ncbi Treatment of Pseudomonas aeruginosa biofilms with a combination of fluoroquinolones and fosfomycin in a rat urinary tract infection model
    Takeshi Mikuniya
    Pharmacology Research Labs, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Morooka Cho 760, Kohoku Ku, Yokohama 222 8567, Japan
    J Infect Chemother 13:285-90. 2007
    ..Such combination therapy with PUFX and FOM may be advantageous for treating biofilm-related infectious diseases...
  17. ncbi Microbiological and clinical study of methicillin-resistant Staphylococcus aureus (MRSA) carrying VraS mutation: changes in susceptibility to glycopeptides and clinical significance
    Yoshihisa Kato
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Int J Antimicrob Agents 31:64-70. 2008
    ..On the other hand, arbekacin and vancomycin were effective in all cases. The results indicate the relationship between antimicrobial susceptibility and therapeutic effect...
  18. doi Synthesis and structure-activity relationships of N-aryl-piperidine derivatives as potent (partial) agonists for human histamine H3 receptor
    Makoto Ishikawa
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Bioorg Med Chem 18:5441-8. 2010
    ..Our results indicate that appropriate conformational restriction, that is, by the piperidine spacer moiety, favors specific binding to the human histamine H3 receptor...
  19. doi Metallo-beta-lactamase inhibitory activity of phthalic acid derivatives
    Yukiko Hiraiwa
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama, Japan
    Bioorg Med Chem Lett 19:5162-5. 2009
    ..On the other hand, 3-substituted with 4-hydroxyphenyl phthalic acid derivative displayed a potent combination effect with biapenem (BIPM) against Pseudomonas aeruginosa that produce IMP-1...
  20. ncbi Active uptake of ulifloxacin from plasma to lung that controls its concentration in epithelial lining fluid
    Makoto Aoki
    Applied Pharmacology Research Laboratories, Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, Yokohama, Japan
    Biol Pharm Bull 32:1095-100. 2009
    ..We believe our study will contribute to much better understanding of antibiotic efficacy against pathogens which cause pneumonia...
  21. doi EF6265, a novel inhibitor of activated thrombin-activatable fibrinolysis inhibitor, protects against sepsis-induced organ dysfunction in rats
    Yuko Muto
    Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, Yokohama, Japan
    Crit Care Med 37:1744-9. 2009
    ..We performed the pharmacologic study to assess the effect of EF6265, a specific inhibitor of activated form of TAFI (TAFIa) on sepsis-induced organ dysfunction models...
  22. doi Synthesis of novel di- and tricationic carbapenems with potent anti-MRSA activity
    Takahisa Maruyama
    Process Development Section Kitakami Plant, Meiji Seika Kaisha, Ltd, 3 3 Kita Kougyoudanchi, Kitakami shi, Iwate 024 0012, Japan
    Bioorg Med Chem Lett 19:447-50. 2009
    ..In order to overcome this drawback, we designed and synthesized di- and tricationic carbapenems and finally discovered a novel carbapenem (15i), which exhibited excellent anti-MRSA activity and good water solubility...
  23. doi Novel azalides derived from 16-membered macrolides. Part II: Isolation of the linear 9-formylcarboxylic acid and its sequential macrocyclization with an amino alcohol or an azidoamine
    Tomoaki Miura
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Bioorg Med Chem 16:10129-56. 2008
    ....
  24. doi Contribution of salicylic acid glucosyltransferase, OsSGT1, to chemically induced disease resistance in rice plants
    Kenji Umemura
    Agricultural and Veterinary Research Laboratories, Meiji Seika Kaisha Ltd, Yokohama 222 8567, Japan
    Plant J 57:463-72. 2009
    ..The OsSGT1 gene may contribute to the SA signaling mechanism by inducing up-regulation of SAG in rice plants...
  25. ncbi Cacao liquor proanthocyanidins inhibit lung injury induced by diesel exhaust particles
    A Yasuda
    Food and Health Laboratories, Meiji Seika Kaisha, Ltd, Sakado, Saitama, Japan
    Int J Immunopathol Pharmacol 21:279-88. 2008
    ..These results suggest that CPs inhibit DEP-induced lung injury by reducing oxidative stress, in association with a reduction in the expression of adhesion molecules...
