Masayuki Nakanishi

Summary

Affiliation: Matsuyama University
Country: Japan

Publications

  1. ncbi request reprint [S-adenosyl-L-homocysteine hydrolase as an attractive target for antimicrobial drugs]
    Masayuki Nakanishi
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan
    Yakugaku Zasshi 127:977-82. 2007
  2. ncbi request reprint [Activation mechanism of an anti-viral ribonuclease, RNase L]
    Masayuki Nakanishi
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan
    Seikagaku 78:767-70. 2006
  3. ncbi request reprint 4'-Fluorinated carbocyclic nucleosides: synthesis and inhibitory activity against S-adenosyl-L-homocysteine hydrolase
    Yukio Kitade
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan
    Bioorg Med Chem 14:5578-83. 2006
  4. doi request reprint Molecular cloning, expression, characterization and mutation of Plasmodium falciparum guanylate kinase
    Mahmoud Kandeel
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, Japan
    Mol Biochem Parasitol 159:130-3. 2008
  5. doi request reprint Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase
    Takayuki Ando
    Center for Emerging Infectious Diseases, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    Bioorg Med Chem 16:3809-15. 2008
  6. doi request reprint Synthesis of carbocyclic 2-substituted adenine nucleoside and related analogs
    Fazila Zulfiqar
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, Japan
    Nucleosides Nucleotides Nucleic Acids 27:1153-7. 2008
  7. ncbi request reprint Functional characterization of 2',5'-linked oligoadenylate binding determinant of human RNase L
    Masayuki Nakanishi
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    J Biol Chem 280:41694-9. 2005
  8. ncbi request reprint Synthesis of linked triple helical DNAs possessing high affinity to triple helical DNA binding protein
    Aya Shibata
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu 501 1193, Japan
    Bioorg Med Chem Lett 16:1410-3. 2006
  9. ncbi request reprint Mutational analyses of Plasmodium falciparum and human S-adenosylhomocysteine hydrolases
    Masayuki Nakanishi
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    Mol Biochem Parasitol 143:146-51. 2005
  10. ncbi request reprint 2-5A induces a conformational change in the ankyrin-repeat domain of RNase L
    Masayuki Nakanishi
    Laboratory of Molecular Biochemistry, Department of Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, Japan
    Proteins 60:131-8. 2005

Collaborators

Detail Information

Publications13

  1. ncbi request reprint [S-adenosyl-L-homocysteine hydrolase as an attractive target for antimicrobial drugs]
    Masayuki Nakanishi
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan
    Yakugaku Zasshi 127:977-82. 2007
    ....
  2. ncbi request reprint [Activation mechanism of an anti-viral ribonuclease, RNase L]
    Masayuki Nakanishi
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan
    Seikagaku 78:767-70. 2006
  3. ncbi request reprint 4'-Fluorinated carbocyclic nucleosides: synthesis and inhibitory activity against S-adenosyl-L-homocysteine hydrolase
    Yukio Kitade
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Japan
    Bioorg Med Chem 14:5578-83. 2006
    ..4'-beta-Fluoro DHCaA and 2-amino-4'-alpha-fluoro DHCaA demonstrated slight inhibitory activity against human and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase, respectively...
  4. doi request reprint Molecular cloning, expression, characterization and mutation of Plasmodium falciparum guanylate kinase
    Mahmoud Kandeel
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, Japan
    Mol Biochem Parasitol 159:130-3. 2008
    ..These results show that P. falciparum guanylate kinase is structurally and biochemically distinct from other guanylate kinases and could be a possible target in drug development...
  5. doi request reprint Synthesis of 2-modified aristeromycins and their analogs as potent inhibitors against Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase
    Takayuki Ando
    Center for Emerging Infectious Diseases, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    Bioorg Med Chem 16:3809-15. 2008
    ..2-Fluoroaristeromycin showed a strong inhibitory activity against PfSAHH selectively and complete resistance to adenosine deaminase...
  6. doi request reprint Synthesis of carbocyclic 2-substituted adenine nucleoside and related analogs
    Fazila Zulfiqar
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, Japan
    Nucleosides Nucleotides Nucleic Acids 27:1153-7. 2008
    ..2-Iodonoraristeromycin, 2-iodoaristeromycin and related analogs were synthesized to investigate their inhibitory activities against human and Plasmodium falciparum S-adenosyl-L-homocysteine hydrolases...
  7. ncbi request reprint Functional characterization of 2',5'-linked oligoadenylate binding determinant of human RNase L
    Masayuki Nakanishi
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    J Biol Chem 280:41694-9. 2005
    ..It was also found that the crystal structure of the ankyrin repeat domain L.2-5A complex accurately portrays the 2-5A binding mode in full-length RNase L...
  8. ncbi request reprint Synthesis of linked triple helical DNAs possessing high affinity to triple helical DNA binding protein
    Aya Shibata
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu 501 1193, Japan
    Bioorg Med Chem Lett 16:1410-3. 2006
    ..It was found that the triplex, which has an anthraquinonecarbonyl group at the 5'-end of the third strand and is connected with the pentaerythritol linker, has greater affinity to the protein than an unmodified triplex...
  9. ncbi request reprint Mutational analyses of Plasmodium falciparum and human S-adenosylhomocysteine hydrolases
    Masayuki Nakanishi
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, 1 1 Yanagido, Gifu 501 1193, Japan
    Mol Biochem Parasitol 143:146-51. 2005
    ..These results showed that steric hindrance between a functional group at the 2-position of an adenine nucleoside inhibitor and Thr60 of the human enzyme, not an electrostatic effect, contributed to inhibitor selectivity...
  10. ncbi request reprint 2-5A induces a conformational change in the ankyrin-repeat domain of RNase L
    Masayuki Nakanishi
    Laboratory of Molecular Biochemistry, Department of Biomolecular Science, Faculty of Engineering, Gifu University, Gifu, Japan
    Proteins 60:131-8. 2005
    ..These results indicated that the ankyrin-repeat domain of RNase L constricts its structure by binding of 2-5A. This observation suggests a revised model of the 2-5A-induced activation of RNase L...
  11. ncbi request reprint A specific substrate-inhibitor, a 2'-deoxy-2'-fluorouridine-containing oligoribonucleotide, against human RNase L
    Yoshihito Ueno
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido, Gifu, 501 1193, Japan
    Bioorg Med Chem 11:5069-73. 2003
    ..Thus, it was found that the analogue, FF, containing 1 is an efficient inhibitor against human RNase L...
  12. ncbi request reprint Crystal structure of S-adenosyl-L-homocysteine hydrolase from the human malaria parasite Plasmodium falciparum
    Nobutada Tanaka
    School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Mol Biol 343:1007-17. 2004
    ..A replacement of Cys59 by Thr results in mutant PfSAHH, which shows HsSAHH-like nucleoside inhibitor sensitivity. The present structure should provide opportunities to design potent and selective PfSAHH inhibitors...
  13. ncbi request reprint Crystallization and preliminary X-ray crystallographic analysis of Plasmodium falciparum S-adenosyl-L-homocysteine hydrolase
    Nobutada Tanaka
    School of Pharmaceutical Sciences, Showa University, Tokyo 142 8555, Japan
    Protein Pept Lett 11:201-5. 2004
    ..There are four subunits (one tetramer) per asymmetric unit. X-ray diffraction data have been collected up to 2.8 A resolution. Self-rotation function studies suggest that the tetrameric PfSAHH molecule has the 222 point group symmetry...