Satoshi O Suzuki

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation
    Satoshi O Suzuki
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, 812 8582 Fukuoka, Japan
    Acta Neuropathol 113:591-9. 2007
  2. doi request reprint An autopsy case of adult-onset hereditary spastic paraplegia type 2 with a novel mutation in exon 7 of the proteolipid protein 1 gene
    Satoshi O Suzuki
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Acta Neuropathol 122:775-81. 2011
  3. ncbi request reprint Multiple cell populations in the early postnatal subventricular zone take distinct migratory pathways: a dynamic study of glial and neuronal progenitor migration
    Satoshi O Suzuki
    Department of Pathology and the Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 23:4240-50. 2003
  4. ncbi request reprint Dynamic analysis of glioma cells: looking into "movement phenotypes"
    Satoshi O Suzuki
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuropathology 25:254-62. 2005
  5. doi request reprint MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance
    Yanlei Guan
    Department of Neurosurgery and Neuropathology, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 16:4289-97. 2010
  6. pmc Prevalence of copy-number neutral LOH in glioblastomas revealed by genomewide analysis of laser-microdissected tissues
    Daisuke Kuga
    Department of Neurosurgery, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Neuro Oncol 10:995-1003. 2008
  7. doi request reprint Molecular characteristics of glioblastoma with 1p/19q co-deletion
    Masahiro Mizoguchi
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Brain Tumor Pathol 29:148-53. 2012
  8. doi request reprint Differential activation of proapoptotic molecules between mouse and rat models of distal motor trigeminal denervation
    Shiori Harada
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Oral Pathol Med 41:354-60. 2012
  9. ncbi request reprint Expression of VEGF and its receptor genes in intracranial schwannomas
    Toshio Uesaka
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurooncol 83:259-66. 2007
  10. pmc Persistent roles of signal transduction of platelet-derived growth factor B in genesis, growth, and anaplastic transformation of gliomas in an in-vivo serial transplantation model
    Rina Torisu
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Brain Tumor Pathol 28:33-42. 2011

Detail Information

Publications67

  1. ncbi request reprint Expression patterns of LIS1, dynein and their interaction partners dynactin, NudE, NudEL and NudC in human gliomas suggest roles in invasion and proliferation
    Satoshi O Suzuki
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, 812 8582 Fukuoka, Japan
    Acta Neuropathol 113:591-9. 2007
    ..These findings are compatible with the idea that LIS1 and its interacting proteins play a role in glioma migration and proliferation analogous to their role during brain development...
  2. doi request reprint An autopsy case of adult-onset hereditary spastic paraplegia type 2 with a novel mutation in exon 7 of the proteolipid protein 1 gene
    Satoshi O Suzuki
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Acta Neuropathol 122:775-81. 2011
    ..The late onset and long clinical course suggest that this novel mutation does not affect the maturation of oligodendrocytes, but is related to insufficient maintenance of myelin...
  3. ncbi request reprint Multiple cell populations in the early postnatal subventricular zone take distinct migratory pathways: a dynamic study of glial and neuronal progenitor migration
    Satoshi O Suzuki
    Department of Pathology and the Center for Neurobiology and Behavior, Columbia University, New York, New York 10032, USA
    J Neurosci 23:4240-50. 2003
    ..These observations indicate that there are at least two distinct migratory pathways within the SVZ used differentially by immature neurons and glia...
  4. ncbi request reprint Dynamic analysis of glioma cells: looking into "movement phenotypes"
    Satoshi O Suzuki
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuropathology 25:254-62. 2005
    ..In this review, we describe a technical aspect of live cell imaging with special regard to time-lapse video imaging and discuss the relevance of the methods to glioma studies...
  5. doi request reprint MiRNA-196 is upregulated in glioblastoma but not in anaplastic astrocytoma and has prognostic significance
    Yanlei Guan
    Department of Neurosurgery and Neuropathology, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 16:4289-97. 2010
    ..They are implicated in tumorigenesis and function both as tumor suppressors and as oncogenes. The clinical significance of miRNA expression profiles in malignant gliomas remains unclear...
  6. pmc Prevalence of copy-number neutral LOH in glioblastomas revealed by genomewide analysis of laser-microdissected tissues
    Daisuke Kuga
    Department of Neurosurgery, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Neuro Oncol 10:995-1003. 2008
    ..The high rate of cnLOH suggests that epigenetic abnormalities of many genes are involved in the development and progression of GBMs...
