Masao Tanaka

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
    Masao Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Pancreatology 12:183-97. 2012
  2. ncbi Controversies in the management of pancreatic IPMN
    Masao Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Nat Rev Gastroenterol Hepatol 8:56-60. 2011
  3. ncbi Laparoscopically assisted resection of choledochal cyst and Roux-en-Y reconstruction
    M Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Surg Endosc 15:545-52. 2001
  4. ncbi Important clues to the diagnosis of pancreatic cancer
    M Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Rocz Akad Med Bialymst 50:69-72. 2005
  5. ncbi Intraductal papillary mucinous neoplasm of the pancreas: diagnosis and treatment
    Masao Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pancreas 28:282-8. 2004
  6. ncbi International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas
    Masao Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pancreatology 6:17-32. 2006
  7. ncbi CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer
    Naoki Ikenaga
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gastroenterology 139:1041-51, 1051.e1-8. 2010
  8. ncbi Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer
    Takuya Egami
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 100:722-9. 2009
  9. ncbi Suppression of metastasis of human pancreatic cancer to the liver by transportal injection of recombinant adenoviral NK4 in nude mice
    Mitsuhiko Murakami
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 117:160-5. 2005
  10. ncbi The Hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24-/low subpopulation and the side population of breast cancer cells
    Haruo Tanaka
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Anticancer Res 29:2147-57. 2009

Collaborators

Detail Information

Publications179 found, 100 shown here

  1. ncbi International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas
    Masao Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Pancreatology 12:183-97. 2012
    ..The present guidelines include recent information and recommendations based on our current understanding, and highlight issues that remain controversial and areas where further research is required...
  2. ncbi Controversies in the management of pancreatic IPMN
    Masao Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Nat Rev Gastroenterol Hepatol 8:56-60. 2011
    ....
  3. ncbi Laparoscopically assisted resection of choledochal cyst and Roux-en-Y reconstruction
    M Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Surg Endosc 15:545-52. 2001
    ..Creation of a Roux-en-Y jejunal limb by midline minilaparotomy and hepaticojejunostomy using a laparoscopic sewing instrument facilitated the procedure...
  4. ncbi Important clues to the diagnosis of pancreatic cancer
    M Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Rocz Akad Med Bialymst 50:69-72. 2005
    ..IPMN may be the only clue to the early diagnosis of pancreatic carcinoma presenting with no clinical symptoms or abnormalities on imaging studies...
  5. ncbi Intraductal papillary mucinous neoplasm of the pancreas: diagnosis and treatment
    Masao Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pancreas 28:282-8. 2004
    ....
  6. ncbi International consensus guidelines for management of intraductal papillary mucinous neoplasms and mucinous cystic neoplasms of the pancreas
    Masao Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pancreatology 6:17-32. 2006
    ..The proposed guidelines represent a consensus of the working group of the International Association of Pancreatology...
  7. ncbi CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer
    Naoki Ikenaga
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gastroenterology 139:1041-51, 1051.e1-8. 2010
    ..However, the functional heterogeneity of PSCs has not been identified until now. Detailed characterization of the PSCs in human pancreatic cancer would provide a set of potential targets for stroma-directed therapy...
  8. ncbi Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer
    Takuya Egami
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 100:722-9. 2009
    ..Furthermore, they will contribute to decreases in the adenovirus doses required for gene transfer, thereby controlling the side-effects of adenovirus infection in normal tissues...
  9. ncbi Suppression of metastasis of human pancreatic cancer to the liver by transportal injection of recombinant adenoviral NK4 in nude mice
    Mitsuhiko Murakami
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 117:160-5. 2005
    ..These results indicate that intraportal injection of Ad-NK4 may be a useful therapeutic modality for the clinical control of hepatic metastasis in pancreatic cancer...
  10. ncbi The Hedgehog signaling pathway plays an essential role in maintaining the CD44+CD24-/low subpopulation and the side population of breast cancer cells
    Haruo Tanaka
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Anticancer Res 29:2147-57. 2009
    ....
  11. ncbi Combination with low-dose gemcitabine and hTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer
    Manabu Onimaru
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Cancer Lett 294:178-86. 2010
    ..This combination therapy may be a promising therapeutic approach for pancreatic cancer...
