Megumu Yoshimura

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. pmc Actions of brain-derived neurotrophic factor on spinal nociceptive transmission during inflammation in the rat
    Satoru Matayoshi
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    J Physiol 569:685-95. 2005
  2. pmc Cell-type-specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro
    Toshiharu Yasaka
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Physiol 581:603-18. 2007
  3. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
  4. pmc Molecular pain, a new era of pain research and medicine
    Jianguo Gu
    Mol Pain 1:1. 2005
  5. pmc Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 1:34. 2005
  6. ncbi request reprint Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord
    Megumu Yoshimura
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Sci 101:107-17. 2006
  7. ncbi request reprint In vivo and in vitro patch-clamp recording analysis of the process of sensory transmission in the spinal cord and sensory cortex
    Megumu Yoshimura
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Physiol Anthropol Appl Human Sci 24:93-7. 2005
  8. ncbi request reprint [Methods for in vivo patch-clamp recordings and their applications: synaptic responses in somatosensory cortex]
    Megumu Yoshimura
    Nihon Yakurigaku Zasshi 128:381-7. 2006
  9. ncbi request reprint Analysis of receptive fields revealed by in vivo patch-clamp recordings from dorsal horn neurons and in situ intracellular recordings from dorsal root ganglion neurons
    M Yoshimura
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi, Fukuoka 812 8582, Japan
    Life Sci 74:2611-8. 2004
  10. ncbi request reprint Application of in vivo patch-clamp technique to pharmacological analysis of synaptic transmission in the CNS
    Megumu Yoshimura
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nihon Yakurigaku Zasshi 124:111-8. 2004

Detail Information

Publications57

  1. pmc Actions of brain-derived neurotrophic factor on spinal nociceptive transmission during inflammation in the rat
    Satoru Matayoshi
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    J Physiol 569:685-95. 2005
    ..BDNF may thereafter induce monosynaptic Abeta afferents to the SG, thereby developing hyperalgesia and/or allodynia during inflammation...
  2. pmc Cell-type-specific excitatory and inhibitory circuits involving primary afferents in the substantia gelatinosa of the rat spinal dorsal horn in vitro
    Toshiharu Yasaka
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Physiol 581:603-18. 2007
    ..These results make it possible to identify primary afferent circuits associated with particular types of SG neurone...
  3. pmc Recent advances in basic neurosciences and brain disease: from synapses to behavior
    Guo Qiang Bi
    Department of Neurobiology, University of Pittsburgh, Pittsburgh, USA
    Mol Pain 2:38. 2006
    ..The second international meeting on Neurons and Brain Disease will be held in Toronto (August 29-31, 2007)...
  4. pmc Molecular pain, a new era of pain research and medicine
    Jianguo Gu
    Mol Pain 1:1. 2005
    ..Molecular Pain, an Open Access, peer-reviewed, online journal, will provide a forum for molecular pain scientists to communicate their research findings in a targeted manner to others in this important and growing field...
  5. pmc Feed-forward inhibition: a novel cellular mechanism for the analgesic effect of substance P
    Long Jun Wu
    Department of Physiology, Faculty of Medicine, University of Toronto, University of Toronto Centre for the Study of Pain, Medical Science Building, 1 King s College Circle, Toronto, Ontario M5S 1A8, Canada
    Mol Pain 1:34. 2005
    ..It is believed that through this inhibition, substance P can balance nociceptive output from the spinal cord...
  6. ncbi request reprint Mechanisms for the anti-nociceptive actions of the descending noradrenergic and serotonergic systems in the spinal cord
    Megumu Yoshimura
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Sci 101:107-17. 2006
    ....
  7. ncbi request reprint In vivo and in vitro patch-clamp recording analysis of the process of sensory transmission in the spinal cord and sensory cortex
    Megumu Yoshimura
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Physiol Anthropol Appl Human Sci 24:93-7. 2005
    ..These observations suggest that the synaptic responses in cortical neurons are processed in a more complex manner; and this may be due to the reciprocal synaptic connection between thalamus and cortex...
