Fumi Takahashi-Yanaga

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy
    F Takahashi-Yanaga
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Mol Cell Cardiol 33:2095-107. 2001
  2. ncbi request reprint The Wnt/beta-catenin signaling pathway as a target in drug discovery
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Sci 104:293-302. 2007
  3. ncbi request reprint GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cell Signal 20:581-9. 2008
  4. ncbi request reprint Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 316:411-5. 2004
  5. doi request reprint Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Biochem Biophys Res Commun 377:1185-90. 2008
  6. ncbi request reprint Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 281:38489-97. 2006
  7. ncbi request reprint Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3beta and degrades cyclin D1 in mammalian cells
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Graduate School of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 278:9663-70. 2003
  8. ncbi request reprint Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: inhibitors of the Wnt/beta-catenin signaling pathway as novel anticancer drugs
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Japan
    J Pharmacol Sci 109:179-83. 2009
  9. ncbi request reprint Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy
    F Yanaga
    Department of Clinical Pharmacology, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 274:8806-12. 1999
  10. ncbi request reprint Effects of troponin T mutations in familial hypertrophic cardiomyopathy on regulatory functions of other troponin subunits
    F Takahashi-Yanaga
    Laboratory of Clinical Pharmacology, Kyushu University Graduated School of Medicine, Fukuoka 812 8582, Japan
    J Biochem 130:127-31. 2001

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Functional consequences of the mutations in human cardiac troponin I gene found in familial hypertrophic cardiomyopathy
    F Takahashi-Yanaga
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Mol Cell Cardiol 33:2095-107. 2001
    ....
  2. ncbi request reprint The Wnt/beta-catenin signaling pathway as a target in drug discovery
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Sci 104:293-302. 2007
    ..Here we provide an overview of the Wnt/beta-catenin signaling pathway: its roles in physiology and pathology and the possibility as a target in development of new drugs...
  3. ncbi request reprint GSK-3beta regulates cyclin D1 expression: a new target for chemotherapy
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cell Signal 20:581-9. 2008
    ..This review highlights the regulatory mechanisms of cyclin D1 expression level, with special attention to the involvement of GSK-3beta...
  4. ncbi request reprint Glycogen synthase kinase-3beta is tyrosine-phosphorylated by MEK1 in human skin fibroblasts
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 316:411-5. 2004
    ..This is the first report to suggest that MEK1/2 phosphorylates not only ERK1/2 but also GSK-3beta...
  5. doi request reprint Celecoxib-induced degradation of T-cell factors-1 and -4 in human colon cancer cells
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Biochem Biophys Res Commun 377:1185-90. 2008
    ..Our results suggest that TCF-1 and TCF-4 degradation may involve the inhibition of the Wnt/beta-catenin signaling pathway induced by celecoxib...
  6. ncbi request reprint Involvement of GSK-3beta and DYRK1B in differentiation-inducing factor-3-induced phosphorylation of cyclin D1 in HeLa cells
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 281:38489-97. 2006
    ..These results suggest that DIF-3 induces degradation of cyclin D1 through the GSK-3beta- and DYRK1B-mediated threonine phosphorylation in HeLa cells...
  7. ncbi request reprint Dictyostelium differentiation-inducing factor-3 activates glycogen synthase kinase-3beta and degrades cyclin D1 in mammalian cells
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Graduate School of Dental Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 278:9663-70. 2003
    ..These results suggested that DIF-3 activates GSK-3beta to accelerate the proteolysis of cyclin D1 and that this mechanism is involved in the DIF-3-induced G(0)/G(1) arrest in mammalian cells...
  8. ncbi request reprint Drug development targeting the glycogen synthase kinase-3beta (GSK-3beta)-mediated signal transduction pathway: inhibitors of the Wnt/beta-catenin signaling pathway as novel anticancer drugs
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Japan
    J Pharmacol Sci 109:179-83. 2009
    ..In this review, we summarize our recent findings on the antiproliferative effect of DIFs and show the possibility for development of a novel anticancer drug from DIFs and their derivatives...
  9. ncbi request reprint Ca2+ sensitization and potentiation of the maximum level of myofibrillar ATPase activity caused by mutations of troponin T found in familial hypertrophic cardiomyopathy
    F Yanaga
    Department of Clinical Pharmacology, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 274:8806-12. 1999
    ....
  10. ncbi request reprint Effects of troponin T mutations in familial hypertrophic cardiomyopathy on regulatory functions of other troponin subunits
    F Takahashi-Yanaga
    Laboratory of Clinical Pharmacology, Kyushu University Graduated School of Medicine, Fukuoka 812 8582, Japan
    J Biochem 130:127-31. 2001
    ..These results indicate that mutations in TnT impair multiple processes of Ca(2+) regulation by troponin, and there are marked differences in the degree of impairment from mutation to mutation...
