Koji Yamada

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Effect of dietary fiber on the lipid metabolism and immune function of aged Sprague-Dawley rats
    Koji Yamada
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biosci Biotechnol Biochem 67:429-33. 2003
  2. ncbi request reprint Dietary effect of guar gum and its partially hydrolyzed product on the lipid metabolism and immune function of Sprague-Dawley rats
    K Yamada
    Department of Bioscience and Biotechnology, Graduate School of Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 63:2163-7. 1999
  3. ncbi request reprint Effect of unsaturated fatty acids and antioxidants on immunoglobulin production by mesenteric lymph node lymphocytes of Sprague-Dawley rats
    K Yamada
    Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, Fukuoka
    J Biochem 120:138-44. 1996
  4. ncbi request reprint Recent topics in anti-oxidative factors
    K Yamada
    Division of Bioresource and Bioenvironmental Science, Graduate School of Kyushu University, Fukuoka, Japan
    Biofactors 13:167-72. 2000
  5. doi request reprint Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo
    Yuhei Hiura
    Faculty of Agriculture, Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka 812 8581, Japan
    J Nutr Biochem 20:607-13. 2009
  6. ncbi request reprint Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice
    Masao Yamasaki
    Department of Biochemistry and Applied BioScience, Faculty of Agriculture, Miyazaki University, Miyazaki, Japan
    Nutrition 22:54-9. 2006
  7. ncbi request reprint Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Agric Food Chem 54:5203-7. 2006
  8. ncbi request reprint Dose-dependent effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84 cells in vivo
    Masao Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:505-11. 2002
  9. ncbi request reprint Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Dept of Bioscience and Biotechnology, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka, 812 8581, Japan
    Eur J Nutr 46:257-63. 2007
  10. ncbi request reprint The 67kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 364:79-85. 2007

Collaborators

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Effect of dietary fiber on the lipid metabolism and immune function of aged Sprague-Dawley rats
    Koji Yamada
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biosci Biotechnol Biochem 67:429-33. 2003
    ..These results suggest that enhancement of the immune function by dietary fiber is mainly expressed in the gut immune system...
  2. ncbi request reprint Dietary effect of guar gum and its partially hydrolyzed product on the lipid metabolism and immune function of Sprague-Dawley rats
    K Yamada
    Department of Bioscience and Biotechnology, Graduate School of Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 63:2163-7. 1999
    ..These data suggest that WSDF indirectly enhanced the Ig production of lymphocytes, and that serum lipid reduction and IgA production-enhancing activities of WSDF were dependent on their molecular sizes...
  3. ncbi request reprint Effect of unsaturated fatty acids and antioxidants on immunoglobulin production by mesenteric lymph node lymphocytes of Sprague-Dawley rats
    K Yamada
    Department of Food Science and Technology, Faculty of Agriculture, Kyushu University, Fukuoka
    J Biochem 120:138-44. 1996
    ..These results suggest that UFA enhance the allergic reaction through the stimulation of IgE production and the inhibition of IgA production, and that hydrophobic antioxidants are partially effective to annul the adverse effect of UFA...
  4. ncbi request reprint Recent topics in anti-oxidative factors
    K Yamada
    Division of Bioresource and Bioenvironmental Science, Graduate School of Kyushu University, Fukuoka, Japan
    Biofactors 13:167-72. 2000
    ..These results suggest that dietary fats and antioxidants are effective for the alleviation of allergic symptom and activation of immune functions...
  5. doi request reprint Specific accumulation of gamma- and delta-tocotrienols in tumor and their antitumor effect in vivo
    Yuhei Hiura
    Faculty of Agriculture, Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Kyushu University, Fukuoka 812 8581, Japan
    J Nutr Biochem 20:607-13. 2009
    ..These results, to our knowledge, are the first demonstration of specific accumulation of gamma-T3 and delta-T3 in tumors and suggest that T3 accumulation is critical for the antitumor activities of T3...
  6. ncbi request reprint Dietary effect of pomegranate seed oil on immune function and lipid metabolism in mice
    Masao Yamasaki
    Department of Biochemistry and Applied BioScience, Faculty of Agriculture, Miyazaki University, Miyazaki, Japan
    Nutrition 22:54-9. 2006
    ..We evaluated the effects of dietary pomegranate seed oil (PSO), which contains high levels of punicic acid (9c, 11t, 13c-octadecatrienoic acid), on immune function and lipid metabolism in C57BL/6N mice...
  7. ncbi request reprint Dietary apigenin suppresses IgE and inflammatory cytokines production in C57BL/6N mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Agric Food Chem 54:5203-7. 2006
    ..These results suggest that a diet containing apigenin can reduce serum IgE and inflammatory cytokines such as RANTES and sTNFRI in mice...
  8. ncbi request reprint Dose-dependent effect of dietary conjugated linoleic acid on the growth of rat hepatoma dRLh-84 cells in vivo
    Masao Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Nutr Sci Vitaminol (Tokyo) 48:505-11. 2002
    ..5 wt.% enhances the growth of transplanted dRLh-84 cells in vivo. It is believed that growth promotion of dRLh-84 cells in vivo by CLA cannot be clarified by the PG synthesis dependent mechanism...
  9. ncbi request reprint Dietary flavones suppresses IgE and Th2 cytokines in OVA-immunized BALB/c mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Dept of Bioscience and Biotechnology, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka, 812 8581, Japan
    Eur J Nutr 46:257-63. 2007
    ..We also demonstrated that dietary apigenin decreased IgE level in C57BL/6N mice sera...
