Koji Yamada

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi [Chemo-pharmaceutical studies on the glycosphingolipid constituents from echinoderm, sea cucumbers, as the medicinal materials]
    Koji Yamada
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Yakugaku Zasshi 122:1133-43. 2002
  2. ncbi Isolation and structure of a monomethylated ganglioside possessing neuritogenic activity from the ovary of the sea urchin Diadema setosum
    Koji Yamada
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 56:734-7. 2008
  3. ncbi Constituents of Holothuroidea, 18. Isolation and structure of biologically active disialo- and trisialo-gangliosides from the sea cucumber Cucumaria echinata
    Fumiaki Kisa
    Faculty of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 54:1293-8. 2006
  4. ncbi The impact of the 67kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Arch Biochem Biophys 476:133-8. 2008
  5. ncbi Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa laminin receptor
    Ju Hye Lee
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki, Japan
    PLoS ONE 5:e11051. 2010
  6. ncbi Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor
    Eui Hong Byun
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    FEBS Lett 585:814-20. 2011
  7. ncbi Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Agric Food Chem 54:5203-7. 2006
  8. ncbi Green tea polyphenol EGCG sensing motif on the 67-kDa laminin receptor
    Yoshinori Fujimura
    Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e37942. 2012
  9. ncbi Constituents of Holothuroidea, 17. Isolation and structure of biologically active monosialo-gangliosides from the sea cucumber Cucumaria echinata
    Fumiaki Kisa
    Faculty of Pharmaceutical Sciences, Kyushu University Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 54:982-7. 2006
  10. ncbi Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cells
    Daisuke Umeda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 371:172-6. 2008

Collaborators

Detail Information

Publications88

  1. ncbi [Chemo-pharmaceutical studies on the glycosphingolipid constituents from echinoderm, sea cucumbers, as the medicinal materials]
    Koji Yamada
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Yakugaku Zasshi 122:1133-43. 2002
    ..It also became apparent that sialic acid is indispensable for the neuritogenic activities...
  2. ncbi Isolation and structure of a monomethylated ganglioside possessing neuritogenic activity from the ovary of the sea urchin Diadema setosum
    Koji Yamada
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 56:734-7. 2008
    ..These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor, in which compound 3 showed the most potent activity...
  3. ncbi Constituents of Holothuroidea, 18. Isolation and structure of biologically active disialo- and trisialo-gangliosides from the sea cucumber Cucumaria echinata
    Fumiaki Kisa
    Faculty of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 54:1293-8. 2006
    ..These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor...
  4. ncbi The impact of the 67kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Arch Biochem Biophys 476:133-8. 2008
    ..These results suggest that both the galloyl moiety and the B-ring hydroxylation pattern contribute to the exertion of biological activities of tea catechins and their 67LR-dependencies...
  5. ncbi Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa laminin receptor
    Ju Hye Lee
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki, Japan
    PLoS ONE 5:e11051. 2010
    ....
  6. ncbi Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor
    Eui Hong Byun
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    FEBS Lett 585:814-20. 2011
    ..Silencing of Toll-interacting protein (Tollip), a negative regulator of TLR signaling impaired the TLR2 signaling inhibitory activity of EGCG, suggesting that TLR2 response could be inhibited by EGCG via 67LR and Tollip...
  7. ncbi Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Agric Food Chem 54:5203-7. 2006
    ..These results suggest that a diet containing apigenin can reduce serum IgE and inflammatory cytokines such as RANTES and sTNFRI in mice...
  8. ncbi Green tea polyphenol EGCG sensing motif on the 67-kDa laminin receptor
    Yoshinori Fujimura
    Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e37942. 2012
    ..However, the underlying mechanism for interaction between EGCG and 67LR remains unclear. In this study, we investigated the possible role of EGCG-67LR interaction responsible for its bioactivities...
  9. ncbi Constituents of Holothuroidea, 17. Isolation and structure of biologically active monosialo-gangliosides from the sea cucumber Cucumaria echinata
    Fumiaki Kisa
    Faculty of Pharmaceutical Sciences, Kyushu University Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 54:982-7. 2006
    ..These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor...
