Hidetaka Yamamoto

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Detection of COL1A1-PDGFB fusion transcripts and PDGFB/PDGFRB mRNA expression in dermatofibrosarcoma protuberans
    Tomonari Takahira
    The Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 20:668-75. 2007
  2. doi request reprint Reduced expression of SMARCB1/INI1 protein in synovial sarcoma
    Kenichi Kohashi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Mod Pathol 23:981-90. 2010
  3. doi request reprint Insulin-like growth factor II messenger RNA-binding protein 3 expression in gastrointestinal mesenchymal tumors
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan Electronic address
    Hum Pathol 45:481-7. 2014
  4. doi request reprint Clinicopathological features of primary leiomyosarcoma of the gastrointestinal tract following recognition of gastrointestinal stromal tumours
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan
    Histopathology 63:194-207. 2013
  5. doi request reprint Fascin-1 overexpression and miR-133b downregulation in the progression of gastrointestinal stromal tumor
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Mod Pathol 26:563-71. 2013
  6. doi request reprint High levels of p53 expression correlate with DNA aneuploidy in (pre)malignancies of the vulva
    Irene A M van der Avoort
    Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Pathol 41:1475-85. 2010
  7. doi request reprint Neurofibromatosis type 1-related gastrointestinal stromal tumors: a special reference to loss of heterozygosity at 14q and 22q
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582, Japan
    J Cancer Res Clin Oncol 135:791-8. 2009
  8. doi request reprint Aggressive invasive micropapillary salivary duct carcinoma of the parotid gland
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pathol Int 58:322-6. 2008
  9. ncbi request reprint Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: a comparative clinicopathologic study
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Surg Pathol 33:1330-40. 2009
  10. doi request reprint Primary gastrointestinal stromal tumor of the liver with PDGFRA gene mutation
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 41:605-9. 2010

Detail Information

Publications82

  1. ncbi request reprint Detection of COL1A1-PDGFB fusion transcripts and PDGFB/PDGFRB mRNA expression in dermatofibrosarcoma protuberans
    Tomonari Takahira
    The Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 20:668-75. 2007
    ..The PDGFB and PDGFRB mRNA expression levels showed a good correlation (r=0.76, P<0.0001). These results indicate that the fusion protein, which is processed by the COL1A1-PDGFB transcripts, can serve as a functional ligand for PDGFRB...
  2. doi request reprint Reduced expression of SMARCB1/INI1 protein in synovial sarcoma
    Kenichi Kohashi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Mod Pathol 23:981-90. 2010
    ..46). Therefore, it was suggested that there is a post-transcriptional SMARCB1/INI1 regulatory mechanism in the tumor cells of synovial sarcoma...
  3. doi request reprint Insulin-like growth factor II messenger RNA-binding protein 3 expression in gastrointestinal mesenchymal tumors
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan Electronic address
    Hum Pathol 45:481-7. 2014
    ..Our results suggest that IMP3 may be an ancillary tool in identifying aggressive abdominal mesenchymal tumors other than GIST. ..
  4. doi request reprint Clinicopathological features of primary leiomyosarcoma of the gastrointestinal tract following recognition of gastrointestinal stromal tumours
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan
    Histopathology 63:194-207. 2013
    ..We aimed to elucidate the clinicopathological and immunohistochemical features of leiomyosarcoma (LMS) of the gastrointestinal (GI) tract...
  5. doi request reprint Fascin-1 overexpression and miR-133b downregulation in the progression of gastrointestinal stromal tumor
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Mod Pathol 26:563-71. 2013
    ..Our results suggest that downregulation of miR-133b and overexpression of fascin-1 may have an important role in the progression of GIST, and that fascin-1 may be a useful biomarker to predict the aggressive behavior...
  6. doi request reprint High levels of p53 expression correlate with DNA aneuploidy in (pre)malignancies of the vulva
    Irene A M van der Avoort
    Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Hum Pathol 41:1475-85. 2010
    ..Furthermore, high p53 expression correlates with increased DNA content and aneuploidy; but it requires further research to unveil a possible causal relation...
  7. doi request reprint Neurofibromatosis type 1-related gastrointestinal stromal tumors: a special reference to loss of heterozygosity at 14q and 22q
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582, Japan
    J Cancer Res Clin Oncol 135:791-8. 2009
    ....