  12. ncbi S100P is an early developmental marker of pancreatic carcinogenesis
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 12:5411-6. 2006
    ..Our goal was to clarify the involvement and clinical significance of S100P in pancreatic carcinogenesis...
  13. ncbi Prospectively isolated cancer-associated CD10(+) fibroblasts have stronger interactions with CD133(+) colon cancer cells than with CD133(-) cancer cells
    Lin Cui
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 5:e12121. 2010
    ..Therefore, these specific interactions may be promising targets for new colon cancer therapies...
  14. ncbi The role of the DNA damage checkpoint pathway in intraductal papillary mucinous neoplasms of the pancreas
    Yoshihiro Miyasaka
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Kyushu University Hospital, Fukuoka, Japan
    Clin Cancer Res 13:4371-7. 2007
    ..ATM-Chk2-p53 DNA damage checkpoint activation, which is involved in prevention of the progression of several tumors, was analyzed to evaluate the role of the DNA damage checkpoint in the progression of IPMNs...
  15. ncbi S100P is a novel marker to identify intraductal papillary mucinous neoplasms
    Kohei Nakata
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 41:824-31. 2010
    ..On the other hand, MUC5AC was expressed in only 23 cases of 32 invasive components (P < .01). These data suggest that the S100P antibody may be a useful marker for detecting all types of intraductal papillary mucinous neoplasms...
  16. ncbi The Hedgehog pathway is a possible therapeutic target for patients with estrogen receptor-negative breast cancer
    Chizu Kameda
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Anticancer Res 29:871-9. 2009
    ....
  17. ncbi Intraperitoneal injection of adenovirus-mediated NK4 gene suppresses peritoneal dissemination of pancreatic cancer cell line AsPC-1 in nude mice
    Michiyo Saimura
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Cancer Gene Ther 9:799-806. 2002
    ..This study indicates that the intraperitoneal transduction of adenovirus-mediated NK4 gene may be a useful therapeutic modality to prevent the development of peritoneal dissemination of pancreatic cancer...
  18. ncbi LIM only 4 is overexpressed in late stage pancreas cancer
    Jun Yu
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Cancer 7:93. 2008
    ..We hypothesized that LMO4 may be related to pancreatic carcinogenesis as it is in breast carcinogenesis. If so, this could result in a better understanding of tumorigenesis in pancreatic cancer...
  19. ncbi Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 120:1634-40. 2007
    ..009). Our results suggest that Twist is involved in tumor progression of pancreatic cancer and that measurement of Twist in pancreatic juice may be useful to differentiate pancreatic cancer from nonmalignant neoplasms such as IPMN...
  20. ncbi Cigarette smoking, genetic polymorphisms and colorectal cancer risk: the Fukuoka Colorectal Cancer Study
    Hoirun Nisa
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    BMC Cancer 10:274. 2010
    ..We investigated the relation of cigarette smoking and related genetic polymorphisms to colorectal cancer risk, with special reference to the interaction between smoking and genetic polymorphism...
  21. ncbi Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells
    Takaharu Yasui
    Department of Surgery and Oncology, Kyushu University, Fukuoka 812 8582, Japan
    Anticancer Res 31:1279-87. 2011
    ..Nevertheless, the effect of adenoviral therapy on chemoresistant cancer cells has not been studied. In this study, we compared the efficacy of adenoviral therapy in parental and chemoresistant pancreatic cancer cells...
  22. ncbi Tumor suppression through angiogenesis inhibition by SUIT-2 pancreatic cancer cells genetically engineered to secrete NK4
    Michiyo Saimura
    Departments of Surgery and Oncology and Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka 812 8582, Japan
    Clin Cancer Res 8:3243-9. 2002
    ..We conclude that the potent angiogenesis inhibitor NK4 may be a promising molecule for gene therapy of pancreatic cancer...
  23. ncbi Nuclear factor kappaB-activated monocytes contribute to pancreatic cancer progression through the production of Shh
    Akio Yamasaki
    Department of Cancer Therapy and Research, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    Cancer Immunol Immunother 59:675-86. 2010
    ....
