Masakazu Tanaka

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint An extended planar C5 conformation and a 310-helical structure of peptide foldamer composed of diverse alpha-ethylated alpha,alpha-disubstituted alpha-amino acids
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences Kyushu University, Fukuoka 812 8582, Japan
    Chemistry 9:3082-90. 2003
  2. ncbi request reprint [Design and synthesis of non-proteinogenic amino acids and secondary structures of their peptides]
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka City, Japan
    Yakugaku Zasshi 126:931-44. 2006
  3. ncbi request reprint Double-chelation-assisted Rh-catalyzed intermolecular hydroacylation
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Org Lett 5:1365-7. 2003
  4. ncbi request reprint Lipase-catalyzed kinetic resolution of cyclic trans-1,2-diols bearing a diester moiety: synthetic application to chiral seven-membered-ring alpha,alpha-disubstituted alpha-amino acid
    Masakazu Tanaka
    Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158 8501, Japan
    J Org Chem 72:7750-6. 2007
  5. ncbi request reprint Asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acids using (S,S)-cyclohexane-1,2-diol as a chiral auxiliary
    M Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Org Chem 66:2667-73. 2001
  6. ncbi request reprint Side-chain chiral centers of amino acid and helical-screw handedness of its peptides
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Am Chem Soc 127:11570-1. 2005
  7. ncbi request reprint Design and synthesis of chiral alpha,alpha-disubstituted amino acids and conformational study of their oligopeptides
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 55:349-58. 2007
  8. ncbi request reprint Chiral centers in the side chains of alpha-amino acids control the helical screw sense of peptides
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Angew Chem Int Ed Engl 43:5360-3. 2004
  9. doi request reprint Three-dimensional structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences in the solid state
    Yosuke Demizu
    Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158 8501, Japan
    J Org Chem 75:5234-9. 2010
  10. doi request reprint Helical-screw directions of diastereoisomeric cyclic alpha-amino acid oligomers
    Masanobu Nagano
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Org Lett 11:1135-7. 2009

Collaborators

Detail Information

Publications91

  1. ncbi request reprint An extended planar C5 conformation and a 310-helical structure of peptide foldamer composed of diverse alpha-ethylated alpha,alpha-disubstituted alpha-amino acids
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences Kyushu University, Fukuoka 812 8582, Japan
    Chemistry 9:3082-90. 2003
    ....
  2. ncbi request reprint [Design and synthesis of non-proteinogenic amino acids and secondary structures of their peptides]
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka City, Japan
    Yakugaku Zasshi 126:931-44. 2006
    ..These results indicate that the side-chain chiral centers affect the secondary structure of their peptides, and the side-chain chiral environment is important for the control of the helical-screw direction of peptides...
  3. ncbi request reprint Double-chelation-assisted Rh-catalyzed intermolecular hydroacylation
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Org Lett 5:1365-7. 2003
    ..The experiments using deuterated salicylaldehyde-d revealed that "double chelation" of salicylaldehyde and 1,5-hexadiene to Rh-complex played vital roles in the catalytic cycle of intermolecular hydroacylation...
  4. ncbi request reprint Lipase-catalyzed kinetic resolution of cyclic trans-1,2-diols bearing a diester moiety: synthetic application to chiral seven-membered-ring alpha,alpha-disubstituted alpha-amino acid
    Masakazu Tanaka
    Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158 8501, Japan
    J Org Chem 72:7750-6. 2007
    ..Furthermore, the optically active diester (-)-8 could be efficiently converted into an optically active seven-membered-ring alpha,alpha-disubstituted amino acid (4R,5R)-(-)-15...
  5. ncbi request reprint Asymmetric synthesis of alpha,alpha-disubstituted alpha-amino acids using (S,S)-cyclohexane-1,2-diol as a chiral auxiliary
    M Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Org Chem 66:2667-73. 2001
    ..The beta-keto esters could be easily converted into optically active alpha-methylated and/or alpha-ethylated alpha,alpha-disubstituted amino acids (12 and 13) in 21-99% yields using Schmidt rearrangement...
  6. ncbi request reprint Side-chain chiral centers of amino acid and helical-screw handedness of its peptides
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Am Chem Soc 127:11570-1. 2005
    ..Both diastereomeric right-handed (P) and left-handed (M) 310-helices exist in homopeptides having twelve chiral centers at the side-chain bicyclic skeletons...
  7. ncbi request reprint Design and synthesis of chiral alpha,alpha-disubstituted amino acids and conformational study of their oligopeptides
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 55:349-58. 2007
    ..The synthetic route would provide various optically-active cyclic alpha,alpha-disubstituted amino acids bearing a pendant chiral moiety...
