Ken Yamamoto

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. pmc Identification of a KEAP1 germline mutation in a family with multinodular goitre
    Risa Teshiba
    Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    PLoS ONE 8:e65141. 2013
  2. ncbi request reprint Self-interaction of heterochromatin protein 1 is required for direct binding to histone methyltransferase, SUV39H1
    Ken Yamamoto
    Division of Molecular Population Genetics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka shi, Fukuoka ken 812 8582, Japan
    Biochem Biophys Res Commun 301:287-92. 2003
  3. ncbi request reprint Polycomb group suppressor of zeste 12 links heterochromatin protein 1alpha and enhancer of zeste 2
    Ken Yamamoto
    Division of Molecular Population Genetics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 279:401-6. 2004
  4. ncbi request reprint Novel triple missense mutations of GUCY2D gene in Japanese family with cone-rod dystrophy: possible use of genotyping microarray
    Shigeo Yoshida
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Vis 12:1558-64. 2006
  5. ncbi request reprint Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro
    Kenji Furuno
    Division of Molecular Population Genetics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 345:1051-8. 2006
  6. doi request reprint The rs6983267 SNP is associated with MYC transcription efficiency, which promotes progression and worsens prognosis of colorectal cancer
    Yasushi Takatsuno
    Department of Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Ann Surg Oncol 20:1395-402. 2013
  7. doi request reprint Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array
    Risa Teshiba
    Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Pediatr Surg Int 27:193-8. 2011
  8. ncbi request reprint P300/CBP-associated factor regulates Y-box binding protein-1 expression and promotes cancer cell growth, cancer invasion and drug resistance
    Masaki Shiota
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 101:1797-806. 2010
  9. ncbi request reprint Identification of independent susceptible and protective HLA alleles in Japanese autoimmune thyroid disease and their epistasis
    Sho Ueda
    Institute for Advanced Study S U, D O, T S, Division of Genome Analysis K Y, Medical Institute of Bioregulation, Department of Medicine and Clinical Science K O, Graduate School of Medicine, and Division of Host Defense H Y, A O, Y Y, Medical Institute of Bioregulation, Kyushu University, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan Ito Hospital J Y N, Y K, K S, K I, Shibuya ku, Tokyo 150 8308, Japan Department of Diabetes and Metabolic Medicine M N, K I, National Center for Global Health and Medicine, Shinjuku ku, Tokyo 16 8655, Japan Department of Laboratory K K, Japanese Red Cross Tokyo Blood Center, Koto ku, Tokyo 135 8639, Japan and Department of Immunogenetics Y N, Graduate School of Medical Sciences, Kumamoto University, Chuo Ku, Self Defense Forces Central Hospital
    J Clin Endocrinol Metab 99:E379-83. 2014
  10. pmc Genetic and infectious profiles of Japanese multiple sclerosis patients
    Satoshi Yoshimura
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e48592. 2012

Detail Information

Publications37

  1. pmc Identification of a KEAP1 germline mutation in a family with multinodular goitre
    Risa Teshiba
    Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    PLoS ONE 8:e65141. 2013
    ..Linkage studies have revealed several genetic loci responsible for familial MNG; however, most of the causative variants remain unknown...
  2. ncbi request reprint Self-interaction of heterochromatin protein 1 is required for direct binding to histone methyltransferase, SUV39H1
    Ken Yamamoto
    Division of Molecular Population Genetics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka shi, Fukuoka ken 812 8582, Japan
    Biochem Biophys Res Commun 301:287-92. 2003
    ..It seems that self-interaction through the chromo shadow domain of HP1 is crucial for recruitment of SUV39H1 onto nucleosomes...
  3. ncbi request reprint Polycomb group suppressor of zeste 12 links heterochromatin protein 1alpha and enhancer of zeste 2
    Ken Yamamoto
    Division of Molecular Population Genetics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 279:401-6. 2004
    ..In addition SU(Z)12 represses transcription activity in the presence of HP1alpha in a reporter assay. These results provide a molecular explanation for the functional link of these epigenetic silencing processes mediated by Su(z)12...
  4. ncbi request reprint Novel triple missense mutations of GUCY2D gene in Japanese family with cone-rod dystrophy: possible use of genotyping microarray
    Shigeo Yoshida
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Vis 12:1558-64. 2006
    ..To report a novel mutation in the GUCY2D gene in a Japanese family with autosomal dominant cone-rod dystrophy (adCORD), and to examine the possible use of arrayed primer extension (APEX)-based genotyping chip in detecting mutations...