  24. ncbi Three-dimensional two-layer collagen matrix gel culture model for evaluating complex biological functions of monocyte-derived dendritic cells
    Akira Tasaki
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8525, Japan
    J Immunol Methods 287:79-90. 2004
    ..This model may be a useful tool for evaluation of the various functions of Mo-DCs used as DC vaccines and for studies of the complex behaviors of Mo-DCs in vivo...
  25. ncbi Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 64:3215-22. 2004
    ..Our present findings further support the potential use of NK4 during radiotherapy for patients with pancreatic cancer...
  26. ncbi REG4 is associated with carcinogenesis in the 'intestinal' pathway of intraductal papillary mucinous neoplasms
    Kohei Nakata
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 22:460-8. 2009
    ..Using the Ki-67 labeling index, REG4 expression was significantly correlated with proliferative activity in borderline lesions. We conclude that REG4 is involved in the 'intestinal' pathway of carcinogenesis in IPMN...
  27. ncbi Gene expression levels as predictive markers of outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy
    Hayato Fujita
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neoplasia 12:807-17. 2010
    ..The aims of this study were to investigate the expression pattern of genes involved in gemcitabine sensitivity in resected PDAC tissues and to determine correlations of gene expression with treatment outcome...
  28. ncbi Pdcd4 expression in intraductal papillary mucinous neoplasm of the pancreas: its association with tumor progression and proliferation
    Akifumi Hayashi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    Hum Pathol 41:1507-15. 2010
    ..Therefore, programmed cell death 4 can be an important biomarker for intraductal papillary mucinous neoplasm...
  29. ncbi Claudin-4 expression predicts survival in pancreatic ductal adenocarcinoma
    Kosuke Tsutsumi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 19:S491-9. 2012
    ..Identification of prognostic markers would be useful in the clinical management of patients with pancreatic ductal adenocarcinoma (PDAC). The clinical relevance of claudin-4 (CLDN4), recently identified as overexpressed in PDAC, is unknown...
  30. ncbi The risk of lymph node metastasis in mucosal gastric carcinoma: especially for a mixture of differentiated and undifferentiated adenocarcinoma
    Kohei Nakata
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hepatogastroenterology 59:1855-8. 2012
    ..Our aims were to confirm the frequency of lymph node metastasis in such cases and clarify the demarcation in indications for ESD...
  31. ncbi MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA1 gene
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 19:2394-402. 2012
    ..Despite progress in analyses of microRNAs in several types of cancers, the functional contributions of microRNAs to pancreatic cancer remain unclear...
  32. ncbi Inclusive estimation of complex antigen presentation functions of monocyte-derived dendritic cells differentiated under normoxia and hypoxia conditions
    Toshitatsu Ogino
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Cancer Immunol Immunother 61:409-24. 2012
    ..Our data could help our understanding of DCs, especially therapeutic DCs, in vivo...
  33. ncbi Strategy for prevention of local recurrence of pancreatic cancer after pancreatectomy: antitumor effect of gemcitabine mixed with fibrin glue in an orthotopic nude mouse model
    Yasuhiro Ogura
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Surgery 140:66-71. 2006
    ..This procedure may be useful clinically to prevent the local recurrence of pancreatic cancer after pancreatectomy...
  34. ncbi Up-regulation of integrin beta3 in radioresistant pancreatic cancer impairs adenovirus-mediated gene therapy
    Takuya Egami
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 100:1902-7. 2009
    ..These results suggest that inhibition of integrin beta3 in radioresistant pancreatic cancer cells could enhance adenovirus-mediated gene therapy...
  35. ncbi Invasive carcinoma derived from the nonintestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derived from the intestinal type
    Yoshihiko Sadakari
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Surgery 147:812-7. 2010
    ....
  36. ncbi Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells
    Taiki Moriyama
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Kyushu University Hospital Cancer Center, Fukuoka, Japan
    Cancer 116:3357-68. 2010
    ..Recently, cancer stem cells have been reported as a new therapeutic target in pancreatic cancer as well as other cancers, but the specific role of these cells is unknown...
  37. ncbi Cyclosporin-A enhances docetaxel-induced apoptosis through inhibition of nuclear factor-kappaB activation in human gastric carcinoma cells
    Chihiro Nakahara
    Departments of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 9:5409-16. 2003
    ..CONCLUSIONS: Treatment with CsA and TXT in combination may be an effective therapeutic strategy for patients with gastric carcinoma...
