Research Topics

Genomes and Genes


Tomoji Ono


Affiliation: Lion Corporation
Country: Japan


  1. Ono T, Morishita S, Fujisaki C, Ohdera M, Murakoshi M, Iida N, et al. Effects of pepsin and trypsin on the anti-adipogenic action of lactoferrin against pre-adipocytes derived from rat mesenteric fat. Br J Nutr. 2011;105:200-11 pubmed publisher
    ..The overall results point to the importance of enteric coating for action of LF as a visceral fat-reducing agent when administered in oral form. ..
  2. Ono T, Murakoshi M, Suzuki N, Iida N, Ohdera M, Iigo M, et al. Potent anti-obesity effect of enteric-coated lactoferrin: decrease in visceral fat accumulation in Japanese men and women with abdominal obesity after 8-week administration of enteric-coated lactoferrin tablets. Br J Nutr. 2010;104:1688-95 pubmed publisher
    ..9 cm; P = 0.073). No adverse effects of the eLF treatment were found with regard to blood lipid or biochemical parameters. From these results, eLF appears to be a promising agent for the control of visceral fat accumulation. ..
  3. request reprint
    Ono T, Fujisaki C, Ishihara Y, Ikoma K, Morishita S, Murakoshi M, et al. Potent lipolytic activity of lactoferrin in mature adipocytes. Biosci Biotechnol Biochem. 2013;77:566-71 pubmed
    ..These data collectively indicate that visceral fat reduction by LF may result from the promotion of lipolysis and the additional anti-adipogenic activity of LF. ..