Kousaku Matsubara

Summary

Country: Japan

Publications

  1. doi request reprint Long-term follow-up of children with refractory immune thrombocytopenia treated with rituximab
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe, 651 2273, Japan
    Int J Hematol 99:429-36. 2014
  2. doi request reprint Early-onset and late-onset group B streptococcal disease in Japan: a nationwide surveillance study, 2004-2010
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    Int J Infect Dis 17:e379-84. 2013
  3. pmc Development of serum IgM antibodies against superantigens of Staphylococcus aureus and Streptococcus pyogenes in Kawasaki disease
    K Matsubara
    Department of Paediatrics, Nishi Kobe Medical Centre, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    Clin Exp Immunol 143:427-34. 2006
  4. ncbi request reprint Three fatal cases of invasive serotype VI group B streptococcal infection
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    J Infect 53:e139-42. 2006
  5. ncbi request reprint Procedures for prevention of perinatal group B streptococcal diseases: a multicenter questionnaire survey of hospitals in the Kyoto Neonatal Disease Study Group, Japan
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Kobe 651 2273, Japan
    J Infect Chemother 13:59-62. 2007
  6. ncbi request reprint Thrombopoietin in the cerebrospinal fluid of patients with aseptic and bacterial meningitis
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    J Interferon Cytokine Res 25:220-6. 2005
  7. ncbi request reprint Acute lymphoblastic leukemia with coexpression of CD56 and CD57: case report
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    Pediatr Hematol Oncol 21:677-82. 2004
  8. ncbi request reprint Recurrence of occult pneumococcal bacteremia by an identical strain in an apparently healthy child
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    J Infect 54:e87-90. 2007
  9. ncbi request reprint The role of superantigens of group A Streptococcus and Staphylococcus aureus in Kawasaki disease
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, Kobe, Japan
    Curr Opin Infect Dis 20:298-303. 2007
  10. ncbi request reprint Reversible splenial lesion in influenza virus encephalopathy
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, Kobe, Japan
    Pediatr Neurol 37:431-4. 2007