  7. doi request reprint Molecular characteristics of glioblastoma with 1p/19q co-deletion
    Masahiro Mizoguchi
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Brain Tumor Pathol 29:148-53. 2012
    ....
  8. doi request reprint Differential activation of proapoptotic molecules between mouse and rat models of distal motor trigeminal denervation
    Shiori Harada
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Oral Pathol Med 41:354-60. 2012
    ..Because motor neurons are reported to be more vulnerable to axotomy in mice than rats, we compared the degeneration process of the trigeminal motor nucleus in the rat model with a similar mouse model...
  9. ncbi request reprint Expression of VEGF and its receptor genes in intracranial schwannomas
    Toshio Uesaka
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurooncol 83:259-66. 2007
    ..Based on these observations, the significance of VEGF and its receptor genes in intracranial schwannomas is discussed...
  10. pmc Persistent roles of signal transduction of platelet-derived growth factor B in genesis, growth, and anaplastic transformation of gliomas in an in-vivo serial transplantation model
    Rina Torisu
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Brain Tumor Pathol 28:33-42. 2011
    ..This model would be useful for investigation of the long-term effects of PDGFB stimulation in glioma tissues on anaplastic evolution...
  11. ncbi request reprint Glial progenitors in the brainstem give rise to malignant gliomas by platelet-derived growth factor stimulation
    Kenta Masui
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Glia 58:1050-65. 2010
    ..Together, these findings are the first implications regarding the cell-of-origin and the gliomagenesis in the brainstem...
  12. pmc Connexin 43 astrocytopathy linked to rapidly progressive multiple sclerosis and neuromyelitis optica
    Katsuhisa Masaki
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 8:e72919. 2013
    ..This study aimed to determine a relationship between connexin (Cx) pathology and disease aggressiveness in Asian patients with MS and NMO...
  13. doi request reprint Usefulness of three-dimensional T1-weighted spoiled gradient-recalled echo and three-dimensional heavily T2-weighted images in preoperative evaluation of spinal dysraphism
    Nobuya Murakami
    Department of Neurosurgery, Kyushu University, Fukuoka, Japan
    Childs Nerv Syst 29:1905-14. 2013
    ....
  14. doi request reprint Differentiating primary CNS lymphoma from glioblastoma multiforme: assessment using arterial spin labeling, diffusion-weighted imaging, and ¹⁸F-fluorodeoxyglucose positron emission tomography
    Koji Yamashita
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Neuroradiology 55:135-43. 2013
    ....
  15. doi request reprint Extensive loss of connexins in Baló's disease: evidence for an auto-antibody-independent astrocytopathy via impaired astrocyte-oligodendrocyte/myelin interaction
    Katsuhisa Masaki
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Acta Neuropathol 123:887-900. 2012
    ....
  16. doi request reprint Reappraisal of aquaporin-4 astrocytopathy in Asian neuromyelitis optica and multiple sclerosis patients
    Takeshi Matsuoka
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Brain Pathol 21:516-32. 2011
    ..Our present and previous findings suggest that antibody-independent AQP4 loss can occur in heterogeneous demyelinating conditions, including NMO, Baló's disease and MS...
  17. doi request reprint Quantitative digital assessment of MGMT immunohistochemical expression in glioblastoma tissue
    Yukie Araki
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Brain Tumor Pathol 28:25-31. 2011
    ..We expect that this method will be useful for assessment of heterogeneous staining with any antibodies...
  18. ncbi request reprint Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival
    Tadahisa Shono
    Department of Neurosurgery, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan
    Int J Cancer 123:787-92. 2008
    ..Based on these observations, enhanced expression of Nox4 appears to be involved in cell proliferation and survival in glioma cells...
  19. ncbi request reprint Transplanted glioma cells migrate and proliferate on host brain vasculature: a dynamic analysis
    Azadeh Farin
    Department Neurological Surgery, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Glia 53:799-808. 2006
    ..This study provides the first dynamic analysis of glioma cell infiltration in living brain tissue and reveals that the migration and proliferation of transplanted glioma cells is directed by interactions with host brain vasculature...
  20. doi request reprint Brain-derived neurotrophic factor induces sustained elevation of intracellular Ca2+ in rodent microglia
    Yoshito Mizoguchi
    Department of Neuropsychiatry, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    J Immunol 183:7778-86. 2009
    ....