  5. ncbi request reprint Association of Polycomb group SUZ12 with WD-repeat protein MEP50 that binds to histone H2A selectively in vitro
    Kenji Furuno
    Division of Molecular Population Genetics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 345:1051-8. 2006
    ..These results suggest that SUZ12 might have a role in transcriptional regulation through physical interaction with MEP50 that can be an adaptor between PRMT5 and its substrate H2A...
  6. doi request reprint The rs6983267 SNP is associated with MYC transcription efficiency, which promotes progression and worsens prognosis of colorectal cancer
    Yasushi Takatsuno
    Department of Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    Ann Surg Oncol 20:1395-402. 2013
    ..21, may affect copy number aberrations and/or expression profiles in colorectal cancer (CRC). We investigated the role of this single nucleotide polymorphism in the clinical outcome of CRC...
  7. doi request reprint Identification of TCTE3 as a gene responsible for congenital diaphragmatic hernia using a high-resolution single-nucleotide polymorphism array
    Risa Teshiba
    Division of Genome Analysis, Research Center for Genetic Information, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Pediatr Surg Int 27:193-8. 2011
    ..In this study, we analyzed copy number variants (CNVs) using a single-nucleotide polymorphism (SNP) array to examine whether microdeletions contribute to the pathogenesis of this disease...
  8. ncbi request reprint P300/CBP-associated factor regulates Y-box binding protein-1 expression and promotes cancer cell growth, cancer invasion and drug resistance
    Masaki Shiota
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 101:1797-806. 2010
    ..The present data suggest that Twist1 and YB-1 as well as PCAF may be promising molecular therapeutic targets...
  9. ncbi request reprint Identification of independent susceptible and protective HLA alleles in Japanese autoimmune thyroid disease and their epistasis
    Sho Ueda
    Institute for Advanced Study S U, D O, T S, Division of Genome Analysis K Y, Medical Institute of Bioregulation, Department of Medicine and Clinical Science K O, Graduate School of Medicine, and Division of Host Defense H Y, A O, Y Y, Medical Institute of Bioregulation, Kyushu University, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan Ito Hospital J Y N, Y K, K S, K I, Shibuya ku, Tokyo 150 8308, Japan Department of Diabetes and Metabolic Medicine M N, K I, National Center for Global Health and Medicine, Shinjuku ku, Tokyo 16 8655, Japan Department of Laboratory K K, Japanese Red Cross Tokyo Blood Center, Koto ku, Tokyo 135 8639, Japan and Department of Immunogenetics Y N, Graduate School of Medical Sciences, Kumamoto University, Chuo Ku, Self Defense Forces Central Hospital
    J Clin Endocrinol Metab 99:E379-83. 2014
    ..Determining the genetic basis that distinguishes GD and HT is a key to understanding the differences between these 2 related diseases...
  10. pmc Genetic and infectious profiles of Japanese multiple sclerosis patients
    Satoshi Yoshimura
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e48592. 2012
    ..We aimed to clarify whether genetic and infectious backgrounds correlate to distinct disease phenotypes of MS in Japanese patients...
  11. ncbi request reprint Tissue inhibitor of metalloproteinase 2 and coronary artery lesions in Kawasaki disease
    Kenji Furuno
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pediatr 151:155-60, 160.e1. 2007
    ..To identify cytokine genes uniquely expressed in peripheral blood mononuclear cells (PBMNCs) in the acute phase of Kawasaki disease (KD) with coronary artery lesions (CALs)...
  12. doi request reprint Identification of independent risk loci for Graves' disease within the MHC in the Japanese population
    Kazuhiko Nakabayashi
    Department of Cell Biology, Fukuoka University, Fukuoka, Japan
    J Hum Genet 56:772-8. 2011
    ..Although causal variants remain to be identified, our results demonstrate the existence of multiple GD susceptibility loci within the MHC region...
  13. ncbi request reprint Female agammaglobulinemia due to the Bruton tyrosine kinase deficiency caused by extremely skewed X-chromosome inactivation
    Hidetoshi Takada
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Blood 103:185-7. 2004
    ..This is the first report of female XLA caused by heterozygous BTK gene abnormality and extreme nonrandom inactivation of X chromosome on which normal BTK gene is located...