Detail Information

Publications39

  1. doi request reprint Long-term follow-up of children with refractory immune thrombocytopenia treated with rituximab
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe, 651 2273, Japan
    Int J Hematol 99:429-36. 2014
    ..Furthermore, repeated rituximab administration may be a promising therapy for those who relapse after an initial response. ..
  2. doi request reprint Early-onset and late-onset group B streptococcal disease in Japan: a nationwide surveillance study, 2004-2010
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    Int J Infect Dis 17:e379-84. 2013
    ..To clarify the incidence and prognosis of early-onset (EOD) and late-onset (LOD) GBS disease in Japan. To evaluate the influence of national guidelines issued in 2008 on the epidemiology of GBS disease...
  3. pmc Development of serum IgM antibodies against superantigens of Staphylococcus aureus and Streptococcus pyogenes in Kawasaki disease
    K Matsubara
    Department of Paediatrics, Nishi Kobe Medical Centre, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    Clin Exp Immunol 143:427-34. 2006
    ..Our results suggest that multiple superantigens involve in the pathogenesis of KD...
  4. ncbi request reprint Three fatal cases of invasive serotype VI group B streptococcal infection
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    J Infect 53:e139-42. 2006
    ..Our results indicated that type VI GBS is pathogenic for humans not only in fetuses but also adults, and has the ability to be fatal, at least in selected patients...
  5. ncbi request reprint Procedures for prevention of perinatal group B streptococcal diseases: a multicenter questionnaire survey of hospitals in the Kyoto Neonatal Disease Study Group, Japan
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Kobe 651 2273, Japan
    J Infect Chemother 13:59-62. 2007
    ..In light of the above results, a larger study under a unifying protocol would be warranted...
  6. ncbi request reprint Thrombopoietin in the cerebrospinal fluid of patients with aseptic and bacterial meningitis
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    J Interferon Cytokine Res 25:220-6. 2005
    ..6, p < 0.01) and controls (181.3 +/- 88.3, p < 0.01). These findings suggest that TPO is not produced in the CNS of patients with meningitis and that TPO did not cross the blood-brain barrier even during meningeal infection...
  7. ncbi request reprint Acute lymphoblastic leukemia with coexpression of CD56 and CD57: case report
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    Pediatr Hematol Oncol 21:677-82. 2004
    ..The patient received chemotherapy for extremely high-risk ALL with a good response. To the authors' knowledge, this is the first pediatric case describing coexpression of CD56 and CD57 on B-lineage ALL...
  8. ncbi request reprint Recurrence of occult pneumococcal bacteremia by an identical strain in an apparently healthy child
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    J Infect 54:e87-90. 2007
    ..This case indicates that occult bacteremia may recur due to an identical pneumococcal strain in an immunocompetent infant, and that early introduction of pneumococcal conjugate vaccine is necessary in Japan...
  9. ncbi request reprint The role of superantigens of group A Streptococcus and Staphylococcus aureus in Kawasaki disease
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, Kobe, Japan
    Curr Opin Infect Dis 20:298-303. 2007
    ..This article reviews recent publications that address the role of superantigens of group A Streptococcus and Staphylococcus aureus in the pathogenesis of Kawasaki disease...
  10. ncbi request reprint Reversible splenial lesion in influenza virus encephalopathy
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, Kobe, Japan
    Pediatr Neurol 37:431-4. 2007
    ..The results did not reveal any elevations of these cytokines in the sera or cerebrospinal fluid, suggesting that this condition is not mediated by augmented cytokine responses...
  11. ncbi request reprint Severe developmental delay and epilepsy in a Japanese patient with severe congenital neutropenia due to HAX1 deficiency
    K Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, Japan
    Haematologica 92:e123-5. 2007
    ..Growth failure and dental development delay were also noted. Neurodevelopmental delay in this patient expands the clinical phenotype of HAX1 deficiency and suggests an important role of HAX1 on neural development as well as myelopoiesis...
  12. doi request reprint Invasive group B streptococcal infections in a tertiary care hospital between 1998 and 2007 in Japan
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    Int J Infect Dis 13:679-84. 2009
    ..To clarify clinical and microbiological features of invasive group B Streptococcus (GBS) disease in Japan...
  13. doi request reprint Serum thrombopoietin level and thrombocytopenia during the neonatal period in infants with Down's syndrome
    K Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, Kobe, Hyogo, Japan
    J Perinatol 30:98-102. 2010
    ..Objective:To elucidate kinetic changes of serum thrombopoietin (TPO) level and platelet count, and their correlation in DS neonates...