  21. doi request reprint Focal cortical dysplasia coexisting with diffuse astrocytoma in childhood: a case report and reappraisal of the glial component in archival FCD cases
    Kenta Masui
    Departments of Neuropathology Neurosurgery, Neurological Institute Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuropathology 31:433-9. 2011
    ..Therefore, a careful pathological assessment has to be made to define a rare case of diffuse glioma occurring in FCD...
  22. doi request reprint Cortical kindling in a focal freeze lesion rat model
    Kei ichiro Takase
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Clin Neurosci 16:94-8. 2009
    ..These results suggest that FCD might not influence vulnerability to epileptogenicity, at least in some patients with mild FCD...
  23. ncbi request reprint Results of a long-term follow-up after neuroendoscopic biopsy procedure and third ventriculostomy in patients with intracranial germinomas
    Tadahisa Shono
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurosurg 107:193-8. 2007
    ..The authors report the results of long-term follow-ups in 12 patients with intracranial germinomas who underwent neuroendoscopic procedures before chemotherapy and radiotherapy, and discuss the usefulness and safety of these procedures...
  24. doi request reprint Pediatric glioblastoma with oligodendroglioma component: aggressive clinical phenotype with distinct molecular characteristics
    Masahiro Mizoguchi
    Department of Neurosurgery, Kyushu University, Fukuoka, Japan
    Neuropathology 33:652-7. 2013
    ..Molecular genetic analysis may provide critical prognostic and therapeutic insights, especially for the pediatric glioma containing oligodendroglioma components. ..
  25. doi request reprint Concurrent spinal nerve root schwannoma and meningioma mimicking single-component schwannoma
    Akira Nakamizo
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuropathology 32:190-5. 2012
    ..We therefore recommend a careful review of preoperative imaging with the possibility of concurrent tumors in mind...
  26. doi request reprint Clinicopathological study on chronic encapsulated expanding hematoma associated with incompletely obliterated AVM after stereotactic radiosurgery
    Akira Nakamizo
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    Acta Neurochir (Wien) 153:883-93. 2011
    ..The aim of this study was to clarify the clinical features and possible mechanisms of formation and expansion of this type of hematoma based on histopathological findings...
  27. ncbi request reprint Validation of HB-EGF and amphiregulin as targets for human cancer therapy
    Fusanori Yotsumoto
    Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Biochem Biophys Res Commun 365:555-61. 2008
    ..In lung cancer cells, any EGFR ligand was not recognized as a validated target for cancer therapy. These results suggest that HB-EGF and amphiregulin are promising targets for cancer therapy...
  28. pmc Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades
    Osamu Togao
    Department of Molecular Imaging and Diagnosis, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan O T Department of Clinical Radiology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan O T, T Y, A H, K Y, K K, H H Philips Research, Hamburg, Germany J K Philips Electronics Japan, Tokyo, Japan Y S Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan S O S, T I Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan N H, M M, K Y Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, Texas K S, M T
    Neuro Oncol 16:441-8. 2014
    ..We prospectively assessed the usefulness of APT imaging in predicting the histological grade of adult diffuse gliomas...
  29. doi request reprint Spontaneous seizures in a rat model of multiple prenatal freeze lesioning
    Takashi Kamada
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Epilepsy Res 105:280-91. 2013
    ..Alterations in the levels of glutamatergic and GABAergic receptors were investigated during growth. This model should enable better clarification of the mechanisms underlying the development of human epilepsy...
  30. doi request reprint Fibrotic nodule arising from the cerebellopontine angle
    Toshiyuki Amano
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Brain Tumor Pathol 30:122-7. 2013
    ..It is, therefore, necessary to be able to perform a differential diagnosis that will distinguish this rare condition from other intracranial fibrous neoplasms that occasionally have malignant features...
  31. doi request reprint Evaluation of sensitivity and specificity of doublecortin immunostatining for the detection of infiltrating glioma cells
    Kenta Masui
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    Brain Tumor Pathol 25:1-7. 2008
    ..Taken together, DCX is applicable for the detection of individual infiltrating glioma cells when combined with other markers...
  32. doi request reprint Arterial spin labeling of hemangioblastoma: differentiation from metastatic brain tumors based on quantitative blood flow measurement
    Koji Yamashita
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Neuroradiology 54:809-13. 2012
    ..Hemangioblastoma and metastatic tumors are the major differential diagnoses for the posterior fossa tumors in adults. Our purpose was to evaluate the efficacy of ASL in differentiating hemangioblastomas from metastatic brain tumors...
