Akihiko Yoshimura

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi Regulation of TLR signaling and inflammation by SOCS family proteins
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Fukuoka, Japan
    J Leukoc Biol 75:422-7. 2004
  2. ncbi Negative regulation of cytokine signaling
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Clin Rev Allergy Immunol 28:205-20. 2005
  3. ncbi Negative regulation of cytokine signaling and immune responses by SOCS proteins
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Arthritis Res Ther 7:100-10. 2005
  4. ncbi [Induction of SOCS family proteins in inflammatory diseases and suppression of inflammatory arthritis model by the adenovirus gene transfer]
    Akihiko Yoshimura
    Tanpakushitsu Kakusan Koso 47:2355-61. 2002
  5. ncbi SOCS proteins, cytokine signalling and immune regulation
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nat Rev Immunol 7:454-65. 2007
  6. ncbi [Intracellular negative signals and allergy]
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology Medical Institute of Bioregulation, Kyushu University, Japan
    Arerugi 56:563-9. 2007
  7. ncbi Signal transduction of inflammatory cytokines and tumor development
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    Cancer Sci 97:439-47. 2006
  8. ncbi Negative regulation of cytokine signaling influences inflammation
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Curr Opin Immunol 15:704-8. 2003
  9. ncbi FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling
    Ryuichi Mashima
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 280:41289-97. 2005
  10. ncbi An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity
    Hitomi Nishinakamura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int Immunol 19:609-19. 2007

Detail Information

Publications101 found, 100 shown here

  1. ncbi Regulation of TLR signaling and inflammation by SOCS family proteins
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Fukuoka, Japan
    J Leukoc Biol 75:422-7. 2004
    ..In this short review, we focused on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in Toll-like receptor signal regulation and inflammatory diseases...
  2. ncbi Negative regulation of cytokine signaling
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Clin Rev Allergy Immunol 28:205-20. 2005
    ..This article focuses on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases...
  3. ncbi Negative regulation of cytokine signaling and immune responses by SOCS proteins
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Arthritis Res Ther 7:100-10. 2005
    ..In this review we focus on the molecular mechanism of the action of CIS/SOCS family proteins and their roles in immune regulation and inflammatory diseases including rheumatoid arthritis...
  4. ncbi [Induction of SOCS family proteins in inflammatory diseases and suppression of inflammatory arthritis model by the adenovirus gene transfer]
    Akihiko Yoshimura
    Tanpakushitsu Kakusan Koso 47:2355-61. 2002
  5. ncbi SOCS proteins, cytokine signalling and immune regulation
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nat Rev Immunol 7:454-65. 2007
    ..In this Review we bring together data from recent studies on SOCS proteins and their role in immunity, and propose a cohesive model of how cytokine signalling regulates immune-cell function...
  6. ncbi [Intracellular negative signals and allergy]
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology Medical Institute of Bioregulation, Kyushu University, Japan
    Arerugi 56:563-9. 2007
  7. ncbi Signal transduction of inflammatory cytokines and tumor development
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    Cancer Sci 97:439-47. 2006
    ..Hence, the inhibition of NF-kappaB and STATs offers a strategy for treatment of a variety of malignancies and can convert inflammation-induced tumor growth into inflammation-induced tumor regression...
  8. ncbi Negative regulation of cytokine signaling influences inflammation
    Akihiko Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Curr Opin Immunol 15:704-8. 2003
    ..Recently, negative feedback regulation of these pathways, mediated by molecules such as A-20, Smad7 and CIS/SOCS family proteins, has been identified. Negative regulation of cytokine signaling is quite important for inflammation...
  9. ncbi FLN29, a novel interferon- and LPS-inducible gene acting as a negative regulator of toll-like receptor signaling
    Ryuichi Mashima
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 280:41289-97. 2005
    ..Taken together, FLN29 is a new negative feedback regulator of TLR signaling...
  10. ncbi An RNA-binding protein alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB transcriptional activity
    Hitomi Nishinakamura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int Immunol 19:609-19. 2007
    ..7 cells, while small interfering RNA against alphaCP-1 reduced it. These data suggest that alphaCP-1 is involved in the STAT3-mediated suppression of NF-kappaB activity...
  11. ncbi Peptidoglycan and lipopolysaccharide activate PLCgamma2, leading to enhanced cytokine production in macrophages and dendritic cells
    Daisuke Aki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Genes Cells 13:199-208. 2008
    ..Moreover, PLCgamma2 was necessary for the full production of TNF-alpha and IL-6. These data indicate that the PLCgamma2 pathway plays an important role in bacterial ligands-induced activation of macrophages and dendritic cells...
