Yuji Ohtsuki

Summary

Affiliation: Matsuyama-shimin Hospital
Country: Japan

Publications

  1. ncbi Composite paraganglioma and ganglioneuroma in the retroperitoneum: a case report
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan
    Med Mol Morphol 45:168-72. 2012
  2. ncbi Marked infiltration of eosinophils in necrotizing granulomas in the resected hepatic bed after cholecystectomy resulting from gallbladder cancer and metastatic liver cancer is associated with peculiar peripheral eosinophilia
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, 790 0067, Japan
    Med Mol Morphol 45:53-7. 2012
  3. ncbi Immunohistochemical and electron microscopic studies of Langerhans cells in a case of multiple eccrine spiradenomas
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan
    Med Mol Morphol 40:221-5. 2007
  4. ncbi Immunohistochemical distribution of SP-D, compared with that of SP-A and KL-6, in interstitial pneumonias
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime 790 0067, Japan
    Med Mol Morphol 40:163-7. 2007
  5. ncbi KL-6 is another useful marker in assessing a micropapillary pattern in carcinomas of the breast and urinary bladder, but not the colon
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, 790 0067, Japan
    Med Mol Morphol 42:123-7. 2009
  6. ncbi Ultrastructural study of the morphogenesis of human herpesvirus 6 type B in human T-lymphotropic virus type I-producing lymphoid cells
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, 790 0067, Japan
    Med Mol Morphol 41:204-10. 2008
  7. ncbi Immunohistochemical and ultrastructural characterization of the signet-ring cell carcinoma component in a case of urothelial carcinoma of the urinary bladder
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, 790 0067, Japan
    Med Mol Morphol 43:96-101. 2010
  8. ncbi Immunohistochemical and immunoelectron microscopic studies of the localization of KL-6 and epithelial membrane antigen (EMA) in presumably normal pulmonary tissue and in interstitial pneumonia
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan
    Med Mol Morphol 40:198-202. 2007
  9. ncbi A rare case of coexistence of pulmonary adenocarcinoma with Langerhans' cell histiocytosis
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime 790 0067, Japan
    Med Mol Morphol 41:175-8. 2008
  10. ncbi Histochemical demonstration of aluminum and iron deposition in pulmonary bony tissues in three cases of diffuse pulmonary ossification
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan
    Histol Histopathol 23:137-41. 2008

Collaborators

Detail Information

Publications89

  1. ncbi Composite paraganglioma and ganglioneuroma in the retroperitoneum: a case report
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan
    Med Mol Morphol 45:168-72. 2012
    ..The immunohistochemical findings of this rare case of a composite PG and GN in the retroperitoneum are reported with a focus on the peculiar arrangement of these two components...
  2. ncbi Marked infiltration of eosinophils in necrotizing granulomas in the resected hepatic bed after cholecystectomy resulting from gallbladder cancer and metastatic liver cancer is associated with peculiar peripheral eosinophilia
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, 790 0067, Japan
    Med Mol Morphol 45:53-7. 2012
    ..Clinicians as well as pathologists should keep in mind that these peculiar phenomena of eosinophil accumulation surrounding the necrotizing granulomas and peripheral eosinophilia after cholecystectomy could occur...
  3. ncbi Immunohistochemical and electron microscopic studies of Langerhans cells in a case of multiple eccrine spiradenomas
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan
    Med Mol Morphol 40:221-5. 2007
    ..Determination of the significance of these LCs in eccrine spiradenoma requires further investigation of a larger number of cases...
  4. ncbi Immunohistochemical distribution of SP-D, compared with that of SP-A and KL-6, in interstitial pneumonias
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime 790 0067, Japan
    Med Mol Morphol 40:163-7. 2007
    ..In addition, the lymph vessels play a very important role in transfer of KL-6 into the bloodstream...
  5. ncbi KL-6 is another useful marker in assessing a micropapillary pattern in carcinomas of the breast and urinary bladder, but not the colon
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, 790 0067, Japan
    Med Mol Morphol 42:123-7. 2009
    ..This heterogeneity of the MP pattern in various cancers needs to be investigated when more cases have been accumulated...
  6. ncbi Ultrastructural study of the morphogenesis of human herpesvirus 6 type B in human T-lymphotropic virus type I-producing lymphoid cells
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, 790 0067, Japan
    Med Mol Morphol 41:204-10. 2008
    ..Further comparisons of HHV-6B with HHV-6A, HHV-7, and HHV-8 are needed with regard to functional activity...