  33. doi request reprint Focal cortical dysplasia type IIa underlying epileptogenesis in patients with epilepsy associated with Sturge-Weber syndrome
    Nobuya Murakami
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Epilepsia 53:e184-8. 2012
    ..FCD should therefore be demonstrated by the collective findings of perioperative neurophysiologic examination, anatomic and functional neuroimaging, and histopathologic examination...
  34. ncbi request reprint Large hypothalamic hamartoma with calcification and cystic components in an adult--case report
    Shinya Yamaguchi
    Department of Neurosurgery, Hamanomachi Hospital, Chuou ku, Fukuoka, Japan
    Neurol Med Chir (Tokyo) 50:495-8. 2010
    ..Excessive unnecessary surgery should be avoided, and intraoperative pathological examination may lead to enhanced assessment and better outcomes...
  35. doi request reprint A simple and high-yield method for preparation of rat microglial cultures utilizing Aclar plastic film
    Yoshihiro Seki
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuropathology 31:215-22. 2011
    ..SMK also showed phagocytic activity. In conclusion, this method resulted in a high-yield preparation of microglial cultures with ease and reproducibility...
  36. doi request reprint Coexistence of a human tail and congenital dermal sinus associated with lumbosacral lipoma
    Kazuhiro Samura
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Childs Nerv Syst 25:137-41. 2009
    ..CISS-MRI is useful for demonstrating the precise anatomical relationship between these complicated pathologies...
  37. ncbi request reprint Utility of 3-T FLAIR and 3D short tau inversion recovery MR imaging in the preoperative diagnosis of hippocampal sclerosis: direct comparison with 1.5-T FLAIR MR imaging
    Kimiaki Hashiguchi
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Epilepsia 51:1820-8. 2010
    ....
  38. ncbi request reprint Gliogenic and neurogenic progenitors of the subventricular zone: who are they, where did they come from, and where are they going?
    Christine A G Marshall
    Center for Neurobiology and Behavior, Division of Neuropathology, Department of Pathology, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    Glia 43:52-61. 2003
    ..Proc Natl Acad Sci USA 93:14895-14900, 1997). Potential relationships among cells within the perinatal and adult SVZ will be discussed. GLIA 43:52-61, 2003...
  39. doi request reprint Detailed anatomy of intracranial venous anomalies associated with atretic parietal cephaloceles revealed by high-resolution 3D-CISS and high-field T2-weighted reversed MR images
    Takato Morioka
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Childs Nerv Syst 25:309-15. 2009
    ....
  40. ncbi request reprint Bursal cyst (bursitis) of the coccygeal region clinically mimics sacrococcygeal meningocele
    Kazuhiro Samura
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Childs Nerv Syst 24:533-5. 2008
    ..Bursal cysts (bursitis) are attributed to repeated microtrauma of the connective tissue around the synovial joint and are rare in the coccygeal region...
  41. doi request reprint Degenerative and protective reactions of the rat trigeminal motor nucleus after removal of the masseter and temporal muscles
    Yoshihiro Seki
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Oral Pathol Med 38:777-84. 2009
    ..To address this issue, in this we developed a rat trigeminal nerve denervation model that closely simulates the effects of oral surgery...
  42. pmc Radiation-induced spinal cord glioblastoma with cerebrospinal fluid dissemination subsequent to treatment of lymphoblastic lymphoma
    Yuichiro Kikkawa
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Surg Neurol Int 4:27. 2013
    ..We report a case of radiation-induced spinal cord glioblastoma with cerebrospinal fluid (CSF) dissemination 10 years after radiotherapy for T-cell lymphoblastic lymphoma...
  43. pmc Spinal endodermal cyst resembling an arachnoid cyst in appearance: Pitfalls in intraoperative diagnosis of cystic lesions
    Yuichiro Kikkawa
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Surg Neurol Int 3:78. 2012
    ..We present a rare case of a spinal endodermal cyst and discuss its diagnostic difficulty during the intraoperative pathological examination...
  44. doi request reprint An autopsied case of sporadic adult-onset amyotrophic lateral sclerosis with FUS-positive basophilic inclusions
    Takeshi Matsuoka
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Maidashi, Higashiku, Japan
    Neuropathology 31:71-6. 2011
    ..There were no Bunina bodies, skein-like inclusions, or Lewy-like inclusions. All exons and exon/intron boundaries of the FUS gene were sequenced but no mutations were identified...