  12. ncbi Loss of suppressor of cytokine signaling 1 in helper T cells leads to defective Th17 differentiation by enhancing antagonistic effects of IFN-gamma on STAT3 and Smads
    Kentaro Tanaka
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 180:3746-56. 2008
    ..SOCS1-deficient T cells will be very useful to investigate the molecular mechanism for the STAT1-mediated suppression of Th17 development...
  13. ncbi Suppressors of cytokine signaling-1 and -3 regulate osteoclastogenesis in the presence of inflammatory cytokines
    Masanobu Ohishi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Faculty of Dental Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 174:3024-31. 2005
    ..Selective suppression of SOCS1 and SOCS3 in osteoclast precursors may be a possible therapeutic strategy for inflammatory bone destruction...
  14. ncbi Prostaglandin E2 is a major soluble factor produced by stromal cells for preventing inflammatory cytokine production from dendritic cells
    Hiroshi Shiraishi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Int Immunol 20:1219-29. 2008
    ....
  15. ncbi Suppressor of cytokine signaling 1 protects mice against concanavalin A-induced hepatitis by inhibiting apoptosis
    Takehiro Torisu
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Hepatology 47:1644-54. 2008
    ..Conclusion: These findings indicate that SOCS1 plays important negative roles in fulminant hepatitis and that forced expression of SOCS1 is therapeutic in preventing hepatitis...
  16. ncbi A major lipid raft protein raftlin modulates T cell receptor signaling and enhances th17-mediated autoimmune responses
    Kazuko Saeki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 182:5929-37. 2009
    ..These data indicate that Raftlin modulates TCR signals and is necessary for the fine-tuning of T cell-mediated immune responses...
  17. ncbi Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1
    Atsuo Sasaki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Cell Cycle 2:281-2. 2003
  18. ncbi Selective expansion of foxp3-positive regulatory T cells and immunosuppression by suppressors of cytokine signaling 3-deficient dendritic cells
    Yumiko Matsumura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 179:2170-9. 2007
    ..These results indicate an important role of SOCS3 in determining on immunity or tolerance by DCs...
  19. ncbi Induction of hyper Th1 cell-type immune responses by dendritic cells lacking the suppressor of cytokine signaling-1 gene
    Toshikatsu Hanada
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 174:4325-32. 2005
    ..We propose that reduction of the SOCS1 gene expression in DCs leads to CD8alpha(+) DC-like phenotype which promotes Th1-type hyperresponses...
  20. ncbi Silencing of SOCS1 in macrophages suppresses tumor development by enhancing antitumor inflammation
    Masayuki Hashimoto
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cancer Sci 100:730-6. 2009
    ..These results suggest that inflammation induced by SOCS1-deficiency in monocytes potentiates antitumor immune responses rather than tumor-promoting inflammation...
  21. ncbi Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism
    Takeru Yoshimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation and Department of Opthalmology, Graduate School of Medical Sciences Kyushu University, Fukuoka, Japan
    J Immunol 177:5377-85. 2006
    ..These data indicated that the preferential activation of STAT3 in fully activated CD4+ T cells plays an important role in the cytokine suppression by IL-27/WSX-1...
  22. ncbi FLN29 deficiency reveals its negative regulatory role in the Toll-like receptor (TLR) and retinoic acid-inducible gene I (RIG-I)-like helicase signaling pathway
    Takahito Sanada
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 283:33858-64. 2008
    ....
  23. ncbi IFNgamma-dependent, spontaneous development of colorectal carcinomas in SOCS1-deficient mice
    Toshikatsu Hanada
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Exp Med 203:1391-7. 2006
    ..These data strongly suggest that SOCS1 is a unique antioncogene which prevents chronic inflammation-mediated carcinogenesis by regulation of the IFNgamma/STAT1 pathways...
  24. ncbi TRAF6 is required for generation of the B-1a B cell compartment as well as T cell-dependent and -independent humoral immune responses
    Takashi Kobayashi
    Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    PLoS ONE 4:e4736. 2009
    ..These results reveal critical roles for TRAF6 in TD and TI humoral immune responses and in inductive fate decisions necessary to generate the B-1 B cell compartment...
  25. ncbi The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization
    Kanta Miyoshi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Oncogene 23:5567-76. 2004
    ..These data suggest that Spreds are key regulators of RhoA-mediated cell motility and signal transduction. Furthermore, our study suggests that the induction of Spreds could be a novel strategy for preventing cancer cell metastasis...
  26. ncbi Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells
    Atsushi Nonami
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 279:52543-51. 2004
    ..These data suggest that Spred-1 negatively regulates hematopoiesis by suppressing not only SCF-induced but also IL-3-induced ERK activation...