  10. ncbi Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cells
    Daisuke Umeda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 371:172-6. 2008
    ..These results suggest that through 67LR, EGCG at a physiological concentration can activate myosin phosphatase by reducing MYPT1 phosphorylation and that may be involved in EGCG-induced cell growth inhibition...
  11. ncbi Determination of the absolute configuration of sialic acids in gangliosides from the sea cucumber Cucumaria echinata
    Fumiaki Kisa
    Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 55:1051-2. 2007
    ....
  12. ncbi Neuritogenic activity of gangliosides from echinoderms and their structure-activity relationship
    Masafumi Kaneko
    Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 55:462-3. 2007
    ..The results show that they displayed neuritogenic activity. Based on the observed results, a structure-activity relationship has been established...
  13. ncbi Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG
    Shuntaro Tsukamoto
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    FEBS Lett 586:3441-7. 2012
    ..In summary, 67LR expression is highly sensitive to O(2) partial pressure, and the activity of EGCG can be regulated in cancer cells by O(2) partial pressure...
  14. ncbi Important role of β1-integrin in fucoidan-induced apoptosis via caspase-8 activation
    Yumi Yamasaki
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 76:1163-8. 2012
    ..Fucoidan also induced recruitment of caspase-8 to the β1-integrin intracellular domain, cleaved it into the activated protein by direct combination with β1-integrin, and induced apoptosis via the caspase cascade in MCF-7 cells...
  15. ncbi Isolation and structure of a galactocerebroside from the sea cucumber Bohadschia argus
    Yuriko Ikeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 57:315-7. 2009
    ..This is the first report of isolation and structure determination of galactocerebroside from sea cucumber...
  16. ncbi Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain
    Shuya Yamashita
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    FEBS Lett 584:775-9. 2010
    ..Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling...
  17. ncbi TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor
    Eui Hong Byun
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    J Immunol 185:33-45. 2010
    ....
  18. ncbi Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    J Nutr Biochem 20:876-81. 2009
    ..These results suggest that apigenin attenuates exacerbation of AD-like symptoms in part through the reduction of serum IgE level and IFN-gamma expression in NC/Nga mice...
  19. ncbi The 67kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 364:79-85. 2007
    ..These results suggest that anti-allergic effects of EGCG3"Me may be triggered by the inhibition of MRLC or ERK1/2 phosphorylation mediated through the cell-surface 67LR...
  20. ncbi Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor
    Daisuke Umeda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    J Biol Chem 283:3050-8. 2008
    ..Additionally, we found that eEF1A is up-regulated by EGCG through 67LR. Overall, these findings implicate both eEF1A and MYPT1 in EGCG signaling for cancer prevention through 67LR...
  21. ncbi H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation
    Daisuke Umeda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Eur J Pharmacol 590:61-6. 2008
    ..These results suggest that H89-induced reduction of the MRLC phosphorylation results from inhibition of Rho-kinase and that H89-induced cell growth inhibition is independent of reduction of the MRLC phosphorylation...
  22. ncbi Mechanisms of thiosulfinates from Allium tuberosum L.-induced apoptosis in HT-29 human colon cancer cells
    Ju Hye Lee
    Department of Bioscience and Biotechnology, Kyushu University, Fukuoka 812 8581, Japan
    Toxicol Lett 188:142-7. 2009
    ..These results indicate that thiosulfinates from A. tuberosum L. inhibited cell proliferation and activated both the caspase-dependent and caspase-independent apoptotic pathways in HT-29 cells...
  23. ncbi Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cδ and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells
    Shuntaro Tsukamoto
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biochem J 443:525-34. 2012
    ..Additionally, orally administered EGCG activated PKCδ and aSMase in a murine MM xenograft model. These results elucidate a novel cell-death pathway triggered by EGCG for the specific killing of MM cells...
  24. ncbi Modulation of proliferation and differentiation of C2C12 skeletal muscle cells by fatty acids
    Ju Hye Lee
    Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Life Sci 84:415-20. 2009
    ..This study was performed to elucidate whether mitogen-activated protein kinases (MAPKs) are involved in the modulation of the proliferation and differentiation of skeletal muscle cells by fatty acids...
