Research Topics
Genomes and Genes
| Hidetaka YamamotoSummaryAffiliation: Kyushu University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Detection of COL1A1-PDGFB fusion transcripts and PDGFB/PDGFRB mRNA expression in dermatofibrosarcoma protuberansTomonari Takahira
The Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 20:668-75. 2007..The PDGFB and PDGFRB mRNA expression levels showed a good correlation (r=0.76, P<0.0001). These results indicate that the fusion protein, which is processed by the COL1A1-PDGFB transcripts, can serve as a functional ligand for PDGFRB...
Reduced expression of SMARCB1/INI1 protein in synovial sarcomaKenichi Kohashi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
Mod Pathol 23:981-90. 2010..46). Therefore, it was suggested that there is a post-transcriptional SMARCB1/INI1 regulatory mechanism in the tumor cells of synovial sarcoma...- Fascin-1 overexpression and miR-133b downregulation in the progression of gastrointestinal stromal tumorHidetaka Yamamoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
Mod Pathol 26:563-71. 2013..Our results suggest that downregulation of miR-133b and overexpression of fascin-1 may have an important role in the progression of GIST, and that fascin-1 may be a useful biomarker to predict the aggressive behavior... - KIT-negative gastrointestinal stromal tumor of the abdominal soft tissue: a clinicopathologic and genetic study of 10 casesHidetaka Yamamoto
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Am J Surg Pathol 35:1287-95. 2011.... - High levels of p53 expression correlate with DNA aneuploidy in (pre)malignancies of the vulvaIrene A M van der Avoort
Department of Obstetrics and Gynecology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Hum Pathol 41:1475-85. 2010..Furthermore, high p53 expression correlates with increased DNA content and aneuploidy; but it requires further research to unveil a possible causal relation... - Prognostic impact of blood vessel invasion in gastrointestinal stromal tumor of the stomachHidetaka Yamamoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hum Pathol 41:1422-30. 2010.... - Primary gastrointestinal stromal tumor of the liver with PDGFRA gene mutationHidetaka Yamamoto
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 41:605-9. 2010..Although KIT-negative gastrointestinal stromal tumor occurring outside the gastrointestinal tract is very rare, this entity should be considered as a potential primary hepatic neoplasm... - Inflammatory myofibroblastic tumor versus IgG4-related sclerosing disease and inflammatory pseudotumor: a comparative clinicopathologic studyHidetaka Yamamoto
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Am J Surg Pathol 33:1330-40. 2009..In addition, the evaluation of IgG4+ plasma cells and the ratio of IgG4+/IgG+ plasma cells and the presence of obstructive phlebitis may be useful for the differential diagnosis between IMT and IgG4-related sclerosing disease... - Absence of human herpesvirus-8 and Epstein-Barr virus in inflammatory myofibroblastic tumor with anaplastic large cell lymphoma kinase fusion geneHidetaka Yamamoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pathol Int 56:584-90. 2006..These results suggest that IMT may be a heterogeneous group in terms of pathogenesis, and EBV and HHV-8 do not play a major role in the pathogenesis of ALK-positive tumor... - Neurofibromatosis type 1-related gastrointestinal stromal tumors: a special reference to loss of heterozygosity at 14q and 22qHidetaka Yamamoto
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582, Japan
J Cancer Res Clin Oncol 135:791-8. 2009.... - Aggressive invasive micropapillary salivary duct carcinoma of the parotid glandHidetaka Yamamoto
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pathol Int 58:322-6. 2008..It is also important for pathologists to recognize that GCDFP-15 and AR expression can be reduced in micropapillary carcinoma in the differential diagnosis of metastatic tumor... - Infrequent SMARCB1/INI1 gene alteration in epithelioid sarcoma: a useful tool in distinguishing epithelioid sarcoma from malignant rhabdoid tumorKenichi Kohashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 40:349-55. 2009..Analysis of alterations in the SMARCB1/INI1 gene may thus be a useful diagnostic tool to distinguish proximal-type epithelioid sarcoma from malignant rhabdoid tumor... - Dysadherin expression as a significant prognostic factor and as a determinant of histologic features in synovial sarcoma: special reference to its inverse relationship with E-cadherin expressionTeiyu Izumi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
Am J Surg Pathol 31:85-94. 2007..Dysadherin expression is considered to be one of the determinants of histologic subtype in synovial sarcoma. Moreover, dysadherin expression is an excellent and independent prognostic indicator... - DNA hypermethylation status of multiple genes in soft tissue sarcomasKen-ichi Kawaguchi