  27. ncbi Foxp3 inhibits RORgammat-mediated IL-17A mRNA transcription through direct interaction with RORgammat
    Kenji Ichiyama
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 283:17003-8. 2008
    ..We propose that induction of Foxp3 is the mechanism for the suppression of Th17 and polarization into inducible Treg...
  28. ncbi Ifi202, an IFN-inducible candidate gene for lupus susceptibility in NZB/W F1 mice, is a positive regulator for NF-kappaB activation in dendritic cells
    Moriyasu Yamauchi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Int Immunol 19:935-42. 2007
    ..In addition, forced expression of Ifi202 enhanced IL-12p40 mRNA induction in NZW BMDCs. Thus, Ifi202 is an important NF-kappaB activator in DCs and involved in IL-12 production, which may account for a T(h)1-prone phenotype of BWF1 mice...
  29. ncbi Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1
    Ichiko Kinjyo
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    J Exp Med 203:1021-31. 2006
    ..From these findings, we propose that SOCS3 regulates the production of the immunoregulatory cytokines TGF-beta1 and IL-10 through modulating STAT3 activation...
  30. ncbi The dual function of hepatic SOCS3 in insulin resistance in vivo
    Takehiro Torisu
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, University of Kyushu, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Genes Cells 12:143-54. 2007
    ..We conclude that hepatic SOCS3 is a mediator of insulin resistance in the liver; however, lack of SOCS3 in the liver promotes systemic insulin resistance by mimicking chronic inflammation...
  31. ncbi WSX-1 over-expression in CD4(+) T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation
    Atsunobu Takeda
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    Int Immunol 17:889-97. 2005
    ....
  32. ncbi Loss of mammalian Sprouty2 leads to enteric neuronal hyperplasia and esophageal achalasia
    Takaharu Taketomi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nat Neurosci 8:855-7. 2005
    ..Anti-GDNF antibody administration corrected nerve hyperplasia in Sprouty2-deficient mice. We show Sprouty2 to be a negative regulator of GDNF for the neonatal development or survival of enteric nerve cells...
  33. ncbi The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1
    Atsushi Nonami
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Genes Cells 10:887-95. 2005
    ..Furthermore, forced expression of exogenous Spred-1 in Cav-1-expressing cells further suppressed proliferation and ERK activation. These data suggest that Spred-1 inhibits ERK activation in collaboration with Cav-1...
  34. ncbi TGF-beta1 suppresses IFN-gamma-induced NO production in macrophages by suppressing STAT1 activation and accelerating iNOS protein degradation
    Hiromi Takaki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Genes Cells 11:871-82. 2006
    ..e. suppression of IFN-gamma-induced STAT1 activation by an association of the IFNGR1 with the TGF-betaRI...
  35. ncbi SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling
    Akiko Kimura
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 279:6905-10. 2004
    ..These data indicate that SOCS3 negatively regulates granulopoiesis and G-CSF signaling in neutrophils and may contribute to neutrophilia or neutropenia...
  36. ncbi TRAF6 and MEKK1 play a pivotal role in the RIG-I-like helicase antiviral pathway
    Ryoko Yoshida
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 283:36211-20. 2008
    ..These data suggest that IPS-1 requires TRAF6 and MEKK1 to activate NF-kappaB and mitogen-activated protein kinases that are critical for the optimal induction of type I interferons...
  37. ncbi Deletion of the SOCS3 gene in liver parenchymal cells promotes hepatitis-induced hepatocarcinogenesis
    Hisanobu Ogata
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Graduate School of Medical Science, Kyushu University, Higashiku, Fukuoka, Japan
    Gastroenterology 131:179-93. 2006
    ..We investigated the effect of deleting the SOCS3 gene on the development of hepatitis and HCC in hepatitis C virus-infected patients and mouse models...
  38. ncbi Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity
    Hiroyuki Mori
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nat Med 10:739-43. 2004
    ..Our study demonstrates the negative regulatory role of Socs3 in leptin signaling in vivo, and thus suppression of Socs3 in the brain is a potential therapy for leptin-resistance in obesity...
  39. ncbi Hyperproduction of proinflammatory cytokines by WSX-1-deficient NKT cells in concanavalin A-induced hepatitis
    Atsushi Yamanaka
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Immunol 172:3590-6. 2004
    ..These data revealed a novel role for WSX-1 as an inhibitory regulator of cytokine production and inflammation in Con A-induced hepatitis...
  40. ncbi Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis
    Koji Taniguchi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    PLoS ONE 4:e5467. 2009
    ..These data suggest that Sproutys are physiologically important negative regulators of angiogenesis in vivo and novel therapeutic targets for treating peripheral ischemic diseases...
