Ichiro Taniuchi

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Mol Cell 10:1083-96. 2002
  2. ncbi request reprint Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 111:621-33. 2002
  3. ncbi request reprint Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    Tian H Chi
    Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 418:195-9. 2002
  4. pmc The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 204:1945-57. 2007
  5. ncbi request reprint Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Immunity 22:705-16. 2005
  6. doi request reprint Antagonistic interplay between ThPOK and Runx in lineage choice of thymocytes
    Takeshi Egawa
    Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Blood Cells Mol Dis 43:27-9. 2009
  7. pmc Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle
    Xiaoxia Wang
    Molecular Neurobiology Program, Molecular Pathogenesis Program and Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, New York 10016, USA
    Genes Dev 19:1715-22. 2005
  8. ncbi request reprint RUNX proteins in transcription factor networks that regulate T-cell lineage choice
    Amélie Collins
    The Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Howard Hughes Medical Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Rev Immunol 9:106-15. 2009
  9. pmc Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity
    Bernardo Sgarbi Reis
    Laboratory of Mucosal Immunology, The Rockefeller University, New York, New York, USA
    Nat Immunol 14:271-80. 2013
  10. doi request reprint Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
    Sawako Muroi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Nat Immunol 9:1113-21. 2008

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Evidence for distinct CD4 silencer functions at different stages of thymocyte differentiation
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Mol Cell 10:1083-96. 2002
    ....
  2. ncbi request reprint Differential requirements for Runx proteins in CD4 repression and epigenetic silencing during T lymphocyte development
    Ichiro Taniuchi
    Howard Hughes Medical Institute, Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Cell 111:621-33. 2002
    ..Runx3-deficient cytotoxic T cells, but not helper cells, have defective responses to antigen, suggesting that Runx proteins have critical functions in lineage specification and homeostasis of CD8-lineage T lymphocytes...
  3. ncbi request reprint Reciprocal regulation of CD4/CD8 expression by SWI/SNF-like BAF complexes
    Tian H Chi
    Department of Pathology and Developmental Biology, Howard Hughes Medical Institute, Stanford University Medical School, Palo Alto, California 94305, USA
    Nature 418:195-9. 2002
    ..These results indicate that BAF complexes contribute to lineage bifurcation by reciprocally regulating lineage-specific genes, reminiscent of the role of the yeast SWI/SNF complex in mediating mating-type switching...
  4. pmc The role of the Runx transcription factors in thymocyte differentiation and in homeostasis of naive T cells
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    J Exp Med 204:1945-57. 2007
    ..These results indicate that Runx proteins have important roles at multiple stages of T cell development and in the homeostasis of mature T cells...
  5. ncbi request reprint Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors
    Takeshi Egawa
    Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Immunity 22:705-16. 2005
    ..Our results indicate that even though CD1d binding DP thymocytes have yet to be observed, Valpha14-Jalpha18 rearrangement in these cells is required for development of iNKT cells...
  6. doi request reprint Antagonistic interplay between ThPOK and Runx in lineage choice of thymocytes
    Takeshi Egawa
    Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    Blood Cells Mol Dis 43:27-9. 2009
    ..Recent studies have revealed that a reciprocal antagonistic interplay between Runx3 and ThPOK is a central component in the transcription factor network governing the helper versus cytotoxic-lineage decision...
  7. pmc Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle
    Xiaoxia Wang
    Molecular Neurobiology Program, Molecular Pathogenesis Program and Howard Hughes Medical Institute, Skirball Institute of Biomolecular Medicine, New York University Medical School, New York, New York 10016, USA
    Genes Dev 19:1715-22. 2005
    ..Moreover, these results suggest that reduced muscle activity could cause or contribute to congenital myopathies if Runx1 or its target genes were compromised...
  8. ncbi request reprint RUNX proteins in transcription factor networks that regulate T-cell lineage choice
    Amélie Collins
    The Kimmel Center for Biology and Medicine, Skirball Institute of Biomolecular Medicine, Howard Hughes Medical Institute, New York University School of Medicine, 540 First Avenue, New York, New York 10016, USA
    Nat Rev Immunol 9:106-15. 2009
    ....
  9. pmc Mutual expression of the transcription factors Runx3 and ThPOK regulates intestinal CD4⁺ T cell immunity
    Bernardo Sgarbi Reis
    Laboratory of Mucosal Immunology, The Rockefeller University, New York, New York, USA
    Nat Immunol 14:271-80. 2013
    ..Our results demonstrate considerable plasticity in the CD4(+) T cell lineage that allows chronic exposure to luminal antigens without pathological inflammation...