  14. doi request reprint Parvovirus B19-associated hemophagocytic lymphohistiocytosis in a child with precursor B-cell acute lymphoblastic leukemia under maintenance chemotherapy
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, Kobe, Japan
    J Pediatr Hematol Oncol 33:565-9. 2011
    ..To our knowledge, this is the first report describing parvovirus B19-associated HLH in ALL. Our case highlights that parvovirus B19 can cause HLH, a potentially fatal disorder, and prolonged unexpected cytopenia in childhood ALL...
  15. ncbi request reprint Age-dependent changes in the incidence and etiology of childhood thrombocytosis
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, Kobe, Japan
    Acta Haematol 111:132-7. 2004
    ..No child had thromboembolic complications. These findings indicate that childhood thrombocytosis is a benign condition and its incidence and etiology seem to depend on age...
  16. ncbi request reprint [Combination therapy with low-dose cyclosporin A, azathiopurine, and prednisolone for a child with refractory chronic idiopathic thrombocytopenic purpura]
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center
    Rinsho Ketsueki 48:235-9. 2007
    ..There were no adverse events during the therapeutic course. This is the first pediatric case of ITP treated with CsA in Japan. Such combination therapy may be promising and tolerable for childhood ITP with splenectomy failure...
  17. doi request reprint Spinal cord compression by epidural involvement over 21 vertebral levels in acute lymphoblastic leukemia
    Ken Ichi Isome
    Department of Pediatrics, Nishi Kobe Medical Center, Kobe, Japan
    J Pediatr Hematol Oncol 33:153-7. 2011
    ..To our knowledge, this patient has shown the most extensive epidural involvement among ALL patients previously reported...
  18. ncbi request reprint Low incidence of febrile convulsion during the acute phase of Kawasaki disease in Japan
    Hideo Nozaki
    Department of Paediatrics, Nishi Kobe Medical Centre, 5 7 1 Kojidai, Nishi ku, 651 2273 Kobe, Japan
    Eur J Pediatr 164:650. 2005
  19. doi request reprint Recurrent bacterial meningitis by three different pathogens in an isolated asplenic child
    Yoshiko Uchida
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe, 651 2273, Japan
    J Infect Chemother 18:576-80. 2012
    ..Our findings indicate that monitoring of immune responses after natural infections and vaccinations, and reevaluations of vaccine schedule, are important for ICA patients to prevent subsequent invasive infections...
  20. ncbi request reprint [Ultra-late onset group B streptococcal disease--a report of two cases]
    Aya Iwata
    Department of Pediatrics, Nishi Kobe Medical Center
    Kansenshogaku Zasshi 86:604-7. 2012
    ..Our findings suggest that ULOD likely develops combined with underlying host disease, immunological factors and highly virulent strains. Continuous investigation of large numbers of cases is needed to better understand ULOD etiology...
  21. ncbi request reprint [ATIC-ALK-positive anaplastic large cell lymphoma: a case report and review of the literature]
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center
    Rinsho Ketsueki 49:325-30. 2008
    ..In eight of these 10 cases, disease occurred within the first three decades. Five of 6 cases that were followed continuously remained in complete remission...
  22. doi request reprint Methylprednisolone pulse therapy for refractory Mycoplasma pneumoniae pneumonia in children
    Akihiro Tamura
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe, 651 2273, Japan
    J Infect 57:223-8. 2008
    ..To determine the efficacy of methylprednisolone pulse therapy for children with Mycoplasma pneumoniae pneumonia (MP) that is refractory to antibiotic treatment...
  23. ncbi request reprint Seroepidemiologic studies of serotype VIII group B Streptococcus in Japan
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, Kobe, Japan
    J Infect Dis 186:855-8. 2002
    ....
  24. ncbi request reprint [A case of group B streptococcal occult bacteremia]
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, Kobe, Japan
    Kansenshogaku Zasshi 77:461-4. 2003
    ..A high index of suspicion is required for correct diagnosis. Further accumulation of such patients is warranted to establish the appropriate treatment...
  25. doi request reprint Reversible splenial lesion associated with novel influenza A (H1N1) viral infection
    Aya Iwata
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, Kobe 651 2273, Japan
    Pediatr Neurol 42:447-50. 2010
    ..Our findings indicate that pandemic 2009 influenza A (H1N1) infection can cause mild encephalopathy with a reversible lesion in the splenium of the corpus callosum...
  26. pmc Low opsonic activity to the infecting serotype in pediatric patients with invasive pneumococcal disease
    Tomohiro Oishi
    Department of Pediatrics, Niigata University Medical and Dental Hospital, Japan
    Vaccine 31:845-9. 2013
    ..2 μg/ml in sera of pediatric patients with IPD, the OIs were low one month after the IPD episode. Low opsonic activities in these patients may, in part, be explained by the low avidity of serotype-specific IgG...
  27. ncbi request reprint Elevation of serum thrombopoietin precedes thrombocytosis in acute infections