  8. ncbi request reprint Chiral centers in the side chains of alpha-amino acids control the helical screw sense of peptides
    Masakazu Tanaka
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Angew Chem Int Ed Engl 43:5360-3. 2004
  9. doi request reprint Three-dimensional structural control of diastereomeric Leu-Leu-Aib-Leu-Leu-Aib sequences in the solid state
    Yosuke Demizu
    Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158 8501, Japan
    J Org Chem 75:5234-9. 2010
    ....
  10. doi request reprint Helical-screw directions of diastereoisomeric cyclic alpha-amino acid oligomers
    Masanobu Nagano
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Org Lett 11:1135-7. 2009
    ..The oligomers are a new class of helical-foldamers possessing two kinds of chiral centers on the helical backbone and at the lateral surface of the helix...
  11. doi request reprint Stabilized alpha-helix-catalyzed enantioselective epoxidation of alpha,beta-unsaturated ketones
    Masanobu Nagano
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Org Lett 12:3564-6. 2010
    ....
  12. doi request reprint Conformational studies on peptides containing α,α-disubstituted α-amino acids: chiral cyclic α,α-disubstituted α-amino acid as an α-helical inducer
    Yosuke Demizu
    Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158 8501, Japan
    Org Biomol Chem 9:3303-12. 2011
    ..The Aib and achiral Ac(5)c residues have the propensity to form 3(10)-helices in short peptides, whereas the chiral Ac(5)c(dOM) residues have a penchant for forming α-helices...
  13. ncbi request reprint Phenotypical characteristics of undifferentiated carcinoma of the pancreas: a comparison with pancreatic ductal adenocarcinoma and relevance of E-cadherin, alpha catenin and beta catenin expression
    H Yonemasu
    Department of Anatomic Pathology, Kyushu University, Maidashi 3-1-1, Higashi-ku, Fukuoka 821-8582, Japan
    Oncol Rep 8:745-52. 2001
    ..The results suggest that the altered expression of adhesion molecules is correlated with dedifferentiated change and is contributory to its aggressive biological behaviour...
  14. doi request reprint Conformations of helical Aib peptides containing a pair of L-amino acid and D-amino acid
    Yosuke Demizu
    Division of Organic Chemistry, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya, Tokyo 158 8501, Japan
    J Pept Sci 18:466-75. 2012
    ..X-ray crystallographic analysis revealed that right-handed (P) 3₁₀-helices were present in 1a and 1b and a mixture of right-handed(P) and left-handed (M) 3₁₀-helices was present in 2b in their crystalline states...
  15. ncbi request reprint Controlling 3(10)-helix and alpha-helix of short peptides in the solid state
    Yosuke Demizu
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 55:840-2. 2007
    ..L-Leu hexapeptide containing alpha-aminoisobutyric acid (Aib) forms a right-handed (P) 3(10)-helix, whereas that containing cyclic alpha,alpha-disubstituted amino acid Ac(5)c(dOM) assumes a right-handed (P) alpha-helix in the solid state...
  16. doi request reprint Conformations of peptides containing a chiral cyclic α, α-disubstituted α-amino acid within the sequence of Aib residues
    Yosuke Demizu
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Pept Sci 16:621-6. 2010
    ..X-ray crystallographic analysis of 1 and 2 revealed that a left-handed (M) 3(10)-helical structure was present in 1 and that a right-handed (P) 3(10)-helical structure was present in 2 in their crystalline states...
  17. doi request reprint A case of recurrent type 1 diabetes mellitus with insulitis of transplanted pancreas in simultaneous pancreas-kidney transplantation from cardiac death donor
    M Ishida-Oku
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Diabetologia 53:341-5. 2010
    ..Unexpectedly, we found insulitis in the transplanted pancreas and characterised the insulitis...
  18. ncbi request reprint Surgical treatment of patients with T2 gallbladder carcinoma invading the subserosal layer
    K Chijiiwa
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Am Coll Surg 192:600-7. 2001
    ..The presence of lymph node metastasis, perineural invasion, or both suggests the necessity of additional treatment after radical surgery...
  19. ncbi request reprint Sonic hedgehog is an early developmental marker of intraductal papillary mucinous neoplasms: clinical implications of mRNA levels in pancreatic juice
    K Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Pathol 210:42-8. 2006
    ....
  20. doi request reprint Twisted structure of a cyclic hexapeptide containing a combination of alternating L-Leu-D-Leu-Aib segments
    Yosuke Demizu
    Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158 8501, Japan
    J Org Chem 77:9361-5. 2012
    ..The conformation of 2 was analyzed in the crystalline state and in solution, which was a unique figure-eight-shaped conformation...