  41. ncbi SOCS1/JAB is a negative regulator of LPS-induced macrophage activation
    Ichiko Kinjyo
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Immunity 17:583-91. 2002
    ..Thus, SOCS1 directly suppresses TLR4 signaling and modulates innate immunity...
  42. ncbi Sprouty4 deficiency potentiates Ras-independent angiogenic signals and tumor growth
    Koji Taniguchi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Cancer Sci 100:1648-54. 2009
    ..These data indicate that Sprouty4 selectively suppresses Ras-independent angiogenic factor signals and is an important negative regulator of pathophysiological angiogenesis...
  43. ncbi A novel Zinc finger protein, ZCCHC11, interacts with TIFA and modulates TLR signaling
    Yasumasa Minoda
    Division of Molecular and Cellular Immunology, The Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 344:1023-30. 2006
    ..We propose that ZCCHC11 is a unique TLR signal regulator, which interacts with TIFA after LPS treatment and suppresses the TRAF6-dependent activation of NF-kappaB...
  44. ncbi Loss of SOCS3 gene expression converts STAT3 function from anti-apoptotic to pro-apoptotic
    Yang Lu
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 281:36683-90. 2006
    ..These data suggest that prolonged activation of STAT3 could induce apoptosis/growth arrest rather than anti-apoptosis and proliferation in certain cases, and SOCS3 is a critical regulator of this balance...
  45. ncbi Suppressor of cytokine signaling-1 regulates inflammatory bowel disease in which both IFNgamma and IL-4 are involved
    Takatoshi Chinen
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Gastroenterology 130:373-88. 2006
    ..However, the role of SOCS1 in inflammatory bowel diseases (IBDs) has not been clarified. To determine the role of SOCS1 in colitis, we generated SOCS1/T-cell receptor alpha (TCRalpha) double knockout (DKO) mice...
  46. ncbi Adaptor protein SH2-B linking receptor-tyrosine kinase and Akt promotes adipocyte differentiation by regulating peroxisome proliferator-activated receptor gamma messenger ribonucleic acid levels
    Daigo Yoshiga
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Mol Endocrinol 21:1120-31. 2007
    ..These data indicate that SH2-B is a key regulator of adipogenesis both in vivo and in vitro by regulating the insulin/IGF-I receptor-Akt-Foxo1-PPARgamma pathway...
  47. ncbi Differential roles for IFN-gamma and IL-17 in experimental autoimmune uveoretinitis
    Takeru Yoshimura
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Int Immunol 20:209-14. 2008
    ..Taken together, our data demonstrated that IL-17/T(h)17 participates in the late phases of EAU and also that T(h)1 and T(h)17 responses are differentially required for EAU...
  48. ncbi Modulation of TLR signalling by the C-terminal Src kinase (Csk) in macrophages
    Daisuke Aki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Fukuoka 812 8582, Japan
    Genes Cells 10:357-68. 2005
    ..The protein expression levels of a tyrosine kinase, Fgr, were reduced in Csk knockdown cells, suggesting that Csk is a critical regulator of TLR4-mediated signalling by modifying the levels of Src-like kinases...
  49. ncbi Spreds are essential for embryonic lymphangiogenesis by regulating vascular endothelial growth factor receptor 3 signaling
    Koji Taniguchi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Fukuoka, Japan
    Mol Cell Biol 27:4541-50. 2007
    ..These data suggest that Spreds play an important role in lymphatic vessel development by negatively regulating VEGF-C/VEGFR-3 signaling...
  50. ncbi STAT6 Inhibits TGF-beta1-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor
    Hiromi Takaki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582
    J Biol Chem 283:14955-62. 2008
    ..We propose that antagonistic agents for neutralizing IL-4 could be a novel strategy to facilitate inducible Treg cell generation and the promotion of tolerance in Th2-dominated diseases such as allergy...
  51. ncbi Involvement of Th17 cells and the effect of anti-IL-6 therapy in autoimmune uveitis
    Takeru Yoshimura
    Department of Ophthalmology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Rheumatology (Oxford) 48:347-54. 2009
    ..We initially confirmed the significant increase of several inflammatory soluble factors including IL-6 in the vitreous fluids from refractory/chronic engogenous uveitis patients...
  52. ncbi Cyclic adenosine monophosphate suppresses the transcription of proinflammatory cytokines via the phosphorylated c-Fos protein
    Keiko Koga
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Immunity 30:372-83. 2009
    ..Multiple sites of c-Fos were phosphorylated by the IKKbeta protein. Thus, we propose that c-Fos is a substrate of IKKbeta and is responsible for the immunosuppressive effect of cAMP...