  38. ncbi Genetic polymorphisms of CYP2E1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study
    Makiko Morita
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Japan
    Cancer Epidemiol Biomarkers Prev 18:235-41. 2009
    ..03). The present study suggests that variation in activity and inducibility of CYP2E1, in relation to alcohol or red meat intake, contributes to the development of colorectal cancer...
  39. ncbi Expression of claudin-4 (CLDN4) mRNA in intraductal papillary mucinous neoplasms of the pancreas
    Kosuke Tsutsumi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 24:533-41. 2011
    ..0001). Our findings suggest that claudin-4 expression is associated with neoplastic progression of intraductal papillary mucinous neoplasms and, especially, with a distinct pathway to intestinal differentiation...
  40. ncbi Manometric evidence of earlier recovery of fasting gastric motility after antecolic duodenojejunostomy than after retrocolic duodenojejunostomy following PPPD
    Reiko Tanabe
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hepatogastroenterology 59:1981-5. 2012
    ..Although some studies reported less prevalence of gastric stasis after antecolic duodenojejunostomy, there have been no reports on detailed comparison of gastric motility after antecolic vs. retrocolic duodenojejunostomy after PPPD...
  41. ncbi The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 11:7785-93. 2005
    ..Our present results suggest that quantitation of S100A6 mRNA is a promising tool for diagnosis of pancreatic cancer, and that S100A6 may be a promising therapeutic target for pancreatic cancer...
  42. ncbi Cyst size indicates malignant transformation in branch duct intraductal papillary mucinous neoplasm of the pancreas without mural nodules
    Yoshihiko Sadakari
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pancreas 39:232-6. 2010
    ..Our aim was to elucidate the malignant potential of branch duct IPMN without mural nodules (flat branch duct IPMN)...
  43. ncbi The contribution of vascular endothelial growth factor to the induction of regulatory T-cells in malignant effusions
    Junji Wada
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Anticancer Res 29:881-8. 2009
    ..Taken together, the data presented here indicate a contribution of VEGF to induction and/or maintenance of Tregs in patients with cancer...
  44. ncbi Inhibition of p600 expression suppresses both invasiveness and anoikis resistance of gastric cancer
    Hiroshi Sakai
    Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 18:2057-65. 2011
    ..p600 (600-kDa protein), recently identified from a cervical cancer cell line, plays a role in both anoikis resistance and cell migration. In this study, we examined whether p600 is involved in the progression of gastric cancer...
  45. ncbi MicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancer
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 18:2381-7. 2011
    ..Our aim was to identify promising microRNAs as markers to predict responses to gemcitabine in patients with resected pancreatic cancer...
  46. ncbi Epidemiological study of gastroenteropancreatic neuroendocrine tumors in Japan
    Tetsuhide Ito
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Gastroenterol 45:234-43. 2010
    ..There have been few epidemiological studies on gastroenteropancreatic neuroendocrine tumors (GEP-NETs) in Japan...
  47. ncbi Quantitative assessment of telomerase activity and human telomerase reverse transcriptase messenger RNA levels in pancreatic juice samples for the diagnosis of pancreatic cancer
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Clin Cancer Res 11:2285-92. 2005
    ..Our present results suggest that the combined assessment of hTERT and telomerase activities in pancreatic juice provides a potent diagnostic method for pancreatic cancer...
  48. ncbi Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway
    Takaharu Yasui
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 102:484-91. 2011
    ..Control of such tumor-stroma interactions may lead to improvements in adenoviral gene therapy for PDAC...
  49. ncbi Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer
    Jun Yu
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    World J Gastroenterol 12:3878-82. 2006
    ..To investigate c-met expression during early pancreatic carcinogenesis...
  50. ncbi Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer
    Hiroshi Nakashima
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 66:7041-9. 2006
    ....
  51. ncbi Expression of GalNAc-T3 and its relationships with clinicopathological factors in 61 extrahepatic bile duct carcinomas analyzed using stepwise sections - special reference to its association with lymph node metastases-
    Takahiro Inoue
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 20:267-76. 2007
    ..Clinically, preoperative evaluation of GalNAc-T3 expression is considered to be useful for decisions regarding operative procedures...