  21. doi request reprint Controlling the helical screw sense of peptides with C-terminal L-valine
    Yosuke Demizu
    Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158 8501, Japan
    J Pept Sci 16:153-8. 2010
    ..X-ray crystallographic analyses of 3 and 4 revealed that only a right-handed (P) 3(10)-helical structure was present in their crystalline states. The conformation of 4 was also studied by molecular-mechanics calculations...
  22. doi request reprint Effect of one D-Leu residue on right-handed helical -L-Leu-Aib- peptides in the crystal state
    Yosuke Demizu
    Division of Organic Chemistry, National Institute of Health Sciences, Setagaya, Tokyo, Japan
    J Pept Sci 17:420-6. 2011
    ....
  23. ncbi request reprint Association between proline-requiring auxotype and fluoroquinolone resistance in Neisseria gonorrhoeae isolated in Japan
    H Tsunoe
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    J Infect Chemother 7:218-23. 2001
    ..gonorrhoeae isolates with GyrA and ParC substitutions may be mainly caused by the dissemination of a single clone in the community...
  24. pmc Development of a Cell-penetrating Peptide that Exhibits Responsive Changes in its Secondary Structure in the Cellular Environment
    Hiroko Yamashita
    National Institute of Health Sciences, Tokyo 158 8501, Japan
    Sci Rep 6:33003. 2016
    ..Thus, l-Pro(Gu)-containing peptide 3 may be a useful candidate as a gene delivery carrier. ..
  25. doi request reprint The side-chain hydroxy groups of a cyclic α,α-disubstituted α-amino acid promote oligopeptide 310 -helix packing in the crystalline state
    Yosuke Demizu
    Division of Organic Chemistry, National Institute of Health Sciences, Tokyo, 158 8501, Japan
    Biopolymers 106:757-68. 2016
    ..2016 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 106: 757-768, 2016. ..
  26. doi request reprint One-handed helical screw direction of homopeptide foldamer exclusively induced by cyclic α-amino acid side-chain chiral centers
    Yosuke Demizu
    National Institute of Health Sciences, Tokyo 158 8501, Japan
    Chemistry 18:2430-9. 2012
    ....
  27. ncbi request reprint Stepwise progression of centrosome defects associated with local tumor growth and metastatic process of human pancreatic carcinoma cells transplanted orthotopically into nude mice
    M Shono
    Department of Surgery and OncologyGraduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Lab Invest 81:945-52. 2001
    ....
  28. ncbi request reprint Nuclear factor-kappaB p65 (RelA) transcription factor is constitutively activated in human gastric carcinoma tissue
    N Sasaki
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan
    Clin Cancer Res 7:4136-42. 2001
    ....
  29. doi request reprint Topological Study of the Structures of Heterochiral Peptides Containing Equal Amounts of l-Leu and d-Leu
    Yosuke Demizu
    Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158 8501, Japan
    J Org Chem 80:8597-603. 2015
    ..In solution, roughly equivalent amounts of (P) and (M) helices were present in 5, whereas the (M) α-helix was present in 6 as its dominant conformation. ..
  30. doi request reprint Gemcitabine synergistically enhances the effect of adenovirus gene therapy through activation of the CMV promoter in pancreatic cancer cells
    M Onimaru
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Cancer Gene Ther 17:541-9. 2010
    ..These results suggest that adenovirus-mediated gene therapy with GEM may be a promising approach for treating pancreatic cancer, and that this combination therapy may decrease the risks of side effects...
  31. ncbi request reprint Asymmetric Rh-catalyzed intermolecular hydroacylation of 1,5-hexadiene with salicylaldehyde
    Yasuhiro Inui
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Chem Pharm Bull (Tokyo) 57:1158-60. 2009
    ..10 eq), (S)-BINAP (0.10 eq), and ZnBr(2) (0.20 eq) afforded an enantiomerically enriched hydroacylated product iso-3 of 84% ee, along with an achiral product normal-3...
  32. doi request reprint A Helix-Stabilized Cell-Penetrating Peptide as an Intracellular Delivery Tool
    Hiroko Yamashita
    National Institute of Health Sciences, Setagaya, Tokyo, 158 8501, Japan
    Chembiochem 17:137-40. 2016
    ..Furthermore, the peptide was able to deliver plasmid DNA into various types of cells in a highly efficient manner...