  7. ncbi Immunohistochemical and ultrastructural characterization of the signet-ring cell carcinoma component in a case of urothelial carcinoma of the urinary bladder
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, 790 0067, Japan
    Med Mol Morphol 43:96-101. 2010
    ..Because UC associated with a sig component carries a worse prognosis than ordinary UC, the presence of the sig component in any UC should be evaluated even within TUR-BT tissues, as in the present case...
  8. ncbi Immunohistochemical and immunoelectron microscopic studies of the localization of KL-6 and epithelial membrane antigen (EMA) in presumably normal pulmonary tissue and in interstitial pneumonia
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan
    Med Mol Morphol 40:198-202. 2007
    ..These findings in pulmonary tissue might be evidence of defense functions...
  9. ncbi A rare case of coexistence of pulmonary adenocarcinoma with Langerhans' cell histiocytosis
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime 790 0067, Japan
    Med Mol Morphol 41:175-8. 2008
    ..The coexistence of adenocarcinoma and LCH appeared to be incidental. The association of adenocarcinoma and LCH is rare, and only several reports of it can be found in the English literature...
  10. ncbi Histochemical demonstration of aluminum and iron deposition in pulmonary bony tissues in three cases of diffuse pulmonary ossification
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan
    Histol Histopathol 23:137-41. 2008
    ....
  11. ncbi Multiple minute nests of incidentally detected paraganglionic cells associated with urothelial carcinoma of the urinary bladder in a 73-year-old woman
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama Ehime 790 0067, Japan
    Med Mol Morphol 41:62-5. 2008
    ..This is the first case of PGCs associated with UC in the human urinary bladder in the English literature...
  12. ncbi Three cases of sclerosing lipogranuloma: an immunohistochemical study
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, 790 0067, and Department of Pathology, Kochi Medical School, Kochi University, Japan
    Med Mol Morphol 40:108-11. 2007
    ..We thus report three cases of SLG including an unusual case in the epidydimal region, with some considerations regarding the histogenesis of SLG...
  13. ncbi Eosinophil infiltration in post-transurethral resection prostatitis and cystitis with special reference to sequential changes of eosinophilia
    Yuji Ohtsuki
    Divisions of Pathology and Urology, Matsuyama Shimin Hospital, Matsuyama, Ehime 790 0067, Japan
    Med Mol Morphol 40:29-33. 2007
    ..Pathologists and urologists should be aware of the potential for increase in eosinophils not only in regions of TUR but also in PB...
  14. ncbi Immunohistochemical and electron microscopy studies of a case of hyalinizing trabecular tumor of the thyroid gland, with special consideration of the hyalinizing mass associated with it
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime 790 0067, Japan
    Med Mol Morphol 42:189-94. 2009
    ..The filiform pattern noted at light microscopic level consisted of long cytoplasmic processes of tumor cells and hyalinized mass at the ultrastructural level...
  15. ncbi Immunohistochemical and electron microscopic studies of a case of duodenal gangliocytic paraganglioma
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime 790 0067, Japan
    Med Mol Morphol 42:245-9. 2009
    ..The immunohistochemical and ultrastructural findings of a case of GPG are reported, focusing on three major cellular components: GCs, ECs, and SCs...
  16. ncbi Carbonic anhydrase-related protein VIII promotes colon cancer cell growth
    Makoto Nishikata
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, Japan
    Mol Carcinog 46:208-14. 2007
    ..These findings indicated that CA-RP VIII plays a role in the growth of colon cancer cells...
  17. ncbi Overexpression of carbonic anhydrase-related protein XI promotes proliferation and invasion of gastrointestinal stromal tumors
    Kaori Morimoto
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi, 783 8505, Japan
    Virchows Arch 447:66-73. 2005
    ..Ectopic expression of CA-RP XI in GIST-T1 cells induced cell proliferation and invasion in vitro. These findings indicate that CA-RP XI plays a role in the development of GIST...
  18. ncbi Establishment of a novel small cell lung carcinoma cell line with specific recoverin expression from a patient with cancer-associated retinopathy
    Makoto Kobayashi
    Department of Haematology, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, and Division of Pathology, Matsuyama Shimin Hospital, Ehime, Japan
    Lung Cancer 56:319-26. 2007
    ..The present study demonstrates that human recoverin is expressed in SCLC cells cultured from an anti-recoverin antibody-negative patient with CAR. KK0206 might be important for further research on SCLC related retinopathy...
  19. ncbi Carbonic anhydrase-related protein VIII increases invasiveness of non-small cell lung adenocarcinoma
    Tsuyoshi Ishihara
    Department of Gastroenterology and Hepatology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan
    Virchows Arch 448:830-7. 2006
    ..CA-RP VIII also appeared to enhance the invasiveness of PC-9 cells in Matrigel invasion assay. The present findings suggest that CA-RP VIII expression in lung adenocarcinoma is related to cancer cell invasion...