Department of Anatomic Pathology, Pathological Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 19:106-14. 2006..Furthermore, MGMT methylation may be associated with tumor aggressiveness and the inactivation of MGMT gene... - Microsatellite instability and hMLH1 and hMSH2 expression analysis in soft tissue sarcomasKen-ichi Kawaguchi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Oncol Rep 13:241-6. 2005..These findings suggest that the inactivation of MMR gene expression might be the cause of MSI in STS cases... - SMARCB1/INI1 protein expression in round cell soft tissue sarcomas associated with chromosomal translocations involving EWS: a special reference to SMARCB1/INI1 negative variant extraskeletal myxoid chondrosarcomaKenichi Kohashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
Am J Surg Pathol 32:1168-74. 2008..The immunohistochemical result of the SMARCB1/INI expression is not an absolute diagnostic criteria for MRT and careful histologic evaluation is required to make a precise diagnosis of MRT... - Prognostic significance of dysadherin expression in epithelioid sarcoma and its diagnostic utility in distinguishing epithelioid sarcoma from malignant rhabdoid tumorTeiyu Izumi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 19:820-31. 2006..However, in malignant rhabdoid tumor, cell growth cycle that is regulated by hSNF5/INI1 gene seems to be critical to lethal biological behavior rather than dysadherin... - Aberrant expression of CHFR in malignant peripheral nerve sheath tumorsChikashi Kobayashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
Mod Pathol 19:524-32. 2006..In addition, MPNST with normal karyotype showed a strong (score, =5) expression of CHFR. Our results support the assertion that CHFR functions as an inhibitor of tumor proliferation... - Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14(ARF) expression both correlate with poor prognosisYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Pathol 207:410-21. 2005..In MLS/RCLS, reduction of p14 protein expression and p53 mutation were related to poor prognosis. Accordingly, the p14(ARF)/p53 pathway may contribute to the presence of an RC component and malignant progression in this tumour... - Possible association between tumor-suppressor gene mutations and hMSH2/hMLH1 inactivation in alveolar soft part sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hum Pathol 34:841-9. 2003..Thus, inactivation of hMSH2/hMLH1 of DNA mismatch repair genes seems to have an important role to play in the mutagenesis of the tumor-suppressor genes in ASPS... - Genetic and epigenetic alterations of the PTEN gene in soft tissue sarcomasKen Ichi Kawaguchi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 36:357-63. 2005..Furthermore, although a further detailed analysis of a larger number of cases is still necessary, the present results suggest that PTEN expression may be a useful indicator of cell proliferation in patients with STS... - Altered expression and molecular abnormalities of cell-cycle-regulatory proteins in rhabdomyosarcomaYukiko Takahashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 17:660-9. 2004..Alveolar type had a significantly higher both mitotic rate and E2F-1 labeling indices when compared with the embryonal type. The current study is the first report of the correlation of E2F-1 with alveolar rhabdomyosarcoma... - Non-mass-like enhancement on contrast-enhanced breast MR imaging: lesion characterization using combination of dynamic contrast-enhanced and diffusion-weighted MR imagesHidetake Yabuuchi
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Eur J Radiol 75:e126-32. 2010.... - Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular studyKohei Fujita
Department of Anatomic Pathology, Kyushu University, Fukuoka, Japan
Am J Surg Pathol 35:295-304. 2011..In addition, our histologic observations suggest a possible close association between SSAN and mucinous adenocarcinoma... - Alterations of RB1 gene in embryonal and alveolar rhabdomyosarcoma: special reference to utility of pRB immunoreactivity in differential diagnosis of rhabdomyosarcoma subtypeKenichi Kohashi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