  33. doi request reprint Amphipathic short helix-stabilized peptides with cell-membrane penetrating ability
    Hiroko Yamashita
    Division of Organic Chemistry, National Institute of Health Sciences, 1 18 1 Kamiyoga, Setagaya, Tokyo 158 8501, Japan Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama 226 8501, Japan
    Bioorg Med Chem 22:2403-8. 2014
    ..Peptides 1 and ent-1 formed stable one-handed α-helical structures and were more effective at penetrating HeLa cells than the non-helical peptides 2 and 3...
  34. ncbi request reprint Postoperative pancreatic exocrine function influences body weight maintenance after pylorus-preserving pancreatoduodenectomy
    T Ohtsuka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 812-8582, Fukuoka, Japan
    Am J Surg 182:524-9. 2001
    ..23). CONCLUSIONS: In patients refractory to an ordinary amount of medicine, a large dosage of enzymes may be necessary to gain weight after PPPD...
  35. ncbi request reprint Simulated microgravity culture system for a 3-D carcinoma tissue model
    K Nakamura
    Kyushu University, Fukuoka, Japan
    Biotechniques 33:1068-70, 1072, 1074-6. 2002
    ..This new 3-D rotary cell culture system with four disposal vessels may be useful for in vitro studies of complex pancreatic carcinoma tissue...
  36. ncbi request reprint Quantitative analysis of hTERT mRNA expression in colorectal cancer
    H Niiyama
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Gastroenterol 96:1895-900. 2001
    ..CONCLUSIONS: Our data suggest that determination of hTERT mRNA by competitive RT-PCR is superior in quantitative accuracy and sensitivity and would support the importance of telomerase activity for the diagnosis of colorectal cancer...
  37. ncbi request reprint Peritumoral injection of adenovirus vector expressing NK4 combined with gemcitabine treatment suppresses growth and metastasis of human pancreatic cancer cells implanted orthotopically in nude mice and prolongs survival
    Y Ogura
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Gene Ther 13:520-9. 2006
    ..These results suggest that peritumoral injection of Ad-NK4 plus GEM is a potent combination therapy for pancreatic cancer...
  38. doi request reprint Effects of D-Leu residues on the helical secondary structures of L-Leu-based nonapeptides
    Yosuke Demizu
    Division of Organic Chemistry, National Institute of Health Sciences
    Chem Pharm Bull (Tokyo) 63:218-24. 2015
    ..Peptides 2 and 3 both formed (P) 310-helices in solution and (P) α-helices in the crystalline state. Peptide 4 formed a (P) α-helix both in solution and in the crystalline state. ..
  39. doi request reprint Oligopeptides with equal amounts of L- and D-amino acids may prefer a helix screw sense
    Yosuke Demizu
    Division of Organic Chemistry, National Institute of Health Sciences, Tokyo 158 8501, Japan
    J Org Chem 78:12106-13. 2013
    ..Furthermore, the decapeptide 7, which possesses four L-Leu residues and three D-Leu residues, was folded into an (M) α-helix...
  40. ncbi request reprint Phase I/II study of irinotecan and UFT for advanced or metastatic colorectal cancer
    R Mibu
    Department of Surgery and Oncology, and 2First Department of Internal Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Anticancer Res 27:2673-7. 2007
    ....
  41. ncbi request reprint Development of a broadband telemedical network based on internet protocol in the Asia-Pacific region
    N Nakashima
    Department of Medical Informatics, Kyushu University Faculty of Medicine, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Methods Inf Med 46:709-15. 2007
    ..To promote the exchange of knowledge and standardization of medical procedures and medical systems in the Asia-Pacific region, we established a medical network with high-quality moving images over broadband Internet lines in February 2003...
  42. ncbi request reprint Effects of cholestyramine on hepatic cholesterol 7alpha-hydroxylase and serum 7alpha-hydroxycholesterol in the hamster
    S Kuroki
    Department of Surgery I, Kyushu University Faculty of Medicine, Fukuoka, Japan
    Lipids 34:817-23. 1999
    ..We conclude that the serum 7alpha-hydroxycholesterol level does not always reflect the activity of hepatic cholesterol 7alpha-hydroxylase, when cholesterol metabolism is severely disturbed by cholestyramine...
  43. ncbi request reprint Therapeutic efficacy of G207, a conditionally replicating herpes simplex virus type 1 mutant, for gallbladder carcinoma in immunocompetent hamsters
    K Nakano
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Mol Ther 3:431-7. 2001
    ..These results indicate that G207 may be useful as a new strategy for gallbladder cancer treatment...
  44. ncbi request reprint Infrasternal mediastinoscopic thymectomy in myasthenia gravis: surgical results in 23 patients
    A Uchiyama
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Thorac Surg 72:1902-5. 2001
    ..Infrasternal mediastinoscopic surgery is a new approach to resection of the anterior mediastinal mass...
