Hideki Sumimoto

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Molecular composition and regulation of the Nox family NAD(P)H oxidases
    Hideki Sumimoto
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 338:677-86. 2005
  2. ncbi request reprint [Roles and activation mechanisms of Nox family oxidases in animals]
    Hideki Sumimoto
    Tanpakushitsu Kakusan Koso 50:302-9. 2005
  3. doi request reprint Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species
    Hideki Sumimoto
    Medical Institute of Bioregulation, Kyushu University, Fukuoka CREST, Japan Science and Technology Agency, Tokyo, Japan
    FEBS J 275:3249-77. 2008
  4. ncbi request reprint Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants
    Hideki Sumimoto
    Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    Sci STKE 2007:re6. 2007
  5. pmc Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phox
    Ikuo Nobuhisa
    Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Biochem J 396:183-92. 2006
  6. pmc The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells
    Junya Hayase
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cell Biol 200:635-50. 2013
  7. doi request reprint A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidase
    Masahiko Taura
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem J 419:329-38. 2009
  8. ncbi request reprint The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators
    Noriko Ueno
    Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Biol Chem 280:23328-39. 2005
  9. ncbi request reprint Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein
    Tomoko Izaki
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 329:211-8. 2005
  10. pmc A conserved region between the TPR and activation domains of p67phox participates in activation of the phagocyte NADPH oxidase
    Yuichi Maehara
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    J Biol Chem 285:31435-45. 2010