  11. ncbi request reprint Knock-in mouse model of dilated cardiomyopathy caused by troponin mutation
    Cheng Kun Du
    Department of Clinical Pharmacology, Kyushu University Graduate School of Medicine, Maidashi, Higashi ku, Fukuoka, Japan
    Circ Res 101:185-94. 2007
    ....
  12. ncbi request reprint Celecoxib inhibits the expression of survivin via the suppression of promoter activity in human colon cancer cells
    Naoko Sakoguchi-Okada
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Pharmacol 73:1318-29. 2007
    ..Our results suggested that NSAIDs could inhibit proliferation and induce apoptosis in colon cancer cells by inhibition of survivin expression and the Wnt/beta-catenin signaling pathway...
  13. doi request reprint Up-regulation of type 2 iodothyronine deiodinase in dilated cardiomyopathy
    Yuan Yuan Wang
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cardiovasc Res 87:636-46. 2010
    ..Thyroid hormone (TH) has prominent effects on the heart, and hyperthyroidism is occasionally found to be a cause of dilated cardiomyopathy (DCM). We aim to explore the potential role of TH in the pathogenesis of DCM...
  14. ncbi request reprint Differentiation-inducing factor-1 induces cyclin D1 degradation through the phosphorylation of Thr286 in squamous cell carcinoma
    Jun Mori
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Exp Cell Res 310:426-33. 2005
    ..These results suggest that DIF-1 induces degradation of cyclin D1 through the GSK-3beta-mediated phosphorylation of Thr286...
  15. ncbi request reprint Differentiation-inducing factor-1 suppresses the expression of c-Myc in the human cancer cell lines
    Kentaro Jingushi
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Sci 121:103-9. 2013
    ..Since c-Myc seems to be profoundly involved in accelerated proliferation of various malignant tumors, DIF-1 may have a potential to develop into a novel anti-cancer agent...
  16. ncbi request reprint Dictyostelium differentiation-inducing factor-1 binds to mitochondrial malate dehydrogenase and inhibits its activity
    Tomoko Matsuda
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Sci 112:320-6. 2010
    ..These results suggest that the inhibition of mMDH activity by DIF-1 and 2-MIDIF-1 could be one of the mechanisms to induce anti-proliferative effects, independent of the inhibition of the Wnt/beta-catenin signaling pathway...
  17. pmc Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction
    Shunichi Kajioka
    Department of Urology, Kyushu University, Japan
    Sci Rep 2:979. 2012
    ..Furthermore, addition of supplemental TnI and TnC reconstructed a troponin system to enhance contraction. The results indicated that a Tn/Tn-like system on actin-filaments cooperates together with the thick-filament pathway...
  18. ncbi request reprint Activator protein-1 mediates shear stress-induced prostaglandin d synthase gene expression in vascular endothelial cells
    Megumi Miyagi
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 25:970-5. 2005
    ..We attempted to determine the molecular mechanism of fluid shear stress-induced lipocalin-type prostaglandin D synthase (l-PGDS) expression in vascular endothelial cells...
  19. ncbi request reprint Differentiation-inducing factor-1 suppresses gene expression of cyclin D1 in tumor cells
    Tania Yasmin
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 338:903-9. 2005
    ..Eliminating the TCF/LEF consensus site from the cyclin D1 promoter diminished the effect of DIF-1. These results suggest that DIF-1 inhibits Wnt/beta-catenin signaling, resulting in the suppression of cyclin D1 promoter activity...
  20. ncbi request reprint 15-deoxy-delta 12,14-prostaglandin J2 and laminar fluid shear stress stabilize c-IAP1 in vascular endothelial cells
    Yoji Taba
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    Am J Physiol Heart Circ Physiol 285:H38-46. 2003
    ..These results suggested that 15d-PGJ2 inhibits endothelial cell apoptosis through, at least in part, c-IAP1 protein stabilization. This mechanism might be involved in the antiapoptotic effect of laminar shear stress...
  21. ncbi request reprint Aryl hydrocarbon receptor mediates laminar fluid shear stress-induced CYP1A1 activation and cell cycle arrest in vascular endothelial cells
    Zhiyi Han
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cardiovasc Res 77:809-18. 2008
    ....