  45. ncbi request reprint Diverse effects of 9-hydroxyellipticine on the chemosensitivity of human pancreatic cancer cells harboring p53 mutations
    K Mizumoto
    Department of Surgery and Oncology, Graduate School of Medicine, Kyushu University, Fukuoka, Japan
    Cancer Lett 149:85-94. 2000
    ..Taken together, these findings suggest that 9-HE may exert different effects on the drug sensitivity of pancreatic cancer cells displaying p53 mutations possibly through restoration of wt p53...
  46. ncbi request reprint Important clues to the diagnosis of pancreatic cancer
    M Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Rocz Akad Med Bialymst 50:69-72. 2005
    ..IPMN may be the only clue to the early diagnosis of pancreatic carcinoma presenting with no clinical symptoms or abnormalities on imaging studies...
  47. doi request reprint Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence
    Y Koga
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Histopathology 52:569-77. 2008
    ..CD10+ colorectal carcinomas have a high risk of giving rise to liver metastasis. The aim was to examine phenotypic expression in colorectal neoplasia and to elucidate changes in such expression through the adenoma-carcinoma sequence...
  48. ncbi request reprint International transmission of uncompressed endoscopic surgery images via superfast broadband Internet connections
    S Shimizu
    Department of Endoscopic Diagnostics and Therapeutics, Kyushu University Hospital, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    Surg Endosc 20:167-70. 2006
    ..Although telecommunication is increasing in popularity, poor-quality images sent through a narrowband network limit its use in the medical field...
  49. ncbi request reprint Laparoscopically assisted distal gastrectomy with standard radical lymph node dissection for gastric cancer
    H Noshiro
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidash, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Endosc 19:1592-6. 2005
    ..However, little data are available on the feasibility or advantages of LADG with standard radical D2 lymph node dissection for patients with gastric cancer...
  50. ncbi request reprint Over-expression of S100A2 in pancreatic cancer correlates with progression and poor prognosis
    K Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pathol 213:275-82. 2007
    ..043). Immunohistochemical analysis was consistent with qRT-PCR. S100A2 may be a marker of tumour progression or prognosis in pancreatic carcinogenesis and pancreatic cancer...
  51. doi request reprint Availability of pancreatic allograft biopsies via a laparotomy
    H Kitada
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Transplant Proc 41:4274-6. 2009
    ..The aim of this study was to evaluate the availability of a pancreatic allograft biopsy via a laparotpmy...
  52. ncbi request reprint Long-term results of tacrolimus therapy for renal transplantation in patients with diabetic nephropathy in Japan
    A Sugitani
    Department of Surgery and Oncology, Kyushu University School of Medicine, Maidashi, Fukuoka, Japan
    Transplant Proc 37:1767-8. 2005
    ..Tacrolimus was also beneficial in association with simultaneous pancreas and kidney transplantation. These data encourage us to perform kidney transplantation in patients with diabetic nephropathy...
  53. ncbi request reprint Urine diacetylspermine as a novel tumour maker for pancreatobiliary carcinomas
    K Yamaguchi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Dig Liver Dis 37:190-4. 2005
    ..A novel urine tumour marker, diacetylspermine, was compared with the two conventional serum tumour markers in 125 patients with pancreatobiliary diseases...
  54. ncbi request reprint Movement of a novel serum tumour marker, RCAS1, in patients with biliary diseases
    M Enjoji
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Dig Liver Dis 36:622-7. 2004
    ..We have demonstrated immunohistochemically that RCAS 1 antigen is expressed in biliary neoplasms. Serum RCAS 1 levels are also elevated in a high percentage of patients with intra-hepatic cholangiocarcinoma...
  55. ncbi request reprint Instability of chromosome 8 as an indicator of aggressive tumor phenotype in pancreatic cancer
    N Sato
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Surg Oncol 76:181-7. 2001
    ..01). CONCLUSIONS: These results suggest that the increased level of chromosomal instability may play a critical role in the development of aggressive tumor phenotype during pancreatic cancer progression. J. Surg. Oncol. 2001;76:181-187...
  56. ncbi request reprint Setting characteristics of five autopolymerizing resins measured by an oscillating rheometer
    T Ogawa
    Department of Removable Prosthodontics, Faculty of Dentistry, Kyushu University, Fukuoka, Japan
    J Prosthet Dent 85:170-6. 2001
    ..Ease of handling and the working time of autopolymerizing resins are directly associated with the setting characteristics during polymerization...