  52. ncbi Radiation enhances adenoviral gene therapy in pancreatic cancer via activation of cytomegalovirus promoter and increased adenovirus uptake
    Takuya Egami
    Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 14:1859-67. 2008
    ..However, there are no reports of definitive effects of radiation on adenovirus-mediated gene therapies. In the present study, we investigated the effect of radiation on the transduction efficiency of an adenovirus-based gene therapy...
  53. ncbi Meat, fish and fat intake in relation to subsite-specific risk of colorectal cancer: The Fukuoka Colorectal Cancer Study
    Yasumi Kimura
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cancer Sci 98:590-7. 2007
    ..34-0.92, trend P=0.02). Our findings do not support the hypothesis that consumption of red meat increases colorectal cancer risk but do suggest that high intake of fish may decrease the risk, particularly of distal colon cancer...
  54. ncbi RCAS1, a useful serum marker to predict the recurrence of cancer: two cases of cholangiocarcinoma and pancreatic cancer
    Munechika Enjoji
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Dig Dis Sci 49:1654-6. 2004
  55. ncbi Down-regulation of deoxycytidine kinase enhances acquired resistance to gemcitabine in pancreatic cancer
    Seiji Ohhashi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Anticancer Res 28:2205-12. 2008
    ..The functional roles of deoxycytidine kinase (dCK) in acquired resistance to gemcitabine remain unknown in pancreatic cancer. Here, the functional involvement of dCK in gemcitabine-resistance of pancreatic cancer was investigated...
  56. ncbi New infusion device for trans-tissue, sustained local delivery of anticancer agent to surgically resected tissue: potential use for suppression of local recurrence of pancreatic cancer
    Tatsuya Manabe
    Division of Biomedical Engineering, Graduate School of Medicine, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan
    J Biomed Mater Res B Appl Biomater 73:203-7. 2005
    ..The preliminary model experimental result appears to provide a promising therapeutic procedure for increased survival rate of the patients undergoing surgery for pancreatic cancer...
  57. ncbi Enhanced efficacy of conditionally replicating herpes simplex virus (G207) combined with 5-fluorouracil and surgical resection in peritoneal cancer dissemination models
    Kenji Nakano
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Gene Med 7:638-48. 2005
    ..The goals of the current study were to examine the performance of combination treatments for peritoneal disseminated cancers and to explore the mechanism of effective combinations...
  58. ncbi Multifocal pancreatic ductal adenocarcinomas concomitant with intraductal papillary mucinous neoplasms of the pancreas detected by intraoperative pancreatic juice cytology. A case report
    Yasuhisa Mori
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    JOP 11:389-92. 2010
    ..Recently, invasive ductal carcinoma of the pancreas concomitant with IPMNs has been the focus of attention...
  59. ncbi Alcohol dehydrogenase and aldehyde dehydrogenase polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study
    Guang Yin
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 98:1248-53. 2007
    ..55, 95% CI = 0.33-0.93). It is unlikely that acetaldehyde metabolism determined by ALDH2 polymorphism contributes to the risk of colorectal cancer, whereas the role of ADH2 polymorphism deserves further investigation...
  60. ncbi Insig2 is overexpressed in pancreatic cancer and its expression is induced by hypoxia
    Tadashi Kayashima
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 102:1137-43. 2011
    ..The present data suggest that Insig2 is associated with the malignant potential of pancreatic cancer under hypoxic conditions...
  61. ncbi S100A6 is increased in a stepwise manner during pancreatic carcinogenesis: clinical value of expression analysis in 98 pancreatic juice samples
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Cancer Epidemiol Biomarkers Prev 16:649-54. 2007
    ..Measurement of S100A6 in pancreatic juice may be useful to detect early pancreatic cancer or identify individuals with high-risk lesions that may progress to pancreatic cancer...
  62. ncbi Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer
    Ming Zhao
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 103:58-66. 2012
    ..These data are promising for the future application of this drug regimen in patients with pancreatic cancer...
  63. ncbi Usefulness of 3-month protocol biopsy of kidney allograft to detect subclinical rejection under triple immunosuppression with basiliximab: a single center experience
    Kohsuke Masutani
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Exp Nephrol 15:264-8. 2011
    ....