  22. pmc Biological actions of green tea catechins on cardiac troponin C
    Naoto Tadano
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Br J Pharmacol 161:1034-43. 2010
    ..In this study, we investigated direct actions of green tea catechins on cardiac muscle function to explore their uses as potential drugs for cardiac muscle disease...
  23. pmc Anti-angiogenic effects of differentiation-inducing factor-1 involving VEGFR-2 expression inhibition independent of the Wnt/β-catenin signaling pathway
    Tatsuya Yoshihara
    Department of Clinical Pharmacology, Kyushu University, Fukuoka, Japan
    Mol Cancer 9:245. 2010
    ..To assess the potential of a novel cancer chemotherapy based on the pharmacological effect of DIF-1, we investigated whether DIF-1 exhibits anti-angiogenic effects in vitro and in vivo...
  24. ncbi request reprint Several aspects of calcium regulator mechanisms linked to troponin
    Iwao Ohtsuki
    Department of Pharmacology, Faculty of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    Adv Exp Med Biol 538:221-9; discussion 229. 2003
  25. ncbi request reprint DIF-1 inhibits tumor growth in vivo reducing phosphorylation of GSK-3β and expressions of cyclin D1 and TCF7L2 in cancer model mice
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan Global Medical Science Education Unit, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan Electronic address
    Biochem Pharmacol 89:340-8. 2014
    ..This is the first report to show that DIF-1 inhibits tumor growth in vivo, consistent with its in-vitro action, suggesting that this compound may have potential as a novel anti-tumor agent. ..
  26. doi request reprint Therapeutic effect of {beta}-adrenoceptor blockers using a mouse model of dilated cardiomyopathy with a troponin mutation
    Dong Yun Zhan
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cardiovasc Res 84:64-71. 2009
    ..Using a mouse model of inherited DCM with a troponin mutation, we aim to study the treatment benefits of beta-blockers...
  27. ncbi request reprint Celecoxib induces apoptosis by inhibiting the expression of survivin in HeLa cells
    Kazuhiro Fukada
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 357:1166-71. 2007
    ..Our findings might provide a new insight into the anti-cancer effects of celecoxib...
  28. ncbi request reprint Differentiation-inducing factor-1 alters canonical Wnt signaling and suppresses alkaline phosphatase expression in osteoblast-like cell lines
    Etsuko Matsuzaki
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Bone Miner Res 21:1307-16. 2006
    ..We found that DIF-1 inhibited this pathway, resulting in the suppression of ALP promoter activity through the TCF/LEF binding site...
  29. doi request reprint DIF-1 inhibits the Wnt/β-catenin signaling pathway by inhibiting TCF7L2 expression in colon cancer cell lines
    Kentaro Jingushi
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biochem Pharmacol 83:47-56. 2012
    ..Our results provide a novel insight into the mechanisms by which DIF-1 inhibits the Wnt/β-catenin signaling pathway...
  30. ncbi request reprint Cardiac troponin T mutation R141W found in dilated cardiomyopathy stabilizes the troponin T-tropomyosin interaction and causes a Ca2+ desensitization
    Qun Wei Lu
    Department of Clinical Pharmacology, Kyushu University Graduate School of Medicine, Fukuoka 812 8582, Japan
    J Mol Cell Cardiol 35:1421-7. 2003
    ....
  31. ncbi request reprint Involvement of clusterin in 15-deoxy-delta12,14-prostaglandin J2-induced vascular smooth muscle cell differentiation
    Yoshikazu Miwa
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 319:163-8. 2004
    ..Our results suggested that clusterin is involved in 15d-PGJ(2)-induced nodule formation and cell differentiation in VSMCs...
  32. ncbi request reprint PKC412 induces apoptosis through a caspase-dependent mechanism in human keloid-derived fibroblasts
    Ayako Nakazono-Kusaba
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Eur J Pharmacol 497:155-60. 2004
    ..These results suggested that PKC412-induced apoptosis, but not staurosporine-induced apoptosis, is mainly mediated by the caspase-dependent mechanism...
  33. doi request reprint Sphingosine-1-phosphate promotes the nuclear translocation of β-catenin and thereby induces osteoprotegerin gene expression in osteoblast-like cell lines
    Etsuko Matsuzaki
    Periodontal Section, Division of Oral Rehabilitation, Faculty of Dental Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Bone 55:315-24. 2013
    ....
  34. ncbi request reprint SCH00013, a novel Ca(2+) sensitizer with positive inotropic and no chronotropic action in heart failure
    Naoto Tadano
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pharmacol Sci 97:53-60. 2005
    ..These results strongly suggested that SCH00013 is a novel Ca(2+) sensitizer that elicits a positive inotropic and no chronotropic effect in heart failure, probably through enhancing the Frank-Starling mechanism...