  57. pmc Laparoscopic cystogastrostomy for pancreatic pseudocyst: a case report
    S Shimizu
    Department of Endoscopic Diagnostics and Therapeutics, Kyushu University Faculty of Medicine, Fukuoka, Japan
    JSLS 4:309-12. 2000
    ..The postoperative course was uneventful. Laparoscopic surgery is recommended as a safe, reliable, and minimally invasive treatment for managing pancreatic pseudocyst...
  58. ncbi request reprint Antimicrobial activity of gemifloxacin (SB-265805), a newer fluoroquinolone, against clinical isolates of Neisseria gonorrhoeae, including fluoroquinolone-resistant isolates
    M Tanaka
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Diagn Microbiol Infect Dis 38:109-13. 2000
    ..Moreover, the activity of gemifloxacin against fluoroquinolone-resistant gonococcal isolates containing multiple amino acid substitutions in both GyrA and ParC proteins was superior to those of the other compounds...
  59. ncbi request reprint Laparoscopic adrenalectomy for pheochromocytoma: comparison with open adrenalectomy and comparison of laparoscopic surgery for pheochromocytoma versus other adrenal tumors
    M Tanaka
    Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Endourol 14:427-31. 2000
    ..To compare the efficacy of laparoscopic adrenalectomy for pheochromocytoma with that of conventional open adrenalectomy for pheochromocytoma and laparoscopic surgery for other adrenal tumors...
  60. ncbi request reprint Effect of water temperature during polymerization on strength of autopolymerizing resin
    T Ogawa
    Faculty of Dentistry, Kyushu University, Fukuoka, Japan
    J Prosthet Dent 84:222-4. 2000
    ..Breakage is a potential problem of provisional resin restorations. A method that effectively increases the strength of the resin is desirable...
  61. pmc Evaluation of a new amplified enzyme immunoassay (EIA) for the detection of Chlamydia trachomatis in male urine, female endocervical swab, and patient obtained vaginal swab specimens
    M Tanaka
    Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Clin Pathol 53:350-4. 2000
    ....
  62. pmc Up-regulation of telomerase activity in human pancreatic cancer cells after exposure to etoposide
    N Sato
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Cancer 82:1819-26. 2000
    ..This telomerase activation pathway may be one of the mechanisms responsible for the development of etoposide resistance in certain pancreatic cancer cells...
  63. ncbi request reprint Long-term and short-term survivors after pancreatectomy for pancreatic cancer
    K Yamaguchi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int Surg 85:71-6. 2000
    ..These findings suggest that, although the aggressive nature of pancreatic cancer has been accepted, the clinical course after pancreatectomy would also depend upon the immunological state of the patient...
  64. ncbi request reprint Radiation-induced centrosome overduplication and multiple mitotic spindles in human tumor cells
    N Sato
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Exp Cell Res 255:321-6. 2000
    ..We conclude that abnormal centrosome duplication could be one of the key events involved in nuclear fragmentation and perhaps even cell death following irradiation...
  65. pmc Antimicrobial resistance of Neisseria gonorrhoeae and high prevalence of ciprofloxacin-resistant isolates in Japan, 1993 to 1998
    M Tanaka
    Department of Urology, Faculty of Medicine, Kyushu University, Japan
    J Clin Microbiol 38:521-5. 2000
    ..Ciprofloxacin-resistant isolates contained three or four amino acid substitutions within the QRDR in the GyrA and ParC proteins...
  66. pmc Susceptibilities of Neisseria gonorrhoeae isolates containing amino acid substitutions in GyrA, with or without substitutions in ParC, to newer fluoroquinolones and other antibiotics
    M Tanaka
    Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Antimicrob Agents Chemother 44:192-5. 2000
    ..Among the strains with various GyrA substitutions, strains with a serine-91-to-phenylalanine mutation required the highest MICs of all of the fluoroquinolones tested and were cross-resistant to structurally unrelated beta-lactams...
  67. ncbi request reprint Effect of water temperature on the fit of provisional crown margins during polymerization
    T Ogawa
    Faculty of Dentistry, Kyushu University, Fukuoka, Japan and GC Dental Products, Kasugai, Japan
    J Prosthet Dent 82:658-61. 1999
    ..When fabricating a provisional crown with the direct technique, dentists are concerned with margin discrepancies that result from polymerization shrinkage...
  68. ncbi request reprint Quantitative determination of apoptotic death in cultured human pancreatic cancer cells by propidium iodide and digitonin
    L Zhang
    Department of Surgery 1, Kyushu University, Faculty of Medicine, Fukuoka, Japan
    Cancer Lett 142:129-37. 1999
    ..Taken together, this simple assay is useful for testing the efficacy of anti-cancer agents and for investigating the molecular mechanisms of apoptosis in the cultured cells...