  20. ncbi Effect of carbonic anhydrase-related protein VIII expression on lung adenocarcinoma cell growth
    Shu-hui Lu
    Department of Tumor Pathology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan
    Lung Cancer 44:273-80. 2004
    ..The present findings suggest that CA-RP VIII expression promotes progression of lung cancer by multifarious mechanisms...
  21. ncbi Zanthoxyli Fructus induces growth arrest and apoptosis of LNCaP human prostate cancer cells in vitro and in vivo in association with blockade of the AKT and AR signal pathways
    Yang Yang
    Department of Hematology and Respiratory Medicine, Kochi University, Okohcho, Nankoku, Kochi 783-8505, Japan
    Oncol Rep 15:1581-90. 2006
    ..Taken together, Zanthoxyli Fructus might be useful as an adjunctive therapeutic agent for the treatment of individuals with a variety of cancer types...
  22. ncbi An adiponectin receptor, T-cadherin, was selectively expressed in intratumoral capillary endothelial cells in hepatocellular carcinoma: possible cross talk between T-cadherin and FGF-2 pathways
    Yoshihiro Adachi
    Department of Pathology, Kochi Medical School, Nankoku, Kochi, Japan
    Virchows Arch 448:311-8. 2006
    ..In addition, cross talk between the signal pathways mediated by fibroblast growth factor-2 and adiponectin was suggested...
  23. ncbi Expression of carbonic anhydrase-related protein CA-RP VIII in non-small cell lung cancer
    Yousuke Akisawa
    First Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Virchows Arch 442:66-70. 2003
    ..Cancer cells at the front of tumor progression expressed CA-RP VIII in particular abundance. The present findings suggest that CA-RP VIII may play a role in non-small lung cell carcinomas...
  24. ncbi Effect of combination therapy with a novel bisphosphonate, minodronate (YM529), and docetaxel on a model of bone metastasis by human transitional cell carcinoma
    Keiji Inoue
    Department of Urology, Kochi Medical School, Nankoku, Kochi, Japan
    Clin Cancer Res 11:6669-77. 2005
    ..Therefore, in this study, we investigated whether or not a newly developed minodronate, YM529, could prevent osteolytic bone metastasis of human TCC and also enhance the effect of docetaxel in a bone tumor model of athymic nude mice...
  25. ncbi Prognostic significance of serine 392 phosphorylation in overexpressed p53 protein in human esophageal squamous cell carcinoma
    Manabu Matsumoto
    Department of Tumor Pathology, Kochi University, Nankoku, Kochi, Japan
    Oncology 67:143-50. 2004
    ..Little is known, however, about the role of phosphorylation of mutant p53 overexpressed in tumors. The aim of this study is to determine the phosphorylation state of p53 in tumors and its contribution to tumor development...
  26. ncbi Zeb1-mediated T-cadherin repression increases the invasive potential of gallbladder cancer
    Yoshihiro Adachi
    Department of Pathology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    FEBS Lett 583:430-6. 2009
    ..Collagen gel invasion assay showed that T-cadherin was a negative regulator for gallbladder cancer invasion. These findings suggest that Zeb1 represses T-cadherin expression and thus increases the invasive activity of gallbladder cancer...
  27. ncbi Ultrastructural study of nuclear inclusions immunohistochemically positive for surfactant protein A in pulmonary adenocarcinoma with special reference to their morphogenesis
    Shu-hui Lu
    Department of Pathology, Kochi Medical School, Kochi University, Kochi, Japan
    Med Mol Morphol 39:214-20. 2006
    ....
  28. ncbi Overexpression of carbonic anhydrase-related protein VIII in human colorectal cancer
    Eiki Miyaji
    First Department of Internal Medicine, Kochi Medical School, Kochi 783-8505, Japan
    J Pathol 201:37-45. 2003
    ..These findings suggest that CA-RP VIII plays a role in the process of invasion in colorectal cancer...
  29. ncbi Diffuse micronodular pulmonary metastasis of lung adenocarcinoma predicts gefitinib response in association with epidermal growth factor receptor mutations
    Makoto Kobayashi
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
    Anticancer Res 26:1621-6. 2006
    ..Therefore, they are most likely to receive benefits from molecular target drugs such as gefitinib and possibly erlotinib...
  30. ncbi Down-regulation of a novel actin-binding molecule, skeletrophin, in malignant melanoma
    Tamotsu Takeuchi
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Am J Pathol 163:1395-404. 2003
    ..The present findings suggest that skeletrophin may be a novel actin-binding cytoskeleton-related molecule, expression of which is silenced in a considerable number of melanoma specimens...
