E Yukawa

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Influence of age and comedication on steady-state clonazepam serum level-dose ratios in Japanese epileptic patients
    E Yukawa
    Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Clin Pharm Ther 26:375-9. 2001
  2. ncbi request reprint Pharmacoepidemiologic investigation of a clonazepam-carbamazepine interaction by mixed effect modeling using routine clinical pharmacokinetic data in Japanese patients
    E Yukawa
    Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Clin Psychopharmacol 21:588-93. 2001
  3. ncbi request reprint Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients
    Eiji Yukawa
    Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Clin Pharmacokinet 41:153-9. 2002
  4. ncbi request reprint Epidemiologic investigation of the relative clearance of haloperidol by mixed-effect modeling using routine clinical pharmacokinetic data in Japanese patients
    E Yukawa
    Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Clin Psychopharmacol 20:685-90. 2000
  5. ncbi request reprint Investigation of phenobarbital-carbamazepine-valproic acid interactions using population pharmacokinetic analysis for optimisation of antiepileptic drug therapy: an overview
    E Yukawa
    Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Drug Metabol Drug Interact 16:86-98. 2000
  6. ncbi request reprint Population-based investigations of drug relative clearance using nonlinear mixed-effect modelling from information generated during the routine clinical care of patients
    E Yukawa
    Division of Pharmaceutical Sciences, Graduate School, Kyushu University, Fukuoka, Japan
    J Clin Pharm Ther 24:103-13. 1999
  7. ncbi request reprint Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling
    E Yukawa
    Division of Pharmaceutical Sciences, Graduate School, Kyushu University, Fukuoka, Japan
    Eur J Clin Pharmacol 54:69-74. 1998
  8. ncbi request reprint Population pharmacokinetics of digoxin in Japanese patients: a 2-compartment pharmacokinetic model
    E Yukawa
    Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Clin Pharmacokinet 40:773-81. 2001
  9. ncbi request reprint CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics
    K Mamiya
    Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Clin Pharmacol 55:821-5. 2000
  10. ncbi request reprint Pharmacoepidemiologic investigation of a clonazepam-valproic acid interaction by mixed effect modeling using routine clinical pharmacokinetic data in Japanese patients
    E Yukawa
    Laboratory of Evidence based Pharmacotherapy, College of Pharmaceutical Sciences, Daiichi University, Minami Ku, Fukuoka, Japan
    J Clin Pharm Ther 28:497-504. 2003

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Influence of age and comedication on steady-state clonazepam serum level-dose ratios in Japanese epileptic patients
    E Yukawa
    Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Clin Pharm Ther 26:375-9. 2001
    ..It is therefore important to identify factors, such as age and comedication, that could contribute to this observed variability...
  2. ncbi request reprint Pharmacoepidemiologic investigation of a clonazepam-carbamazepine interaction by mixed effect modeling using routine clinical pharmacokinetic data in Japanese patients
    E Yukawa
    Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Clin Psychopharmacol 21:588-93. 2001
    ..Concomitant administration of clonazepam and carbamazepine resulted in a 22% increase in clonazepam clearance and a 20.5% decrease in carbamazepine clearance...
  3. ncbi request reprint Population pharmacokinetics of haloperidol using routine clinical pharmacokinetic data in Japanese patients
    Eiji Yukawa
    Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Clin Pharmacokinet 41:153-9. 2002
    ..To clarify the observed variability of haloperidol disposition in patients with psychiatric disorders...
  4. ncbi request reprint Epidemiologic investigation of the relative clearance of haloperidol by mixed-effect modeling using routine clinical pharmacokinetic data in Japanese patients
    E Yukawa
    Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Clin Psychopharmacol 20:685-90. 2000
    ..Concomitant administration of haloperidol and antiepileptic drugs resulted in a 32% increase in haloperidol clearance. Patients aged 55 years or older showed a 13.3% reduction in clearance values compared with the younger population...