  10. ncbi request reprint The 67kDa laminin receptor as a primary determinant of anti-allergic effects of O-methylated EGCG
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 364:79-85. 2007
    ..These results suggest that anti-allergic effects of EGCG3"Me may be triggered by the inhibition of MRLC or ERK1/2 phosphorylation mediated through the cell-surface 67LR...
  11. ncbi request reprint Cytotoxity of the trans10,cis12 isomer of conjugated linoleic acid on rat hepatoma and its modulation by other fatty acids, tocopherol, and tocotrienol
    Masao Yamasaki
    Department of Biochemistry and Applied BioScience, Faculty of Agriculture, Miyazaki University, 1 1 Gakuenkibanadai nishi, Miyazaki 889 2192, Japan
    In Vitro Cell Dev Biol Anim 41:239-44. 2005
    ..When cells were treated with 10 microM 10t,12c-CLA for more than 48 h, treatment with additional CLA or alpha-toc could not prevent cell death...
  12. pmc 67-kDa laminin receptor increases cGMP to induce cancer-selective apoptosis
    Motofumi Kumazoe
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    J Clin Invest 123:787-99. 2013
    ..These results suggest that PDE5 inhibitors could be used to elevate cGMP levels to induce 67LR-mediated, cancer-specific cell death...
  13. ncbi request reprint Isolation and structure of a monomethylated ganglioside possessing neuritogenic activity from the ovary of the sea urchin Diadema setosum
    Koji Yamada
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 56:734-7. 2008
    ..These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor, in which compound 3 showed the most potent activity...
  14. doi request reprint Flavones suppress type I IL-4 receptor signaling by down-regulating the expression of common gamma chain
    Shuya Yamashita
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    FEBS Lett 584:775-9. 2010
    ..Furthermore, flavones reduced the expression of common gamma chain, a characteristic constituent subunit of type I IL-4R, suggesting that flavones suppress type I IL-4R signaling...
  15. pmc Green tea extract containing a highly absorbent catechin prevents diet-induced lipid metabolism disorder
    Takashi Suzuki
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Sci Rep 3:2749. 2013
    ..These results suggested that Benifuuki had much greater lipid-lowering effects than Yabukita. Taken together, these data suggest that methylated catechins direct the strong lipid-lowering activity of Benifuuki. ..
  16. ncbi request reprint Relationship between the biological activities of methylated derivatives of (-)-epigallocatechin-3-O-gallate (EGCG) and their cell surface binding activities
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Fukuoka, Japan
    J Agric Food Chem 55:7144-8. 2007
    ....
  17. ncbi request reprint The impact of the 67kDa laminin receptor on both cell-surface binding and anti-allergic action of tea catechins
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Arch Biochem Biophys 476:133-8. 2008
    ..These results suggest that both the galloyl moiety and the B-ring hydroxylation pattern contribute to the exertion of biological activities of tea catechins and their 67LR-dependencies...
  18. ncbi request reprint Effect of dietary conjugated linoleic acid on liver regeneration after a partial hepatectomy in rats
    Akira Hirao
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Nutr Sci Vitaminol (Tokyo) 50:9-12. 2004
    ..In conclusion, the data suggests that dietary CLA inhibits DNA synthesis after PH, which results in hepatocyte proliferation inhibition...
  19. ncbi request reprint Green tea polyphenol epigallocatechin-3-gallate signaling pathway through 67-kDa laminin receptor
    Daisuke Umeda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    J Biol Chem 283:3050-8. 2008
    ..Additionally, we found that eEF1A is up-regulated by EGCG through 67LR. Overall, these findings implicate both eEF1A and MYPT1 in EGCG signaling for cancer prevention through 67LR...
  20. doi request reprint Phosphodiesterase 5 inhibitor acts as a potent agent sensitizing acute myeloid leukemia cells to 67-kDa laminin receptor-dependent apoptosis
    Motofumi Kumazoe
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    FEBS Lett 587:3052-7. 2013
    ..This combination regimen killed AML cells via overexpressed 67-kDa laminin receptors...
  21. ncbi request reprint IgM production of lymphocytes from C57BL/6N mice was stimulated by estrogen treated splenic adherent cells
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Immunol Lett 98:225-31. 2005
    ....
  22. ncbi request reprint The involvement of the 67 kDa laminin receptor-mediated modulation of cytoskeleton in the degranulation inhibition induced by epigallocatechin-3-O-gallate
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 348:524-31. 2006
    ..These findings suggest that EGCG-induced inhibition of the degranulation includes the primary binding of EGCG to the cell surface 67LR and subsequent modulation of cytoskeleton...
  23. ncbi request reprint Constituents of Holothuroidea, 18. Isolation and structure of biologically active disialo- and trisialo-gangliosides from the sea cucumber Cucumaria echinata
    Fumiaki Kisa
    Faculty of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 54:1293-8. 2006
    ..These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor...
  24. pmc Vitamin A enhances antitumor effect of a green tea polyphenol on melanoma by upregulating the polyphenol sensing molecule 67-kDa laminin receptor
    Ju Hye Lee
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki, Japan
    PLoS ONE 5:e11051. 2010
    ....