J Cancer Res Clin Oncol 134:1097-103. 2008..Therefore, there might be a correlation between the tumorigenesis of RMS and RB1 alteration... - PTEN and other tumor suppressor gene mutations as secondary genetic alterations in synovial sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Oncol Rep 11:1011-5. 2004..8%), although the mutation status in TSG was not associated with overall survival rate in patients with SS. Secondary genetic alterations in these TSG seem to have a less important prognostic impact on patients with SS... - Death-associated protein kinase (DAP kinase) alteration in soft tissue leiomyosarcoma: Promoter methylation or homozygous deletion is associated with a loss of DAP kinase expressionKen Ichi Kawaguchi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hum Pathol 35:1266-71. 2004..Furthermore, although further detailed analyses are necessary, promoter methylation or homozygous deletion status of DAP kinase may present a major alternative mechanism of a loss of or decrease in DAP kinase expression... - Highly aggressive behavior of malignant rhabdoid tumor: a special reference to SMARCB1/INI1 gene alterations using molecular genetic analysis including quantitative real-time PCRKenichi Kohashi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, 812 8582, Japan
J Cancer Res Clin Oncol 133:817-24. 2007..Moreover, we investigated the status of hyperphosphorylation in RB protein, known as a key cell cycle molecule... - Glypican 3 expression in tumors with loss of SMARCB1/INI1 protein expressionKenichi Kohashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
Hum Pathol 44:526-33. 2013..Therefore, evaluation of GPC3 immunoexpression may be a useful diagnostic tool to distinguish ES from MRT, especially extrarenal MRT. It was suggested that MRTs with GPC3 overexpression may become a new target of GPC3 immunotherapy... - HER-2/neu gene amplification in carcinoma ex pleomorphic adenoma in relation to progression and prognosis: a chromogenic in-situ hybridization studyKazuki Hashimoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Histopathology 60:E131-42. 2012..The aim of this study was to investigate the potential role of HER-2/neu in the stepwise progression of carcinoma ex pleomorphic adenoma (CXPA) and to evaluate its prognostic significance in CXPA... - The Akt/mammalian target of rapamycin pathway is activated and associated with adverse prognosis in soft tissue leiomyosarcomasNokitaka Setsu
Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
Cancer 118:1637-48. 2012..Here the authors investigated the significance of activation of the Akt/mTOR pathway in soft tissue leiomyosarcomas... - Mechanisms of inactivation of the p16INK4a gene in leiomyosarcoma of soft tissue: decreased p16 expression correlates with promoter methylation and poor prognosisKen-ichi Kawaguchi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Pathol 201:487-95. 2003..Furthermore, promoter methylation was more frequent than either homozygous deletion or mutation in this tumour, and promoter methylation was also shown to have a strong association with inactivation of the p16INK4a gene... - E-cadherin mutation and Snail overexpression as alternative mechanisms of E-cadherin inactivation in synovial sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Oncogene 23:8629-38. 2004..Thus, E-cadherin downregulation is associated with the loss or absence of glandular epithelial differentiation in certain SS... - Correlation between beta-catenin widespread nuclear expression and matrix metalloproteinase-7 overexpression in sporadic desmoid tumorsHiroshi Matono
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582 Japan
Hum Pathol 39:1802-8. 2008.... - Prognostic significance of expressions of cell-cycle regulatory proteins in gastrointestinal stromal tumor and the relevance of the risk gradeNorimoto Nakamura
Department of Anatomic Pathology, Graduate School of Medical Sciences of Kyushu University, Fukuoka 812-8582, Japan
Hum Pathol 36:828-37. 2005..Furthermore, alteration of G2-M regulators, such as cyclin A, cyclin B1, and cdc2, is also a useful marker for predicting aggressive behavior and play an important role, at least in part, in the cell proliferation of GIST... - Phosphorylation of signal transducer and activator of transcription 3 in soft tissue leiomyosarcoma is associated with a better prognosisNokitaka Setsu
Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
Int J Cancer 132:109-15. 2013..STAT3 might not contribute to the progression of soft tissue LMS, and the phosphorylation status of STAT3 has the potential to be a favorable prognostic marker of LMS... - Alterations of the RB1 gene in dedifferentiated liposarcomaTomonari Takahira
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Mod Pathol 18:1461-70. 2005..These results suggest that retinoblastoma protein has a major role to play in dedifferentiation and that a 'two-hit' mechanism is involved in the altered retinoblastoma protein expression in dedifferentiated liposarcoma... - c-kit and PDGFRA mutations in extragastrointestinal stromal tumor (gastrointestinal stromal tumor of the soft tissue)Hidetaka Yamamoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Am J Surg Pathol 28:479-88. 2004..Furthermore, STI-571, targeting c-kit and PDGFR tyrosine kinase, seems to be a possible therapeutic strategy for EGISTs, especially advanced cases... - Down-regulation of artery in moderately differentiated hepatocellular carcinoma related to tumor developmentNobuhiro Fujita