    Akira Ishiguro
    Department of Paediatrics, Mizonokuchi Hospital, Teikyo University School of Medicine, Kawasaki, Japan
    Br J Haematol 116:612-8. 2002
    ..688, P < 0.001) and IL-6 levels (r = 0.481, P = 0.027). These results suggest that TPO contributes to thrombocytosis following infections in conjunction with IL-6, arguing for additional regulatory mechanisms of blood TPO levels...
  28. ncbi request reprint [Seasonal changes of invasive pneumococcal disease in children and association with day care attendance]
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center
    Kansenshogaku Zasshi 86:7-12. 2012
    ..This first peak may, however, be related to circumstances in Japan, where preschool children usually enter day care center or kindergarten in April...
  29. ncbi request reprint [FISH detected 11q23 microdeletion and translocation at the long arm of chromosome 11 in a child with normal karyotypic acute lymphoblastic leukemia]
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center
    Rinsho Ketsueki 45:61-5. 2004
    ..The findings from the present case and recent literature indicate that the FISH-based approach is complementary to conventional cytogenetics, and should be systematically used in childhood ALL at diagnosis...
  30. ncbi request reprint Serum immunoglobulin levels at onset: association with the prognosis of childhood idiopathic thrombocytopenic purpura
    Masaru Kubota
    Department of Pediatrics, Kobe City General Hospital, Kobe, Japan
    Int J Hematol 77:304-7. 2003
    ..In predicting the prognosis of childhood ITP, high serum immunoglobulin levels at initial presentation can be considered a good prognostic marker for the acute form of the disease...
  31. ncbi request reprint [Salmonella enteritidis osteomyelitis of the tibia--a case report and review of literature on Salmonella osteomyelitis of Japanese patients]
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, Kobe, Japan
    Kansenshogaku Zasshi 77:516-20. 2003
    ..Since Salmonella enteritidis has been a leading serotype among human isolates of Salmonella species during the past decade, it would be warranted to determine whether osteomyelitis due to this organism is likely to increase...
  32. ncbi request reprint A randomized study of two long-course prednisolone regimens for nephrotic syndrome in children
    Masahiro Hiraoka
    Department of Pediatrics, Fukui Medical University School of Medicine, Fukui, Japan
    Am J Kidney Dis 41:1155-62. 2003
    ..However, the most beneficial approach among the long-course regimens remains unknown...
  33. doi request reprint Prognostic value of brain injury biomarkers in acute encephalitis/encephalopathy
    Hirokazu Tsukahara
    Department of Pediatrics, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan
    Pediatr Int 55:461-4. 2013
    ..Assessing ongoing brain injury and predicting outcomes using bedside point-of-care testing is expected to be extremely valuable...
  34. ncbi request reprint Clinical study of the time course of clinical symptoms of Pandemic (H1N1) 2009 influenza observed in young adults during an initial epidemic in Kobe, Japan
    Hiroshi Otera
    Department of Respiratory Medicine, Nishi Kobe Medical Center, Japan
    Intern Med 50:1163-7. 2011
    ..In this study, we carefully reviewed the progress of each patient after hospitalization and clarified the clinical course of the symptoms...
  35. ncbi request reprint Acute coalescent mastoiditis and acoustic sequelae in an infant with severe congenital neutropenia
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center, 5 7 1 Kojidai, Nishi ku, 651 2273, Kobe, Japan
    Int J Pediatr Otorhinolaryngol 62:63-7. 2002
    ..Much attention should be given to prompt diagnosis of otomastoiditis in SCN, a rare congenital disorder, since resultant acoustic sequelae may affect subsequent speech development and intellectual ability...
  36. doi request reprint Spontaneous rupture of benign ovarian cystic teratoma in a premenarcheal girl
    Aya Iwata
    Department of Pediatrics, Nishi Kobe Medical Center, Nishi ku, Kobe, Japan
    J Pediatr Adolesc Gynecol 22:e121-3. 2009
    ..Spontaneous rupture of benign cystic ovarian teratoma is an unusual occurrence...
  37. ncbi request reprint [Osteonecroses of the bilateral tali during maintenance therapy in a child with acute lymphoblastic leukemia]
    Hideo Nozaki
    Department of Pediatrics, Nishi Kobe Medical Center
    Rinsho Ketsueki 47:106-10. 2006
    ..Early indication of ALL patients predisposed to genetic, treatment-related risk factors for osteonecrosis and appropriate preventive strategy for such patients await a further multicenter study in Japan...
  38. ncbi request reprint [Childhood acute lymphoblastic leukemia with t(1;19) lacking E2A-pBX1 chimeric transcripts]
    Kousaku Matsubara
    Department of Pediatrics, Nishi Kobe Medical Center
    Rinsho Ketsueki 46:7-12. 2005
    ..However, there was substantial heterogeneity in the demographic features and prognosis. Further accumulation of such patients will facilitate the determination of the appropriate treatment for childhood t(1;19)+E2A-PBX1- ALL...
  39. ncbi request reprint Thrombopoietin in human milk
    Kousaku Matsubara
    Int J Hematol 75:109-10. 2002