  26. pmc Crystallization and preliminary crystallographic analysis of the transpeptidase domain of penicillin-binding protein 2B from Streptococcus pneumoniae
    Mototsugu Yamada
    Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Acta Crystallogr Sect F Struct Biol Cryst Commun 64:284-8. 2008
    ..39, c = 143.27 A. Diffraction data were collected to 2.4 A resolution using the BL32B2 beamline at SPring-8. The asymmetric unit contains one protein molecule and 63.7% solvent...
  27. doi Pharmacokinetic and pharmacodynamic properties of biapenem, a carbapenem antibiotic, in rat experimental model of severe acute pancreatitis
    Yuko Muto
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Pancreas 36:125-32. 2008
    ..In this study,we modified a rat experimental model of severe acute pancreatitis for antibiotic evaluation, and the effect of biapenem was compared with that of imipenem to determine the usefulness of biapenem...
  28. pmc Comparison of the efficacies of oral beta-lactams in selection of Haemophilus influenzae transformants with mutated ftsI genes
    Sho Takahata
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Antimicrob Agents Chemother 52:1880-3. 2008
    ..Compared to the penicillins and the carbapenem, the cephalosporins showed a wide selection window for the genetic transfer...
  29. doi Design and synthesis of novel leucomycin analogues modified at the C-3 position. Part II: 3-O-(3-Aryl-2-propenyl)leucomycin analogues
    Takeshi Furuuchi
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Yokohama 222 8567, Japan
    Bioorg Med Chem 16:4401-18. 2008
    ..SAR analysis of derivatives modified at the C-3 and C-3'' positions suggested that single modification at C-3 or C-3'' was effective for in vitro antibacterial activity...
  30. pmc Crystal structure of enoyl-acyl carrier protein reductase (FabK) from Streptococcus pneumoniae reveals the binding mode of an inhibitor
    Jun Saito
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Kohoku Ku, Yokohama 222 8567, Japan
    Protein Sci 17:691-9. 2008
    ..We propose that the primary basis of the inhibitory activity is competition with NADH for binding to FabK, which is the first step of the two-step ping-pong catalytic mechanism...
  31. ncbi Mechanisms of rolipram-induced increase in the incidence of mammary adenocarcinoma: histopathological study of a 104-week oral carcinogenicity study in female Sprague-Dawley rats
    Shoji Nishiyama
    General Toxicology Department of Toxicological Research Laboratory, Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, 760 Morooka, Kohoku, Yokohama, 222 0002, Japan
    Arch Toxicol 80:88-97. 2006
    ..These events might cause progression of the mammary gland tissues from hyperplasia to carcinoma...
  32. ncbi Suppressive effects of cacao liquor polyphenols (CLP) on LDL oxidation and the development of atherosclerosis in Kurosawa and Kusanagi-hypercholesterolemic rabbits
    Tohru Kurosawa
    Toxicology Laboratory, Pharmaceutical Development Department, Meiji Seika Kaisha Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Atherosclerosis 179:237-46. 2005
    ..Therefore, CLP suppressed the generation of atherosclerosis, and its antioxidative effect appeared to have an important role in its anti-atherosclerotic activity...
  33. ncbi Absorption and urinary excretion of procyanidin B2 [epicatechin-(4beta-8)-epicatechin] in rats
    Seigo Baba
    Nutritional Science Center, Health Laboratory, Meiji Seika Kaisha, Ltd, Sakado shi, Saitama, Japan
    Free Radic Biol Med 33:142-8. 2002
    ..Moreover, PB2 reduces the accumulation of lipid peroxide in plasma oxidized by copper ions...
  34. ncbi In vitro evaluation of skin sensitivity of povidone-iodine and other antiseptics using a three-dimensional human skin model
    Mieko Nagasawa
    Pharmaceutical Research Center, Meiji Seika Kaisha, Yokohama, Japan
    Dermatology 204:109-13. 2002
    ..The present in vitro study results revealed a correlation with the results of previously conducted in vivo skin irritancy tests using rabbits...