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 41:838-47. 2010..The changes of arterial vessel density in moderately differentiated hepatocellular carcinomas were suggested... - CXCR4 and VEGF expression in the primary site and the metastatic site of human osteosarcoma: analysis within a group of patients, all of whom developed lung metastasisYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
Mod Pathol 19:738-45. 2006..0053). Our results suggested that CXCR4 expression was associated with metastatic progression, and immunohistochemical VEGF expression in the primary site had predictive value for the osteosarcoma patients, who developed lung metastasis... - Alterations of the p16INK4a/p14ARF pathway in clear cell sarcomaTomonari Takahira
Department of Anatomic Pathology (Second Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi-ku, Fukuoka 812-8582, Japan
Cancer Sci 95:651-5. 2004..3%). All tumors with genetic alterations of the p16INK4a/p14ARF or p53 gene showed a high mitotic rate or tumor necrosis. These alterations were considered to be influential in the poor prognosis of CCS patients... - Expression level of the mitotic checkpoint protein and G2-M cell cycle regulators and prognosis in gastrointestinal stromal tumors in the stomachAya Fujita
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Virchows Arch 460:163-9. 2012..In addition, decreased CHFR expression may play a role in increased proliferative activity of higher grade GISTs... - Diagnostic performance in differentiation of breast lesion on digital mammograms: comparison among hard-copy film, 3-megapixel LCD monitor, and 5-megapixel LCD monitorTakeshi Kamitani
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Clin Imaging 35:341-5. 2011..The soft-copy reading using the 3M LCD monitor took a slightly longer time, although there were no significant differences... - Heterozygosity loss at 22q and lack of INI1 gene mutation in gastrointestinal stromal tumorHidetaka Yamamoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan hidetaka surgpath med kyushu u ac jp
Pathobiology 78:132-9. 2011..The INI1 gene, located at 22q11.23, is a tumor suppressor gene that is frequently altered in malignant rhabdoid tumor... - Overexpression of A disintegrin and metalloproteinase 28 is correlated with high histologic grade in conventional chondrosarcomaSuguru Matsuura
Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 41:343-51. 2010.... - H-ras mutation is an additional event of sarcomatous transformation in aerodigestive spindle cell carcinomaHideki Shiratsuchi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Oncol Rep 11:597-604. 2004.... - Different expression profiles of Y-box-binding protein-1 and multidrug resistance-associated proteins between alveolar and embryonal rhabdomyosarcomaYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Cancer Sci 99:726-32. 2008..Apart from ERMS, frequent P-gp expression in ARMS may be independent from YB-1 regulation. However, YB-1 may be a candidate for a molecular target in rhabdomyosarcoma therapy, especially in ERMS... - Altered expression of cell cycle regulators in myxofibrosarcoma, with special emphasis on their prognostic implicationsYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Information Science, Kyushu University, Fukuoka, Japan
Hum Pathol 34:1035-42. 2003..Our results suggest that reduced expression of p21 could be considered a new parameter to be evaluated, along with classical clinicopathologic prognostic factors, for identifying those at high risk for myxofibrosarcoma... - Nuclear beta-catenin correlates with cyclin D1 expression in spindle and pleomorphic sarcomas but not in synovial sarcomaTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Hum Pathol 37:689-97. 2006..Thus, cyclin D1 could be considered as one of the targets of the nuclear beta-catenin in spindle cell and pleomorphic sarcomas. A possible association between beta-catenin accumulation and spindle cell morphogenesis may exist in SS... - Epithelial and cartilaginous differentiation in clear cell chondrosarcomaSuguru Matsuura
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
Hum Pathol 44:237-43. 2013..On the other hand, tumor cells of clear cell chondrosarcoma have no osteoblastic immunohistochemical expression in comparison with chondroblastoma... - Tumor-to-tumor metastasis: lung adenocarcinoma metastasizing to a follicular variant of papillary thyroid carcinomaKazuki Hashimoto
Department of Anatomic Pathology Department of Otolaryngology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pathol Int 61:435-41. 2011..These results demonstrate that a panel of immunohistochemical staining and molecular analysis is helpful for both diagnosis and appropriate postoperative treatment for a patient with cancer-to-cancer metastasis... - Microsatellite instability and p53 mutation associated with tumor progression in dermatofibrosarcoma protuberansTomonari Takahira