  69. ncbi request reprint Genotypic evolution in a quinolone-resistant Neisseria gonorrhoeae isolate from a patient with clinical failure of levofloxacin treatment
    M Tanaka
    Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Urol Int 62:64-8. 1999
    ..Our results indicate that levofloxacin selects a mutant having an additional alteration within the gene cording for the ParC protein during treatment, which may have enhanced quinolone resistance in the organism...
  70. ncbi request reprint Three-dimensional structures of c-Kit-positive cellular networks in the guinea pig small intestine and colon
    H Toma
    Department of Anatomy, Faculty of Medicine, Kyushu University, Maidashi, Fukuoka 812 8582, Japan
    Cell Tissue Res 295:425-36. 1999
    ..The characteristic profiles of c-Kit-positive cellular networks provide a morphological basis upon which to investigate the mechanisms regulating intestinal movement...
  71. ncbi request reprint Nucleosides and nucleotides. 175. Structural requirements of the sugar moiety for the antitumor activities of new nucleoside antimetabolites, 1-(3-C-ethynyl-beta-D-ribo-pentofuranosyl)cytosine and -uracil1
    H Hattori
    Graduate School of Pharmaceutical Sciences, Hokkaido University, Kita 12, Nishi 6, Kita ku, Sapporo 060 0812, Japan
    J Med Chem 41:2892-902. 1998
    ..Only 3'-C-1-propynyl and -ethenyl derivatives of ECyd showed greatly reduced cytotoxicity. We found that the cytotoxic activity of these nucleosides predominantly depended on their first phosphorylation by uridine/cytidine kinase...
  72. pmc Reduced clinical efficacy of pazufloxacin against gonorrhea due to high prevalence of quinolone-resistant isolates with the GyrA mutation. The Pazufloxacin STD Group
    M Tanaka
    Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Antimicrob Agents Chemother 42:579-82. 1998
    ..The results obtained in this study suggest that a high prevalence of fluoroquinolone-resistant gonococcal isolates with the Ser-91-to-Phe mutation in GyrA reduced the efficacy of pazufloxacin as treatment for gonococcal urethritis...
  73. pmc Video-assisted parathyroidectomy by a skin-lifting method for primary hyperparathyroidism
    M Okido
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    JSLS 5:197-200. 2001
    ..Several surgeons initiated endoscopic parathyroidectomy using CO2 insufflation to create the working space; however, they reported various complications. We describe here a skin-lifting method that may have few complications...
  74. ncbi request reprint Pancreas-kidney transplantation in Japan: impact of cyclosporine on the development of immunosuppressive therapy
    A Sugitani
    Central Pancreas Transplantation Committee, Graduate College of Medical Sciences, Kyushu University, Fukuoka, Japan
    Transplant Proc 36:356S-361S. 2004
    ..This investigation presents the results of pancreas-kidney transplantation in Japan, in comparison with those worldwide, and describes a recent case in Japan...
  75. ncbi request reprint Laparoscopic pancreatic surgery: current indications and surgical results
    S Shimizu
    Department of Endoscopic Diagnostics and Therapeutics, Kyushu University Faculty of Medicine, Fukuoka 812 8582, Japan
    Surg Endosc 18:402-6. 2004
    ..The purpose of this study was to evaluate the outcomes and feasibility of laparoscopic pancreatic surgery...
  76. ncbi request reprint Hand-assisted laparoscopic nephrectomy
    M Tanaka
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Aktuelle Urol 34:267-9. 2003
    ..We report our experience in performing a hand-assisted laparoscopic radical nephrectomy (HALRN) for renal cell carcinoma (RCC) and a hand-assisted laparoscopic live donor nephrectomy (HALDN) for renal transplantation...
  77. ncbi request reprint Pancreatoduodenectomy for pancreatic head carcinoma with or without pylorus preservation
    K Yamaguchi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 82, Japan
    Hepatogastroenterology 48:1479-85. 2001
    ..The aim of this paper is to compare early and late postoperative results of PpPD and Whipple for pancreatic head carcinoma...
  78. ncbi request reprint A useful approach to the differential diagnosis of small polypoid lesions of the gallbladder, utilizing an endoscopic ultrasound scoring system
    Y Sadamoto
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Endoscopy 34:959-65. 2002
    ..The purpose of this study was to assess the accuracy of endoscopic ultrasonography (EUS) in making a differential diagnosis of small (< or = 20 mm in diameter) polypoid lesions of the gallbladder, and to construct an EUS scoring system...