  25. ncbi Constituents of holothuroidea, 16. Determination of Absolute configuration of the branched methyl group in ante-iso type side chain moiety on long chain base of glucocerebroside from the sea cucumber Holothuria leucospilota
    Koji Yamada
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 53:1333-4. 2005
    ..The optically active C13-fragment was synthesized asymmetrically by using the Wittig reaction from chiral synton for comparison with the natural fragment...
  26. ncbi Lipid raft-associated catechin suppresses the FcepsilonRI expression by inhibiting phosphorylation of the extracellular signal-regulated kinase1/2
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, 812-8581, Fukuoka, Japan
    FEBS Lett 556:204-10. 2004
    ..Thus, these results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcepsilonRI expression, and ERK1/2 may be involved in this suppression signal...
  27. ncbi Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo
    Yuhei Hiura
    Faculty of Agriculture, Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka 812 8581, Japan
    J Nutr Biochem 20:607-13. 2009
    ..These results, to our knowledge, are the first demonstration of specific accumulation of gamma-T3 and delta-T3 in tumors and suggest that T3 accumulation is critical for the antitumor activities of T3...
  28. ncbi Metabolomics-driven nutraceutical evaluation of diverse green tea cultivars
    Yoshinori Fujimura
    Innovation Center for Medical Redox Navigation, Kyushu University, Higashi ku, Fukuoka, Japan
    PLoS ONE 6:e23426. 2011
    ..Here, we performed metabolomic analyses to explore the relationship between the metabolome and health-promoting attributes (bioactivity) of diverse Japanese green tea cultivars...
  29. ncbi Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 cells
    Yumi Yamasaki-Miyamoto
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Agric Food Chem 57:8677-82. 2009
    ..However, caspase-9-specific inhibitor exerted a moderate inhibitory effect on the cytotoxicity of fucoidan. These data indicated that fucoidan could induce apoptotic cell death through a caspase-8-dependent pathway in MCF-7 cells...
  30. ncbi Dose-dependent effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84 cells in vivo
    Masao Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:505-11. 2002
    ..5 wt.% enhances the growth of transplanted dRLh-84 cells in vivo. It is believed that growth promotion of dRLh-84 cells in vivo by CLA cannot be clarified by the PG synthesis dependent mechanism...
  31. ncbi Effect of dietary fiber on the lipid metabolism and immune function of aged Sprague-Dawley rats
    Koji Yamada
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biosci Biotechnol Biochem 67:429-33. 2003
    ..These results suggest that enhancement of the immune function by dietary fiber is mainly expressed in the gut immune system...
  32. ncbi Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid
    Masao Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka 812 8581, Japan
    J Nutr 133:784-8. 2003
    ..These results suggest that 9c,11t and 10t,12c-CLA can stimulate different immunological effects and that the simultaneous intake of the two isomers can change the T cell population...
  33. ncbi Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets
    Masao Yamasaki
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Nutrition 19:30-5. 2003
    ..CONCLUSION: In conclusion, dietary CLA, especially the low-fat diet, reduced body fat without hepatic injury to Sprague-Dawley rats...
  34. ncbi Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Dept of Bioscience and Biotechnology, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka, 812 8581, Japan
    Eur J Nutr 46:257-63. 2007
    ..We also demonstrated that dietary apigenin decreased IgE level in C57BL/6N mice sera...
  35. ncbi Isoflavone genistein and daidzein up-regulate LPS-induced inducible nitric oxide synthase activity through estrogen receptor pathway in RAW264.7 cells
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Pharmacol 71:108-14. 2005
    ..7 cells, while an ERbeta agonist could not. In conclusion, our results suggest E2, genistein and daidzein activate iNOS, and then up-regulate NO production. This enhancing effect is aroused through ERalpha pathway in RAW264.7 cells...
  36. ncbi A receptor for green tea polyphenol EGCG
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Nat Struct Mol Biol 11:380-1. 2004
    ..Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K (d) value...
  37. ncbi Cholesterol esterase accelerates intestinal cholesterol absorption
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1571:34-44. 2002
    ..This may be a major cause of the acceleration of cholesterol absorption by cholesterol esterase...