  64. ncbi Quantitative analysis of hTERT mRNA levels in cells microdissected from cytological specimens
    Hayato Fujita
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 99:2244-51. 2008
    ..Quantitative assessment of hTERT mRNA levels in cells microdissected from cytological specimens is a potential diagnostic tool to potentiate cytological examination in diagnosing malignancy...
  65. ncbi In situ-formed, tissue-adhesive co-gel composed of styrenated gelatin and styrenated antibody: potential use for local anti-cytokine antibody therapy on surgically resected tissues
    Tatsuya Manabe
    Division of Surgery and Oncology, Graduate School of Medicine, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan
    Biomaterials 25:5867-73. 2004
    ....
  66. ncbi High EGFR mRNA expression is a prognostic factor for reduced survival in pancreatic cancer after gemcitabine-based adjuvant chemotherapy
    Hayato Fujita
    Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan
    Int J Oncol 38:629-41. 2011
    ....
  67. ncbi S100A11, a putative tumor suppressor gene, is overexpressed in pancreatic carcinogenesis
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 12:5417-22. 2006
    ..Recent microarray analyses revealed that expression of S100A11 is up-regulated in pancreatic cancer. The aim of the present study was to evaluate the association of S100A11 with pancreatic carcinogenesis...
  68. ncbi MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance
    Taiki Moriyama
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Mol Cancer Ther 8:1067-74. 2009
    ..These data suggest that miR-21 expression is increased in pancreatic cancer cells and that miR-21 contributes to the cell proliferation, invasion, and chemoresistance of pancreatic cancer...
  69. ncbi Total pancreatectomy for intraductal papillary-mucinous tumor of the pancreas: reappraisal of total pancreatectomy
    Koji Yamaguchi
    Department of Surgery and Oncology, Graduate School of Medical Sciences Kyushu University, Fukuoka, Japan
    Hepatogastroenterology 52:1585-90. 2005
    ..Intraductal papillary-mucinous tumor (IPMT) of the pancreas is characterized by extensive intraductal spread and favorable outcome even in its invasive stage. The role of total pancreatectomy was reappraised in the treatment of IPMT...
  70. ncbi Cell-based protein delivery system for the inhibition of the growth of pancreatic cancer: NK4 gene-transduced oral mucosal epithelial cell sheet
    Tatsuya Manabe
    Divisions of Biomedical Engineering and Surgery and Oncology, Graduate School of Medicine, Kyushu University, Maidashi, Fukuoka, Japan
    Clin Cancer Res 9:3158-66. 2003
    ....
  71. ncbi S100A4 mRNA is a diagnostic and prognostic marker in pancreatic carcinoma
    Naoki Ikenaga
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    J Gastrointest Surg 13:1852-8. 2009
    ..The aim of this study is to evaluate the clinical significance of S100A4 mRNA expression in pancreatic cancer...
  72. ncbi Midkine mRNA is overexpressed in pancreatic cancer
    Seiji Ohhashi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    Dig Dis Sci 54:811-5. 2009
    ..We investigated the feasibility of quantitative analysis of MK mRNA by quantitative real-time RT-PCR (qRT-PCR) as a promising tool for the diagnosis of pancreatic cancer...
  73. ncbi Monocyte-derived dendritic cells that capture dead tumor cells secrete IL-12 and TNF-alpha through IL-12/TNF-alpha/NF-kappaB autocrine loop
    Hideya Onishi
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    Cancer Immunol Immunother 53:1093-100. 2004
    ..e., an IL-12/TNF-alpha/NF-kappaB autocrine loop, in Mo-DCs-Tum. Thus, Mo-DCs-Tum secrete a large amount of IL-12 and TNF-alpha through accelerated NF-kappaB activation induced by the IL-12/TNF-alpha/NF-kappaB autocrine loop...
  74. ncbi Genetic polymorphism in cytochrome P450 7A1 and risk of colorectal cancer: the Fukuoka Colorectal Cancer Study
    Tomoko Hagiwara
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    Cancer Res 65:2979-82. 2005
    ....