  79. ncbi request reprint Laparoscopic wedge resection of gastric submucosal tumors
    S Shimizu
    Department of Endoscopic Diagnostics and Therapeutics, Kyushu University Faculty of Medicine, Fukuoka, Japan
    Dig Surg 19:169-73. 2002
    ..The purpose of this study was to evaluate the clinical utility of laparoscopic surgery for gastric submucosal tumor...
  80. ncbi request reprint Effect of retinoic acid on morphological changes of human pancreatic cancer cells on collagen gels: a possible association with the metastatic potentials
    S Jimi
    Department of Biochemistry, Kyushu University School of Medicine, Fukuoka, Japan
    Oncol Res 10:7-14. 1998
    ..The effect of retinoic acid and its derivatives on the growth pattern was discussed in a possible association with their antimetastatic activities of pancreatic cancer...
  81. ncbi request reprint A case of drug-induced colitis complicating the administration of hydroxycarbamide
    Y Sadamoto
    Dept of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Endoscopy 34:511. 2002
  82. ncbi request reprint Video-assisted parathyroidectomy for primary hyperparathyroidism: a new approach involving a skin-lifting method
    M Okido
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University 3 1 1, Maidashi, Fukuoka 812 8582, Japan
    Surg Endosc 15:1120-3. 2001
    ..Carbon dioxide (CO2) insufflation can be used to create a working space in the anterior neck, but it has been associated with a number of complications. We have devised a skin-lifting method to overcome these problems...
  83. ncbi request reprint Association of enhanced cyclooxygenase-2 expression with possible local immunosuppression in human colorectal carcinomas
    M Kojima
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 8:458-65. 2001
    ..We examined if cyclooxygenase (COX)-2 is involved in local immunosuppression in human colon carcinoma cell lines and in clinical tumor specimens...
  84. ncbi request reprint Intraductal papillary-mucinous tumor of the pancreas: a historical review of the nomenclature and recent controversy
    K Yamaguchi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pancreas 23:12-9. 2001
    ..Some confusion and problems remain betweeen the two lesions. In this review, we review their historical background, terminology, WHO and AFIP classification, and problems with classification...
  85. ncbi request reprint Morphine metabolism in the opium poppy and its possible physiological function. Biochemical characterization of the morphine metabolite, bismorphine
    S Morimoto
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    J Biol Chem 276:38179-84. 2001
    ..The constitutive presence of morphine, together with bismorphine-forming peroxidase, enables the opium poppy to rapidly induce the defense system...
  86. ncbi request reprint Hand-assisted laparoscopic live donor nephrectomy using newly produced LAP DISC: initial three cases
    N Tokuda
    Department of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    J Endourol 15:571-4. 2001
    ..The LAP DISC is made of three layers of rings connected by a rubber membrane, which covers the peritoneum and abdominal wall. The upper ring can adjust to the surgeon's hand size for insertion...
  87. ncbi request reprint Resection of an L-shaped kidney with renal cell carcinoma using a microwave tissue coagulator
    H Tsunoe
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Urol 8:459-62. 2001
    ..A literature review of this topic is also reported and the findings are discussed...
  88. ncbi request reprint Laparoscopically assisted resection of choledochal cyst and Roux-en-Y reconstruction
    M Tanaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Surg Endosc 15:545-52. 2001
    ..Creation of a Roux-en-Y jejunal limb by midline minilaparotomy and hepaticojejunostomy using a laparoscopic sewing instrument facilitated the procedure...
  89. ncbi request reprint Constituents of holothuroidea, 16. Determination of Absolute configuration of the branched methyl group in ante-iso type side chain moiety on long chain base of glucocerebroside from the sea cucumber Holothuria leucospilota
    Koji Yamada
    Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 53:1333-4. 2005
    ..The optically active C13-fragment was synthesized asymmetrically by using the Wittig reaction from chiral synton for comparison with the natural fragment...
  90. ncbi request reprint Cell-free human T-cell leukemia virus type 1 binds to, and efficiently enters mouse cells
    Binlian Sun
    Department of Biochemistry and Molecular Oncology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Ibaraki 305 8575, Japan
    Jpn J Cancer Res 93:760-6. 2002
    ..Our results suggest that mouse cell experiments would give useful information to dissect the early steps of cell-free HTLV-1 infection...
  91. ncbi request reprint Nitrile-promoted Rh-catalyzed intermolecular hydroacylation of olefins with salicylaldehyde
    Masanori Imai
    Hokkaido College of Pharmacy, Hokkaido 047 0264, Japan
    J Org Chem 72:2543-6. 2007
    ..Plausible mechanisms for the regioselections are also described...