  53. ncbi Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness
    Hiromasa Inoue
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    J Exp Med 201:73-82. 2005
    ..These data indicate that Spred-1 negatively controls eosinophil numbers and functions by modulating IL-5 signaling in allergic asthma...
  54. ncbi Suppression of SOCS3 expression in the pancreatic beta-cell leads to resistance to type 1 diabetes
    Hiroyuki Mori
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 359:952-8. 2007
    ..These results suggest that enhanced STAT3 signaling protects beta-cells from destruction induced by a genotoxic stress and that STAT3/SOCS3 can be a potential therapeutic target for the treatment of type 1 diabetes...
  55. ncbi T cell treatment with small interfering RNA for suppressor of cytokine signaling 3 modulates allergic airway responses in a murine model of asthma
    Atsushi Moriwaki
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Am J Respir Cell Mol Biol 44:448-55. 2011
    ..These findings suggest that the therapeutic modulation of SOCS3 expression in CD4(+) T cells might be effective in preventing the development of allergic asthma...
  56. ncbi Suppressor of cytokine signaling-1 is essential for suppressing dendritic cell activation and systemic autoimmunity
    Toshikatsu Hanada
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Immunity 19:437-50. 2003
    ..SOCS1-deficient DCs efficiently stimulated B cell proliferation in vitro and autoantibody production in vivo. These results indicate that SOCS1 plays an essential role in the normal DC functions and suppression of systemic autoimmunity...
  57. ncbi SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis
    Takafumi Yoshida
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Exp Med 199:1701-7. 2004
    ..These findings suggest that SOCS1 contributes to protection against hepatic injury and fibrosis, and may also protect against hepatocarcinogenesis...
  58. ncbi Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1
    Atsuo Sasaki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Nat Cell Biol 5:427-32. 2003
    ..Our results show that receptor tyrosine kinases use distinct pathways for Raf and ERK activation and that Sprouty4 differentially regulates these pathways...
  59. ncbi Sprouty2 and Sprouty4 are essential for embryonic morphogenesis and regulation of FGF signaling
    Koji Taniguchi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 352:896-902. 2007
    ..These findings suggest both redundant and non-redundant functions for Sprouty2 and Sprouty4 on embryonic development and FGF signaling...
  60. ncbi Effects of a Janus kinase inhibitor, pyridone 6, on airway responses in a murine model of asthma
    Yuko Matsunaga
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 404:261-7. 2011
    ..These findings suggest that the JAK inhibitor P6 suppresses asthmatic responses by inhibiting Th2 inflammation and that application of PLGA nanoparticles improves the therapeutic potency of P6...
  61. ncbi Negative regulation of cytokine signaling and inflammatory diseases
    Kyoko Inagaki-Ohara
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Curr Opin Pharmacol 3:435-42. 2003
    ..Several recent advances have been made in this field, including treatment of inflammatory diseases by modulating extracellular and intracellular signaling pathways...
  62. ncbi Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    Atsunobu Takeda
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, and Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 170:4886-90. 2003
    ..Thus, during the initiation of Th1 differentiation, the IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system...
  63. ncbi Regulation of cytokine signaling and inflammation
    Toshitkatsu Hanada
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Cytokine Growth Factor Rev 13:413-21. 2002
    ..Furthermore, we illustrate several approaches for treating inflammatory diseases by modulating extracellular and intracellular signaling pathways...
  64. ncbi [Regulation of cytokine and toll-like receptor signaling by SOCS family genes]
    Hiromi Takagi
    Department of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University
    Nippon Rinsho 62:2189-96. 2004
    ..SOCS3 protein was strongly induced by both IL-6 and IL-10 in the presence of LPS, but selectively inhibited IL-6 signaling. Therefore lack of SOCS3 gene in macrophages resulted in suppression of TLR signaling by hyperactivation of STAT3...
  65. ncbi STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression
    Akiko Joo
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Oncogene 23:726-34. 2004
    ..These data indicate that MITF and STAT3 cooperatively induce c-fos, resulting in cellular transformation...
  66. ncbi Keeping DCs awake by putting SOCS1 to sleep
    Takashi Kobayashi
    Molecular and Cellular Immunology Medical Institute of Bioregulation, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan
    Trends Immunol 26:177-9. 2005
    ..This recent study demonstrates the importance of negative regulation of DC maturation and functions for DC-based immunotherapy...