  35. ncbi Differentiation of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae from other H. influenzae strains by a disc method
    Kimiko Ubukata
    Center for Epideniology and Clinical Microbiology, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morookacho, Kohoku Ku, Yokohama 222 8567, Japan
    J Infect Chemother 8:50-8. 2002
    ....
  36. ncbi Catechins and their oligomers linked by C4 --> C8 bonds are major cacao polyphenols and protect low-density lipoprotein from oxidation in vitro
    Naomi Osakabe
    Functional Foods Research and Development Laboratory, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Exp Biol Med (Maywood) 227:51-6. 2002
    ..It is suggested that these compounds contribute to the activity of cacao products to protect LDL from oxidation...
  37. ncbi Absorption and urinary excretion of (-)-epicatechin after administration of different levels of cocoa powder or (-)-epicatechin in rats
    S Baba
    Functional Foods Research and Development Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    J Agric Food Chem 49:6050-6. 2001
    ....
  38. ncbi Up-regulation of carnitine transporters helps maintain tissue carnitine levels in carnitine deficiency induced by pivalic acid
    N Okudaira
    Meiji Seika Kaisha, Ltd, Pharmaceutical Research Center, Yokohama, Japan
    Pharm Res 18:439-45. 2001
    ..The purpose of this study is to determine whether tissue carnitine levels decrease in parallel with plasma levels in carnitine deficiency induced by PVA...
  39. ncbi Thromboxane A(2) synthase inhibitor enhanced antithrombotic efficacy of GPIIb-IIIa receptor antagonist without increasing bleeding
    K I Kawano
    Department of Pharmacology, Hamamatsu University School of Medicine, Hamamatsu 431 3192, Japan
    Eur J Pharmacol 417:217-22. 2001
    ..Therefore, the thromboxane A(2) synthase inhibitor allowed a reduction in the dose level of the platelet integrin GPIIb-IIIa receptor antagonist for cerebral thrombosis, which resulted in a reduced risk of bleeding...
  40. ncbi Mechanisms of fluconazole resistance in Candida albicans isolates from Japanese AIDS patients
    K Maebashi
    Teikyo University Institute of Medical Mycology, 359 Otsuka, Hachioji, Tokyo 192 0395, Japan
    J Antimicrob Chemother 47:527-36. 2001
    ....
  41. ncbi Orally administered delphinidin 3-rutinoside and cyanidin 3-rutinoside are directly absorbed in rats and humans and appear in the blood as the intact forms
    H Matsumoto
    Bioscience Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1 Chiyoda, Sakado shi, Saitama 350 0289, Japan
    J Agric Food Chem 49:1546-51. 2001
    ..11 +/- 0.05% of the dose ingested. These results indicate that 3-O-beta-rutinosyl anthocyanins were directly absorbed and distributed to the blood...
  42. ncbi Analyses of polyphenols in cacao liquor, cocoa, and chocolate by normal-phase and reversed-phase HPLC
    M Natsume
    Functional Foods R and D Laboratory, Meiji Seika Kaisha Ltd, Saitama, Japan
    Biosci Biotechnol Biochem 64:2581-7. 2000
    ....
  43. ncbi A study of the intestinal absorption of an ester-type prodrug, ME3229, in rats: active efflux transport as a cause of poor bioavailability of the active drug
    N Okudaira
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Yokohama, Japan
    J Pharmacol Exp Ther 294:580-7. 2000
    ..Transport of the main metabolite across rat intestinal tissue mounted on an Ussing chamber suggested that an active efflux system pumped out any ionic metabolite(s) present...
  44. ncbi Structural requirements for alkylglycoside-type renal targeting vector
    K Suzuki
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, Yokohama shi, Kanagawa, Japan
    Pharm Res 16:1026-34. 1999
    ..Thus, "alkylglycoside" is considered to be a novel targeting vector for the kidney (1,2). The present study is designed to clarify the structural requirements for alkylglycoside as a renal targeting vector...