  35. ncbi request reprint Propyl gallate, a strong antioxidant, increases the Ca2+ sensitivity of cardiac myofilament
    Naoto Tadano
    Depertment of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Japan
    J Pharmacol Sci 109:456-8. 2009
    ....
  36. doi request reprint Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure
    Lei Li
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Mol Cell Cardiol 53:760-7. 2012
    ..These results strongly suggest that genetic backgrounds involving brain serotonin dysfunction, such as TPH2 gene SNP, may play an important role in the development of congestive HF in DCM...
  37. doi request reprint Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle
    Nouval Shahab
    Department of Urology, Kyushu University, Fukuoka, Japan
    Neurourol Urodyn 31:593-9. 2012
    ....
  38. ncbi request reprint [Caspase-3-mediated alpha-smooth muscle actin cleavage during staurosporine-induced myofibroblast apoptosis]
    Ayako Nakazono
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Nihon Yakurigaku Zasshi 120:94P-95P. 2002
    ..These results suggested that alpha-smooth muscle actin is directly degraded by caspase-3 in response to apoptotic stimuli in myofibroblasts...
  39. ncbi request reprint β(1)-Adrenergic receptor gene polymorphisms and the acute response to atenolol in healthy young Japanese subjects
    Toshiyuki Sasaguri
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Japan
    J Pharmacol Sci 115:490-9. 2011
    ..There was also no difference in the changes in heart rate or blood pressure among the diplotypes. The results of the present study do not support clinical use of genotyping for these polymorphisms to predict responses to β-blockers...
  40. ncbi request reprint Functional consequences of a carboxyl terminal missense mutation Arg278Cys in human cardiac troponin T
    S Morimoto
    Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Biochem Biophys Res Commun 261:79-82. 1999
    ....
  41. doi request reprint Acceleration of bone development and regeneration through the Wnt/β-catenin signaling pathway in mice heterozygously deficient for GSK-3β
    Masaki Arioka
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan Department of Oral and Maxillofacial Surgery, Faculty of Dental Science, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 440:677-82. 2013
    ..These results suggest that bone formation and regeneration in vivo are accelerated by inhibition of GSK-3β, probably through activation of the Wnt/β-catenin signaling pathway...
  42. doi request reprint Association between arterial stiffness and cerebral white matter lesions in community-dwelling elderly subjects
    Takahiro Ohmine
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fuuoka, Japan
    Hypertens Res 31:75-81. 2008
    ..Although further study is needed to clarify the difference between WML subtypes, our study suggests that the measurement of ba-PWV is a simple and useful tool for detecting cerebral arterial dysfunction...
  43. doi request reprint Celecoxib and 2,5-dimethyl-celecoxib prevent cardiac remodeling inhibiting Akt-mediated signal transduction in an inherited dilated cardiomyopathy mouse model
    Xueli Fan
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Pharmacol Exp Ther 338:2-11. 2011
    ..05). These results suggested that not only celecoxib but also DM-celecoxib prevents cardiac remodeling and reduces mortality in DCM through a COX-2-independent mechanism involving Akt and its downstream mediators...
  44. ncbi request reprint The involvement of aldosterone in cyclic stretch-mediated activation of NADPH oxidase in vascular smooth muscle cells
    Takahiro Ohmine
    Faculty of Medical Sciences, Department of Clinical Pharmacology, Kyushu University, Fukuoka 812 8582, Japan
    Hypertens Res 32:690-9. 2009
    ..We also suggest the potential benefit of eplerenone in the treatment of cardiovascular diseases...
  45. ncbi request reprint Staurosporine-induced cleavage of alpha-smooth muscle actin during myofibroblast apoptosis
    Ayako Nakazono-Kusaba
    Department of Clinical Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Invest Dermatol 119:1008-13. 2002
    ..In addition, bleomycin (100 ng per ml) and cisplatin (1 mM) also induced myofibroblast apoptosis by activating caspase-3, suggesting that these agents have a potential therapeutic value for abnormal scar formation...
  46. doi request reprint Knockout of the l-pgds gene aggravates obesity and atherosclerosis in mice
    Reiko Tanaka
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 378:851-6. 2009
    ..In conclusion, l-pgds deficiency induces obesity and facilitates atherosclerosis, probably through the regulation of inflammatory responses...