  8. doi request reprint Aggressive invasive micropapillary salivary duct carcinoma of the parotid gland
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pathol Int 58:322-6. 2008
    ..It is also important for pathologists to recognize that GCDFP-15 and AR expression can be reduced in micropapillary carcinoma in the differential diagnosis of metastatic tumor...
  9. ncbi request reprint Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: a comparative clinicopathologic study
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Surg Pathol 33:1330-40. 2009
    ..In addition, the evaluation of IgG4+ plasma cells and the ratio of IgG4+/IgG+ plasma cells and the presence of obstructive phlebitis may be useful for the differential diagnosis between IMT and IgG4-related sclerosing disease...
  10. doi request reprint Primary gastrointestinal stromal tumor of the liver with PDGFRA gene mutation
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 41:605-9. 2010
    ..Although KIT-negative gastrointestinal stromal tumor occurring outside the gastrointestinal tract is very rare, this entity should be considered as a potential primary hepatic neoplasm...
  11. doi request reprint KIT-negative gastrointestinal stromal tumor of the abdominal soft tissue: a clinicopathologic and genetic study of 10 cases
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Surg Pathol 35:1287-95. 2011
    ....
  12. ncbi request reprint Absence of human herpesvirus-8 and Epstein-Barr virus in inflammatory myofibroblastic tumor with anaplastic large cell lymphoma kinase fusion gene
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pathol Int 56:584-90. 2006
    ..These results suggest that IMT may be a heterogeneous group in terms of pathogenesis, and EBV and HHV-8 do not play a major role in the pathogenesis of ALK-positive tumor...
  13. doi request reprint Prognostic impact of blood vessel invasion in gastrointestinal stromal tumor of the stomach
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 41:1422-30. 2010
    ....
  14. doi request reprint Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumor
    Kenichi Kohashi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 40:349-55. 2009
    ..Analysis of alterations in the SMARCB1/INI1 gene may thus be a useful diagnostic tool to distinguish proximal-type epithelioid sarcoma from malignant rhabdoid tumor...
  15. ncbi request reprint Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expression
    Teiyu Izumi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Am J Surg Pathol 31:85-94. 2007
    ..Dysadherin expression is considered to be one of the determinants of histologic subtype in synovial sarcoma. Moreover, dysadherin expression is an excellent and independent prognostic indicator...
  16. ncbi request reprint DNA hypermethylation status of multiple genes in soft tissue sarcomas
    Ken Ichi Kawaguchi
    Department of Anatomic Pathology, Pathological Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 19:106-14. 2006
    ..Furthermore, MGMT methylation may be associated with tumor aggressiveness and the inactivation of MGMT gene...
  17. ncbi request reprint Microsatellite instability and hMLH1 and hMSH2 expression analysis in soft tissue sarcomas
    Ken Ichi Kawaguchi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Oncol Rep 13:241-6. 2005
    ..These findings suggest that the inactivation of MMR gene expression might be the cause of MSI in STS cases...
  18. doi request reprint SMARCB1/INI1 protein expression in round cell soft tissue sarcomas associated with chromosomal translocations involving EWS: a special reference to SMARCB1/INI1 negative variant extraskeletal myxoid chondrosarcoma
    Kenichi Kohashi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
    Am J Surg Pathol 32:1168-74. 2008
    ..The immunohistochemical result of the SMARCB1/INI expression is not an absolute diagnostic criteria for MRT and careful histologic evaluation is required to make a precise diagnosis of MRT...
  19. ncbi request reprint Aberrant expression of CHFR in malignant peripheral nerve sheath tumors
    Chikashi Kobayashi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Mod Pathol 19:524-32. 2006
    ..In addition, MPNST with normal karyotype showed a strong (score, =5) expression of CHFR. Our results support the assertion that CHFR functions as an inhibitor of tumor proliferation...
  20. ncbi request reprint Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosis
    Yoshinao Oda
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pathol 207:410-21. 2005
    ..In MLS/RCLS, reduction of p14 protein expression and p53 mutation were related to poor prognosis. Accordingly, the p14(ARF)/p53 pathway may contribute to the presence of an RC component and malignant progression in this tumour...