  45. ncbi Specific renal delivery of sugar-modified low-molecular-weight peptides
    K Suzuki
    Drug Delivery System Institute, Ltd, Noda shi, Chiba, Japan
    J Pharmacol Exp Ther 288:888-97. 1999
    ..Thus, the renal uptake may not be dependent on derivatives having a cationic nature. We conclude that there is a novel transport mechanism in the kidneys that can be used for the specific renal delivery of glycosylated peptides...
  46. ncbi Rosmarinic acid, a major polyphenolic component of Perilla frutescens, reduces lipopolysaccharide (LPS)-induced liver injury in D-galactosamine (D-GalN)-sensitized mice
    Naomi Osakabe
    Functional Foods Research and Development Laboratory, Meiji Seika Kaisha Ltd, Chiyoda Sakado, Japan
    Free Radic Biol Med 33:798-806. 2002
    ..These results suggest that the liver protection of RA is due to the scavenging or reducing activities-superoxide or peroxynitirite rather than to inhibition of TNF-alpha production...
  47. ncbi Isolation of temperature-sensitive Saccharomyces cerevisiae with a mutation in erg25 for C-4 sterol methyl oxidase
    Hiroshi Nose
    Drug Discovery, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 0002, Japan
    J Antibiot (Tokyo) 55:962-8. 2002
    ..Sequence analysis of the mERG25 mutant indicated three amino acid substitutions in ERG25p, namely N48D, V133A, and F135S. These results indicate that the ERG25 gene product is a new antifungal target...
  48. ncbi Proliferation of intracellular structure corresponding to reduced affinity of fluconazole for cytochrome P-450 in two low-susceptibility strains of Candida albicans isolated from a Japanese AIDS patient
    Kazunori Maebashi
    Teikyo University Institute of Medical Mycology, Hachioji, Tokyo 192 0395, Japan
    Microbiol Immunol 47:117-24. 2003
    ..In addition to the reduced intracellular accumulation, the decreased affinity of fluconazole for CYP in TIMM 3164 and 3165 is assumed to be associated with the fluconazole-resistance phenotype...
  49. ncbi In vitro antioxidative activity of (-)-epicatechin glucuronide metabolites present in human and rat plasma
    Midori Natsume
    Healthcare R and D Laboratories, Meiji Seika Kaisha Ltd, Sakado shi, Saitama 350 0289, Japan
    Free Radic Res 38:1341-8. 2004
    ..In contrast, the other metabolites had light antioxidative activities over the range of physiological concentrations found in plasma...
  50. ncbi Delphinidin-3-rutinoside relaxes the bovine ciliary smooth muscle through activation of ETB receptor and NO/cGMP pathway
    Hitoshi Matsumoto
    Food and Health Laboratories, Meiji Seika Ltd, 5 3 1, Chiyoda, Saitama 350 0289, Japan
    Exp Eye Res 80:313-22. 2005
    ....
  51. ncbi [Type IV secretion system in Helicobacter pylori: comparison with bacterial type III secretion apparatus]
    Jiro Tanaka
    Tanpakushitsu Kakusan Koso 50:36-43. 2005
  52. ncbi A newly synthesized poly(ADP-ribose) polymerase inhibitor, DR2313 [2-methyl-3,5,7,8-tetrahydrothiopyrano[4,3-d]-pyrimidine-4-one]: pharmacological profiles, neuroprotective effects, and therapeutic time window in cerebral ischemia in rats
    Hidemitsu Nakajima
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Moro oka cho, Kohoku Ku, Yokohama 222 8567, Japan
    J Pharmacol Exp Ther 312:472-81. 2005
    ..Thus, a PARP inhibitor like DR2313 may be more useful in treating acute stroke than a free radical scavenger...
  53. ncbi The kanamycin biosynthetic gene cluster from Streptomyces kanamyceticus
    Koji Yanai
    Microbiological Resources and Technology Laboratories, Meiji Seika Kaisha, Ltd, 788 Kayama, Odawara shi, Kanagawa 250 0852, Japan
    J Antibiot (Tokyo) 57:351-4. 2004
  54. pmc In vitro activities of ME1036 (CP5609), a novel parenteral carbapenem, against methicillin-resistant staphylococci
    Mizuyo Kurazono
    Pharmaceutical Research Center, Meiji Seika Kaisha Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Antimicrob Agents Chemother 48:2831-7. 2004
    ..In conclusion, ME1036 demonstrated a broad antibacterial spectrum and high levels of activity in vitro against staphylococci, including beta-lactam-resistant strains...