  8. ncbi request reprint [Methods for in vivo patch-clamp recordings and their applications: synaptic responses in somatosensory cortex]
    Megumu Yoshimura
    Nihon Yakurigaku Zasshi 128:381-7. 2006
  9. ncbi request reprint Analysis of receptive fields revealed by in vivo patch-clamp recordings from dorsal horn neurons and in situ intracellular recordings from dorsal root ganglion neurons
    M Yoshimura
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi, Fukuoka 812 8582, Japan
    Life Sci 74:2611-8. 2004
    ..Thus, the in vivo patch-clamp recordings from dorsal horn neurons and the intracellular recordings from DRG neurons will be useful for well understanding the sensory processing in the spinal cord...
  10. ncbi request reprint Application of in vivo patch-clamp technique to pharmacological analysis of synaptic transmission in the CNS
    Megumu Yoshimura
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nihon Yakurigaku Zasshi 124:111-8. 2004
    ..Thus, combinatorial studies with dissociated or cultured neurons or with slice preparations are clearly required for further understanding of pharmacological properties of neurons in the CNS...
  11. doi request reprint Actions of propofol on substantia gelatinosa neurones in rat spinal cord revealed by in vitro and in vivo patch-clamp recordings
    Tomonori Takazawa
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Neurosci 29:518-28. 2009
    ..We conclude that systemic bolus injection of propofol reversibly depressed nociceptive transmission, at least in part, by enhancing postsynaptic GABA(A) receptor-mediated responses in the SG...
  12. doi request reprint TRPA1-expressing primary afferents synapse with a morphologically identified subclass of substantia gelatinosa neurons in the adult rat spinal cord
    Daisuke Uta
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Neurosci 31:1960-73. 2010
    ..The presence of TRPA1 channels on the central terminals raises the possibility of bidirectional modulatory action in morphologically identified subclasses of SG neurons...
  13. ncbi request reprint Slow oscillation of membrane currents mediated by glutamatergic inputs of rat somatosensory cortical neurons: in vivo patch-clamp analysis
    Atsushi Doi
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Eur J Neurosci 26:2565-75. 2007
    ..In addition, GABAergic system in the thalamus can affect the frequency, but is not essentially implicated in the genesis of the slow oscillation...
  14. pmc Direct excitation of deep dorsal horn neurones in the rat spinal cord by the activation of postsynaptic P2X receptors
    Hiroaki Shiokawa
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Japan
    J Physiol 573:753-63. 2006
    ..In addition, the data relating to the developmental increase in the functional P2X receptors suggest that purinergic signalling may thus be more common in somatosensory transmission with maturation...
  15. pmc Actions of noradrenaline on substantia gelatinosa neurones in the rat spinal cord revealed by in vivo patch recording
    Motoki Sonohata
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Physiol 555:515-26. 2004
    ....
  16. ncbi request reprint Reduced pain behaviors and extracellular signal-related protein kinase activation in primary sensory neurons by peripheral tissue injury in mice lacking platelet-activating factor receptor
    Makoto Tsuda
    Department of Molecular and System Pharmacology, Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    J Neurochem 102:1658-68. 2007
    ..Furthermore, U0126, a specific inhibitor of the ERK pathway suppressed the persistent pain by formalin. Thus, PAFR may play an important role in both persistent pain and the sensitization of primary sensory neurons after tissue injury...
  17. ncbi request reprint Tonic inhibitory role of alpha4beta2 subtype of nicotinic acetylcholine receptors on nociceptive transmission in the spinal cord in mice
    Md Harunor Rashid
    Department of Integrative Physiology, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Pain 125:125-35. 2006
    ....
  18. pmc Electrophysiological mapping of the nociceptive inputs to the substantia gelatinosa in rat horizontal spinal cord slices
    Go Kato
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Physiol 560:303-15. 2004
    ..In addition, the widespread distribution of the inhibitory inputs may thus play a role as a lateral inhibitory network and thereby prevent the expansion of the excitatory inputs of noxious stimuli...
  19. ncbi request reprint Direct GABAergic and glycinergic inhibition of the substantia gelatinosa from the rostral ventromedial medulla revealed by in vivo patch-clamp analysis in rats
    Go Kato
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurosci 26:1787-94. 2006
    ..These findings suggest that the RVM-mediated antinociceptive effects on noxious inputs to the SG may be exerted preferentially by the direct GABAergic and glycinergic pathways to the SG...
  20. pmc Bone cancer induces a unique central sensitization through synaptic changes in a wide area of the spinal cord
    Yoshikazu Yanagisawa
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Pain 6:38. 2010
    ..In this study, we examined excitatory synaptic responses evoked in substantia gelatinosa (SG, lamina II) neurons in spinal cord slices of adult mice bearing bone cancer, using whole-cell voltage-clamp recording techniques...