  5. ncbi request reprint Investigation of phenobarbital-carbamazepine-valproic acid interactions using population pharmacokinetic analysis for optimisation of antiepileptic drug therapy: an overview
    E Yukawa
    Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Drug Metabol Drug Interact 16:86-98. 2000
    ....
  6. ncbi request reprint Population-based investigations of drug relative clearance using nonlinear mixed-effect modelling from information generated during the routine clinical care of patients
    E Yukawa
    Division of Pharmaceutical Sciences, Graduate School, Kyushu University, Fukuoka, Japan
    J Clin Pharm Ther 24:103-13. 1999
    ..In this report I describe this approach and its application using several examples previously reported by us and others...
  7. ncbi request reprint Detection of a drug-drug interaction on population-based phenobarbitone clearance using nonlinear mixed-effects modeling
    E Yukawa
    Division of Pharmaceutical Sciences, Graduate School, Kyushu University, Fukuoka, Japan
    Eur J Clin Pharmacol 54:69-74. 1998
    ..4-33.3 years). Patients received phenobarbitone as monotherapy or in combination with either of the antiepileptic drugs carbamazepine or valproic acid...
  8. ncbi request reprint Population pharmacokinetics of digoxin in Japanese patients: a 2-compartment pharmacokinetic model
    E Yukawa
    Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Clin Pharmacokinet 40:773-81. 2001
    ..To clarify the observed variability of digoxin disposition by performing a population pharmacokinetic analysis in a Japanese population...
  9. ncbi request reprint CYP2C19 polymorphism effect on phenobarbitone. Pharmacokinetics in Japanese patients with epilepsy: analysis by population pharmacokinetics
    K Mamiya
    Department of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Clin Pharmacol 55:821-5. 2000
    ..The aim of this study was to clarify the effect of genetic polymorphisms of CYP2C19 on the pharmacokinetics of phenobarbitone (PB) using a nonlinear mixed-effects model (NONMEM) analysis in Japanese adults with epilepsy...
  10. ncbi request reprint Pharmacoepidemiologic investigation of a clonazepam-valproic acid interaction by mixed effect modeling using routine clinical pharmacokinetic data in Japanese patients
    E Yukawa
    Laboratory of Evidence based Pharmacotherapy, College of Pharmaceutical Sciences, Daiichi University, Minami Ku, Fukuoka, Japan
    J Clin Pharm Ther 28:497-504. 2003
    ..Concomitant administration of clonazepam and valproic acid resulted in a 14% increase in clonazepam clearance, and a 17.9% decrease in valproic acid clearance...
  11. ncbi request reprint Population pharmacokinetic investigation of digoxin in Japanese neonates
    E Yukawa
    Laboratory of Evidence based Pharmacotherapy, College of Pharmaceutical Sciences, Daiichi University, Minami Ku, Fukuoka, Japan
    J Clin Pharm Ther 32:381-6. 2007
    ..To establish the role of patient characteristics in estimating doses of digoxin for neonates using routine therapeutic drug monitoring data...
  12. doi request reprint Population pharmacokinetics of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants: an update
    M Yukawa
    Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan ku, Fukuoka, Japan
    J Clin Pharm Ther 36:704-10. 2011
    ..This study was conducted to establish the role of patient characteristics in estimating doses of phenobarbital for neonates and infants using routine therapeutic drug monitoring data...
  13. ncbi request reprint Basis for dosing time-dependent changes in the antiviral activity of interferon-alpha in mice
    S Ohdo
    Department of Clinical Pharmacokinetics, Division of Pharmaceutical Science, Graduate School, Kyushu University, Fukuoka, Japan
    J Pharmacol Exp Ther 294:488-93. 2000
    ....