  21. ncbi request reprint Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcoma
    Tsuyoshi Saito
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 34:841-9. 2003
    ..Thus, inactivation of hMSH2/hMLH1 of DNA mismatch repair genes seems to have an important role to play in the mutagenesis of the tumor-suppressor genes in ASPS...
  22. doi request reprint Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study
    Kohei Fujita
    Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan
    Am J Surg Pathol 35:295-304. 2011
    ..In addition, our histologic observations suggest a possible close association between SSAN and mucinous adenocarcinoma...
  23. ncbi request reprint Altered expression and molecular abnormalities of cell-cycle-regulatory proteins in rhabdomyosarcoma
    Yukiko Takahashi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 17:660-9. 2004
    ..Alveolar type had a significantly higher both mitotic rate and E2F-1 labeling indices when compared with the embryonal type. The current study is the first report of the correlation of E2F-1 with alveolar rhabdomyosarcoma...
  24. ncbi request reprint Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomas
    Ken Ichi Kawaguchi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 36:357-63. 2005
    ..Furthermore, although a further detailed analysis of a larger number of cases is still necessary, the present results suggest that PTEN expression may be a useful indicator of cell proliferation in patients with STS...
  25. doi request reprint Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtype
    Kenichi Kohashi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
    J Cancer Res Clin Oncol 134:1097-103. 2008
    ..Therefore, there might be a correlation between the tumorigenesis of RMS and RB1 alteration...
  26. doi request reprint Non-mass-like enhancement on contrast-enhanced breast MR imaging: lesion characterization using combination of dynamic contrast-enhanced and diffusion-weighted MR images
    Hidetake Yabuuchi
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Eur J Radiol 75:e126-32. 2010
    ....
  27. ncbi request reprint Mechanisms of inactivation of the p16INK4a gene in leiomyosarcoma of soft tissue: decreased p16 expression correlates with promoter methylation and poor prognosis
    Ken Ichi Kawaguchi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pathol 201:487-95. 2003
    ..Furthermore, promoter methylation was more frequent than either homozygous deletion or mutation in this tumour, and promoter methylation was also shown to have a strong association with inactivation of the p16INK4a gene...
  28. ncbi request reprint Prognostic significance of dysadherin expression in epithelioid sarcoma and its diagnostic utility in distinguishing epithelioid sarcoma from malignant rhabdoid tumor
    Teiyu Izumi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 19:820-31. 2006
    ..However, in malignant rhabdoid tumor, cell growth cycle that is regulated by hSNF5/INI1 gene seems to be critical to lethal biological behavior rather than dysadherin...
  29. ncbi request reprint Highly aggressive behavior of malignant rhabdoid tumor: a special reference to SMARCB1/INI1 gene alterations using molecular genetic analysis including quantitative real-time PCR
    Kenichi Kohashi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582, Japan
    J Cancer Res Clin Oncol 133:817-24. 2007
    ..Moreover, we investigated the status of hyperphosphorylation in RB protein, known as a key cell cycle molecule...
  30. ncbi request reprint PTEN and other tumor suppressor gene mutations as secondary genetic alterations in synovial sarcoma
    Tsuyoshi Saito
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Oncol Rep 11:1011-5. 2004
    ..8%), although the mutation status in TSG was not associated with overall survival rate in patients with SS. Secondary genetic alterations in these TSG seem to have a less important prognostic impact on patients with SS...
  31. ncbi request reprint c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue)
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Surg Pathol 28:479-88. 2004
    ..Furthermore, STI-571, targeting c-kit and PDGFR tyrosine kinase, seems to be a possible therapeutic strategy for EGISTs, especially advanced cases...
  32. ncbi request reprint Death-associated protein kinase (DAP kinase) alteration in soft tissue leiomyosarcoma: Promoter methylation or homozygous deletion is associated with a loss of DAP kinase expression
    Ken Ichi Kawaguchi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 35:1266-71. 2004
    ..Furthermore, although further detailed analyses are necessary, promoter methylation or homozygous deletion status of DAP kinase may present a major alternative mechanism of a loss of or decrease in DAP kinase expression...