  38. ncbi The involvement of the 67 kDa laminin receptor-mediated modulation of cytoskeleton in the degranulation inhibition induced by epigallocatechin-3-O-gallate
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 348:524-31. 2006
    ..These findings suggest that EGCG-induced inhibition of the degranulation includes the primary binding of EGCG to the cell surface 67LR and subsequent modulation of cytoskeleton...
  39. ncbi Physiological difference between free and triglyceride-type conjugated linoleic acid on the immune function of C57BL/6N mice
    Masao Yamasaki
    Research and Development Division, Omu Milk Products Company, Ltd, 1 38 1 Shin katsudachi Omuta, Fukuoka 836 0895, Japan
    J Agric Food Chem 52:3644-8. 2004
    ..In addition, seven cytokines were 2-fold down-regulated by TG-CLA. These data show that there is a slight but significant difference between the functionalities of FFA- and TG-CLA...
  40. ncbi Effect of estrogens on the interferon-gamma producing cell population of mouse splenocytes
    Mako Nakaya
    Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 70:47-53. 2006
    ..The ligand specific to plasma membrane-associated ER (mER) enhanced the IFN-gamma production. In conclusion, our results indicated that E2 up-regulated the IFN-gamma production by mediating ERalpha, ERbeta and mERs...
  41. ncbi Simultaneous determination of isoflavones and bisphenol A in rat serum by high-performance liquid chromatography coupled with coulometric array detection
    Shin Yasuda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 68:51-8. 2004
    ..Compound 7 in the serum was not detected until after enzymatic hydrolysis (72 ng/ml). These results suggest that this analytical method would be useful for metabolic and pharmacokinetic studies on isoflavones and bisphenol A...
  42. ncbi Cholesterol esterase bound to intestinal brush border membranes does not accelerate incorporation of micellar cholesterol into absorptive cells
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 67:2381-7. 2003
    ..The results suggest that the accelerated incorporation of micellar cholesterol by cholesterol esterase into absorptive cells is not mediated by the enzyme bound to the brush border membranes...
  43. ncbi Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Japan
    Biosci Biotechnol Biochem 71:253-5. 2007
    ..Royal jelly inhibited the growth-promoting effect of BPA on MCF-7 cells, even though it did not affect the proliferation of cells in the absence of BPA. In addition, this inhibiting effect of royal jelly was heat-stable...
  44. ncbi Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: lipid rafts mediate anti-allergic action of the catechin
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biofactors 21:383-5. 2004
    ..These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcepsilonRI expression...
  45. ncbi Estrogenic compounds suppressed interferon-gamma production in mouse splenocytes through direct cell-cell interaction
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    In Vitro Cell Dev Biol Anim 39:383-7. 2003
    ..In addition, E2 conjugated with bovine serum albumin inhibited IFN-gamma production as well as E2. This result suggests that the plasma membrane-associated estrogen receptor plays a prominent role in this suppression mechanism...
  46. ncbi Antioxidant and anti-inflammatory effects of a diet supplemented with sesamin on hepatic ischemia-reperfusion injury in rats
    Tohru Utsunomiya
    Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Beppu, Japan
    Hepatogastroenterology 50:1609-13. 2003
    ..We investigated the effects of a diet containing sesamin on hepatic ischemia-reperfusion injury in rats...
  47. ncbi IgM production of lymphocytes from C57BL/6N mice was stimulated by estrogen treated splenic adherent cells
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Immunol Lett 98:225-31. 2005
    ....
  48. ncbi A comparison of the immunostimulatory effects of the medicinal herbs Echinacea, Ashwagandha and Brahmi
    Koji Yamada
    Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Fukuoka 812 8581, Japan
    J Ethnopharmacol 137:231-5. 2011
    ..Here, we investigated the potential for two herbs commonly found in India, Ashwagandha (Withania somnifera) and Brahmi (Bacopa monnieri), to enhance immune function and compared their effects to that of Echinacea...