  55. ncbi Para-position derivatives of fungal anthelmintic cyclodepsipeptides engineered with Streptomyces venezuelae antibiotic biosynthetic genes
    Koji Yanai
    Microbiological Resources and Technology Laboratories, Meiji Seika Kaisha, Ltd, 788 Kayama, Odawara shi, Kanagawa 250 0852, Japan
    Nat Biotechnol 22:848-55. 2004
    ..This fermentation method is environmentally safe and can be used for the industrial scale production of PF1022A derivatives...
  56. pmc Complete sequences of six penicillin-binding protein genes from 40 Streptococcus pneumoniae clinical isolates collected in Japan
    Yumiko Sanbongi
    Pharmaceutical Research Department, Meiji Seika Kaisha Ltd, 760 Morooka cho, Kohoku Ku, Yokohama 222 8567, Japan
    Antimicrob Agents Chemother 48:2244-50. 2004
    ..pneumoniae resistance to beta-lactam antibiotics. Our findings also suggest that the Thr411Ala mutation in PBP 2A may be associated with beta-lactam resistance...
  57. ncbi Orally administered rosmarinic acid is present as the conjugated and/or methylated forms in plasma, and is degraded and metabolized to conjugated forms of caffeic acid, ferulic acid and m-coumaric acid
    Seigo Baba
    Nutritional Science Center, Health and Bioscience Laboratories, Meiji Seika Kaisha, Ltd, 5 3 1, Chiyoda, Sakado shi, Saitama 350 0289, Japan
    Life Sci 75:165-78. 2004
    ....
  58. ncbi SF2809 compounds, novel chymase inhibitors from Dactylosporangium sp. 1. Taxonomy, fermentation, isolation and biological properties
    Masato Tani
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd Morooka Cho 760, Kohoku Ku, Yokohama 222 8567, Japan
    J Antibiot (Tokyo) 57:83-8. 2004
    ..This result indicates that these compounds work as specific chymase inhibitors...
  59. ncbi Rosmarinic acid inhibits epidermal inflammatory responses: anticarcinogenic effect of Perilla frutescens extract in the murine two-stage skin model
    Naomi Osakabe
    Health and Bioscience Laboratories, Meiji Seika Kaisha Ltd, 5 3 1, Chiyoda Sakado 350 0289, Japan
    Carcinogenesis 25:549-57. 2004
    ..Thus, we conclude that part of the anticarcinogenic effects of P.frutescens extract is due to RA via two independent mechanisms: inhibition of the inflammatory response and scavenging of reactive oxygen radicals...
  60. ncbi CP0569, a new broad-spectrum injectable carbapenem. Part 1: synthesis and structure-activity relationships
    Kazuhiro Aihara
    Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760Morooka cho, Kohoku Ku, 222 8567, Yokohama, Japan
    Bioorg Med Chem 11:3475-85. 2003
    ....
  61. ncbi Cloning and overexpression of the avi2 gene encoding a major cellulase produced by Humicola insolens FERM BP-5977
    Tatsuki Moriya
    Microbiological Resources and Technology Laboratories, Meiji Seika Kaisya Ltd, 788 Kayama, Odawara shi 250 0852, Japan
    Biosci Biotechnol Biochem 67:1434-7. 2003
    ..The expression vector pNCE4 containing the avi2 gene was constructed, and this strain was transformed using a protoplast method. As a result, the pNCE4 transformant secreted 8-fold more Avi2 than the recipient strain...
  62. ncbi Effects of polyphenol substances derived from Theobroma cacao on gastric mucosal lesion induced by ethanol
    N Osakabe
    Functional Food Research and Development Laboratories, Meiji Seika Kaisha, Ltd, Saitama, Japan
    Biosci Biotechnol Biochem 62:1535-8. 1998
    ..According to an in vitro study, CWSP directly reducted XOD but not MPO. These results suggest that the antiulcer mechanism of CWSP was not only radical scavenging but also modulation of leukocyte function...