  14. pmc A definitive haplotype map as determined by genotyping duplicated haploid genomes finds a predominant haplotype preference at copy-number variation events
    Yoji Kukita
    Division of Genome Analysis, Research Center for Genetic Information, Kyushu University, Fukuoka 812 8582, Japan
    Am J Hum Genet 86:918-28. 2010
    ....
  15. doi request reprint Genomic copy number of a carcinogenic single nucleotide polymorphism at 8q24 in non-risk allele colorectal cancer associated with insulin growth factor 2 receptor expression
    Yusuke Takahashi
    Department of Surgical Oncology, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
    J Gastroenterol Hepatol 27:95-9. 2012
    ..The association between the SNP genotype and genes associated with diabetes or hyperlipidemia was investigated in cases of CRC...
  16. pmc SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians
    Akinori Miyashita
    Department of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan
    PLoS ONE 8:e58618. 2013
    ..Our study highlights the importance of examining associations in multiple ethnic populations...
  17. ncbi request reprint A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population
    Masayuki Aoki
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 335:566-74. 2005
    ..0001, odds ratio=1.59). These results suggest that, in the Japanese population, STCH might be a new candidate for conferring susceptibility to this disease...
  18. doi request reprint Multiple lysine methylation of PCAF by Set9 methyltransferase
    Toshihiro Masatsugu
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 381:22-6. 2009
    ..Our data may lead to a new insight into PCAF functions and provide additional information to identify unknown targets of Set9...
  19. doi request reprint Stomach cancer-derived del223V-226L mutation of the STCH gene causes loss of sensitization to TRAIL-mediated apoptosis
    Nobushige Yamagata
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 376:499-503. 2008
    ..These results suggest that STCH has a role in cell survival via modulation of the TRAIL-mediated cell death pathway...
  20. doi request reprint Behavioral and clinical correlates of high-sensitivity C-reactive protein in Japanese men and women
    Akie Hirata
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Chem Lab Med 50:1469-76. 2012
    ..Few studies have evaluated relative importance of behavioral and clinical covariates of high-sensitivity C-reactive protein in Japanese population...
  21. ncbi request reprint Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people
    Ken Yamamoto
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Hum Genet 50:600-3. 2005
    ..The patients had no mutations and 10% had one polymorphism (146G>A) of syntaxin 11, while no mutation of SNAP23 was observed. Our results indicate that aberrations in the SNARE system may not cause FHL in Japanese families...
  22. ncbi request reprint Rapid detection of SAG 926delA mutation using real-time polymerase chain reaction
    Shigeo Yoshida
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Vis 12:1552-7. 2006
    ..Mutation 926delA of the arrestin/S-antigen SAG gene is the main cause of Oguchi disease in the Japanese. The purpose of this study was to develop a rapid diagnostic assay to detect mutations in the SAG gene...
  23. ncbi request reprint Association analysis of glutathione-S-transferase P1 (GSTP1) polymorphism with urothelial cancer susceptibility and myelosuppression after M-VAC chemotherapy
    Akira Yokomizo
    Department of Urology, Kyushu University Graduate School of Medical Science, Fukuoka, Japan
    Int J Urol 14:500-4. 2007
    ....
  24. ncbi request reprint [Genome-wide approach to identify genes involved in gastric cancer]
    Ken Yamamoto
    Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University
    Fukuoka Igaku Zasshi 96:25-33. 2005
  25. ncbi request reprint Genome-wide linkage analysis of type 2 diabetes mellitus reconfirms the susceptibility locus on 11p13-p12 in Japanese
    Hajime Nawata
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Hum Genet 49:629-34. 2004
    ..These results taken together suggest that a susceptibility gene for type 2 diabetes mellitus in Japanese will reside in 11p13-p12...
  26. doi request reprint Replication of genome-wide association studies of type 2 diabetes susceptibility in Japan
    Yukio Horikawa
    Department of Diabetes and Endocrinology, Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan
    J Clin Endocrinol Metab 93:3136-41. 2008
    ....
  27. ncbi request reprint Association of TCF7L2 polymorphisms with susceptibility to type 2 diabetes in 4,087 Japanese subjects
    Kazuaki Miyake
    Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7 5 1 Kusunoki cho, Chuo Ku, Kobe 650 0017, Japan
    J Hum Genet 53:174-80. 2008
    ..However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population...