  10. doi request reprint Cascading suppression of transcriptional silencers by ThPOK seals helper T cell fate
    Sawako Muroi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama, Japan
    Nat Immunol 9:1113-21. 2008
    ..Our results show how an initial lineage-specification signal can be amplified and stabilized during the lineage-commitment process...
  11. doi request reprint Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity
    Yoichi Maekawa
    Department of Immunology and Parasitology, Tokushima, Japan
    Nat Immunol 9:1140-7. 2008
    ..Our results suggest that the highly regulated, dynamic control of T cell cytotoxicity depends on the integration of Notch2 and CREB1 signals...
  12. ncbi request reprint Decreased pathology and prolonged survival of human DC-SIGN transgenic mice during mycobacterial infection
    Martin Schaefer
    Institute for Medical Microbiology, Immunology, and Hygiene, Technische Universitat Munchen, Munich, Germany
    J Immunol 180:6836-45. 2008
    ..Based on our in vivo data, we propose that instead of favoring the immune evasion of mycobacteria, human DC-SIGN may have evolved as a pathogen receptor promoting protection by limiting tuberculosis-induced pathology...
  13. doi request reprint Phosphorylation of Runx1 at Ser249, Ser266, and Ser276 is dispensable for bone marrow hematopoiesis and thymocyte differentiation
    Masashi Tachibana
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Biochem Biophys Res Commun 368:536-42. 2008
    ....
  14. doi request reprint Repression of the transcription factor Th-POK by Runx complexes in cytotoxic T cell development
    Ruka Setoguchi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama 230 0045, Japan
    Science 319:822-5. 2008
    ..Identification of the transcription factors network in CD4 and CD8 lineage choice provides insight into how distinct T cell subsets are developed for regulating the adaptive immune system...
  15. ncbi request reprint Shared and distinct roles mediated through C-terminal subdomains of acute myeloid leukemia/Runt-related transcription factor molecules in murine development
    Yoko Fukushima-Nakase
    Department of Molecular Targeting Cancer Prevention, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo ku, Kyoto 602 8566, Japan
    Blood 105:4298-307. 2005
    ..Thus, the C-terminal portions of Runx family members have both similar and distinct biologic functions...
  16. ncbi request reprint The CD4/CD8 lineage choice: new insights into epigenetic regulation during T cell development
    Ichiro Taniuchi
    RIKEN Research Center, Yokohama 230 0045, Japan
    Adv Immunol 83:55-89. 2004
  17. pmc Repression of interleukin-4 in T helper type 1 cells by Runx/Cbf beta binding to the Il4 silencer
    Yoshinori Naoe
    Institute of Physical and Chemical Research, Research Center for Allergy and Immunology, Turumi ku, Yokohama, Kanagawa 230 0045, Japan
    J Exp Med 204:1749-55. 2007
    ..These results demonstrate critical roles of Runx complexes in regulating immune responses, at least in part, through the repression of the Il4 gene...
  18. ncbi request reprint A role for Runx transcription factor signaling in dorsal root ganglion sensory neuron diversification
    Ina Kramer
    Biozentrum, Department of Cell Biology, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland
    Neuron 49:379-93. 2006
    ..Together, our findings suggest that Runx transcription factor signaling plays a key role in sensory neuron diversification...
  19. ncbi request reprint Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells
    Baerbel Grueter
    Institute of Molecular Biology Cancer Research, University of Essen, Medical School, Essen, Germany
    J Immunol 175:1694-705. 2005
    ..Thus, Runx3 is a main regulator of CD4 silencing and CD103 induction and thus contributes to the phenotype of CD8 SP T cells during thymocyte development...
  20. ncbi request reprint Epigenetic gene silencing by Runx proteins
    Ichiro Taniuchi
    Laboratory for Transcriptional Regulation, RIKEN Research Center for Allergy and Immunology, Yokohama 230 0045, Japan
    Oncogene 23:4341-5. 2004
    ..These findings link Runx function to epigenetic gene regulation, and shed new light on the mechanisms by which Runx represses target gene expression...
  21. ncbi request reprint Runx1 protects hematopoietic stem/progenitor cells from oncogenic insult
    Lena Motoda
    Institute of Molecular and Cell Biology, 61 Biopolis Drive, Singapore
    Stem Cells 25:2976-86. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  22. ncbi request reprint Construction of an open-access database that integrates cross-reference information from the transcriptome and proteome of immune cells
    Atsushi Hijikata
    RIKEN Research Center for Allergy and Immunology, 1 7 22 Suehiro cho, Tsurumi ku, Yokohama, Kanagawa, Japan
    Bioinformatics 23:2934-41. 2007
    ..To address this, we constructed an open-access database that enabled us to cross-reference transcriptomic and proteomic data obtained from immune cells...