  21. ncbi request reprint Enhancement of GABAergic tonic currents by midazolam and noradrenaline in rat substantia gelatinosa neurons in vitro
    Aiko Maeda
    Department of Anesthesiology, Kyushu University, Fukuoka, Japan
    Anesthesiology 113:429-37. 2010
    ..Thus, the effects of midazolam on extrasynaptic gamma-aminobutyric acid (GABA) type A receptors in substantia gelatinosa neurons and interaction with noradrenaline, a transmitter of the descending inhibitory systems, were investigated...
  22. ncbi request reprint Brain cytokines and the 5-HT system during poly I:C-induced fatigue
    Toshihiko Katafuchi
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Ann N Y Acad Sci 1088:230-7. 2006
    ....
  23. ncbi request reprint [Mechanism of antinociceptive action of calcitonin--involvement of descending serotonergic system]
    Megumu Yoshimura
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University
    Nihon Rinsho 63:211-3. 2005
  24. ncbi request reprint Effects of baclofen on mechanical noxious and innocuous transmission in the spinal dorsal horn of the adult rat: in vivo patch-clamp analysis
    Kaori Fukuhara
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Eur J Neurosci 38:3398-407. 2013
    ....
  25. pmc Selective activation of primary afferent fibers evaluated by sine-wave electrical stimulation
    Kohei Koga
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Mol Pain 1:13. 2005
    ..Thus, the transcutaneous sine-wave stimulation can be applied to evaluate functional changes of sensory transmission by comparing thresholds with the three stimulus frequencies...
  26. ncbi request reprint Enhanced expression of brain interferon-alpha and serotonin transporter in immunologically induced fatigue in rats
    Toshihiko Katafuchi
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Eur J Neurosci 22:2817-26. 2005
    ..These findings, taken together, suggest that disorders in brain IFN-alpha and 5-HTT expression may be involved in the neuronal mechanisms of the poly I:C-induced fatigue...
  27. ncbi request reprint Cytokine-induced suppression of medial preoptic neurons: mechanisms and neuroimmunomodulatory effects
    Toshihiko Katafuchi
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann N Y Acad Sci 1153:76-81. 2009
    ..We suggest that the cytokine-induced decrease in the firing rates of MPO neurons may be a result of an increase in interspike intervals caused by PGE(2)-induced enhancement of KCa in the presence of glutamatergic inputs...
  28. ncbi request reprint Alterations in primary afferent input to substantia gelatinosa of adult rat spinal cord after neonatal capsaicin treatment
    Kun Yang
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurosci Res 74:928-33. 2003
    ..Our electrophysiological data suggest that NCT diminishes primary afferent C-fiber inputs while enhancing Abeta-fiber direct innervation in the SG in adulthood...
  29. ncbi request reprint Involvement of Kv channel subtypes on GABA release in mechanically dissociated neurons from the rat substantia nigra
    Hideki Shimada
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Brain Res 1141:74-83. 2007
    ..Based on the sensitivities of mIPSCs to the Kv channel blockers, we concluded that Kv channels, in particular Kv1.2 subunit play the most significant role in the release of GABA at the presynaptic terminals projecting to the SNr neurons...
  30. ncbi request reprint Somatostatin directly inhibits substantia gelatinosa neurons in adult rat spinal dorsal horn in vitro
    Nan Jiang
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Neurosci Res 47:97-107. 2003
    ....
  31. ncbi request reprint Sensory processing and functional reorganization of sensory transmission under pathological conditions in the spinal dorsal horn
    Hidemasa Furue
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Neurosci Res 48:361-8. 2004
    ..We review here recent results demonstrating plastic changes in SG under pathological conditions...
  32. pmc Presynaptic modulation by neuromedin U of sensory synaptic transmission in rat spinal dorsal horn neurones
    Maiko Moriyama
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashiku, Fukuoka 812 8582, Japan
    J Physiol 559:707-13. 2004
    ..This may account for the spinal mechanisms of the NMU-induced hyperalgesia reported previously...
  33. ncbi request reprint [Spinal anti-nociceptive effect of calcitonin in an osteoporotic model rat--functional recovery of descending serotonergic inhibition]
    Hidemasa Furue
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University
    Clin Calcium 15:163-7. 2005
    ..Inhibitory effect of serotonin on mechanical noxious inputs to dorsal horn neurons was reduced in OVX rats. This mechanical hyperalgesia observation in OVX rats was attenuated by calcitonin treatment...