  49. ncbi Mode of interaction of ganglioside Langmuir monolayer originated from echinoderms: three binary systems of ganglioside/DPPC, ganglioside/DMPE, and ganglioside/cholesterol
    Kazuki Hoda
    Division of Biointerfacial Science, Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Colloids Surf B Biointerfaces 52:57-75. 2006
    ..The observations using fluorescence microscopy and AFM image also provide us the miscibility in the monolayer state...
  50. ncbi Effect of dietary conjugated linoleic acid on liver regeneration after a partial hepatectomy in rats
    Akira Hirao
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:9-12. 2004
    ..In conclusion, the data suggests that dietary CLA inhibits DNA synthesis after PH, which results in hepatocyte proliferation inhibition...
  51. ncbi Antiallergic tea catechin, (-)-epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses FcepsilonRI expression in human basophilic KU812 cells
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Agric Food Chem 50:5729-34. 2002
    ..EGCG' '3Me treatment inhibited the FcepsilonRI cross-linking-induced histamine release. These results suggested that EGCG' '3Me can negatively regulate basophil activation through the suppression of FcepsilonRI expression...
  52. ncbi Epigallocatechin-3-O-gallate disrupts stress fibers and the contractile ring by reducing myosin regulatory light chain phosphorylation mediated through the target molecule 67 kDa laminin receptor
    Daisuke Umeda
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 333:628-35. 2005
    ..These results suggest that EGCG inhibits the cell growth by reducing the MRLC phosphorylation and this effect is mediated by the 67LR...
  53. ncbi A difference between epigallocatechin-3-gallate and epicatechin-3-gallate on anti-allergic effect is dependent on their distinct distribution to lipid rafts
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan
    Biofactors 21:133-5. 2004
    ..On the other hand, the level of ECG in rafts was lower than that of EGCG, suggesting that the association with lipid rafts may have an important role in the FcepsilonRI-suppressive effect of catechins...
  54. ncbi Protein-bound polysaccharide-K (PSK) directly enhanced IgM production in the human B cell line BALL-1
    Shinjiro Maruyama
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka, Japan
    Biomed Pharmacother 63:409-12. 2009
    ..These results show that there is a possibility that PSK directly acts on B cells and simultaneously enhances both humoral immunity and cellular immunity...
  55. ncbi Constituents of Holothuroidea, 13. Structure of neuritogenic active ganglioside molecular species from the sea cucumber Stichopus chloronotus
    Koji Yamada
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 51:46-52. 2003
    ..Moreover, these three gangliosides exhibited neuritogenic activity toward the rat pheochromocytoma PC12 cells in the presence of nerve growth factor...
  56. ncbi A lipid raft-associated 67kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on FcepsilonRI expression
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 336:674-81. 2005
    ..Thus, these results suggest that the lipid raft-associated 67LR plays an important role in mediating the FcepsilonRI-suppressive action of EGCG...
  57. ncbi Tea catechin, epigallocatechin-3-gallate suppresses myosin II regulatory light chain phosphorylation
    Daisuke Umeda
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    Biofactors 21:387-9. 2004
    ..None of the inhibitors mimic the activity of EGCG. These results suggest that EGCG is a compound that can suppress MRLC phosphorylation...
  58. ncbi Effect of conjugated linoleic acid isomers on growth factor-induced proliferation of human breast cancer cells
    Hitomi Chujo
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    Cancer Lett 202:81-7. 2003
    ..In conclusion, although both c9, t11 and t10, c12-CLA can inhibit the proliferation of MCF-7 cells, our results suggested that they have separate mechanisms and different targets of actions...
  59. ncbi Recombinant perchloric acid-soluble protein suppresses the immunoglobulin production of human-human hybridoma HB4C5 cells
    Hiroaki Kanouchi
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    In Vitro Cell Dev Biol Anim 39:263-5. 2003
    ..These results suggest that the Ig production suppressed by PSP, which has been previously reported to inhibit protein synthesis, contributed to the incorporation of PSP into the HB4C5 cells...
  60. ncbi Flavones suppress the expression of the high-affinity IgE receptor FcepsilonRI in human basophilic KU812 cells
    Satomi Yano
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Agric Food Chem 53:1812-7. 2005
    ..These results suggested that chrysin and apigenin have the ability to downregulate FcepsilonRI expression and this suppressive effect may be due to the reduction of ERK1/2 phosphorylation...
