Affiliation: Lion Corporation
Ono T, Morishita S, Fujisaki C, Ohdera M, Murakoshi M, Iida N, et al
. Effects of pepsin and trypsin on the anti-adipogenic action of lactoferrin against pre-adipocytes derived from rat mesenteric fat. Br J Nutr. 2011;105:200-11 pubmed publisher
..The overall results point to the importance of enteric coating for action of LF as a visceral fat-reducing agent when administered in oral form. ..
Ono T, Murakoshi M, Suzuki N, Iida N, Ohdera M, Iigo M, et al
. Potent anti-obesity effect of enteric-coated lactoferrin: decrease in visceral fat accumulation in Japanese men and women with abdominal obesity after 8-week administration of enteric-coated lactoferrin tablets. Br J Nutr. 2010;104:1688-95 pubmed publisher
..9 cm; P = 0.073). No adverse effects of the eLF treatment were found with regard to blood lipid or biochemical parameters. From these results, eLF appears to be a promising agent for the control of visceral fat accumulation. ..
Ono T, Fujisaki C, Ishihara Y, Ikoma K, Morishita S, Murakoshi M, et al
. Potent lipolytic activity of lactoferrin in mature adipocytes. Biosci Biotechnol Biochem. 2013;77:566-71 pubmed
..These data collectively indicate that visceral fat reduction by LF may result from the promotion of lipolysis and the additional anti-adipogenic activity of LF. ..