  31. ncbi Phosphorylation state of tumor-suppressor gene p53 product overexpressed in skin tumors
    Manabu Matsumoto
    Department of Tumor Pathology, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
    Oncol Rep 12:1039-43. 2004
    ..Moreover, the decreased level of the phosphorylation might be characteristic of BCC, but the Ser15 phosphorylation seems to have an influence on BCC development...
  32. ncbi Downregulation of expression of a novel cadherin molecule, T-cadherin, in basal cell carcinoma of the skin
    Tamotsu Takeuchi
    Department of Pathology, Kochi Medical School, Japan
    Mol Carcinog 35:173-9. 2002
    ....
  33. ncbi In vitro Epstein-Barr virus-immortalized lymphoma cell line carrying t(9;14)(p13;q32) chromosome abnormality, derived from splenic lymphoma with villous lymphocytes
    Masanori Daibata
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Kochi, Japan
    Int J Cancer 118:513-7. 2006
    ..The validated SLVL-derived cell line provide a useful model system to study molecular biology of t(9;14)(p13;q32)-bearing B-cell malignancies as well as lymphomagenesis of SLVL in vitro and in vivo...
  34. ncbi Differential gene-expression profiling in the leukemia cell lines derived from indolent and aggressive phases of CD56+ T-cell large granular lymphocyte leukemia
    Masanori Daibata
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi 783 8505, Japan
    Int J Cancer 108:845-51. 2004
    ....
  35. ncbi Skeletrophin, a novel RING molecule controlled by the chromatin remodeling complex, is downregulated in malignant melanoma
    Tamotsu Takeuchi
    Department of Pathology, Kochi Medical School, Kochi 783 8505, Japan
    DNA Cell Biol 24:339-44. 2005
    ..Here, we summarize the characterization of skeletrophin, with emphasis on its biological activity, the disruption of which is linked with melanoma progression...
  36. ncbi Fibroblast growth factor receptor 3 protein expression in urothelial carcinoma of the urinary bladder, exhibiting no association with low-grade and/or non-invasive lesions
    Manabu Matsumoto
    Department of Tumor Pathology, Kochi Medical School, Kochi University, Nankoku, Kochi 783 8505, Japan
    Oncol Rep 12:967-71. 2004
    ..These results suggest that FGFR3 protein expression in bladder cancer is unlikely to affect tumor behavior as a unique single factor...
  37. ncbi Immunohistochemical characterisation of pulmonary hyaline membrane in various types of interstitial pneumonia
    A-Ping Sun
    Department of Pathology, Kochi Medical School, Nankoku, Kochi 783-8505, Japan
    Pathology 35:120-4. 2003
    ..The immunohistochemical characteristics of HM in DAD pattern will aid understanding of the significance of HM formation in IP...
  38. ncbi Frequent phosphorylation at serine 392 in overexpressed p53 protein due to missense mutation in carcinoma of the urinary tract
    Mutsuo Furihata
    Department of Pathology II, Kochi Medical School, Nankoku, Japan
    J Pathol 197:82-8. 2002
    ....
  39. ncbi p53 mutation arising in Arg72 allele in the tumorigenesis and development of carcinoma of the urinary tract
    Mutsuo Furihata
    Department of Pathology II, Kochi Medical School, Nankoku, 783 8505, Japan
    Clin Cancer Res 8:1192-5. 2002
    ..In addition, the relationship between the status of p53 codon 72 polymorphism and clinicopathological factors of this tumor were also analyzed...
  40. ncbi Application of reverse transcription in situ PCR in cancer analysis
    Tamotsu Takeuchi
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Methods Mol Biol 334:169-79. 2006
    ..Here, we introduce the application of RT in situ PCR to detect a hybrid, SYT-SSX messenger RNA in synovial sarcoma. We expect that the principle of this protocol also may be applied to detect other chimeric gene products...
  41. ncbi HIV-1 protease inhibitor induces growth arrest and apoptosis of human prostate cancer LNCaP cells in vitro and in vivo in conjunction with blockade of androgen receptor STAT3 and AKT signaling
    Yang Yang
    Department of Hematology and Respiratory Medicine, Kochi University, Kochi Medical School, Nankoku, Japan
    Cancer Sci 96:425-33. 2005
    ....
  42. ncbi A case of salivary gland-type mixed tumor of the lung differentiating toward type II alveolar epithelial cells in glandular components with a literature review
    Manabu Matsumoto
    Department of Pathology II, Kochi Medical School, Nankoku, Japan
    Virchows Arch 441:618-21. 2002
    ..These findings clearly demonstrate for the first time that glandular epithelial cells in the present salivary gland-type mixed tumor exhibited differentiation toward type II alveolar epithelial cells...