  34. pmc Responsiveness of C neurons in rat dorsal root ganglion to 5-hydroxytryptamine-induced pruritic stimuli in vivo
    Junichi Hachisuka
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Neurophysiol 104:271-9. 2010
    ..These observations suggest that the long-lasting-firing C neurons in rat DRG sensitive to 5-HT are responsible for conveying pruritic information to the spinal cord...
  35. ncbi request reprint Modulation of glutamate-induced outward current by prostaglandin E(2) in rat dissociated preoptic neurons
    Toshihiko Katafuchi
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582 Japan
    Brain Res 1037:180-6. 2005
    ..The KCa induced by activation of NMDA receptors may serve as a feedback mechanism and the modulatory effects of PGE(2) on the KCa may have an important physiological significance...
  36. pmc Organization of intralaminar and translaminar neuronal connectivity in the superficial spinal dorsal horn
    Go Kato
    Department of Anesthesia, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Neurosci 29:5088-99. 2009
    ..These results reveal a specific three-dimensional organization in the local patterns of excitatory and inhibitory connectivity that has implications for the processing of information related to both somatotopy and sensory modality...
  37. ncbi request reprint Methyl mercaptan production by periodontal bacteria
    Y Nakano
    Department of Preventive Dentistry, Kyushu University Faculty of Dental Science, Fukuoka, Japan
    Int Dent J 52:217-20. 2002
    ..Many papers have reported the periodontal pathogenesis of VSC. It has been argued that methyl mercaptan may play a significant role in the pathogenicity of P. gingivalis...
  38. ncbi request reprint Prolonged effects of polyriboinosinic:polyribocytidylic acid on spontaneous running wheel activity and brain interferon-alpha mRNA in rats: a model for immunologically induced fatigue
    T Katafuchi
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Neuroscience 120:837-45. 2003
    ....
  39. ncbi request reprint [New perspective of chronic pain mechanisms]
    Megumu Yoshimura
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University
    Fukuoka Igaku Zasshi 97:153-9. 2006
  40. doi request reprint Neurotropin reverses paclitaxel-induced neuropathy without affecting anti-tumour efficacy
    Takehiro Kawashiri
    Department of Pharmacy, Kyushu University Hospital, Higashi ku, Fukuoka, Japan
    Eur J Cancer 45:154-63. 2009
    ..These results suggest that neurotropin reverses the paclitaxel-induced neuropathy without affecting anti-tumour activity of paclitaxel, and therefore may be useful for the paclitaxel-induced neuropathy in clinical settings...
  41. ncbi request reprint Pre- and postsynaptic inhibition mediated by GABA(B) receptors in rat ventrolateral periaqueductal gray neurons
    Kun Yang
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 302:233-7. 2003
    ..The overall effects might influence an output of ventrolateral PAG neurons that build up the descending pain control system to the spinal dorsal horn...
  42. ncbi request reprint Comparative study on the actions of toxin extracts from two different puffer fishes on I(Na) and respiratory N-M transmission in the rat
    Sokatsu Yamamoto
    Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 101:173-81. 2010
    ....
  43. ncbi request reprint Endotoxin inhibitor blocks heat exposure-induced expression of brain cytokine mRNA in aged rats
    Toshihiko Katafuchi
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Brain Res Mol Brain Res 118:24-32. 2003
    ....
  44. ncbi request reprint Responses to 5-HT in morphologically identified neurons in the rat substantia gelatinosa in vitro
    K Abe
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Neuroscience 159:316-24. 2009
    ..These findings also suggest that the inward currents are post- and presynaptically evoked through 5-HT(3) receptors, probably in inhibitory neurons...
  45. ncbi request reprint Action of neuropeptide Y on nociceptive transmission in substantia gelatinosa of the adult rat spinal dorsal horn
    A Miyakawa
    Department of Integrative Physiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Neuroscience 134:595-604. 2005
    ..The inhibition of the synaptic transmission from the primary fibers to the substantia gelatinosa neurons is considered to contribute to the antinociceptive effects of NPY...
  46. ncbi request reprint GABA-mediated inhibition of glutamate release during ischemia in substantia gelatinosa of the adult rat
    Noriaki Matsumoto
    Department of Physiology, Saga Medical School, Japan
    J Neurophysiol 89:257-64. 2003
    ..This action might protect SG neurons from an excessive excitation mediated by L-glutamate during ischemia...