  47. ncbi request reprint [Wnt/beta-catenin signaling pathway and drug discovery]
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University
    Fukuoka Igaku Zasshi 98:93-9. 2007
  48. pmc Ca(2+)-desensitizing effect of a deletion mutation Delta K210 in cardiac troponin T that causes familial dilated cardiomyopathy
    S Morimoto
    Laboratory of Clinical Pharmacology, Department of Pharmacology, Graduate School of Medicine, Kyushu University, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 99:913-8. 2002
    ..The present study strongly suggests that Ca(2+) desensitization of force generation in sarcomere is a primary mechanism for the pathogenesis of DCM associated with the deletion mutation Delta K210 in cTnT...
  49. pmc Differential effects of organic nitrates on arterial diameter among healthy Japanese participants with different mitochondrial aldehyde dehydrogenase 2 genotypes: randomised crossover trial
    Satoko Sakata
    Department of Medicine and Clinical Science, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    BMJ Open 1:e000133. 2011
    ..GTN dilated the artery more quickly than ISDN in *1/*1 and *1/*2, but not in *2/*2. Trial registration number UMIN000001492 (UMIN-CTR database)...
  50. doi request reprint Association of serum lipocalin-type prostaglandin D synthase levels with subclinical atherosclerosis in untreated asymptomatic subjects
    Yoshikazu Miwa
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertens Res 31:1931-9. 2008
    ..084, p=0.075). In conclusion, our results suggest that an increase in serum L-PGDS concentration is associated with the progression of atherosclerosis...
  51. doi request reprint Activator or inhibitor? GSK-3 as a new drug target
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Pharmacol 86:191-9. 2013
    ..Finally, the possibility of new drug development targeting this kinase is discussed with recent information about inhibitors and activators of GSK-3. ..
  52. ncbi request reprint Effects of U-37883A on intracellular Ca2+ -activated large-conductance K+ channels in pig proximal urethral myocytes
    Noriyoshi Teramoto
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi Ward, Fukuoka 812 8582, Japan
    Eur J Pharmacol 506:1-7. 2004
    ..These results shows that U-37883A affects channels other than the vascular KATP channel, and demonstrates how it inhibits the activities of BKCa channels in urethral smooth muscles...
  53. ncbi request reprint Cell-specific toxicity of fibrates in human embryonal rhabdomyosarcoma cells
    Takayoshi Maiguma
    Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, 812 8582 Fukuoka, Japan
    Naunyn Schmiedebergs Arch Pharmacol 367:289-96. 2003
    ..Moreover, our present cell injury model using HRMSC may be useful for elucidating the mechanisms of clinical rhabdomyolysis induced by lipid-lowering agents...
  54. doi request reprint Diphosphate regulation of adenosine triphosphate sensitive potassium channel in human bladder smooth muscle cells
    Shunichi Kajioka
    Department of Urology, Graduate School of Medical Sciences, Kyushu University, and Special Patient Oral Care Unit, Kyushu University Hospital, Fukuoka, Japan
    J Urol 186:736-44. 2011
    ....
  55. ncbi request reprint Targeting Wnt signaling: can we safely eradicate cancer stem cells?
    Fumi Takahashi-Yanaga
    Department of Clinical Pharmacology, Faculty of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 16:3153-62. 2010
    ..We provide an overview on the function of the Wnt/beta-catenin signaling pathway in CSC, and the possibility of the development of novel therapeutics to target this pathway...
  56. ncbi request reprint Molecular cloning and the functional expression of two isoforms of human metabotropic glutamate receptor subtype 5
    R Minakami
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 199:1136-43. 1994
    ..We compared some of the pharmacological profiles of these two isoforms, but no clear differences could be observed. Finally, we also examined the effect of exogenous G proteins on the mGluR5-evoked responses...
  57. ncbi request reprint Phosphorylation and calmodulin binding of the metabotropic glutamate receptor subtype 5 (mGluR5) are antagonistic in vitro
    R Minakami
    School of Health Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 82, Japan
    J Biol Chem 272:20291-8. 1997
    ..These antagonisms of the CaM binding and phosphorylation thus suggest the possibility that they regulate the receptor responses in vivo...
  58. ncbi request reprint A variant of metabotropic glutamate receptor subtype 5: an evolutionally conserved insertion with no termination codon
    R Minakami
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 194:622-7. 1993
    ..Northern blot analyses with the mGluR5b-specific probe showed that the expression of mRNA for this species is regulated in a region-specific manner in the rat brain...
  59. ncbi request reprint Interaction of Vesl-1L/Homer 1c with syntaxin 13
    R Minakami
    School of Health Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 272:466-71. 2000
    ..We thus propose that the association of Vesl-1L with syntaxin 13 plays a role in the translocation of Vesl-1L to the intracellular organelles...