  43. ncbi Micropapillary component of urothelial carcinoma detected in transurethral resection of bladder tumor (TUR-BT) tissues: a case report
    Yuji Ohtsuki
    Division of Pathology, Matsuyama Shimin Hospital, Matsuyama, Ehime, Japan
    Med Mol Morphol 41:113-6. 2008
    ..MPC and MPC components in cancers should be recognized as a marker of poor prognosis, even when detected in less than 10% of UC within TUR-BT tissues, as in the present case...
  44. ncbi Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease
    Tamotsu Takeuchi
    Department of Pathology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Med Mol Morphol 40:115-20. 2007
    ..In the present review, we describe recent progress in research on adiponectin receptors, with emphasis on the unique vascular adiponectin receptor, T-cadherin, and its role in vascular disease...
  45. ncbi Distribution of tumor-infiltrating dendritic cells in human non-small cell lung carcinoma in relation to apoptosis
    Atsushi Kurabayashi
    Department of Tumor Pathology, Kochi Medical School, Kochi, Japan
    Pathol Int 54:302-10. 2004
    ..These findings reveal differences in the in vivo condition between S100DC and CD68MØ in tumors, and suggest there is a relationship between tumor-infiltrating S100DC aggregation and apoptosis in in vivo non-small cell lung cancers...
  46. ncbi Association between inducible nitric oxide synthase expression and p53 status in human esophageal squamous cell carcinoma
    Manabu Matsumoto
    Department of Pathology I, Kochi Medical School, Kochi, Japan
    Oncology 64:90-6. 2003
    ..Our in vivo findings suggest that iNOS activity might be associated with p53 alteration and contribute to tumorigenesis in ESCC...
  47. ncbi Typical nemaline bodies presenting in a patient with polymyositis
    A Ping Sun
    Second Department of Pathology, Kochi Medical School, Kochi 783 8505, Japan
    Med Electron Microsc 35:167-72. 2002
    ..Given the clinical criteria of polymyositis, we believe that the occurrence of nemaline bodies in our patient should be interpreted primarily as an epiphenomenon of primary myopathy...
  48. ncbi Multiple eccrine spiradenomas on the hand, forearm and head
    Hisashi Ohtsuka
    Surgical Division Section of Plastic and Reconstructive Surgery, Ehime University Hospital, Ehime, Japan
    Dermatology 205:401-4. 2002
    ..Ultrastructural observations often showed an intracellular lumen with numerous microvilli in larger pale-staining cells...
  49. ncbi WT1 (Wilms' tumor 1) peptide immunotherapy for renal cell carcinoma
    Tatsuo Iiyama
    Department of Immunology, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Microbiol Immunol 51:519-30. 2007
    ..To our knowledge, this is the first report of WT1 immunotherapy for renal cell carcinoma. Hopefully, the results will stimulate more extensive clinical studies...
  50. ncbi [Sjögren's syndrome with solitary nodular pulmonary amyloidosis]
    Kimiko Sakai
    Department of Respiratory Medicine, Ehime Prefectural Imabari Hospital, 4-5-5, Ishii-cho, Imabari, Ehime, 794-0006, Japan
    Nihon Kokyuki Gakkai Zasshi 42:330-5. 2004
    ..Nodular pulmonary amyloidosis with Sjögren syndrome is very rare condition, and most cases present multiple nodules. As far as is known, this is the first report of a solitary nodule in pulmonary amyloidosis with Sjögren syndrome...
  51. ncbi Overexpression of p53 protein in human tumors
    Keiji Inoue
    Department of Urology, Kochi Medical School, Nankoku, Kochi, Japan
    Med Mol Morphol 45:115-23. 2012
    ....
  52. ncbi Absence of human herpesvirus 8 in lung tissues from Japanese patients with primary pulmonary hypertension
    Masanori Daibata
    Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Kohasu, Okoh-cho, Nankoku, Kochi 783 8505, Japan
    Respir Med 98:1231-2. 2004
  53. ncbi Primary gastric small cell carcinoma: report of a case and review of the literature
    Tsutomu Namikawa
    Department of Tumor Surgery, Kochi Medical School, Kohasu-Okocho, Nankoku, Kochi, 783-8505, Japan
    Med Mol Morphol 38:256-61. 2005
    ..Small cell carcinoma is an aggressive, malignant tumor. Intensive chemotherapy is essential for patient survival even when curative surgical resection is carried out...