Department of Anatomic Pathology, Graduate School of Medicine, Kyushu University, Fukuoka, Japan
Hum Pathol 35:240-5. 2004..These results suggest that MSI and p53 mutations are involved in tumor progression of DFSP to fibrosarcoma as early and late events, respectively... - Detection of non-palpable breast cancer in asymptomatic women by using unenhanced diffusion-weighted and T2-weighted MR imaging: comparison with mammography and dynamic contrast-enhanced MR imagingHidetake Yabuuchi
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
Eur Radiol 21:11-7. 2011.... - Chromosomal aberrations and microsatellite instability of malignant peripheral nerve sheath tumors: a study of 10 tumors from nine patientsChikashi Kobayashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Cancer Genet Cytogenet 165:98-105. 2006..These findings suggest that chromosomal aberration as a consequence of CIN has a greater role in the pathogenesis of MPNST than does that due to MSI... - Close correlation between CXCR4 and VEGF expression and their prognostic implications in nasopharyngeal carcinomaYuichi Segawa
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Oncol Rep 21:1197-202. 2009..0044). Our findings suggest that the expression of CXCR4 and VEGF is associated with metastatic progression, and that VEGF expression is a valuable prognostic marker in nasopharyngeal carcinoma... - Microsatellite instability and proliferating activity in sinonasal carcinoma: molecular genetic and immunohistochemical comparison with oral squamous cell carcinomaHideoki Uryu
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 812-8582, Japan
Oncol Rep 14:1133-42. 2005..These findings suggest that sinonasal carcinoma and HNSCC have quite different molecular backgrounds regarding carcinogenesis, and the role of MSI is relatively minor in cases of advanced sinonasal carcinoma... - Prognostic significance of angiogenesis in gastrointestinal stromal tumorMasakazu Imamura
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashiku, Fukuoka, Japan
Mod Pathol 20:529-37. 2007.... - Decreased expression of transforming growth factor-beta II receptor is associated with that of p27KIP1 in giant cell tumor of bone: a possible link between transforming growth factor-beta and cell cycle-related proteinKen-ichi Kawaguchi
Department of Anatomic Pathology, Pathological Sciences, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
Hum Pathol 35:61-8. 2004..Furthermore, our results provide a possible link between the effects of extracellular growth factors and cell cycle control. In addition, p27 expression may be a useful indicator of cell proliferation in MSCs of this tumor... - ATP-binding cassette superfamily transporter gene expression in human soft tissue sarcomasYoshinao Oda
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Int J Cancer 114:854-62. 2005..In addition, the high levels of both MDR1 and MRP3 mRNA expression in MPNST may help to explain the poor response of this tumor to anticancer-drugs... - Inhibin-α and synaptophysin immunoreactivity in synovial sarcoma with granular cell featuresNokitaka Setsu
Department of Anatomic Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka 812 8582, Japan
Hum Pathol 43:850-7. 2012..This is the first report of immunoreactivity for inhibin-α and synaptophysin in synovial sarcoma. These immunohistochemical findings might be characteristic of synovial sarcomas with granular cell features... - S100P expression in ductal type of carcinoma ex pleomorphic adenomaKazuki Hashimoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Japan
Am J Surg Pathol 35:346-55. 2011.... - Multifocal metanephric adenoma in childhoodKenichi Kohashi
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Pathol Int 59:49-52. 2009..Thus, the histological and immunohistochemical features of the present case were compatible with metanephric adenoma... - Malignant perivascular epithelioid cell tumor of the colon: report of a case with molecular analysisHidetaka Yamamoto
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Japan
Pathol Int 56:46-50. 2006..The result suggests that the overexpression of cyclin D1 may play an important role in the tumorigenesis of PEComa. Because PEComas can behave in an aggressive manner, careful follow up is warranted... - Enhanced mass on contrast-enhanced breast MR imaging: Lesion characterization using combination of dynamic contrast-enhanced and diffusion-weighted MR imagesHidetake Yabuuchi
Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Magn Reson Imaging 28:1157-65. 2008.... - Prognostic significance of p14ARF, p15INK4b, and p16INK4a inactivation in malignant peripheral nerve sheath tumorsMakoto Endo
Departments of Anatomic Pathology and Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka Sanno Hospital, Fukuoka, Japan