  61. ncbi Relationship between the biological activities of methylated derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) and their cell surface binding activities
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Fukuoka, Japan
    J Agric Food Chem 55:7144-8. 2007
    ....
  62. ncbi Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells
    Yumi Miyamoto-Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Fukuoka 812 8581, Japan
    Cell Biol Int 31:1501-6. 2007
    ..Our data show that basic JNK activity plays an important role in the progression of the cell cycle at G2/M cell phase...
  63. ncbi Constituents of Holothuroidea, 15. Isolation of ante-iso type regio-isomer on long chain base moiety of glucocerebroside from the sea cucumber Holothuria leucospilota
    Koji Yamada
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 53:788-91. 2005
    ..Other typical glucocerebroside molecular species HLC-1 and HLC-3 were obtained together with HLC-2. The structures of these glucocerebrosides were determined on the basis of chemical and spectroscopic evidence...
  64. ncbi Induction of apoptosis by tocotrienol in rat hepatoma dRLh-84 cells
    Midori Sakai
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    Anticancer Res 24:1683-8. 2004
    ..The difference in terms of apoptosis induction by vitamin E homologues seems to be related to their different rates of cellular incorporation...
  65. ncbi Peroxisome proliferator-activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Division of Bioresources and Bioenvironmental Sciences, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    Biochem Biophys Res Commun 297:193-201. 2002
    ..These results suggest that the suppression of Fc epsilon RI expression by PPARs may be due to the down-regulation of Fc epsilon RI alpha or gamma mRNA...
  66. ncbi Constituents of holothuroidea, 12. Isolation and structure of glucocerebrosides from the sea cucumber Holothuria pervicax
    Koji Yamada
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 50:1467-70. 2002
    ..Reversed-phase HPLC, including a recycling system, was effective in isolating these glucocerebrosides, revealing a very close resemblance in structure, though the problem due to regio-isomers remains...
  67. ncbi Inhibitory effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39
    Yoshiyuki Miyazaki
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Laboratory of Food Chemistry, Faculty of Agriculture, Kyushu University, 46-09, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    Biochem Biophys Res Commun 295:547-52. 2002
    ..These results suggest that PPAR gamma ligands inhibit IL-4-induced IgE class switching in B lymphocytes...
  68. ncbi Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells
    Midori Sakai
    Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6-10-1 Hakozaki, Higashi-ku, Fukuoka 812-8581, Japan
    J Nutr Biochem 17:672-6. 2006
    ..These data indicate that gamma-T3 induced apoptosis in Hep3B cells and that caspase-8 and caspase-9 were involved in apoptosis induction. Moreover, these results suggest that Bax and Bid regulated apoptosis induction by gamma-T3...
  69. ncbi Improvement of biological activity and proteolytic stability of peptides by coupling with a cyclic peptide
    Kenji Shibata
    Tokyo Research Laboratories, Kyowa Hakko Kogyo Co, Ltd, 3-6-6, Asahi-machi, Machida-shi, Tokyo 194-8533, Japan
    Bioorg Med Chem Lett 13:2583-6. 2003
    ..Coupling of our cyclic peptide is anticipated to be a novel conformational stabilizing method for biologically active peptides, results to improve their activity and stability...
  70. ncbi Effects of estrogenic compounds on immunoglobulin production by mouse splenocytes
    Dalho Han
    Department of Environmental Toxicology, University of California, Davis 95616 8588, USA
    Biol Pharm Bull 25:1263-7. 2002
    ..These results suggest that environmental estrogens affect Ig production of mouse Splenocytes in a complex and class-specific manner...
  71. ncbi Conjugated linoleic acid reduces body fats and cytokine levels of mice
    Asuka Akahoshi
    Faculty of Environmental and Symbiotic Sciences, Prefectural University of Kumamoto, Japan
    Biosci Biotechnol Biochem 66:916-20. 2002
    ..There was a positive correlation between cytokine production and body-fat reducing potential of CLA. These results indicated that mice appeared to be a hyperresponder to dietary CLA insofar as the reduction of body fat size is concerned...