  33. doi request reprint Glypican 3 expression in tumors with loss of SMARCB1/INI1 protein expression
    Kenichi Kohashi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Hum Pathol 44:526-33. 2013
    ..Therefore, evaluation of GPC3 immunoexpression may be a useful diagnostic tool to distinguish ES from MRT, especially extrarenal MRT. It was suggested that MRTs with GPC3 overexpression may become a new target of GPC3 immunotherapy...
  34. doi request reprint HER-2/neu gene amplification in carcinoma ex pleomorphic adenoma in relation to progression and prognosis: a chromogenic in-situ hybridization study
    Kazuki Hashimoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Histopathology 60:E131-42. 2012
    ..The aim of this study was to investigate the potential role of HER-2/neu in the stepwise progression of carcinoma ex pleomorphic adenoma (CXPA) and to evaluate its prognostic significance in CXPA...
  35. doi request reprint The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomas
    Nokitaka Setsu
    Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Cancer 118:1637-48. 2012
    ..Here the authors investigated the significance of activation of the Akt/mTOR pathway in soft tissue leiomyosarcomas...
  36. doi request reprint Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumors
    Hiroshi Matono
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582 Japan
    Hum Pathol 39:1802-8. 2008
    ....
  37. ncbi request reprint Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk grade
    Norimoto Nakamura
    Department of Anatomic Pathology, Graduate School of Medical Sciences of Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 36:828-37. 2005
    ..Furthermore, alteration of G2-M regulators, such as cyclin A, cyclin B1, and cdc2, is also a useful marker for predicting aggressive behavior and play an important role, at least in part, in the cell proliferation of GIST...
  38. ncbi request reprint ATP-binding cassette superfamily transporter gene expression in human soft tissue sarcomas
    Yoshinao Oda
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Int J Cancer 114:854-62. 2005
    ..In addition, the high levels of both MDR1 and MRP3 mRNA expression in MPNST may help to explain the poor response of this tumor to anticancer-drugs...
  39. ncbi request reprint Altered expression of cell cycle regulators in myxofibrosarcoma, with special emphasis on their prognostic implications
    Yoshinao Oda
    Department of Anatomic Pathology, Graduate School of Medical Information Science, Kyushu University, Fukuoka, Japan
    Hum Pathol 34:1035-42. 2003
    ..Our results suggest that reduced expression of p21 could be considered a new parameter to be evaluated, along with classical clinicopathologic prognostic factors, for identifying those at high risk for myxofibrosarcoma...
  40. ncbi request reprint E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcoma
    Tsuyoshi Saito
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Oncogene 23:8629-38. 2004
    ..Thus, E-cadherin downregulation is associated with the loss or absence of glandular epithelial differentiation in certain SS...
  41. doi request reprint Phosphorylation of signal transducer and activator of transcription 3 in soft tissue leiomyosarcoma is associated with a better prognosis
    Nokitaka Setsu
    Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Int J Cancer 132:109-15. 2013
    ..STAT3 might not contribute to the progression of soft tissue LMS, and the phosphorylation status of STAT3 has the potential to be a favorable prognostic marker of LMS...
  42. doi request reprint Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor development
    Nobuhiro Fujita
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 41:838-47. 2010
    ..The changes of arterial vessel density in moderately differentiated hepatocellular carcinomas were suggested...
  43. ncbi request reprint Alterations of the p16INK4a/p14ARF pathway in clear cell sarcoma
    Tomonari Takahira
    Department of Anatomic Pathology Second Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Cancer Sci 95:651-5. 2004
    ..3%). All tumors with genetic alterations of the p16INK4a/p14ARF or p53 gene showed a high mitotic rate or tumor necrosis. These alterations were considered to be influential in the poor prognosis of CCS patients...
  44. ncbi request reprint CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasis
    Yoshinao Oda
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Mod Pathol 19:738-45. 2006
    ..0053). Our results suggested that CXCR4 expression was associated with metastatic progression, and immunohistochemical VEGF expression in the primary site had predictive value for the osteosarcoma patients, who developed lung metastasis...
  45. ncbi request reprint Alterations of the RB1 gene in dedifferentiated liposarcoma
    Tomonari Takahira
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 18:1461-70. 2005
    ..These results suggest that retinoblastoma protein has a major role to play in dedifferentiation and that a 'two-hit' mechanism is involved in the altered retinoblastoma protein expression in dedifferentiated liposarcoma...