  25. doi request reprint Involvement of 67-kDa laminin receptor-mediated myosin phosphatase activation in antiproliferative effect of epigallocatechin-3-O-gallate at a physiological concentration on Caco-2 colon cancer cells
    Daisuke Umeda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 371:172-6. 2008
    ..These results suggest that through 67LR, EGCG at a physiological concentration can activate myosin phosphatase by reducing MYPT1 phosphorylation and that may be involved in EGCG-induced cell growth inhibition...
  26. pmc Green tea polyphenol EGCG sensing motif on the 67-kDa laminin receptor
    Yoshinori Fujimura
    Innovation Center for Medical Redox Navigation, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e37942. 2012
    ..However, the underlying mechanism for interaction between EGCG and 67LR remains unclear. In this study, we investigated the possible role of EGCG-67LR interaction responsible for its bioactivities...
  27. ncbi request reprint Induction of apoptosis by tocotrienol in rat hepatoma dRLh-84 cells
    Midori Sakai
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Anticancer Res 24:1683-8. 2004
    ..The difference in terms of apoptosis induction by vitamin E homologues seems to be related to their different rates of cellular incorporation...
  28. ncbi request reprint Tea polyphenol epigallocatechin-3-gallate associates with plasma membrane lipid rafts: lipid rafts mediate anti-allergic action of the catechin
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biofactors 21:383-5. 2004
    ..These results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcepsilonRI expression...
  29. doi request reprint Green tea polyphenol epigallocatechin-3-gallate inhibits TLR2 signaling induced by peptidoglycan through the polyphenol sensing molecule 67-kDa laminin receptor
    Eui Hong Byun
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    FEBS Lett 585:814-20. 2011
    ..Silencing of Toll-interacting protein (Tollip), a negative regulator of TLR signaling impaired the TLR2 signaling inhibitory activity of EGCG, suggesting that TLR2 response could be inhibited by EGCG via 67LR and Tollip...
  30. ncbi request reprint Apoptosis induction by gamma-tocotrienol in human hepatoma Hep3B cells
    Midori Sakai
    Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Nutr Biochem 17:672-6. 2006
    ..These data indicate that gamma-T3 induced apoptosis in Hep3B cells and that caspase-8 and caspase-9 were involved in apoptosis induction. Moreover, these results suggest that Bax and Bid regulated apoptosis induction by gamma-T3...
  31. ncbi request reprint TLR4 signaling inhibitory pathway induced by green tea polyphenol epigallocatechin-3-gallate through 67-kDa laminin receptor
    Eui Hong Byun
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    J Immunol 185:33-45. 2010
    ....
  32. ncbi request reprint H89 (N-[2-(p-bromocinnamylamino)ethyl]-5-isoquinolinesulfonamide) induces reduction of myosin regulatory light chain phosphorylation and inhibits cell proliferation
    Daisuke Umeda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Eur J Pharmacol 590:61-6. 2008
    ..These results suggest that H89-induced reduction of the MRLC phosphorylation results from inhibition of Rho-kinase and that H89-induced cell growth inhibition is independent of reduction of the MRLC phosphorylation...
  33. doi request reprint A comparison of the immunostimulatory effects of the medicinal herbs Echinacea, Ashwagandha and Brahmi
    Koji Yamada
    Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Fukuoka 812 8581, Japan
    J Ethnopharmacol 137:231-5. 2011
    ..Here, we investigated the potential for two herbs commonly found in India, Ashwagandha (Withania somnifera) and Brahmi (Bacopa monnieri), to enhance immune function and compared their effects to that of Echinacea...
  34. ncbi request reprint Flavones suppress the expression of the high-affinity IgE receptor FcepsilonRI in human basophilic KU812 cells
    Satomi Yano
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Agric Food Chem 53:1812-7. 2005
    ..These results suggested that chrysin and apigenin have the ability to downregulate FcepsilonRI expression and this suppressive effect may be due to the reduction of ERK1/2 phosphorylation...
  35. ncbi request reprint Isoflavone genistein and daidzein up-regulate LPS-induced inducible nitric oxide synthase activity through estrogen receptor pathway in RAW264.7 cells
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Pharmacol 71:108-14. 2005
    ..7 cells, while an ERbeta agonist could not. In conclusion, our results suggest E2, genistein and daidzein activate iNOS, and then up-regulate NO production. This enhancing effect is aroused through ERalpha pathway in RAW264.7 cells...
  36. ncbi request reprint Determination of the absolute configuration of sialic acids in gangliosides from the sea cucumber Cucumaria echinata
    Fumiaki Kisa
    Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 55:1051-2. 2007
    ....
  37. doi request reprint Modulation of proliferation and differentiation of C2C12 skeletal muscle cells by fatty acids
    Ju Hye Lee
    Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Life Sci 84:415-20. 2009
    ..This study was performed to elucidate whether mitogen-activated protein kinases (MAPKs) are involved in the modulation of the proliferation and differentiation of skeletal muscle cells by fatty acids...
  38. ncbi request reprint Immunoglobulin and cytokine production from spleen lymphocytes is modulated in C57BL/6J mice by dietary cis-9, trans-11 and trans-10, cis-12 conjugated linoleic acid
    Masao Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka 812 8581, Japan
    J Nutr 133:784-8. 2003
    ..These results suggest that 9c,11t and 10t,12c-CLA can stimulate different immunological effects and that the simultaneous intake of the two isomers can change the T cell population...