  67. ncbi Role of endogenous inhibitors of cytokine signaling in allergic asthma
    Hiromasa Inoue
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Curr Med Chem 14:181-9. 2007
    ..Here, we discuss the role of SOCS and SPRED proteins in allergic asthma and explore the potential of these proteins as targets for therapeutic strategies in allergic asthma...
  68. ncbi The apoptotic protease-activating factor 1-mediated pathway of apoptosis is dispensable for negative selection of thymocytes
    Hiromitsu Hara
    Department of Immunology and Technical Support Laboratory, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Immunol 168:2288-95. 2002
    ..We assume that mechanisms for the negative selection are composed of several cell death pathways to avoid failure of elimination of autoreactive clones...
  69. ncbi Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation
    Takafumi Yoshida
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Exp Med 196:641-53. 2002
    ..Additional expression of STAT3 in HCV core-expressing cells resulted in anchorage-independent growth and tumorigenesis. We propose that the HCV core protein cooperates with STAT3, which leads to cellular transformation...
  70. ncbi Inhibition of STAT3 prevents neointima formation by inhibiting proliferation and promoting apoptosis of neointimal smooth muscle cells
    Rei Shibata
    Cardiovascular Research Institute and The Third Department of Internal Medicine, Kurume University School of Medicine, Fukuoka, Japan
    Hum Gene Ther 14:601-10. 2003
    ..In conclusion, the STAT3-mediated pathway plays an important role in neointima formation through enhanced vascular SMC accumulation by promoting cell proliferation and survival...
  71. ncbi STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif
    Mayu Minoguchi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    J Biol Chem 278:11182-9. 2003
    ..These data suggest that STAP-2 is a new class of adaptor molecule that modulates STAT3 activity through its YXXQ motif...
  72. ncbi Pulmonary suppressor of cytokine signaling-1 induced by IL-13 regulates allergic asthma phenotype
    Satoru Fukuyama
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Respir Crit Care Med 179:992-8. 2009
    ....
  73. ncbi The N-terminal truncated isoform of SOCS3 translated from an alternative initiation AUG codon under stress conditions is stable due to the lack of a major ubiquitination site, Lys-6
    Atsuo Sasaki
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 278:2432-6. 2003
    ..Our findings provide strong evidence for the first time that translational control plays an important role in stabilization and function of SOCS3...
  74. ncbi WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production
    Shinjiro Hamano
    The Department of Parasitology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    Immunity 19:657-67. 2003
    ....
  75. ncbi Positive and negative roles of IL-6, STAT3, and SOCS3 in inflammatory arthritis
    Ichiko Kinjyo
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Adv Exp Med Biol 602:113-24. 2007
  76. ncbi The role of the inhibitors of interleukin-6 signal transduction SHP2 and SOCS3 for desensitization of interleukin-6 signalling
    Patrick Fischer
    Department of Biochemistry, Faculty of Medicine, RWTH Aachen, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Biochem J 378:449-60. 2004
    ..Furthermore, cells lacking SOCS3 show constitutive STAT3 activation which is not affected by pre-stimulation with IL-6. All these observations suggest that desensitization and inhibition of signalling are mechanistically distinct...
  77. ncbi SOCS3/CIS3 negative regulation of STAT3 in HGF-induced keratinocyte migration
    Sho Tokumaru
    Department of Dermatology, Ehime University School of Medicine, Ehime, Japan
    Biochem Biophys Res Commun 327:100-5. 2005
    ..In conclusion, SOCS3/CIS3 regulates HGF-induced keratinocyte migration by inhibiting STAT3 phosphorylation...
  78. ncbi Regulation and function of the cytokine-inducible SH-2 domain proteins, CIS and SOCS3, in mammary epithelial cells
    Sibylle Tonko-Geymayer
    Institut für Medizinische Chemie und Biochemie, Abteilung Molekulare Pathophysiologie, Universitat Innsbruck, Austria
    Mol Endocrinol 16:1680-95. 2002
    ....
  79. ncbi Preparation and expression of biologically active prolactin and growth hormone receptors and suppressor of cytokine signaling proteins 1, 2, 3, and 6 tagged with cyan and yellow fluorescent proteins
    Liora Ben-Yair
    Food Science and Nutrition, Faculty of Agricultural, Food and Environmental Quality Sciences, Institute of Biochemistry, The Hebrew University, Rehovot 76100, Israel
    Protein Expr Purif 25:456-64. 2002
    ..Cells transfected with eight of these tagged constructs expressed the fluorescent proteins in both the nucleus and cytosol; the tagged SOCS2 was localized mostly in the latter compartment...