  72. ncbi Relationship between estrogen receptor-binding and estrogenic activities of environmental estrogens and suppression by flavonoids
    Dal Ho Han
    Department of Environmental Toxicology, University of California, Davis 95616 8588, USA
    Biosci Biotechnol Biochem 66:1479-87. 2002
    ..The suppressive effect of flavonoids suggests that these compounds have anti-estrogenic and anti-cancer activities...
  73. ncbi Increase of immunoglobulin productivity of human-human hybridoma HB4C5 cells by histone
    Takeaki Okamoto
    Department of Bioscience and Biotechnology, Graduate School of Kyushu University, Hakozaki, Fukuoka, Japan
    Biosci Biotechnol Biochem 66:1241-5. 2002
    ..These facts strongly suggest that histone acts as an immunoglobulin production-stimulating factor (IPSF) after internalization into the human B cell lines and the native structure of histone is required for the IPSF activity...
  74. ncbi Dietary conjugated linolenic acid in relation to CLA differently modifies body fat mass and serum and liver lipid levels in rats
    Kazunori Koba
    Faculty of Nursing and Nutrition, Siebold University of Nagasaki, Japan
    Lipids 37:343-50. 2002
    ..1; vs. epididymal: r = 0.382, P < 0.05). Although the mechanism for the specific effect of CLNA is not clear at present, these findings indicate that in rats CLNA modulated the body fat and TG metabolism differently from CLA...
  75. ncbi Trans10, cis12-conjugated linoleic acid induces mitochondria-related apoptosis and lysosomal destabilization in rat hepatoma cells
    Masao Yamasaki
    Division of Food Science and Nutrition, Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, Miyazaki University, Miyazaki 889 2192, Japan
    Biochim Biophys Acta 1735:176-84. 2005
    ..10t, 12c-CLA directly degraded the isolated lysosomes from the rat liver. Our observations indicate that 10t, 12c-CLA induces mitochondria-related apoptosis accompanied by lysosomal destabilization in rat hepatoma cells...
  76. ncbi Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice
    Masao Yamasaki
    Department of Biochemistry and Applied BioScience, Faculty of Agriculture, Miyazaki University, Miyazaki, Japan
    Nutrition 22:54-9. 2006
    ..We evaluated the effects of dietary pomegranate seed oil (PSO), which contains high levels of punicic acid (9c, 11t, 13c-octadecatrienoic acid), on immune function and lipid metabolism in C57BL/6N mice...
  77. ncbi Comparative study on the modulation of IgE and cytokine production by Phellinus linteus grown on germinated brown Rice, Phellinus Linteus and germinated brown rice in murine splenocytes
    Beong Ou Lim
    Department of Life Science, Konkuk University, Chungbuk, Korea
    Biosci Biotechnol Biochem 68:2391-4. 2004
    ..These results may be related to the suppression of IgE production. We conclude that PB modulated the immune responses of IgE production and Th1/Th2 cytokine secretion in murine splenocytes...
  78. ncbi Cytotoxity of the trans10,cis12 isomer of conjugated linoleic acid on rat hepatoma and its modulation by other fatty acids, tocopherol, and tocotrienol
    Masao Yamasaki
    Department of Biochemistry and Applied BioScience, Faculty of Agriculture, Miyazaki University, 1 1 Gakuenkibanadai nishi, Miyazaki 889 2192, Japan
    In Vitro Cell Dev Biol Anim 41:239-44. 2005
    ..When cells were treated with 10 microM 10t,12c-CLA for more than 48 h, treatment with additional CLA or alpha-toc could not prevent cell death...
  79. ncbi Oleic acid prevents apoptotic cell death induced by trans10, cis12 isomer of conjugated linoleic acid via p38 MAP kinase dependent pathway
    Masao Yamasaki
    Department of Biochemistry and Applied BioScience, Faculty of Agriculture, Miyazaki University, 1 1 Gakuenkibanadai nishi, Miyazaki 889 2192, Japan
    In Vitro Cell Dev Biol Anim 44:290-4. 2008
    ..However, oleic acid completely inhibited this effect. These observations indicated the involvement of blockade of a p38 MAPK pathway in the ameliorative effect of oleic acid on apoptosis induced by t10, c12-conjugated linoleic acid...