  39. ncbi request reprint IL-4 receptor α in non-lipid rafts is the target molecule of strictinin in inhibiting STAT6 activation
    Yoon Hee Kim
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 450:824-30. 2014
    ..In addition, strictinin directly bound to IL-4Rα and inhibited binding of IL-4 to IL-4Rα. These results suggest that IL-4Rα locating in non-lipid raft region is a target molecule for strictinin in inhibiting STAT6 activation. ..
  40. ncbi request reprint Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Japan
    Biosci Biotechnol Biochem 71:253-5. 2007
    ..Royal jelly inhibited the growth-promoting effect of BPA on MCF-7 cells, even though it did not affect the proliferation of cells in the absence of BPA. In addition, this inhibiting effect of royal jelly was heat-stable...
  41. doi request reprint Oxygen partial pressure modulates 67-kDa laminin receptor expression, leading to altered activity of the green tea polyphenol, EGCG
    Shuntaro Tsukamoto
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    FEBS Lett 586:3441-7. 2012
    ..In summary, 67LR expression is highly sensitive to O(2) partial pressure, and the activity of EGCG can be regulated in cancer cells by O(2) partial pressure...
  42. ncbi request reprint Neuritogenic activity of gangliosides from echinoderms and their structure-activity relationship
    Masafumi Kaneko
    Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 55:462-3. 2007
    ..The results show that they displayed neuritogenic activity. Based on the observed results, a structure-activity relationship has been established...
  43. ncbi request reprint Lipid raft-associated catechin suppresses the FcepsilonRI expression by inhibiting phosphorylation of the extracellular signal-regulated kinase1/2
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, 812 8581, Fukuoka, Japan
    FEBS Lett 556:204-10. 2004
    ..Thus, these results suggest that the interaction between EGCG and the lipid rafts is important for EGCG's ability to downregulate FcepsilonRI expression, and ERK1/2 may be involved in this suppression signal...
  44. ncbi request reprint Induction of endoreduplication by a JNK inhibitor SP600125 in human lung carcinoma A 549 cells
    Yumi Miyamoto-Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Fukuoka 812 8581, Japan
    Cell Biol Int 31:1501-6. 2007
    ..Our data show that basic JNK activity plays an important role in the progression of the cell cycle at G2/M cell phase...
  45. pmc In situ label-free imaging for visualizing the biotransformation of a bioactive polyphenol
    Yoon Hee Kim
    1 Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan 2
    Sci Rep 3:2805. 2013
    ..Although this approach has limitations of the detection sensitivity, it will overcome the drawbacks associated with conventional molecular imaging techniques, and could contribute to biological discovery. ..
  46. ncbi request reprint Important role of β1-integrin in fucoidan-induced apoptosis via caspase-8 activation
    Yumi Yamasaki
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 76:1163-8. 2012
    ..Fucoidan also induced recruitment of caspase-8 to the β1-integrin intracellular domain, cleaved it into the activated protein by direct combination with β1-integrin, and induced apoptosis via the caspase cascade in MCF-7 cells...
  47. doi request reprint Green tea polyphenol EGCG induces lipid-raft clustering and apoptotic cell death by activating protein kinase Cδ and acid sphingomyelinase through a 67 kDa laminin receptor in multiple myeloma cells
    Shuntaro Tsukamoto
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biochem J 443:525-34. 2012
    ..Additionally, orally administered EGCG activated PKCδ and aSMase in a murine MM xenograft model. These results elucidate a novel cell-death pathway triggered by EGCG for the specific killing of MM cells...
  48. ncbi request reprint Comparisons of uptake and cell surface binding among pyridoxal, pyridoxine, and pyridoxamine in RAW264.7 cells
    Hiroaki Kanouchi
    Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Kagoshima, Japan
    Nutrition 26:648-52. 2010
    ..However, it has not been elucidated why PL has the strongest effect. We compared the uptakes and cell surface interactions among PL, PM, PN, and PLP in RAW264.7 cells...
  49. ncbi request reprint Epigallocatechin-3-O-gallate disrupts stress fibers and the contractile ring by reducing myosin regulatory light chain phosphorylation mediated through the target molecule 67 kDa laminin receptor
    Daisuke Umeda
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 333:628-35. 2005
    ..These results suggest that EGCG inhibits the cell growth by reducing the MRLC phosphorylation and this effect is mediated by the 67LR...
  50. ncbi request reprint Trans10, cis12-conjugated linoleic acid induces mitochondria-related apoptosis and lysosomal destabilization in rat hepatoma cells
    Masao Yamasaki
    Division of Food Science and Nutrition, Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, Miyazaki University, Miyazaki 889 2192, Japan
    Biochim Biophys Acta 1735:176-84. 2005
    ..10t, 12c-CLA directly degraded the isolated lysosomes from the rat liver. Our observations indicate that 10t, 12c-CLA induces mitochondria-related apoptosis accompanied by lysosomal destabilization in rat hepatoma cells...
  51. ncbi request reprint A lipid raft-associated 67kDa laminin receptor mediates suppressive effect of epigallocatechin-3-O-gallate on FcepsilonRI expression
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 336:674-81. 2005
    ..Thus, these results suggest that the lipid raft-associated 67LR plays an important role in mediating the FcepsilonRI-suppressive action of EGCG...