  46. doi request reprint Expression level of the mitotic checkpoint protein and G2-M cell cycle regulators and prognosis in gastrointestinal stromal tumors in the stomach
    Aya Fujita
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Virchows Arch 460:163-9. 2012
    ..In addition, decreased CHFR expression may play a role in increased proliferative activity of higher grade GISTs...
  47. doi request reprint Diagnostic performance in differentiation of breast lesion on digital mammograms: comparison among hard-copy film, 3-megapixel LCD monitor, and 5-megapixel LCD monitor
    Takeshi Kamitani
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Imaging 35:341-5. 2011
    ..The soft-copy reading using the 3M LCD monitor took a slightly longer time, although there were no significant differences...
  48. doi request reprint Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcoma
    Suguru Matsuura
    Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 41:343-51. 2010
    ....
  49. ncbi request reprint H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinoma
    Hideki Shiratsuchi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Oncol Rep 11:597-604. 2004
    ....
  50. doi request reprint Heterozygosity loss at 22q and lack of INI1 gene mutation in gastrointestinal stromal tumor
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan hidetaka surgpath med kyushu u ac jp
    Pathobiology 78:132-9. 2011
    ..The INI1 gene, located at 22q11.23, is a tumor suppressor gene that is frequently altered in malignant rhabdoid tumor...
  51. doi request reprint Different expression profiles of Y-box-binding protein-1 and multidrug resistance-associated proteins between alveolar and embryonal rhabdomyosarcoma
    Yoshinao Oda
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cancer Sci 99:726-32. 2008
    ..Apart from ERMS, frequent P-gp expression in ARMS may be independent from YB-1 regulation. However, YB-1 may be a candidate for a molecular target in rhabdomyosarcoma therapy, especially in ERMS...
  52. doi request reprint Ossifying fibromyxoid tumor presenting EP400-PHF1 fusion gene
    Makoto Endo
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 44:2603-8. 2013
    ..3) translocation. Our results suggest that the EP400-PHF1 fusion gene is a reproducible finding in ossifying fibromyxoid tumor. ..
  53. ncbi request reprint Nuclear beta-catenin correlates with cyclin D1 expression in spindle and pleomorphic sarcomas but not in synovial sarcoma
    Tsuyoshi Saito
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 37:689-97. 2006
    ..Thus, cyclin D1 could be considered as one of the targets of the nuclear beta-catenin in spindle cell and pleomorphic sarcomas. A possible association between beta-catenin accumulation and spindle cell morphogenesis may exist in SS...
  54. doi request reprint Low-grade central osteosarcoma arising from bone infarct
    Makoto Endo
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 812 8582
    Hum Pathol 44:1184-9. 2013
    ..Here, we present clinical and pathologic findings of our case in detail and discuss the differential diagnoses of this extremely rare condition...
  55. doi request reprint Epithelial and cartilaginous differentiation in clear cell chondrosarcoma
    Suguru Matsuura
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Hum Pathol 44:237-43. 2013
    ..On the other hand, tumor cells of clear cell chondrosarcoma have no osteoblastic immunohistochemical expression in comparison with chondroblastoma...
  56. doi request reprint Tumor-to-tumor metastasis: lung adenocarcinoma metastasizing to a follicular variant of papillary thyroid carcinoma
    Kazuki Hashimoto
    Department of Anatomic Pathology Department of Otolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pathol Int 61:435-41. 2011
    ..These results demonstrate that a panel of immunohistochemical staining and molecular analysis is helpful for both diagnosis and appropriate postoperative treatment for a patient with cancer-to-cancer metastasis...
  57. doi request reprint Detection of non-palpable breast cancer in asymptomatic women by using unenhanced diffusion-weighted and T2-weighted MR imaging: comparison with mammography and dynamic contrast-enhanced MR imaging
    Hidetake Yabuuchi
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Eur Radiol 21:11-7. 2011
    ....
  58. ncbi request reprint Prognostic significance of angiogenesis in gastrointestinal stromal tumor
    Masakazu Imamura
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashiku, Fukuoka, Japan
    Mod Pathol 20:529-37. 2007
    ....