  80. ncbi Thiosulfinates from Allium tuberosum L. induce apoptosis via caspase-dependent and -independent pathways in PC-3 human prostate cancer cells
    So Yeon Kim
    Department of Food and Nutrition, Sunchon National University, 315 Maegok, Suncheon, Jeonnam 540 742, Republic of Korea
    Bioorg Med Chem Lett 18:199-204. 2008
    ..These results indicate that thiosulfinates from A. tuberosum L. inhibit cell proliferation and induce apoptosis in PC-3 cells, which may be mediated via both caspase-dependent and -independent pathways...
  81. ncbi Novel diphenylalkyl piperazine derivatives with dual calcium antagonistic and antioxidative activities
    Makoto Kimura
    Pharmaceutical R and D Laboratories, POLA Chemical Industries Inc, 560, Kashio cho, Totsuka ku, Yokohama, Kanagawa 244 0812, Japan
    Bioorg Med Chem Lett 12:1947-50. 2002
    ..Both compounds showed the most potent inhibitions to basilar artery...
  82. ncbi Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents
    Kyoko Nakagawa-Goto
    Natural Products Research Laboratories, School of Pharmacy, University of North Carolina, Chapel Hill, NC 27599, USA
    Bioorg Med Chem Lett 17:5204-9. 2007
    ....
  83. ncbi N-acyl 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline: the first orexin-2 receptor selective non-peptidic antagonist
    Masaaki Hirose
    Banyu Tsukuba Research Institute, Banyu Pharmaceutical Co, Ltd, Okubo 3, Tsukuba 300 2611, Ibaraki, Japan
    Bioorg Med Chem Lett 13:4497-9. 2003
    ..Thus, compound 29 is a promising tool to investigate the role of orexin-2 receptors...
  84. ncbi Induction of apoptosis by thiosulfinates in primary human prostate cancer cells
    So Yeon Kim
    Department of Food and Nutrition, Sunchon National University, Suncheon, Jeonnam 540 742, Republic of Korea
    Int J Oncol 32:869-75. 2008
    ..These results indicate that thiosulfinates from Allium tuberosum L. inhibit cell proliferation by inducing apoptosis in RC-58T/h/#4 cells which may be mediated via both caspase-dependent and caspase-independent pathways...
  85. ncbi Novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter
    Makoto Kimura
    POLA Chemical Industries, Inc, Pharmaceutical R and D Laboratories, 560 Kashio cho, Totsuka ku, Yokohama, Kanagawa 244 0812, Japan
    Bioorg Med Chem 11:3953-63. 2003
    ....
  86. ncbi Effects of hypoxic cell radiosensitizer doranidazole (PR-350) on the radioresponse of murine and human tumor cells in vitro and in vivo
    Tomoaki Yahiro
    POLA Chemical Industries, Inc, Pharmaceutical R and D Labs, 560 Kashio cho, Totsuka ku, Yokohama 244 0812, Japan
    J Radiat Res 46:363-72. 2005
    ....
  87. ncbi Antioxidative activities of novel diphenylalkyl piperazine derivatives with high affinities for the dopamine transporter
    Makoto Kimura
    POLA Chemical Industries, Inc, Pharmaceutical R and D Laboratories, 560 Kashio cho, Totsuka ku, Yokohama, Kanagawa 244 0812, Japan
    Bioorg Med Chem Lett 14:4287-90. 2004
    ..32 microM, exhibiting approximately 5-fold more potent activity than alpha-tocopherol. The structure-activity relationship (SAR) studies of the antioxidative activity of these derivatives are presented...
  88. ncbi IPC synthase as a useful target for antifungal drugs
    Yuichi Sugimoto
    Banyu Tsukuba Research Institute, Okuba 3, Tsukuba 300 2611, Ibaraki, Japan
    Curr Drug Targets Infect Disord 4:311-22. 2004
    ....