Research Topics
| Futoshi TauraSummaryAffiliation: Kyushu University Country: Japan Publications
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Detail Information
Publications
Phytocannabinoids in Cannabis sativa: recent studies on biosynthetic enzymesFutoshi Taura
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan
Chem Biodivers 4:1649-63. 2007
Characterization of olivetol synthase, a polyketide synthase putatively involved in cannabinoid biosynthetic pathwayFutoshi Taura
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
FEBS Lett 583:2061-6. 2009..The possibility that OLS could be involved in OLA biosynthesis was discussed based on its catalytic properties and expression profile...- Cannabidiolic-acid synthase, the chemotype-determining enzyme in the fiber-type Cannabis sativaFutoshi Taura
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
FEBS Lett 581:2929-34. 2007..The structural and functional properties of CBDA synthase are quite similar to those of tetrahydrocannabinolic-acid (THCA) synthase, which is responsible for the biosynthesis of THCA, the major cannabinoid in drug-type Cannabis plants... - Production of Delta(1)-tetrahydrocannabinolic acid by the biosynthetic enzyme secreted from transgenic Pichia pastorisFutoshi Taura
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
Biochem Biophys Res Commun 361:675-80. 2007.... - Expression, purification, and characterization of anti-plumbagin single-chain variable fragment antibody in Sf9 insect cellSeiichi Sakamoto
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Hybridoma (Larchmt) 29:481-8. 2010.... 
Crystallization and preliminary X-ray diffraction studies of polyketide synthase-1 (PKS-1) from Cannabis sativaChiho Taguchi
Faculty of Pharmaceutical Sciences, Kyushu University, Japan
Acta Crystallogr Sect F Struct Biol Cryst Commun 64:217-20. 2008..55 A resolution and belonged to space group P2(1)2(1)2(1), with unit-cell parameters a = 54.3, b = 110, c = 130 A. These data will enable us to determine the crystal structure of PKS-1...- Development of sensitivity-improved fluorescence-linked immunosorbent assay using a fluorescent single-domain antibody against the bioactive naphthoquinone, plumbaginSeiichi Sakamoto
Department of Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
Anal Bioanal Chem 396:2955-63. 2010..2 microg mL(-1)), indicating that a sensitive immunoassay could be developed by using fluobody instead of monoclonal antibody or scFv... - The gene controlling marijuana psychoactivity: molecular cloning and heterologous expression of Delta1-tetrahydrocannabinolic acid synthase from Cannabis sativa LSupaart Sirikantaramas
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812-8582, Japan
J Biol Chem 279:39767-74. 2004..Thus, we concluded that the FAD binding residue is His-114 and that the THCA synthase reaction is FAD-dependent. This is the first report on molecular characterization of an enzyme specific to cannabinoid biosynthesis... - Identification and characterization of cannabinoids that induce cell death through mitochondrial permeability transition in Cannabis leaf cellsSatoshi Morimoto
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
J Biol Chem 282:20739-51. 2007..Based on these results, we conclude that CBCA and THCA have the ability to induce necrotic cell death via mitochondrial dysfunction in the leaf cells of C. sativa... - Flavone-catalyzed apoptosis in Scutellaria baicalensisMotosuke Hirunuma
Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Phytochemistry 72:752-60. 2011..Thus, S. baicalensis possesses a unique apoptosis-inducing system that is linked with metabolism of baicalin... - Recent advances in Cannabis sativa research: biosynthetic studies and its potential in biotechnologySupaart Sirikantaramas
Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
Curr Pharm Biotechnol 8:237-43. 2007..Transgenic tobacco hairy roots expressing THCA synthase can produce THCA upon feeding of CBGA. These results open the way for biotechnological production of cannabinoids in the future... - Tetrahydrocannabinolic acid synthase, the enzyme controlling marijuana psychoactivity, is secreted into the storage cavity of the glandular trichomesSupaart Sirikantaramas
Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582 Japan
Plant Cell Physiol 46:1578-82. 2005..These results also showed that secretory cells of the glandular trichomes secrete not only metabolites but also biosynthetic enzyme... - Molecular cloning and functional expression of geranylgeranyl pyrophosphate synthase from Coleus forskohlii BriqSurang Engprasert
Graduate School of Pharmaceutical Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
BMC Plant Biol 4:18. 2004..Therefore, GGPP synthase is thought to be a key enzyme in biosynthesis of forskolin. Herein we report the first confirmation of the GGPP synthase gene in Coleus forskohlii Briq... - Crystallization of Delta1-tetrahydrocannabinolic acid (THCA) synthase from Cannabis sativaYoshinari Shoyama
Faculty of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan
Acta Crystallograph Sect F Struct Biol Cryst Commun 61:799-801. 2005..2 A. The calculated Matthews coefficient was approximately 4.1 or 2.0 A3 Da(-1) assuming the presence of one or two molecules of THCA synthase in the asymmetric unit, respectively... - Construction and expression of specificity-improved single-chain variable fragments against the bioactive naphthoquinone, plumbaginSeiichi Sakamoto
Department of Medicinal Plants Breeding and Pharmacognosy, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
Biol Pharm Bull 32:434-9. 2009..These notable properties of the recombinant antibody against PL made it possible to develop an enzyme-linked immunosorbent assay (ELISA) for reliable determination of PL... - New dimeric morphine from opium poppy (Papaver somuniferum) and its physiological functionSatoshi Morimoto
Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
J Nat Prod 66:987-9. 2003....