  59. ncbi request reprint Close correlation between CXCR4 and VEGF expression and their prognostic implications in nasopharyngeal carcinoma
    Yuichi Segawa
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Oncol Rep 21:1197-202. 2009
    ..0044). Our findings suggest that the expression of CXCR4 and VEGF is associated with metastatic progression, and that VEGF expression is a valuable prognostic marker in nasopharyngeal carcinoma...
  60. ncbi request reprint Chromosomal aberrations and microsatellite instability of malignant peripheral nerve sheath tumors: a study of 10 tumors from nine patients
    Chikashi Kobayashi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cancer Genet Cytogenet 165:98-105. 2006
    ..These findings suggest that chromosomal aberration as a consequence of CIN has a greater role in the pathogenesis of MPNST than does that due to MSI...
  61. ncbi request reprint Microsatellite instability and proliferating activity in sinonasal carcinoma: molecular genetic and immunohistochemical comparison with oral squamous cell carcinoma
    Hideoki Uryu
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Oncol Rep 14:1133-42. 2005
    ..These findings suggest that sinonasal carcinoma and HNSCC have quite different molecular backgrounds regarding carcinogenesis, and the role of MSI is relatively minor in cases of advanced sinonasal carcinoma...
  62. ncbi request reprint Decreased expression of transforming growth factor-beta II receptor is associated with that of p27KIP1 in giant cell tumor of bone: a possible link between transforming growth factor-beta and cell cycle-related protein
    Ken Ichi Kawaguchi
    Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Hum Pathol 35:61-8. 2004
    ..Furthermore, our results provide a possible link between the effects of extracellular growth factors and cell cycle control. In addition, p27 expression may be a useful indicator of cell proliferation in MSCs of this tumor...
  63. ncbi request reprint Microsatellite instability and p53 mutation associated with tumor progression in dermatofibrosarcoma protuberans
    Tomonari Takahira
    Department of Anatomic Pathology, Graduate School of Medicine, Kyushu University, Fukuoka, Japan
    Hum Pathol 35:240-5. 2004
    ..These results suggest that MSI and p53 mutations are involved in tumor progression of DFSP to fibrosarcoma as early and late events, respectively...
  64. doi request reprint Inhibin-α and synaptophysin immunoreactivity in synovial sarcoma with granular cell features
    Nokitaka Setsu
    Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 43:850-7. 2012
    ..This is the first report of immunoreactivity for inhibin-α and synaptophysin in synovial sarcoma. These immunohistochemical findings might be characteristic of synovial sarcomas with granular cell features...
  65. doi request reprint S100P expression in ductal type of carcinoma ex pleomorphic adenoma
    Kazuki Hashimoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Japan
    Am J Surg Pathol 35:346-55. 2011
    ....
  66. doi request reprint Multifocal metanephric adenoma in childhood
    Kenichi Kohashi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pathol Int 59:49-52. 2009
    ..Thus, the histological and immunohistochemical features of the present case were compatible with metanephric adenoma...
  67. doi request reprint Enhanced mass on contrast-enhanced breast MR imaging: Lesion characterization using combination of dynamic contrast-enhanced and diffusion-weighted MR images
    Hidetake Yabuuchi
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Magn Reson Imaging 28:1157-65. 2008
    ....
  68. ncbi request reprint Malignant perivascular epithelioid cell tumor of the colon: report of a case with molecular analysis
    Hidetaka Yamamoto
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Japan
    Pathol Int 56:46-50. 2006
    ..The result suggests that the overexpression of cyclin D1 may play an important role in the tumorigenesis of PEComa. Because PEComas can behave in an aggressive manner, careful follow up is warranted...
  69. doi request reprint Prognostic significance of p14ARF, p15INK4b, and p16INK4a inactivation in malignant peripheral nerve sheath tumors
    Makoto Endo
    Departments of Anatomic Pathology and Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka Sanno Hospital, Fukuoka, Japan
    Clin Cancer Res 17:3771-82. 2011
    ..Here we carried out a genetic, epigenetic, and expression analysis of p14(ARF), p15(INK4b), and p16(INK4a), and clarified the prognostic significance of their inactivation in MPNSTs...
  70. ncbi request reprint Low-grade fibrosarcoma of the proximal humerus
    Tsuyoshi Saito
    Department of Anatomic Pathology, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan
    Pathol Int 53:115-20. 2003
    ..The patient demonstrates no evidence of disease 42 months after surgery. It is important to detect the scant atypical cells for the differential diagnosis of low-grade fibrosarcoma and desmoplastic fibroma of bone...