Clin Cancer Res 17:3771-82. 2011..Here we carried out a genetic, epigenetic, and expression analysis of p14(ARF), p15(INK4b), and p16(INK4a), and clarified the prognostic significance of their inactivation in MPNSTs... - Low-grade fibrosarcoma of the proximal humerusTsuyoshi Saito
Department of Anatomic Pathology, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan
Pathol Int 53:115-20. 2003..The patient demonstrates no evidence of disease 42 months after surgery. It is important to detect the scant atypical cells for the differential diagnosis of low-grade fibrosarcoma and desmoplastic fibroma of bone... - Congenital pseudarthrosis of the tibia: analysis of the histology and the NF1 geneAkio Sakamoto
Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, Japan
J Orthop Sci 12:361-5. 2007..Congenital pseudarthrosis of the tibia (CPT) is frequently, but not always, associated with neurofibromatosis type 1 (NF1). Double inactivation of the NF1 gene has been reported to be the pathogenesis of CPT in NF1 cases... - Detection and characterization of vascular endothelial growth factors and their receptors in a series of angiosarcomasEijun Itakura
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Surg Oncol 97:74-81. 2008..The majority of angiosarcomas are thought to originate from vascular endothelia and spread via bloodstream to lung, but lymphatic metastases can occur... - PTEN/MMAC1 gene mutation is a rare event in soft tissue sarcomas without specific balanced translocationsTsuyoshi Saito
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
Int J Cancer 104:175-8. 2003.... - Mucinous cystic tumor of the pancreas: immunohistochemical assessment of "ovarian-type stroma"Akihiko Izumo
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Oncol Rep 10:515-25. 2003..We therefore conclude there is a possibility that MCT-P originates from the left remnant primordial gonadal cells which migrated to the pancreatic anlage during the early development of the fetus... - Follicular dendritic cell sarcoma of the neck; a case report and literature reviewTorahiko Nakashima
Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
Auris Nasus Larynx 29:401-3. 2002..Adjuvant chemotherapy of cyclophosphamide/doxorubicin/vincristine/prednisone (CHOP) was given. Literature review provides the current information for the diagnosis and treatment of this unusual tumor... - Phosphoglyceride crystal deposition disease originating from the myocardiumFumihiro Shoji
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
J Thorac Cardiovasc Surg 134:508-9. 2007 - Severe pulmonary hypertension in a patient with systemic lupus erythematosus and minimal lupus activityNobutoshi Kawamura
Department of Cardiovascular Medicine, Kyushu University, Fukuoka
Intern Med 41:109-12. 2002..After 17 months of epoprostenol treatment, she died of pulmonary infarction. SLE-associated PH is often severe and progressive even in association with minimal activity... - A case of breast cholesterol granuloma accompanied by cancerChizu Furuhira
Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
Breast Cancer 11:210-3. 2004..Histopathologic examination revealed cholesterol granuloma together with breast cancer, and additional partial mastectomy was subsequently performed. It is noted that breast cholesterol granuloma could be accompanied by cancer... - An unexpected cause of a febrile patient with huge splenomegalyAtsushi Nonami
Medicine and Biosystemic Science, Graduate School of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
Clin Rheumatol 27:941-3. 2008..Our case suggests that when we see patients with fever and huge splenomegaly, differential diagnosis should include retroperitoneal fibrosis... - VEGF-C and VEGFR-3 in a series of lymphangiomas: is superficial lymphangioma a true lymphangioma?Eijun Itakura
Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
Virchows Arch 454:317-25. 2009..In cystic hygroma and intraabdominal lymphangioma, VEGF-C was limited in its distribution. Superficial lymphangiomas more likely represent from peripheral lymphatic dilatation rather than due to growth factor... - Circumscribed mass lesions on mammography: dynamic contrast-enhanced MR imaging to differentiate malignancy and benignancyTakashi Okafuji
Department of Clinical Radiology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
Magn Reson Med Sci 7:195-204. 2008..We evaluated the magnetic resonance (MR) features of breast lesions showing circumscribed mass on mammography to understand the characteristics that differentiate malignancy and benignancy... - [A case of rapidly growing inflammatory myofibroblastic tumor in the lung]Saiko Suetsugu
Research Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University
Nihon Kokyuki Gakkai Zasshi 47:1156-60. 2009..In the future, new therapy incorporating ALK inhibitors would be expected to treat those cases of IMT in which local recurrences and distant metastases occur...