  45. ncbi request reprint Focal cortical dysplasia with calcification: a case report
    Kazuhiro Samura
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Childs Nerv Syst 24:619-22. 2008
    ..Histological examination showed that the calcified lesion was not independent of the FCD lesion but located in the subcortical area of the FCD lesion. A neoplastic nature was ruled out for the lesion...
  46. ncbi request reprint MAP-2e, a novel MAP-2 isoform, is expressed in gliomas and delineates tumor architecture and patterns of infiltration
    Satoshi O Suzuki
    Division of Neuropathology, Columbia University College of P and S, New York, New York, USA
    J Neuropathol Exp Neurol 61:403-12. 2002
    ..MAP-2e immunostaining also delineated tumor invasion into adjacent gray and white matter, indicating that MAP-2e appears to be a useful marker for examining the infiltration of malignant cells into surrounding tissue...
  47. ncbi request reprint Foreign body granuloma associated with dura-cranioplasty after resection of convexity meningioma with extracranial extension: case report
    Nobuhiro Hata
    Department of Neurosurgery, Hachisuga Hospital, Munakata, Fukuoka, Japan
    Neurol Med Chir (Tokyo) 51:236-8. 2011
    ....
  48. ncbi request reprint Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia
    Kei ichiro Takase
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Epilepsia 49:997-1010. 2008
    ..However, its epileptogenicity remains unclear. Therefore, we created a novel rat model by freeze lesioning during the late embryonic stage to verify whether FCD influences seizure activities...
  49. ncbi request reprint Narrowing of the regions of allelic losses of chromosome 1p36 in meningioma tissues by an improved SSCP analysis
    Yanlei Guan
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
    Int J Cancer 122:1820-6. 2008
    ..39, 84.62 and 100.00%, respectively, using LOQUS-AC. Subsequently, we detected a candidate common LOH region on 1p36.11 that might harbor tumor suppressor genes related to malignant progression of meningioma...
  50. pmc Extensive dysregulations of oligodendrocytic and astrocytic connexins are associated with disease progression in an amyotrophic lateral sclerosis mouse model
    Yiwen Cui
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neuroinflammation 11:42. 2014
    ..The role of Cxs in motor neuron disease has never been investigated; therefore, we aimed to evaluate alterations of Cxs in mSOD1-transgenic (mSOD1-Tg) mice in comparison with their non-transgenic (non-Tg) littermates at the same ages...
  51. doi request reprint Protease-resistant PrP and PrP oligomers in the brain in human prion diseases after intraventricular pentosan polysulfate infusion
    Hiroyuki Honda
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuropathology 32:124-32. 2012
    ..Although intraventricular PPS infusion might modify the accumulation of PrP oligomers in the brains of patients with prion diseases, the therapeutic effects are still uncertain...
  52. doi request reprint Histological considerations of the cleavage plane for preservation of facial and cochlear nerve functions in vestibular schwannoma surgery
    Tomio Sasaki
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurosurg 110:648-55. 2009
    ..The authors analyzed the tumor capsule and the tumor-nerve interface in vestibular schwannomas (VSs) to define the ideal cleavage plane for maximal tumor removal with preservation of facial and cochlear nerve functions...
  53. doi request reprint Aquaporin-4 astrocytopathy in Baló's disease
    Takeshi Matsuoka
    Department of Neuropathology, Kyushu University, Higashi ku, Fukuoka, Japan
    Acta Neuropathol 120:651-60. 2010
    ..Furthermore, acute BCS lesions are characterized by extensive AQP4 loss without vasculocentric deposition of complement or immunoglobulin...
  54. ncbi request reprint Enhanced expression of DNA topoisomerase II genes in human medulloblastoma and its possible association with etoposide sensitivity
    Toshio Uesaka
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurooncol 84:119-29. 2007
    ..Based on these observations, Topo IIalpha and beta mRNA expression, but not the Topo IIalpha labeling index, might be a useful marker for sensitivity to etoposide in human malignant neuroepithelial tumors...