  54. ncbi [A case of pulmonary Langerhans' cell histiocytosis]
    Kimiko Sakai
    Department of Respiratory Medicine, Kita-ishikai Uchiyama Hospital, 275-1, Shiromawari, Uchiko-cho, Kita-gun, Ehime, 791-3310, Japan
    Nihon Kokyuki Gakkai Zasshi 41:685-90. 2003
    ..Therefore, these smoking-related diseases may have been superimposed on the LCH in this patient...
  55. ncbi The distribution and number of Leu-7 (CD57) positive cells in lung tissue from patients with pulmonary fibrosis
    Hideo Yamanouchi
    Department of Pathology II, Kochi Medical School, Japan
    Acta Med Okayama 56:83-9. 2002
    ..05). Our present study demonstrates a significant decrease in the number of Leu-7 positive cells in areas of advanced fibrosis. This evidence may partly explain the high incidence of lung cancer associated with pulmonary fibrosis...
  56. ncbi Molecular polymerase chain reaction diagnosis of pulmonary mucormycosis caused by Cunninghamella bertholletiae
    Makoto Kobayashi
    Third Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi, Japan
    Respirology 9:397-401. 2004
    ..In this study, we report a case of pulmonary mucormycosis associated with acute lymphocytic leukaemia caused by Cunninghamella bertholletiae, a rare pathogen...
  57. ncbi Immunohistochemical and fluorescence in situ hybridization studies on noninvasive and invasive extramammary Paget's disease
    Tomonori Hikita
    Kochi Medical School, Kochi University, Matsuyama, Kochi, Japan
    Int J Surg Pathol 20:441-8. 2012
    ..Four patients with dermal invasion were strongly positive for HER-2, although negative results were obtained in the FISH study. Further investigations are required to confirm the results of the FISH study...
  58. ncbi Granulocytic sarcoma of the testis
    Isao Miyoshi
    Department of Medicine, Kochi Medical School, Kochi 738-8505, Japan
    Br J Haematol 124:695. 2004
  59. ncbi Infiltrations of Epstein-Barr virus-carrying cells in granular lymphocyte-proliferative disorders corresponding to chronic active Epstein-Barr virus infection
    Tomoki Takechi
    Department of Pediatrics, Kochi Medical School, Kochi, Japan
    Pediatr Hematol Oncol 19:459-65. 2002
    ..At autopsy, microscopic studies revealed marked infiltrations of LGL in the liver and spleen, and the infiltrating cells were NK-cell immunophenotype. The infiltrated LGLs showed latency I...
  60. ncbi Erythropoietin-producing cerebellar tumour
    Isao Miyoshi
    Department of Medicine, Kochi Medical School, Kochi 783-8505, Japan
    Br J Haematol 125:105. 2004
  61. ncbi Levels of angiogenesis and expression of angiogenesis-related genes are prognostic for organ-specific metastasis of renal cell carcinoma
    Satoshi Fukata
    Department of Urology, Kochi Medical School, Kochi, Japan
    Cancer 103:931-42. 2005
    ..Therefore, MMPs and E-cadherin could be relevant targets for novel therapeutic strategies to control or prevent the metastasis of RCC...
  62. ncbi cDNA cloning and developmental expression of murine carbonic anhydrase-related proteins VIII, X, and XI
    Keisuke Taniuchi
    First Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi 783 8505, Japan
    Brain Res Mol Brain Res 109:207-15. 2002
    ..Although the exact function of CA-RPs is still undefined, these findings suggest an important role of CA-RPs in the CNS...
  63. ncbi [A case of pulmonary carcinomatous lymphangiosis exhibiting multiple patchy opacities, caused by CA 19-9 producing metastatic stomach cancer]
    Kousuke Mori
    Division of Internal Medicine, Syuso Public Hospital, 131 Nyuugawa, Tohyo City, Ehime, 799-1341, Japan
    Nihon Kokyuki Gakkai Zasshi 40:360-4. 2002
    ..In this case, liver metastasis had also occurred with carcinomatous lymphangiosis. This case is very interesting in that type I and II carbohydrate antigens were correlated with blood-borne metastasis...
  64. ncbi Loss of T-cadherin (CDH13, H-cadherin) expression in cutaneous squamous cell carcinoma
    Tamotsu Takeuchi
    Department of Pathology, Kochi Medical School, Kochi, Japan
    Lab Invest 82:1023-9. 2002
    ..These findings suggest that a combination of deletion and aberrant methylation of the T-cadherin gene may play a role in loss of gene expression in a considerable number of invasive cutaneous squamous cell carcinomas...
  65. ncbi Immunohistochemical distribution of epithelioid cell, myofibroblast, and transforming growth factor-beta1 in the granuloma caused by Mycobacterium avium intracellulare complex pulmonary infection
    Jiro Fujita
    First Department of Internal Medicine, Kagawa Medical University, Japan
    Microbiol Immunol 46:67-74. 2002
    ....