  47. ncbi request reprint Anandamide inhibits excitatory transmission to rat substantia gelatinosa neurones in a manner different from that of capsaicin
    Ceng Luo
    Department of Physiology, Saga Medical School, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Neurosci Lett 321:17-20. 2002
    ..It is concluded that unlike capsaicin, anandamide inhibits more effectively Adelta-fibre than C-fibre-mediated excitatory transmission in the SG, possibly through the activation of the cannabinoid receptor...
  48. pmc Direct inhibition of substantia gelatinosa neurones in the rat spinal cord by activation of dopamine D2-like receptors
    Akihiro Tamae
    Department of Physiology, Faculty of Medicine, Saga University, Saga 849 8501, Japan
    J Physiol 568:243-53. 2005
    ..This may be a possible mechanism for antinociception by the descending dopaminergic pathway...
  49. doi request reprint N-ethylmaleimide-sensitive fusion protein (NSF) is involved in central sensitization in the spinal cord through GluR2 subunit composition switch after inflammation
    Tayo Katano
    Department of Medical Chemistry, Kansai Medical University, Moriguchi 570 8506, Japan
    Eur J Neurosci 27:3161-70. 2008
    ..These results suggest that peripheral inflammation gives rise to central sensitization in the spinal cord through subunit composition switch of AMPA receptors in the late phase...
  50. ncbi request reprint [Recent insights into mechanisms for analgesic effect by calcitonin]
    Akitoshi Ito
    Research Center, Asahi Kasei Pharma Co Ltd
    Nihon Rinsho 65:386-90. 2007
  51. ncbi request reprint [Function of spinal GABA receptor and its modulation]
    Megumu Yoshimura
    Columbia University, USA
    Masui 56:S141-51. 2007
  52. ncbi request reprint Alpha 2 adrenoceptor-mediated presynaptic inhibition of primary afferent glutamatergic transmission in rat substantia gelatinosa neurons
    Yasuhiko Kawasaki
    Department of Physiology, Saga Medical School, Japan
    Anesthesiology 98:682-9. 2003
    ..Although intrathecal administration of norepinephrine is known to produce analgesia, cellular mechanisms for this action have not yet been fully understood...
  53. ncbi request reprint [Functional analysis of pain pathway in posterior horn cells using spinal cord slice and in-vivo patch clamp method]
    Megumu Yoshimura
    Masui 51:S79-88. 2002
  54. ncbi request reprint Cadherin-8 is required for the first relay synapses to receive functional inputs from primary sensory afferents for cold sensation
    Sachihiro C Suzuki
    RIKEN Center for Developmental Biology, Chuo Ku, Kobe 650 0047, Japan
    J Neurosci 27:3466-76. 2007
    ..The cad8-/- mice also showed a reduced sensitivity to cold temperature. These results demonstrate that cad8 is essential for establishing the physiological coupling between cold-sensitive sensory neurons and their target DH neurons...
  55. ncbi request reprint Activation of central terminal vanilloid receptor-1 receptors and alpha beta-methylene-ATP-sensitive P2X receptors reveals a converged synaptic activity onto the deep dorsal horn neurons of the spinal cord
    Terumasa Nakatsuka
    McKnight Brain Institute of the University of Florida and Division of Neuroscience, Department of Oral Surgery, College of Dentistry, University of Florida, Gainesville, Florida 32610, USA
    J Neurosci 22:1228-37. 2002
    ..These convergent pathways may provide a mechanism of sensory integration for two chemically defined sensory inputs and may have implications in different sensory states...
  56. ncbi request reprint Changes in properties of substantia gelatinosa neurons after surgical incision in the rat: in vivo patch-clamp analysis
    Mikito Kawamata
    Department of Anesthesiology, Sapporo Medical University School of Medicine, Sapporo, Japan
    Anesthesiology 104:432-40. 2006
    ..In this study, changes in properties of substantia gelatinosa neurons and their sensitivity to systemic administration of lidocaine after surgical incision were investigated using the in vivo patch-clamp technique...
  57. ncbi request reprint [Analysis of hypnotic or analgesic effect of anesthetic agents by in-vivo patch clamp recordings from somatosensory cortex in rats]
    Hiroaki Shiokawa
    University of Chicago, USA
    Masui 56:S99-107. 2007