  28. ncbi request reprint The bromodomain mediates transcriptional intermediary factor 1alpha -nucleosome interactions
    Eumorphia Remboutsika
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM Universite Louis Pasteur, BP 163, F 67404 Illkirch Cedex, France
    J Biol Chem 277:50318-25. 2002
    ..Based on our results, we propose that the BrD plays a critical role in vivo by directing transregulators to their cognate location on nucleosomal DNA...
  29. ncbi request reprint SNPs in the promoter of a B cell-specific antisense transcript, SAS-ZFAT, determine susceptibility to autoimmune thyroid disease
    Senji Shirasawa
    Department of Pathology, Research Institute, International Medical Center of Japan, Toyama 1 21 1, Shinjuku ku, Tokyo 162 8655, Japan
    Hum Mol Genet 13:2221-31. 2004
    ....
  30. ncbi request reprint [Anesthetic management of a patient with severe combined pulmonary disease under epidural anesthesia with spontaneous respiration]
    Ai Usukura
    Department of Anesthesiology, School of Medicine, Kanazawa University, Kanazawa 920 8641
    Masui 57:624-7. 2008
    ..No respiratory complications developed postoperatively. Maintaining spontaneous breathing during abdominal surgery using epidural anesthesia and light general anesthesia is a good option for COPD patients...
  31. ncbi request reprint Effects of various forms of surfactant protein C on tidal volume in ventilated immature newborn rabbits
    Katsumi Tashiro
    Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medicine, Kanazawa University, Kanazawa 920 8641, Japan
    J Appl Physiol (1985) 94:1519-26. 2003
    ..The physiological effect of basic mixture was not improved by monomeric SP-C. We conclude that palmitoyl groups are important for the physiological effects of SP-C and that the dimeric form also improves physiological effects...
  32. ncbi request reprint Evidence for shared recognition of a peptide ligand by a diverse panel of non-obese diabetic mice-derived, islet-specific, diabetogenic T cell clones
    Kenji Yoshida
    Department of Molecular Immunology, Research Institute for Microbial Diseases, Osaka University, 3 1 Yamada oka, Suita 565 0871, Japan
    Int Immunol 14:1439-47. 2002
    ..The results suggest that our islet-reactive T cell clones recognize in islet beta cells a natural ligand that is similar to these peptides...
  33. ncbi request reprint Genetic subtypes of familial hemophagocytic lymphohistiocytosis: correlations with clinical features and cytotoxic T lymphocyte/natural killer cell functions
    Eiichi Ishii
    Department of Pediatrics, Faculty of Medicine, Saga University, 5 1 1 Nabeshima, Saga 849 8501, Japan
    Blood 105:3442-8. 2005
    ..These results suggest an association between the type of genetic mutation in FHL cases and the magnitude of CTL cytolytic activity and age at onset...
  34. ncbi request reprint A novel perforin gene mutation in a Japanese family with hemophagocytic lymphohistiocytosis
    Ikuyo Ueda
    Department of Pediatrics, Kyoto Prefectural University of Medicine, Kyoto, Japan
    Int J Hematol 83:51-4. 2006
    ....
  35. ncbi request reprint Which is a better position for insertion of a high thoracic epidural catheter: sitting or lateral decubitus?
    Masatoshi Nishi
    Department of Anesthesiology and Intensive Care Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Cardiothorac Vasc Anesth 20:656-8. 2006
    ..The purpose of this study was to compare the safety and success rates associated with the placement of a high thoracic epidural catheter in the sitting vs. the lateral decubitus position...
  36. ncbi request reprint Dynamics of ultrasonically induced birefringence of in rod-like colloidal solutions
    Tatsuro Matsuoka
    Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Chikusa ku, Nagoya 464 8603, Japan
    Colloids Surf B Biointerfaces 56:72-9. 2007
    ..For rod-like micelles, the birefringence showed anomalous damping oscillation when the rod-like micelle was in an entangling state. The mechanism of damping oscillation was discussed using the results of the rheological measurements...
  37. ncbi request reprint Involvement of alpha1-acid glycoprotein in inter-individual variation of disposition kinetics of ropivacaine following epidural infusion in off-pump coronary artery bypass grafting
    Koichi Yokogawa
    Department of Hospital Pharmacy, School of Medicine, Kanazawa University, 13 1, Takara machi, Kanazawa 920 8641, Japan
    J Pharm Pharmacol 59:67-73. 2007
    ..However, in combination therapy, it is also important to consider the AGP variant-dependence of the inhibitory effect of concomitantly administered drugs...