  66. ncbi Differences in the immunolocalization of surfactant protein (SP)-A, SP-D, and KL-6 in pulmonary alveolar proteinosis
    Makoto Kobayashi
    Department of Respiratory Medicine, Hosogi Hospital, Kochi, Japan
    Pathol Int 58:203-7. 2008
    ..On western blot the specificity of mAb was shown. In conclusion, this is the first report demonstrating the striking difference in the distribution of SP-A and SP-D in the intra-alveolar substance of a patient with idiopathic PAP...
  67. ncbi Myofibroblasts proliferation of idiopathic and collagen vascular disorders associated nonspecific interstitial pneumonia
    Takashi Niimi
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Science, Nagoya 467 8601, Japan
    Acta Med Okayama 57:33-8. 2003
    ..We found a significantly higher myofibroblast proliferation in the intra-alveolar organization of CVD-NSIP compared to idiopathic NSIP. Clinically, idiopathic NSIP and CVD-NSIP are similar, but are pathologically different...
  68. ncbi High molecular weight vimentin complex is formed after proteolytic digestion of vimentin by caspase-3: detection by sera of patients with interstitial pneumonia
    Jiro Fujita
    First Department of Internal Medicine, Kagawa Medical University, Kagawa 761 0793, Japan
    Microbiol Immunol 47:447-51. 2003
    ..In addition, it is suggested that this high molecular weight vimentin acted as an autoantigen to form anti-vimentin autoantibody in vivo...
  69. ncbi Nonspecific interstitial pneumonia/fibrosis completely recovered by adding cyclophosphamide to corticosteroids
    Nobuki Nanki
    Department of Respiratory Medicine, Mitoyo General Hospital, Kagawa
    Intern Med 41:867-70. 2002
    ..This case demonstrates that the addition of cyclophosphamide to corticosteroids might be a useful treatment for patients with NSIP...
  70. ncbi Giant lamellar bodies in a case of Mycobacterium avium complex lung disease
    A-Ping Sun
    Pathology 34:473-5. 2002
  71. ncbi Pathological analysis of the cavitary wall in Mycobacterium avium intracellulare complex pulmonary infection
    Jiro Fujita
    First Department of Internal Medicine, Kagawa Medical University, Kita-gun
    Intern Med 41:617-21. 2002
    ....
  72. ncbi A study on intraalveolar exudates in acute mycoplasma pneumoniae infection
    Takeo Yoshinouchi
    Department of Internal Medicine II, Nagoya City University, Medical School, Nagoya, Japan
    Acta Med Okayama 56:111-6. 2002
    ..pneumonia, myofibroblasts were not observed. These results suggest that M. pneumonia with intraalveolar exudates responds well to corticosteroid and its intraalveolar lesions apparently differed from those in BOOP...
  73. ncbi Early-phase neutrophilia in cigarette smoke-induced acute eosinophilic pneumonia
    Keisuke Miki
    Department of Internal Medicine, JA Kochi Hospital, Nankoku, Kochi
    Intern Med 42:839-45. 2003
    ..We suggest that IL-8 released from HBECs is involved in neutrophilia in the lung in AEP, and is newly recognized as an important factor in the early phase of AEP development...
  74. ncbi Full-length cytokeratin 8 is released and circulates in patients with non-small cell lung cancer
    Tomoya Ishii
    First Department of Internal Medicine, Faculty of Medicine, Kagawa University, Kagawa, Japan
    Tumour Biol 29:57-62. 2008
    ..The aim is to clarify the dynamics of CK8 during apoptosis in vitro and the nature of circulating CK8 in patients with lung cancer...
  75. ncbi Infrequent alteration in the p53R2 gene in human transitional cell carcinoma of the urinary tract
    Hideki Hayashi
    Division of Urology, Fujisaki Hospital, Saga, Japan
    Pathobiology 71:103-6. 2004
    ..CONCLUSION: This finding provides the in vivo evidence for the infrequent involvement of alterations in p53R2 inhuman urothelial TCCs...
  76. ncbi Establishment of three novel human malignant pleural mesothelioma cell lines: morphological and cytogenetical studies and EGFR mutation status
    Makoto Kobayashi
    Department of Respiratory Medicine, Hosogi Hospital, 37 Daizen cho, Kochi, Kochi 780 8535, Japan
    Anticancer Res 28:197-208. 2008
    ..This paper describes the characterization of novel human malignant pleural mesothelioma cell lines representing the sarcomatoid, epithelioid and biphasic subtypes...