  75. ncbi Blockade of constitutively activated Janus kinase/signal transducer and activator of transcription-3 pathway inhibits growth of human pancreatic cancer
    Takayuki Toyonaga
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-Ward, Fukuoka 812-8582, Japan
    Cancer Lett 201:107-16. 2003
    ....
  76. ncbi Quantitative analysis of MUC1 and MUC5AC mRNA in pancreatic juice for preoperative diagnosis of pancreatic cancer
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 118:405-11. 2006
    ....
  77. ncbi Severe localized stenosis and marked dilatation of the main pancreatic duct are indicators of pancreatic cancer instead of chronic pancreatitis on endoscopic retrograde balloon pancreatography
    Ken Inoue
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gastrointest Endosc 58:510-5. 2003
    ..CONCLUSIONS: Severe stenosis, marked proximal dilatation, double duct sign, and combinations of these findings are useful indicators of malignant localized stenosis of the pancreatic duct...
  78. ncbi Gamma-secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells
    Takashi Akiyoshi
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gastroenterology 134:131-44. 2008
    ..However, the therapeutic usefulness of gamma-secretase inhibitors against colorectal cancers remains unclear...
  79. ncbi Interleukin 1beta enhances invasive ability of gastric carcinoma through nuclear factor-kappaB activation
    Naoki Yamanaka
    Departments of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 10:1853-9. 2004
    ..We examined the role of interleukin (IL)-1beta in activation of nuclear factor kappaB (NF-kappaB) and the biological function of activated NF-kappaB in gastric carcinoma cells...
  80. ncbi Phenotypical characteristics of undifferentiated carcinoma of the pancreas: a comparison with pancreatic ductal adenocarcinoma and relevance of E-cadherin, alpha catenin and beta catenin expression
    H Yonemasu
    Department of Anatomic Pathology, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 821-8582, Japan
    Oncol Rep 8:745-52. 2001
    ..The results suggest that the altered expression of adhesion molecules is correlated with dedifferentiated change and is contributory to its aggressive biological behaviour...
  81. ncbi Sonic hedgehog is an early developmental marker of intraductal papillary mucinous neoplasms: clinical implications of mRNA levels in pancreatic juice
    K Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan
    J Pathol 210:42-8. 2006
    ....
  82. ncbi Surgical treatment of patients with T2 gallbladder carcinoma invading the subserosal layer
    K Chijiiwa
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Am Coll Surg 192:600-7. 2001
    ..The presence of lymph node metastasis, perineural invasion, or both suggests the necessity of additional treatment after radical surgery...
  83. ncbi A case of recurrent type 1 diabetes mellitus with insulitis of transplanted pancreas in simultaneous pancreas-kidney transplantation from cardiac death donor
    M Ishida-Oku
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Diabetologia 53:341-5. 2010
    ..Unexpectedly, we found insulitis in the transplanted pancreas and characterised the insulitis...
  84. ncbi Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study
    Guang Yin
    Department of Preventive Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582
    Cancer Sci 95:908-13. 2004
    ..Because very few individuals had the 1298CC genotype, the findings regarding the A1298C polymorphism need careful interpretation and confirmation in larger studies...
  85. ncbi Association between proline-requiring auxotype and fluoroquinolone resistance in Neisseria gonorrhoeae isolated in Japan
    H Tsunoe
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    J Infect Chemother 7:218-23. 2001
    ..gonorrhoeae isolates with GyrA and ParC substitutions may be mainly caused by the dissemination of a single clone in the community...
  86. ncbi Hedgehog signaling pathway is a possible therapeutic target for gastric cancer
    Kosuke Yanai
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Surg Oncol 95:55-62. 2007
    ..It has been shown that the hedgehog (Hh) signaling pathway is activated in gastric cancer. To investigate the viability of the Hh pathway as a therapeutic target, we analyzed activation of the Hh pathway in gastric cancer...
  87. ncbi Clinical aspects of intraductal papillary mucinous neoplasm of the pancreas
    Masao Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka, 812-8582, Japan
    J Gastroenterol 40:669-75. 2005
    ..On the other hand, asymptomatic branch duct IPMNs without mural nodules can be observed without resection for a considerably long time. This review addresses available data, current understanding, controversy, and future directions...