  52. doi request reprint Fucoidan induces apoptosis through activation of caspase-8 on human breast cancer MCF-7 cells
    Yumi Yamasaki-Miyamoto
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Agric Food Chem 57:8677-82. 2009
    ..However, caspase-9-specific inhibitor exerted a moderate inhibitory effect on the cytotoxicity of fucoidan. These data indicated that fucoidan could induce apoptotic cell death through a caspase-8-dependent pathway in MCF-7 cells...
  53. ncbi request reprint Oleic acid prevents apoptotic cell death induced by trans10, cis12 isomer of conjugated linoleic acid via p38 MAP kinase dependent pathway
    Masao Yamasaki
    Department of Biochemistry and Applied BioScience, Faculty of Agriculture, Miyazaki University, 1 1 Gakuenkibanadai nishi, Miyazaki 889 2192, Japan
    In Vitro Cell Dev Biol Anim 44:290-4. 2008
    ..However, oleic acid completely inhibited this effect. These observations indicated the involvement of blockade of a p38 MAPK pathway in the ameliorative effect of oleic acid on apoptosis induced by t10, c12-conjugated linoleic acid...
  54. ncbi request reprint Effect of estrogens on the interferon-gamma producing cell population of mouse splenocytes
    Mako Nakaya
    Laboratory of Food Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 70:47-53. 2006
    ..The ligand specific to plasma membrane-associated ER (mER) enhanced the IFN-gamma production. In conclusion, our results indicated that E2 up-regulated the IFN-gamma production by mediating ERalpha, ERbeta and mERs...
  55. ncbi request reprint Dietary apigenin attenuates the development of atopic dermatitis-like skin lesions in NC/Nga mice
    Satomi Yano
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    J Nutr Biochem 20:876-81. 2009
    ..These results suggest that apigenin attenuates exacerbation of AD-like symptoms in part through the reduction of serum IgE level and IFN-gamma expression in NC/Nga mice...
  56. ncbi request reprint Modulation of body fat and serum leptin levels by dietary conjugated linoleic acid in Sprague-Dawley rats fed various fat-level diets
    Masao Yamasaki
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Nutrition 19:30-5. 2003
    ..In this study, we examined the effect of dietary conjugated linoleic acid (CLA) on body fat levels in Sprague-Dawley rats...
  57. ncbi request reprint Effect of conjugated linoleic acid isomers on growth factor-induced proliferation of human breast cancer cells
    Hitomi Chujo
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Cancer Lett 202:81-7. 2003
    ..In conclusion, although both c9, t11 and t10, c12-CLA can inhibit the proliferation of MCF-7 cells, our results suggested that they have separate mechanisms and different targets of actions...
  58. ncbi request reprint Isolation and structure of a galactocerebroside from the sea cucumber Bohadschia argus
    Yuriko Ikeda
    Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 57:315-7. 2009
    ..This is the first report of isolation and structure determination of galactocerebroside from sea cucumber...
  59. ncbi request reprint Antioxidant and anti-inflammatory effects of a diet supplemented with sesamin on hepatic ischemia-reperfusion injury in rats
    Tohru Utsunomiya
    Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Beppu, Japan
    Hepatogastroenterology 50:1609-13. 2003
    ..We investigated the effects of a diet containing sesamin on hepatic ischemia-reperfusion injury in rats...
  60. doi request reprint Mechanisms of thiosulfinates from Allium tuberosum L.-induced apoptosis in HT-29 human colon cancer cells
    Ju Hye Lee
    Department of Bioscience and Biotechnology, Kyushu University, Fukuoka 812 8581, Japan
    Toxicol Lett 188:142-7. 2009
    ..These results indicate that thiosulfinates from A. tuberosum L. inhibited cell proliferation and activated both the caspase-dependent and caspase-independent apoptotic pathways in HT-29 cells...
  61. pmc Metabolomics-driven nutraceutical evaluation of diverse green tea cultivars
    Yoshinori Fujimura
    Innovation Center for Medical Redox Navigation, Kyushu University, Higashi ku, Fukuoka, Japan
    PLoS ONE 6:e23426. 2011
    ..Here, we performed metabolomic analyses to explore the relationship between the metabolome and health-promoting attributes (bioactivity) of diverse Japanese green tea cultivars...
  62. ncbi request reprint Constituents of holothuroidea, 16. Determination of Absolute configuration of the branched methyl group in ante-iso type side chain moiety on long chain base of glucocerebroside from the sea cucumber Holothuria leucospilota
    Koji Yamada
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 53:1333-4. 2005
    ..The optically active C13-fragment was synthesized asymmetrically by using the Wittig reaction from chiral synton for comparison with the natural fragment...
  63. doi request reprint Protein-bound polysaccharide-K (PSK) directly enhanced IgM production in the human B cell line BALL-1
    Shinjiro Maruyama
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Higashi ku, Fukuoka, Japan
    Biomed Pharmacother 63:409-12. 2009
    ..These results show that there is a possibility that PSK directly acts on B cells and simultaneously enhances both humoral immunity and cellular immunity...
  64. ncbi request reprint Peroxisome proliferator-activated receptor ligands negatively regulate the expression of the high-affinity IgE receptor Fc epsilon RI in human basophilic KU812 cells
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Division of Bioresources and Bioenvironmental Sciences, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 297:193-201. 2002
    ..These results suggest that the suppression of Fc epsilon RI expression by PPARs may be due to the down-regulation of Fc epsilon RI alpha or gamma mRNA...