  14. ncbi request reprint Interindividual variation of serum haloperidol concentrations in Japanese patients--clinical considerations on steady-state serum level-dose ratios
    E Yukawa
    Laboratory of Evidence based Pharmacotherapy, College of Pharmaceutical Sciences, Daiichi University, Fukuoka, Japan
    J Clin Pharm Ther 28:97-101. 2003
    ..Marked interpatient variability in haloperidol (HAL) level-dose (L/D) ratios makes it difficult to use the administered dose for predicting serum concentrations...
  15. ncbi request reprint Population pharmacokinetic investigation of phenobarbital by mixed effect modelling using routine clinical pharmacokinetic data in Japanese neonates and infants
    E Yukawa
    Laboratory of Evidence based Pharmacotherapy, College of Pharmaceutical Sciences, Daiichi University, Fukuoka, Japan
    J Clin Pharm Ther 30:159-63. 2005
    ....
  16. ncbi request reprint Dosing time-dependent tolerance of catalepsy by repetitive administration of haloperidol in mice
    J Viyoch
    Department of Clinical Pharmacokinetics, Division of Pharmaceutical Sciences, Graduate School, Kyushu University, Higashi-ku, Fukuoka, Japan
    J Pharmacol Exp Ther 298:964-9. 2001
    ..These findings demonstrate the importance of dosing time on the susceptibility to extrapyramidal effects and the relation of administration time to D(2) receptor change and tolerance...
  17. ncbi request reprint Population pharmacokinetic investigation of disopyramide by mixed effect modelling using routine clinical pharmacokinetic data in Japanese patients
    E Yukawa
    Laboratory of Evidence based Pharmacotherapy, College of Pharmaceutical Sciences, Daiichi University, Fukuoka, Japan
    J Clin Pharm Ther 30:401-5. 2005
    ..To estimate the population pharmacokinetic parameters of disopyramide using non-linear mixed effects modelling...
  18. ncbi request reprint Effect of CYP2C19 genetic polymorphism on pharmacokinetics of phenytoin and phenobarbital in Japanese epileptic patients using Non-linear Mixed Effects Model approach
    E Yukawa
    Laboratory of Evidence based Pharmacotherapy, College of Pharmaceutical Sciences, Daiichi University, Minami Ku, Fukuoka, Japan
    J Clin Pharm Ther 31:275-82. 2006
    ..To clarify the effect of genetic polymorphism of CYP2C19 on pharmacokinetics of phenytoin and phenobarbital using a Non-linear Mixed Effects Modelling analysis in Japanese epileptic patients...
  19. ncbi request reprint Relationship between diurnal rhythm of cell cycle and interferon receptor expression in implanted-tumor cells
    H Takane
    Department of Clinical Pharmacokinetics, Graduate School, Kyushu University, Fukuoka, Japan
    Life Sci 68:1449-55. 2001
    ..The present result suggests that the rhythm of IFNAR expression is closely related to that of cell cycle distribution in implanted-tumor cells...
  20. ncbi request reprint New and simple method for estimating metildigoxin dosing regimens by multiple trough screen analysis
    E Yukawa
    Division of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Int J Clin Pharmacol Ther 33:605-11. 1995
    ....
  21. ncbi request reprint Phenytoin intoxication induced by fluvoxamine
    K Mamiya
    Hizen National Hospital, Saga, Japan
    Ther Drug Monit 23:75-7. 2001
    ..The interaction may be a result of inhibition of both CYP2C9 and 2C19 by fluvoxamine...
  22. ncbi request reprint Estimation of rhG-CSF absorption kinetics after subcutaneous administration using a modified Wagner-Nelson method with a nonlinear elimination model
    N Hayashi
    Clinical Pharmacology Section, Clinical Research and Development Division, Chugai Pharmaceutical Co, Ltd, Kyobashi 2-Chome, Chuo-ku, 104-8301, Tokyo, Japan
    Eur J Pharm Sci 13:151-8. 2001
    ..The reason for this is probably that the amount eliminated through the saturable process, which might indicate the amount consumed by the G-CSF receptor, was identical for each formulation...