  88. ncbi Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue
    N Sasaki
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Clin Cancer Res 7:4136-42. 2001
    ....
  89. ncbi Stepwise progression of centrosome defects associated with local tumor growth and metastatic process of human pancreatic carcinoma cells transplanted orthotopically into nude mice
    M Shono
    Department of Surgery and OncologyGraduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Lab Invest 81:945-52. 2001
    ....
  90. ncbi [Current strategy to cure pancreatic cancer]
    Masao Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Nippon Geka Gakkai Zasshi 103:290-3. 2002
    ..At the moment, careful checks for the presence of these hints seem to be the only strategy to offer a chance for cure to patients with pancreatic cancer...
  91. ncbi Pancreatic juice cytology in IPMN of the pancreas
    Koji Yamaguchi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pancreatology 5:416-21; discussion 421. 2005
    ....
  92. ncbi MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation
    Jun Yu
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Cancer 9:169. 2010
    ..However, the significance of miR-200c in pancreatic cancer is unknown...
  93. ncbi All-trans retinoic acid inhibits the cell proliferation but enhances the cell invasion through up-regulation of c-met in pancreatic cancer cells
    Kawin Leelawat
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Fukuoka 812-8582, Japan; Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
    Cancer Lett 224:303-10. 2005
    ..In addition, ATRA also increased the protein level of c-Met. These findings may indicate that the use of retinoic acid as an anti-cancer therapeutic drug needs some additional treatments to control cell invasion or scattering...
  94. ncbi Inhibition of interferon-gamma-activated nuclear factor-kappa B by cyclosporin A: A possible mechanism for synergistic induction of apoptosis by interferon-gamma and cyclosporin A in gastric carcinoma cells
    Kiichiro Beppu
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyusyu University, Fukuoka 812-8582, Japan
    Biochem Biophys Res Commun 305:797-805. 2003
    ....
  95. ncbi Ki-ras mutations in codon 12 and p53 mutations (biomarkers) and cytology in bile in patients with hepatobiliary-pancreatic carcinoma
    Koji Yamaguchi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hepatogastroenterology 52:713-8. 2005
    ..CONCLUSIONS: These findings suggest that genetic examinations of the bile, when used in conjunction with cytology, may improve the diagnostic yield for suspected malignant tumors of the hepatobiliary and pancreatic system...
  96. ncbi Telomerase as a new target for pancreatic cancer treatment
    Norihiro Sato
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582, Japan
    J Hepatobiliary Pancreat Surg 9:322-7. 2002
    ..On the other hand, several issues still need to be addressed before these drugs are moved into clinical trials. This review focuses on the recent progress in telomerase research and its implications in pancreatic cancer treatment...
  97. ncbi Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells
    M Onimaru
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Cancer Gene Ther 17:541-9. 2010
    ..These results suggest that adenovirus-mediated gene therapy with GEM may be a promising approach for treating pancreatic cancer, and that this combination therapy may decrease the risks of side effects...
  98. ncbi Characterization of CD24 expression in intraductal papillary mucinous neoplasms and ductal carcinoma of the pancreas
    Naoki Ikenaga
    Departments of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 41:1466-74. 2010
    ..In conclusion, CD24 is involved in the progression of intraductal papillary mucinous neoplasms of the pancreas and in the malignant behavior of pancreatic cancers...
  99. ncbi Regulation of bile acid synthesis under reconstructed enterohepatic circulation in rats
    Masahiro Nagano
    Department of Surgery and Oncology, Kyushu University School of Medicine, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Steroids 69:701-9. 2004
    ..It was concluded that an unidentified regulatory factor other than the nuclear receptors may be involved in bile acid synthesis in vivo...
  100. ncbi Appleby operation for pancreatic body-tail carcinoma: report of three cases
    Koji Yamaguchi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, 812-8582 Fukuoka, Japan
    Surg Today 33:873-8. 2003
    ....
  101. ncbi [Recent advances in diagnosis of pancreatic cancer]
    Koji Yamaguchi
    Dept. of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gan To Kagaku Ryoho 32:612-6. 2005
    ..Possible discovery of pancreatic carcinoma as a diagnostic clue to diabetes mellitus, and intraductal papillary-mucinous neoplasm are introduced based on our clinical experience...