  80. ncbi Suppressors of cytokine signaling and immunity
    Masato Kubo
    Department of Immunobiology, Research Institute for Biological Sciences, Tokyo University of Science, Noda 278-0022, Japan
    Nat Immunol 4:1169-76. 2003
    ..Here we review the function of SOCS1 and SOCS3 in innate and adaptive immunity, with particular emphasis on the relationship between immune regulation and SOCS...
  81. ncbi Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation
    Chiara Berlato
    Department of Pathology, Section of General Pathology, University of Verona, Verona, Italy
    J Immunol 168:6404-11. 2002
    ..Therefore, SOCS-3 functions both as an LPS signal inhibitor and as a negative feedback regulator of IL-10/STAT3 signaling...
  82. ncbi Spred-2 suppresses aorta-gonad-mesonephros hematopoiesis by inhibiting MAP kinase activation
    Ikuo Nobuhisa
    Department of Cell Fate Modulation, Institute of Molecular Embryology and Genetics, Kumamoto University, 2 2 1, Honjo, 860 0811, Japan
    J Exp Med 199:737-42. 2004
    ..These data indicate that Spred-2 functions as a negative regulator of AGM hematopoiesis by inhibiting hematopoietic cytokine signaling...
  83. ncbi Hepatitis C virus down-regulates insulin receptor substrates 1 and 2 through up-regulation of suppressor of cytokine signaling 3
    Takumi Kawaguchi
    Second Department of Medicine, Kurume University School of Medicine 67 Asahi machi, Kurume 830 0011, Japan
    Am J Pathol 165:1499-508. 2004
    ..In conclusion, HCV infection changes a subset of hepatic molecules regulating glucose metabolism. A possible mechanism is that HCV core-induced SOCS3 promotes proteosomal degradation of IRS1 and IRS2 through ubiquitination...
  84. ncbi Target cell defense prevents the development of diabetes after viral infection
    Malin Flodström
    Department of Immunology, IMM 23, The Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA
    Nat Immunol 3:373-82. 2002
    ..Thus, alterations in target cell defenses can critically influence susceptibility to disease...
  85. ncbi SH2-B is required for both male and female reproduction
    Satoshi Ohtsuka
    Division of Molecular Genetics, Institute of Life Science, Kurume University, Kurume 839 0861, USA
    Mol Cell Biol 22:3066-77. 2002
    ..SH2-B(-/-) cumulus cells do not respond to either follicle-stimulating hormone or IGF-I. These data suggest that SH2-B plays a critical role in the IGF-I-mediated reproductive pathway in mice...
  86. ncbi Recombinant human CIS2 (SOCS2) protein: subcloning, expression, purification, and characterization
    Eva Biener
    Institute of Biochemistry, Food Science and Nutrition, Faculty of Agricultural, Food, and Environmental Quality Sciences, The Hebrew University of Jerusalem, P O Box 12, Rehovot 76100, Israel
    Protein Expr Purif 25:305-12. 2002
    ..Recombinant CIS2 was compared by biochemical, immunological, and molecular methods to the CIS2 protein expressed in eukaryotic cells. This report describes the first substantial production of biologically active recombinant human CIS2...
  87. ncbi Combined hypermethylation and chromosome loss associated with inactivation of SSI-1/SOCS-1/JAB gene in human hepatocellular carcinomas
    Hisaki Nagai
    Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-0063, Japan
    Cancer Lett 186:59-65. 2002
    ..These results indicate that the SSI-1 gene is silenced in a substantial portion of HCC though the combined mechanisms of methylation of either 5' or exon CpG rich regions and by a chromosomal loss of the remaining allele...
  88. ncbi The role of suppressor of cytokine signaling 1 as a negative regulator for aberrant expansion of CD8alpha+ dendritic cell subset
    Jun Tsukada
    Laboratory for Signal Network, Research Center for Allergy and Immunology RCAI, RIKEN Yokohama Institute, Suehiro cho 1 7 22, Tsurumi, Yokohama, Kanagawa 230 0045, Japan
    Int Immunol 17:1167-78. 2005
    ..Therefore, SOCS1 expression during DC maturation plays a role in surveillance in controlling the aberrant expansion of abnormal DC subset to maintain homeostasis of immune system...
  89. ncbi A role of suppressor of cytokine signaling 3 (SOCS3/CIS3/SSI3) in CD28-mediated interleukin 2 production
    Akira Matsumoto
    Research Institute for Biological Sciences, Tokyo University of Science, Chiba 278 0022, Japan
    J Exp Med 197:425-36. 2003
    ..Therefore, the SOCS3 may play an alternative role in prohibiting excessive progression of CD28-mediated IL-2 production...