  65. ncbi request reprint A difference between epigallocatechin-3-gallate and epicatechin-3-gallate on anti-allergic effect is dependent on their distinct distribution to lipid rafts
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812 8581, Japan
    Biofactors 21:133-5. 2004
    ..On the other hand, the level of ECG in rafts was lower than that of EGCG, suggesting that the association with lipid rafts may have an important role in the FcepsilonRI-suppressive effect of catechins...
  66. ncbi request reprint Tea catechin, epigallocatechin-3-gallate suppresses myosin II regulatory light chain phosphorylation
    Daisuke Umeda
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biofactors 21:387-9. 2004
    ..None of the inhibitors mimic the activity of EGCG. These results suggest that EGCG is a compound that can suppress MRLC phosphorylation...
  67. ncbi request reprint Mode of interaction of ganglioside Langmuir monolayer originated from echinoderms: three binary systems of ganglioside/DPPC, ganglioside/DMPE, and ganglioside/cholesterol
    Kazuki Hoda
    Division of Biointerfacial Science, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Colloids Surf B Biointerfaces 52:57-75. 2006
    ..The observations using fluorescence microscopy and AFM image also provide us the miscibility in the monolayer state...
  68. ncbi request reprint Estrogenic compounds suppressed interferon-gamma production in mouse splenocytes through direct cell-cell interaction
    Mako Nakaya
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    In Vitro Cell Dev Biol Anim 39:383-7. 2003
    ..In addition, E2 conjugated with bovine serum albumin inhibited IFN-gamma production as well as E2. This result suggests that the plasma membrane-associated estrogen receptor plays a prominent role in this suppression mechanism...
  69. ncbi request reprint Constituents of Holothuroidea, 17. Isolation and structure of biologically active monosialo-gangliosides from the sea cucumber Cucumaria echinata
    Fumiaki Kisa
    Faculty of Pharmaceutical Sciences, Kyushu University Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 54:982-7. 2006
    ..These gangliosides showed neuritogenic activity toward the rat pheochromocytoma cell line PC-12 in the presence of nerve growth factor...
  70. ncbi request reprint Cholesterol esterase bound to intestinal brush border membranes does not accelerate incorporation of micellar cholesterol into absorptive cells
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 67:2381-7. 2003
    ..The results suggest that the accelerated incorporation of micellar cholesterol by cholesterol esterase into absorptive cells is not mediated by the enzyme bound to the brush border membranes...
  71. ncbi request reprint A receptor for green tea polyphenol EGCG
    Hirofumi Tachibana
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Nat Struct Mol Biol 11:380-1. 2004
    ..Experiments using surface plasmon resonance demonstrate binding of EGCG to the 67-kDa laminin receptor with a nanomolar K (d) value...
  72. ncbi request reprint Simultaneous determination of isoflavones and bisphenol A in rat serum by high-performance liquid chromatography coupled with coulometric array detection
    Shin Yasuda
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka, Japan
    Biosci Biotechnol Biochem 68:51-8. 2004
    ..Compound 7 in the serum was not detected until after enzymatic hydrolysis (72 ng/ml). These results suggest that this analytical method would be useful for metabolic and pharmacokinetic studies on isoflavones and bisphenol A...
  73. ncbi request reprint Cholesterol esterase accelerates intestinal cholesterol absorption
    Ikuo Ikeda
    Laboratory of Nutrition Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate School, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1571:34-44. 2002
    ..This may be a major cause of the acceleration of cholesterol absorption by cholesterol esterase...
  74. ncbi request reprint Physiological difference between free and triglyceride-type conjugated linoleic acid on the immune function of C57BL/6N mice
    Masao Yamasaki
    Research and Development Division, Omu Milk Products Company, Ltd, 1 38 1 Shin katsudachi Omuta, Fukuoka 836 0895, Japan
    J Agric Food Chem 52:3644-8. 2004
    ..In addition, seven cytokines were 2-fold down-regulated by TG-CLA. These data show that there is a slight but significant difference between the functionalities of FFA- and TG-CLA...
  75. ncbi request reprint [Chemo-pharmaceutical studies on the glycosphingolipid constituents from echinoderm, sea cucumbers, as the medicinal materials]
    Koji Yamada
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Yakugaku Zasshi 122:1133-43. 2002
    ..It also became apparent that sialic acid is indispensable for the neuritogenic activities...
  76. ncbi request reprint Antiallergic tea catechin, (-)-epigallocatechin-3-O-(3-O-methyl)-gallate, suppresses FcepsilonRI expression in human basophilic KU812 cells
    Yoshinori Fujimura
    Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    J Agric Food Chem 50:5729-34. 2002
    ..EGCG' '3Me treatment inhibited the FcepsilonRI cross-linking-induced histamine release. These results suggested that EGCG' '3Me can negatively regulate basophil activation through the suppression of FcepsilonRI expression...
  77. ncbi request reprint Constituents of Holothuroidea, 13. Structure of neuritogenic active ganglioside molecular species from the sea cucumber Stichopus chloronotus
    Koji Yamada
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 51:46-52. 2003
    ..Moreover, these three gangliosides exhibited neuritogenic activity toward the rat pheochromocytoma PC12 cells in the presence of nerve growth factor...