  55. ncbi request reprint [Migration patterns of glia and glioma cells--their origins, pathways, and destinations]
    Satoshi O Suzuki
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University
    Fukuoka Igaku Zasshi 98:64-72. 2007
  56. ncbi request reprint Accumulation of MDM2 in pleomorphic xanthoastrocytomas
    Kenichi Matsumoto
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pathol Int 54:387-91. 2004
    ..However, none of the samples showed mdm2 gene amplification. These results suggest that accumulation of MDM2 without gene amplification may be one of the major molecular events occurring in the tumorigenesis of PXA...
  57. ncbi request reprint Impairment of mitochondrial DNA repair enzymes against accumulation of 8-oxo-guanine in the spinal motor neurons of amyotrophic lateral sclerosis
    Hitoshi Kikuchi
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Acta Neuropathol 103:408-14. 2002
    ..Our results indicate that the oxidative damage accumulates in the mitochondria of motor neurons in ALS, and that hOGG1 does not repair the damage efficiently, which may lead to a loss of motor neurons in ALS...
  58. ncbi request reprint Down-regulation of MET in hippocampal neurons of Alzheimer's disease brains
    Hideomi Hamasaki
    Department of Neuropathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neuropathology 34:284-90. 2014
    ..Because it has been reported that HGF is also up-regulated around senile plaques, β-amyloid deposition might be associated with astrocytosis through the HGF signaling pathway. ..
  59. pmc Investigation of encephalopathy caused by Shiga toxin 2c-producing Escherichia coli infection in mice
    Muhammad Yunus Amran
    Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 8:e58959. 2013
    ..We also report the effectiveness of azithromycin (AZM) in our model. Moreover, AZM strongly inhibited the release of Stx2c from E32511 in vitro...
  60. pmc Cancer susceptibility and embryonic lethality in Mob1a/1b double-mutant mice
    Miki Nishio
    Division of Cancer Genetics, Medical Institute of Bioregulation, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Clin Invest 122:4505-18. 2012
    ..Our results clearly demonstrate that MOB1A and MOB1B have overlapping functions in skin homeostasis, and exert their roles as tumor suppressors by regulating downstream elements of the Hippo pathway...
  61. ncbi request reprint Inhibitory effects of aripiprazole on interferon-gamma-induced microglial activation via intracellular Ca2+ regulation in vitro
    Takahiro Kato
    Department of Neuropsychiatry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurochem 106:815-25. 2008
    ..Antipsychotics may therefore have a potentially useful therapeutic effect on patients with schizophrenia by reducing the microglial inflammatory reactions...
  62. doi request reprint Selenium-binding protein 1: its physiological function, dependence on aryl hydrocarbon receptors, and role in wasting syndrome by 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Sayuri Tsujimoto
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1830:3616-24. 2013
    ..However, the mechanism or likelihood is largely unknown because of the limited information available about the physiological role of Selenbp1...
  63. pmc Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy
    Akiko Furuta
    Department of Neuropathology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Pathol 163:779-87. 2003
    ..Our results suggest that the transient EAAC1 internalization participates in the modulation of the transporter function preventing excessive glutamate uptake to pyramidal neurons during the early stage of epilepsy...
  64. pmc Mutant fusion proteins with enhanced fusion activity promote measles virus spread in human neuronal cells and brains of suckling hamsters
    Shumpei Watanabe
    Department of Virology and Department of Neuropathology, Kyushu University, Fukuoka, Japan
    J Virol 87:2648-59. 2013
    ....
  65. doi request reprint Prenatal diagnosis of trisomy 16 mosaicism manifested as pulmonary artery stenosis
    Nobuhiro Hidaka
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka, Japan
    J Clin Ultrasound 37:107-11. 2009
    ..The pregnancy was legally terminated. A review of previous reports suggests that abnormalities of outlet tracts are rarely encountered in fetuses with trisomy 16 mosaicism revealed via amniocentesis...
  66. ncbi request reprint Purely cystic form of choroid plexus papilloma with acute hydrocephalus in an infant. Case report
    Yasushi Miyagi
    Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurosurg 105:480-4. 2006
    ..Purely cystic CPP is a very rare pathological entity; however, when it does occur, it can cause obstructive hydrocephalus which, without rapid diagnosis and surgical intervention, could lead to sudden death...
  67. ncbi request reprint Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer
    Yoshihiro Tanaka
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 11:4783-92. 2005
    ..We aimed to investigate the clinical significance of EGFR ligands and ADAM family in the lysophosphatidic acid-induced pathogenesis of ovarian cancer...