  90. ncbi The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury
    Hideo Yasukawa
    Institute of Molecular Medicine, Department of Medicine, and. Division of Cardiothoracic Surgery, University of California at San Diego, La Jolla, California 92093-0613, USA
    J Clin Invest 111:469-78. 2003
    ..These results indicate that strategies directed at inhibition of SOCS in the heart and perhaps other organs can augment the host-cell antiviral system, thus preventing viral-mediated end-organ damage during the early stages of infection...
  91. ncbi Exacerbation of experimental allergic asthma by augmented Th2 responses in WSX-1-deficient mice
    Yoshiyuki Miyazaki
    PRESTO, Japan Science and Technology Agency, Saitama, Japan
    J Immunol 175:2401-7. 2005
    ....
  92. ncbi IL-6 induces an anti-inflammatory response in the absence of SOCS3 in macrophages
    Hideo Yasukawa
    Institute of Molecular Medicine and Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093 0641, USA
    Nat Immunol 4:551-6. 2003
    ..SOCS3 specifically prevents activation of STAT3 by IL-6 but not IL-10. Taken together, these data indicate that SOCS3 selectively blocks signaling by IL-6, thereby preventing its ability to inhibit LPS signaling...
  93. ncbi CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation
    Takaho Endo
    Institute of Life Science, Kurume University, Aikawa-machi 2432-3, Kurume 839-0861
    J Biochem (Tokyo) 133:109-13. 2003
    ..These data suggest that the suppression of STAT5 activation by CIS1 is not due to a simple competition with STAT5 but rather to a modification of the receptor by CIS1 binding...
  94. ncbi Suppressor of cytokine signaling 1/JAB and suppressor of cytokine signaling 3/cytokine-inducible SH2 containing protein 3 negatively regulate the signal transducers and activators of transcription signaling pathway in normal human epidermal keratinocytes
    Kenshi Yamasaki
    Department of Dermatology, Ehime University School of Medicine, Japan
    J Invest Dermatol 120:571-80. 2003
    ....
  95. ncbi Control mechanism of JAK/STAT signal transduction pathway
    Satoshi Yamada
    Advanced Technology R and D Center, Mitsubishi Electric Corporation, 8 1 1, Tsukaguchi Honmachi, Amagasaki, Hyogo 661 8661, Japan
    FEBS Lett 534:190-6. 2003
    ..So nuclear phosphatase is considered to be the most important in this system. By changing parameters of the model, dynamical characteristics and control mechanism were investigated...
  96. ncbi SHP2 and SOCS3 contribute to Tyr-759-dependent attenuation of interleukin-6 signaling through gp130
    Ute Lehmann
    Department of Biochemistry, Rheinisch Westfälische Technische Hochschule Aachen, Pauwelsstrasse 30, Aachen D 52074, Germany
    J Biol Chem 278:661-71. 2003
    ..These data suggest, that there are two, largely distinct modes of negative regulation of gp130 activity, despite the fact that both SOCS3 and SHP2 are recruited to the same site within gp130...
  97. ncbi SOCS-3 regulates onset and maintenance of T(H)2-mediated allergic responses
    Yoh Ichi Seki
    Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda City, Chiba 278 0022, Japan
    Nat Med 9:1047-54. 2003
    ..These data indicate that SOCS-3 has an important role in regulating the onset and maintenance of T(H)2-mediated allergic immune disease, and suggest that SOCS-3 may be a new therapeutic target for the development of antiallergic drugs...
  98. ncbi Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation
    Yoh Ichi Seki
    Research Institute for Biological Sciences, Tokyo University of Science, 2669 Yamazaki, Noda City, Chiba 278 0022, Japan
    Proc Natl Acad Sci U S A 99:13003-8. 2002
    ..Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance...
  99. ncbi Interaction of the growth hormone receptor with cytokine-induced Src homology domain 2 protein in rat adipocytes
    Ling Du
    Department of Physiology, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Endocrinology 144:868-76. 2003
    ..These findings demonstrate the interaction of CIS with the GHR in vivo and suggest that CIS may enhance degradation of the receptor by a proteasomal pathway...
  100. ncbi Stat5a inhibits IL-12-induced Th1 cell differentiation through the induction of suppressor of cytokine signaling 3 expression
    Hiroaki Takatori
    Department of Allergy and Clinical Immunology, Chiba University School of Medicine, Chiba City, Japan
    J Immunol 174:4105-12. 2005
    ..These results suggest that Stat5a forces the Th1/Th2 balance toward a Th2-type by preventing IL-12-induced Th1 cell differentiation through the induction of SOCS3...
  101. ncbi Negative regulation of cytokine and TLR signalings by SOCS and others
    Tetsuji Naka
    Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan
    Adv Immunol 87:61-122. 2005