  78. ncbi request reprint Recombinant perchloric acid-soluble protein suppresses the immunoglobulin production of human-human hybridoma HB4C5 cells
    Hiroaki Kanouchi
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    In Vitro Cell Dev Biol Anim 39:263-5. 2003
    ..These results suggest that the Ig production suppressed by PSP, which has been previously reported to inhibit protein synthesis, contributed to the incorporation of PSP into the HB4C5 cells...
  79. ncbi request reprint Increase of immunoglobulin productivity of human-human hybridoma HB4C5 cells by histone
    Takeaki Okamoto
    Department of Bioscience and Biotechnology, Graduate School of Kyushu University, Hakozaki, Fukuoka, Japan
    Biosci Biotechnol Biochem 66:1241-5. 2002
    ..These facts strongly suggest that histone acts as an immunoglobulin production-stimulating factor (IPSF) after internalization into the human B cell lines and the native structure of histone is required for the IPSF activity...
  80. ncbi request reprint Inhibitory effect of peroxisome proliferator-activated receptor-gamma ligands on the expression of IgE heavy chain germline transcripts in the human B cell line DND39
    Yoshiyuki Miyazaki
    Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Laboratory of Food Chemistry, Faculty of Agriculture, Kyushu University, 46 09, 6 10 1 Hakozaki, Higashi ku, Fukuoka 812 8581, Japan
    Biochem Biophys Res Commun 295:547-52. 2002
    ..These results suggest that PPAR gamma ligands inhibit IL-4-induced IgE class switching in B lymphocytes...
  81. ncbi request reprint Differential effects of social isolation upon body weight, food consumption, and responsiveness to novel and social environment in bombesin receptor subtype-3 (BRS-3) deficient mice
    K Yamada
    Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo, Japan
    Physiol Behav 68:555-61. 2000
    ..These results suggest that BRS-3 expression in the CNS may affect the neural mechanisms that regulate isolation effects in wild-type animals...
  82. ncbi request reprint Enhanced oxidative damage induced by total body irradiation in mice fed a low protein diet
    S J Shin
    Department of Food Science Research for Health, National Institute of Health and Nutrition, 1 23 1 Toyama, Shinjuku ku, Tokyo 162 8636, Japan
    Int J Radiat Biol 78:425-32. 2002
    ..To examine the influence of the level of dietary protein on oxidative damage to lipid and protein in the liver and on chromosomal damage in the bone marrow after total body irradiation (TBI)...
  83. ncbi request reprint Structure of the rat PRPS1 gene encoding phosphoribosylpyrophosphate synthetase subunit I
    H Shimada
    Department of Biochemistry, Chiba University School of Medicine, Japan
    J Biol Chem 265:3956-60. 1990
    ..A comparison of the promoter region for PRPS1 with those of other housekeeping genes revealed a homology resembling that of the beta-actin gene...
  84. ncbi request reprint Inhibition of aromatase activity by green tea extract catechins and their endocrinological effects of oral administration in rats
    K Satoh
    Department of Toxicology, The Tokyo Metropolitan Research Laboratory of Public Health, 24 1 Hyakunincho 3 chome, Shinjuku ku, Japan
    Food Chem Toxicol 40:925-33. 2002
    ..The endocrinological changes observed in vivo were in conformity with antithyroid effects and aromatase inhibition effects of P-60 and its constituents...
  85. ncbi request reprint Cloning and expression of pleckstrin 2, a novel member of the pleckstrin family
    T Inazu
    Department of Biochemistry, Fukui Medical University, Matsuoka, Fukui, 910 1193, Japan
    Biochem Biophys Res Commun 265:87-93. 1999
    ..Distributions of N-terminal and C-terminal PH domains of pleckstrin 2 were quite different from each other, suggesting that these PH domains may interact with distinct factor(s)...
  86. ncbi request reprint Paradoxical action of activin A on folliculogenesis in immature and adult mice
    H Yokota
    Department of Obstetrics and Gynecology, Gunma University School of Medicine, Maebashi, Japan
    Endocrinology 138:4572-6. 1997
    ..The inhibitory action of activin A was in part restored by co-culture with follistatin (100 ng/ml). These results indicate that activin A is folliculogenetic in the prepubertal mouse, but not in adults...
  87. ncbi request reprint High sensitivity to hepato-tumorigenesis in hypocatalasemic C3H/C(s)b/Gen mice exposed to low doses of 252Cf fission neutrons and 60Co gamma-rays
    K Yamada
    Department of Cancer Research, Hiroshima University, Japan
    Anticancer Res 17:2041-7. 1997
    ..Therefore, the implication of oxygen radicals in hepato-tumorigenesis was strongly suggested and high sensitivity of C(s)b to low doses of radiation would be useful to investigate the mechanism of radiation tumorigenesis...
  88. ncbi request reprint Chronic activation of protein kinase C in soleus muscles and other tissues of insulin-resistant type II diabetic Goto-Kakizaki (GK), obese/aged, and obese/Zucker rats. A mechanism for inhibiting glycogen synthesis
    A Avignon
    J A Haley Veterans Hospital, Tampa, Florida 33612, USA
    Diabetes 45:1396-404. 1996
    ....
  89. ncbi request reprint Elevation of the level of thiobarbituric acid-reactive products in hindleg skeletal muscle of dystrophic mice, but non-elevation in tongue muscle
    K Watanabe
    Department of Physiology, Institute for Developmental Research, Aichi Prefectural Colony, Japan
    Free Radic Res Commun 19:93-100. 1993
    ..However, the TBARS content in the tongues of dystrophic mice was identical to that of normal mice. This finding supports our bone-muscle growth imbalance hypothesis for the pathogenesis of mouse muscular dystrophy...