  77. ncbi Concomitant deposition of aluminum and iron in bone marrow trabeculae
    Isao Miyoshi
    Department of Medicine, Kochi University School of Medicine, Kochi
    Intern Med 45:117-8. 2006
  78. ncbi Differing distributions of CXCR3- and CCR4-positive cells among types of interstitial pneumonia associated with collagen vascular diseases
    Shigeki Shimizu
    Department of Internal Medicine and Molecular Science, Nagoya City University Medical School, Kawasumi 1, Mizyho ku, Nagoya, Aichi, 467 8601, Japan
    Virchows Arch 450:51-8. 2007
    ..However, Th1-type immune responses may predominate in RA-IP and PM/DM-IP. Our findings suggest that the pathogenesis of CVD-IPs differs with the helper T cell subset...
  79. ncbi Expression of chemokine receptors CXCR3 and CCR4 in lymphocytes of idiopathic nonspecific interstitial pneumonia
    Takeo Yoshinouchi
    Department of Internal Medicine, Toyokawa City Hospital, Aichi, Japan
    Respir Med 101:1258-64. 2007
    ....
  80. ncbi Renal tuberculosis (mortar kidney)
    Miyoshi Isao
    Department of Medicine, Kochi University School of Medicine, Kochi
    Intern Med 45:111-2. 2006
  81. ncbi Non-specific interstitial pneumonia; as the first clinical presentation of various collagen vascular disorders
    Toshio Sato
    National Okayama Medical Center, Okayama, Japan
    Rheumatol Int 26:551-5. 2006
    ..In these cases, it was difficult to speculate the development of CVD at the point of first presentation. Therefore, association of CVD should be considered in patients with NSIP even in the absence of classical systemic involvement...
  82. ncbi Idiopathic non-specific interstitial pneumonia: as an "autoimmune interstitial pneumonia"
    Jiro Fujita
    First Department of Internal Medicine, Faculty of Medicine, Kagawa University, Ikenobe, Mikicho, Kita gun, Kagawa, Japan
    Respir Med 99:234-40. 2005
    ....
  83. ncbi HIV-1 protease inhibitor, ritonavir: a potent inhibitor of CYP3A4, enhanced the anticancer effects of docetaxel in androgen-independent prostate cancer cells in vitro and in vivo
    Takayuki Ikezoe
    Division of Hematology Oncology, Cedars Sinai Medical Center and UCLA School of Medicine, Los Angeles, California, USA
    Cancer Res 64:7426-31. 2004
    ..In summary, combination therapy of ritonavir and anticancer drugs holds promise for the treatment of individuals with advanced, drug resistant cancers...
  84. ncbi Three cases of non-specific interstitial pneumonia associated with primary lung cancer
    Toshio Sato
    National Okayama Medical Center, Okayama
    Intern Med 43:721-6. 2004
    ..Although the association between lung cancer and NSIP has been rarely documented, this combination was considered to be one of the paraneoplastic phenomena. The possible association between primary lung cancer and NSIP is discussed...
  85. ncbi Distribution of CXCR3- or CCR4-positive cells in interstitial pneumonia associated with primary Sjogren's syndrome
    Shigeki Shimizu
    Department of Pathology, Nagoya City University Medical School, Mizuho ku, 467 8601 Nagoya, Japan
    Virchows Arch 445:477-84. 2004
    ..The present findings suggest that the pathogenesis of interstitial pneumonia is different between SS-IP and IPF in regard to the roles of helper T-cell subsets...
  86. ncbi Lipoma-like tumor mass probably arising in the retroperitoneal heterotopic pancreas: a previously undescribed lesion
    Toshiaki Moriki
    Department of Clinical Laboratory, Kochi Medical School Hospital, Kochi, Japan
    Pathol Int 54:527-31. 2004
    ..The present case is very unusual; however, heterotopic pancreas should be considered in the differential diagnosis of retroperitoneal tumors...
  87. ncbi [A case of adult onset idiopathic pulmonary hemosiderosis markedly improved by steroid therapy]
    Mami Inayama
    Department of Respiratory Medicine, National Hospital Organization Kochi Hospital
    Nihon Kokyuki Gakkai Zasshi 45:971-6. 2007
    ..It may be important to establish a definitive diagnosis early, even in IPH, using VATS, for further effective therapy...
  88. ncbi Psammoma bodies in lung cancer
    Isao Miyoshi
    Department of Medicine, Kochi University School of Medicine
    Intern Med 45:335-6. 2006
  89. ncbi Immunohistochemical localisation of surfactant proteins A and D, and KL-6 in pulmonary alveolar proteinosis
    Yuji Ohtsuki
    Pathology 40:536-9. 2008