  71. ncbi request reprint Congenital pseudarthrosis of the tibia: analysis of the histology and the NF1 gene
    Akio Sakamoto
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, Japan
    J Orthop Sci 12:361-5. 2007
    ..Congenital pseudarthrosis of the tibia (CPT) is frequently, but not always, associated with neurofibromatosis type 1 (NF1). Double inactivation of the NF1 gene has been reported to be the pathogenesis of CPT in NF1 cases...
  72. ncbi request reprint Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomas
    Eijun Itakura
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Surg Oncol 97:74-81. 2008
    ..The majority of angiosarcomas are thought to originate from vascular endothelia and spread via bloodstream to lung, but lymphatic metastases can occur...
  73. ncbi request reprint PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocations
    Tsuyoshi Saito
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 104:175-8. 2003
    ....
  74. ncbi request reprint Mucinous cystic tumor of the pancreas: immunohistochemical assessment of "ovarian-type stroma"
    Akihiko Izumo
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Oncol Rep 10:515-25. 2003
    ..We therefore conclude there is a possibility that MCT-P originates from the left remnant primordial gonadal cells which migrated to the pancreatic anlage during the early development of the fetus...
  75. ncbi request reprint Phosphoglyceride crystal deposition disease originating from the myocardium
    Fumihiro Shoji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Thorac Cardiovasc Surg 134:508-9. 2007
  76. ncbi request reprint Follicular dendritic cell sarcoma of the neck; a case report and literature review
    Torahiko Nakashima
    Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    Auris Nasus Larynx 29:401-3. 2002
    ..Adjuvant chemotherapy of cyclophosphamide/doxorubicin/vincristine/prednisone (CHOP) was given. Literature review provides the current information for the diagnosis and treatment of this unusual tumor...
  77. ncbi request reprint Severe pulmonary hypertension in a patient with systemic lupus erythematosus and minimal lupus activity
    Nobutoshi Kawamura
    Department of Cardiovascular Medicine, Kyushu University, Fukuoka
    Intern Med 41:109-12. 2002
    ..After 17 months of epoprostenol treatment, she died of pulmonary infarction. SLE-associated PH is often severe and progressive even in association with minimal activity...
  78. ncbi request reprint A case of breast cholesterol granuloma accompanied by cancer
    Chizu Furuhira
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Breast Cancer 11:210-3. 2004
    ..Histopathologic examination revealed cholesterol granuloma together with breast cancer, and additional partial mastectomy was subsequently performed. It is noted that breast cholesterol granuloma could be accompanied by cancer...
  79. doi request reprint VEGF-C and VEGFR-3 in a series of lymphangiomas: is superficial lymphangioma a true lymphangioma?
    Eijun Itakura
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Virchows Arch 454:317-25. 2009
    ..In cystic hygroma and intraabdominal lymphangioma, VEGF-C was limited in its distribution. Superficial lymphangiomas more likely represent from peripheral lymphatic dilatation rather than due to growth factor...
  80. ncbi request reprint Circumscribed mass lesions on mammography: dynamic contrast-enhanced MR imaging to differentiate malignancy and benignancy
    Takashi Okafuji
    Department of Clinical Radiology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Magn Reson Med Sci 7:195-204. 2008
    ..We evaluated the magnetic resonance (MR) features of breast lesions showing circumscribed mass on mammography to understand the characteristics that differentiate malignancy and benignancy...
  81. doi request reprint An unexpected cause of a febrile patient with huge splenomegaly
    Atsushi Nonami
    Medicine and Biosystemic Science, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Clin Rheumatol 27:941-3. 2008
    ..Our case suggests that when we see patients with fever and huge splenomegaly, differential diagnosis should include retroperitoneal fibrosis...
  82. ncbi request reprint [A case of rapidly growing inflammatory myofibroblastic tumor in the lung]
    Saiko Suetsugu
    Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
    Nihon Kokyuki Gakkai Zasshi 47:1156-60. 2009
    ..In the future, new therapy incorporating ALK inhibitors would be expected to treat those cases of IMT in which local recurrences and distant metastases occur...