  90. ncbi request reprint St. John's Wort (Hypericum perforatum) induces overexpression of multidrug resistance protein 2 (MRP2) in rats: a 30-day ingestion study
    Y Shibayama
    Department of Clinical Pharmacy and Pharmacology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8 35 1 Sakuragaoka, Kagoshima 890 8520, Japan
    Food Chem Toxicol 42:995-1002. 2004
    ..These results suggest that SJW induces hepatic MRP2, GST-P and CYP1A2 overexpressions, and thus, it could affect drug metabolism, conjugation and disposition...
  91. ncbi request reprint Characterization of the 5' flanking region of rat glucokinase gene
    T Noguchi
    Department of Nutrition and Physiological Chemistry, Osaka University Medical School, Japan
    Biochem Biophys Res Commun 164:1247-52. 1989
    ..These results suggest that the 5' flanking region of the glucokinase gene up to -5.5 k does not contain enhancer elements responsible for tissue-specific expression or insulin regulation...
  92. ncbi request reprint [Developmental changes in the concentrations of CSF neurotransmitter metabolites]
    H Yamamoto
    Department of Pediatrics, St. Marianna University School of Medicine, Kanagawa
    No To Hattatsu 25:40-4. 1993
    ..These findings demonstrated that changes in major CSF neurotransmitters occurred with aging during childhood. The importance of age-matched controls in studies of CSF neurotransmitter metabolites in the developing brain was emphasized...
  93. ncbi request reprint Rat pyruvate kinase M gene. Its complete structure and characterization of the 5'-flanking region
    M Takenaka
    Department of Nutrition and Physiological Chemistry, Osaka University Medical School, Japan
    J Biol Chem 264:2363-7. 1989
    ..This activity was not present in adult rat hepatocytes, indicating that the 0.5-kb fragment has tissue-specific promoter activity. A processed-type pseudogene that resembles the M2-type pyruvate kinase cDNA was also characterized...
  94. ncbi request reprint Impact of adiposity and plasma adipocytokines on diabetic angiopathies in Japanese Type 2 diabetic subjects
    M Matsuda
    Diabetes and Endocrine Division, Kawasaki Medical School, Kurashiki shi, Okayama, Japan
    Diabet Med 21:881-8. 2004
    ....
  95. ncbi request reprint Subchondral bone of the human knee joint in aging and osteoarthritis
    K Yamada
    Department of Orthopaedics, University of California, San Diego, 9500 Gilman Dr 0630, La Jolla 92093 0630, USA
    Osteoarthritis Cartilage 10:360-9. 2002
    ..The relationships between aging, severity of OA change and the SCB thickness and density in the human knee joint specimens from a wide range of ages were examined...
  96. ncbi request reprint Effect of dietary conjugated linoleic acid on the in vivo growth of rat hepatoma dRLh-84
    M Yamasaki
    Laboratory of Food Chemistry, Division of Applied Biological Chemistry, Department of Bioscience and Biotechnology, Faculty of Agriculture, Kyushu University, Fukuoka 812-8581, Japan
    Nutr Cancer 40:140-8. 2001
    ..Serum interferon-gamma and tumor necrosis factor-alpha levels were higher in injected than in sham rats. Moreover, these levels were higher in 2% CLA groups than in the respective 0% CLA groups...
  97. ncbi request reprint Inhibitory action of leptin on early follicular growth differs in immature and adult female mice
    N Kikuchi
    Department of Obstetrics and Gynecology, Gunma University School of Medicine, Maebashi, Gunma 371-8511, Japan
    Biol Reprod 65:66-71. 2001
    ..These results indicate that leptin causes an inhibitory effect on the early follicular development of both immature and adult mice, but the inhibitory mechanisms of leptin are different...
  98. ncbi request reprint Possible involvement of EBV-mediated alpha-fodrin cleavage for organ-specific autoantigen in Sjogren's syndrome
    H Inoue
    Department of Pathology, Tokushima University School of Dentistry, Tokushima, Japan
    J Immunol 166:5801-9. 2001
    ..Thus, an increase in apoptotic protease activities induced by EBV reactivation may be involved in the progression of alpha-fodrin proteolysis in the development of SS...
  99. ncbi request reprint Decreased triglyceride-rich lipoproteins in transgenic skinny mice overexpressing leptin
    N Matsuoka
    Diabetes Center and Clinical Research Institute of Kyoto National Hospital, Kyoto 612 8555, Japan
    Am J Physiol Endocrinol Metab 280:E334-9. 2001
    ....
  100. ncbi request reprint Ginkgo biloba extract EGb 761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats
    K Takuma
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Neuroscience 149:256-62. 2007
    ..These results have important implications for neuroprotective and cognition enhancing effects of EGb 761 in postmenopausal women and suggest that the effects are mediated by a different mechanism from estrogen...
  101. ncbi request reprint Effect of fructose-rich high-fat diet on glucose sensitivity and atherosclerosis in nonhuman primate
    M Suzuki
    HAMRI Company, Ltd, Ibaraki, Japan
    Methods Find Exp Clin Pharmacol 28:609-17. 2006
    ....