Research Topics
Genomes and Genes | Ichiro TaniuchiSummaryAffiliation: Kyushu University Country: Japan Publications
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Publications
Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiationIchiro Taniuchi
Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Mol Cell 10:1083-96. 2002....- Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte developmentIchiro Taniuchi
Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
Cell 111:621-33. 2002..Runx3-deficient cytotoxic T cells, but not helper cells, have defective responses to antigen, suggesting that Runx proteins have critical functions in lineage specification and homeostasis of CD8-lineage T lymphocytes... - Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexesTian H Chi
Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
Nature 418:195-9. 2002..These results indicate that BAF complexes contribute to lineage bifurcation by reciprocally regulating lineage-specific genes, reminiscent of the role of the yeast SWI/SNF complex in mediating mating-type switching... 
The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cellsTakeshi Egawa
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
J Exp Med 204:1945-57. 2007..These results indicate that Runx proteins have important roles at multiple stages of T cell development and in the homeostasis of mature T cells...- Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursorsTakeshi Egawa
Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Immunity 22:705-16. 2005..Our results indicate that even though CD1d binding DP thymocytes have yet to be observed, Valpha14-Jalpha18 rearrangement in these cells is required for development of iNKT cells... 
Antagonistic interplay between ThPOK and Runx in lineage choice of thymocytesTakeshi Egawa
Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Blood Cells Mol Dis 43:27-9. 2009..Recent studies have revealed that a reciprocal antagonistic interplay between Runx3 and ThPOK is a central component in the transcription factor network governing the helper versus cytotoxic-lineage decision...- Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscleXiaoxia Wang
Molecular Neurobiology Program, Molecular Pathogenesis Program and Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, New York 10016, USA
Genes Dev 19:1715-22. 2005..Moreover, these results suggest that reduced muscle activity could cause or contribute to congenital myopathies if Runx1 or its target genes were compromised... - RUNX proteins in transcription factor networks that regulate T-cell lineage choiceAmélie Collins
The Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Howard Hughes Medical Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
Nat Rev Immunol 9:106-15. 2009.... - Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine developmentYoko Fukushima-Nakase
Department of Molecular Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
Blood 105:4298-307. 2005..Thus, the C-terminal portions of Runx family members have both similar and distinct biologic functions... - Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fateSawako Muroi
Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
Nat Immunol 9:1113-21. 2008..Our results show how an initial lineage-specification signal can be amplified and stabilized during the lineage-commitment process... - Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicityYoichi Maekawa
Department of Immunology and Parasitology, Tokushima, Japan
Nat Immunol 9:1140-7. 2008..Our results suggest that the highly regulated, dynamic control of T cell cytotoxicity depends on the integration of Notch2 and CREB1 signals... - Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infectionMartin Schaefer
Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universitat Munchen, Munich, Germany
J Immunol 180:6836-45. 2008..Based on our in vivo data, we propose that instead of favoring the immune evasion of mycobacteria, human DC-SIGN may have evolved as a pathogen receptor promoting protection by limiting tuberculosis-induced pathology... - Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiationMasashi Tachibana
Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
Biochem Biophys Res Commun 368:536-42. 2008.... - Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell developmentRuka Setoguchi
Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
Science 319:822-5. 2008..Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system... - Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencerYoshinori Naoe
Institute of Physical and Chemical Research, Research Center for Allergy and Immunology, Turumi ku, Yokohama, Kanagawa 230 0045, Japan
J Exp Med 204:1749-55. 2007..These results demonstrate critical roles of Runx complexes in regulating immune responses, at least in part, through the repression of the Il4 gene... - The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell developmentIchiro Taniuchi
RIKEN Research Center, Yokohama 230-0045, Japan
Adv Immunol 83:55-89. 2004 - Epigenetic gene silencing by Runx proteinsIchiro Taniuchi
Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
Oncogene 23:4341-5. 2004..These findings link Runx function to epigenetic gene regulation, and shed new light on the mechanisms by which Runx represses target gene expression... - A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversificationIna Kramer
Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
Neuron 49:379-93. 2006..Together, our findings suggest that Runx transcription factor signaling plays a key role in sensory neuron diversification... - Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cellsBaerbel Grueter
Institute of Molecular Biology Cancer Research, University of Essen, Medical School, Essen, Germany
J Immunol 175:1694-705. 2005..Thus, Runx3 is a main regulator of CD4 silencing and CD103 induction and thus contributes to the phenotype of CD8 SP T cells during thymocyte development... - Runx1 protects hematopoietic stem/progenitor cells from oncogenic insultLena Motoda
Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore
Stem Cells 25:2976-86. 2007..Disclosure of potential conflicts of interest is found at the end of this article... - Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cellsAtsushi Hijikata
RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, Japan
Bioinformatics 23:2934-41. 2007..To address this, we constructed an open-access database that enabled us to cross-reference transcriptomic and proteomic data obtained from immune cells...