Detail Information

Publications85

  1. ncbi request reprint Molecular composition and regulation of the Nox family NAD(P)H oxidases
    Hideki Sumimoto
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 338:677-86. 2005
    ..Here, we describe a current view on the molecular composition and post-translational regulation of Nox-family oxidases in animals...
  2. ncbi request reprint [Roles and activation mechanisms of Nox family oxidases in animals]
    Hideki Sumimoto
    Tanpakushitsu Kakusan Koso 50:302-9. 2005
  3. doi request reprint Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species
    Hideki Sumimoto
    Medical Institute of Bioregulation, Kyushu University, Fukuoka CREST, Japan Science and Technology Agency, Tokyo, Japan
    FEBS J 275:3249-77. 2008
    ..Here I describe the regulation of Nox-family oxidases on the basis of three-dimensional structures and evolutionary conservation...
  4. ncbi request reprint Structure and function of the PB1 domain, a protein interaction module conserved in animals, fungi, amoebas, and plants
    Hideki Sumimoto
    Medical Institute of Bioregulation, Kyushu University, Maidashi, Higashi ku, Fukuoka, Japan
    Sci STKE 2007:re6. 2007
    ..This Review describes various aspects of PB1 domains at the molecular and cellular levels...
  5. pmc Activation of the superoxide-producing phagocyte NADPH oxidase requires co-operation between the tandem SH3 domains of p47phox in recognition of a polyproline type II helix and an adjacent alpha-helix of p22phox
    Ikuo Nobuhisa
    Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Biochem J 396:183-92. 2006
    ....
  6. pmc The WD40 protein Morg1 facilitates Par6-aPKC binding to Crb3 for apical identity in epithelial cells
    Junya Hayase
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    J Cell Biol 200:635-50. 2013
    ..Thus, Par6-aPKC recruitment to the premature apical membrane appears to be required for definition of apical identity of epithelial cells...
  7. doi request reprint A region N-terminal to the tandem SH3 domain of p47phox plays a crucial role in the activation of the phagocyte NADPH oxidase
    Masahiko Taura
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem J 419:329-38. 2009
    ..Thus the Ile152-containing region of p47phox plays a crucial role in oxidase activation, probably by functioning at a process after oxidase assembly...
  8. ncbi request reprint The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators
    Noriko Ueno
    Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Biol Chem 280:23328-39. 2005
    ..Thus Nox3 functions together with p22(phox) as an enzyme constitutively producing superoxide, which can be distinctly regulated by combinatorial use of the organizers and activators...
  9. ncbi request reprint Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein
    Tomoko Izaki
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 329:211-8. 2005
    ....
  10. pmc A conserved region between the TPR and activation domains of p67phox participates in activation of the phagocyte NADPH oxidase
    Yuichi Maehara
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    J Biol Chem 285:31435-45. 2010
    ..Thus the extended activation domain of p67(phox) (amino acids 190-210) containing the D(Y/F)LGK motif plays an essential role in oxidase activation probably by interacting with gp91(phox)...
  11. doi request reprint Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1
    Asataro Yamamoto
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    FEBS J 280:5145-59. 2013
    ..Thus phosphorylation of Noxo1 at Thr341 and at Ser154 appears to regulate Nox1 activity in different manners...
  12. ncbi request reprint Increased expression of NAD(P)H oxidase in islets of animal models of Type 2 diabetes and its improvement by an AT1 receptor antagonist
    Mieko Nakayama
    Department of Medicine and Bioregulatory Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 332:927-33. 2005
    ..Angiotensin II-related increased expression of NAD(P)H oxidase may play an important role in increased oxidative stress in islets of Type 2 diabetes. This mechanism may be a novel therapeutic target for preventing beta-cell damage...
  13. ncbi request reprint A region C-terminal to the proline-rich core of p47phox regulates activation of the phagocyte NADPH oxidase by interacting with the C-terminal SH3 domain of p67phox
    Kazuhito Mizuki
    Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Arch Biochem Biophys 444:185-94. 2005
    ....
  14. ncbi request reprint Galpha12/13-mediated production of reactive oxygen species is critical for angiotensin receptor-induced NFAT activation in cardiac fibroblasts
    Tomomi Fujii
    Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Biol Chem 280:23041-7. 2005
    ....
  15. ncbi request reprint Molecular recognition in dimerization between PB1 domains
    Yukiko Noda
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 278:43516-24. 2003
    ..Thus the PB1 domain appears to be a protein module that fully exploits its two mutually interacting elements in molecular recognition to expand its repertoire of protein-protein interactions...
  16. ncbi request reprint Expression and function of Noxo1gamma, an alternative splicing form of the NADPH oxidase organizer 1
    Ryu Takeya
    Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    FEBS J 273:3663-77. 2006
    ....
  17. doi request reprint The domain organization of p67 phox, a protein required for activation of the superoxide-producing NADPH oxidase in phagocytes
    Satoru Yuzawa
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Innate Immun 1:543-55. 2009
    ....
  18. ncbi request reprint Direct involvement of the small GTPase Rac in activation of the superoxide-producing NADPH oxidase Nox1
    Kei Miyano
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 281:21857-68. 2006
    ..Furthermore, a mutant Noxa1 carrying the substitution of Ala for Val-205 in the activation domain, which is expected to undergo a conformational change upon Rac binding, fully localizes to the membrane but fails to activate Nox1...
  19. ncbi request reprint Statin attenuates high glucose-induced and diabetes-induced oxidative stress in vitro and in vivo evaluated by electron spin resonance measurement
    Hirotaka Tsubouchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Free Radic Biol Med 39:444-52. 2005
    ..In conclusion, pitavastatin attenuated a high glucose-induced and a diabetes-induced oxidative stress in vitro and in vivo. Thus, our data may provide a new insight into antioxidative therapy in diabetes...
  20. ncbi request reprint Two forms of human Inscuteable-related protein that links Par3 to the Pins homologues LGN and AGS3
    Tomoko Izaki
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 341:1001-6. 2006
    ....
  21. doi request reprint Role for the first SH3 domain of p67phox in activation of superoxide-producing NADPH oxidases
    Yuichi Maehara
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 379:589-93. 2009
    ..Thus p67(phox)-SH3(N) specifically functions in gp91(phox)/Nox2 activation probably via facilitating oxidase assembly...
  22. ncbi request reprint Interaction between the SH3 domains and C-terminal proline-rich region in NADPH oxidase organizer 1 (Noxo1)
    Asataro Yamamoto
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 352:560-5. 2007
    ..These findings suggest that Nox activation involves a conformational change leading to disruption of the bis-SH3-PRR interaction in Noxo1...
  23. doi request reprint Membrane phospholipid metabolism during phagocytosis in human neutrophils
    Reiko Minakami
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Genes Cells 15:409-24. 2010
    ....
  24. pmc Structural basis for interaction between the conserved cell polarity proteins Inscuteable and Leu-Gly-Asn repeat-enriched protein (LGN)
    Satoru Yuzawa
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 108:19210-5. 2011
    ..We also demonstrate, using mutant proteins, that mInsc-LGN interaction is vital for stabilization of LGN and for intracellular localization of mInsc...
  25. ncbi request reprint The superoxide-producing NAD(P)H oxidase Nox4 in the nucleus of human vascular endothelial cells
    Junya Kuroda
    Medical Institute of Bioregulation, Kyushu University, Higashi ku, Fukuoka, Japan
    Genes Cells 10:1139-51. 2005
    ..Thus Nox4 appears to produce superoxide in the nucleus of HUVECs, thereby regulating gene expression via a mechanism for oxidative stress response...
  26. ncbi request reprint Regulation of superoxide-producing NADPH oxidases in nonphagocytic cells
    Ryu Takeya
    Medical Institute of Bioregulation, Kyushu University, Fuku oka, Japan
    Methods Enzymol 406:456-68. 2006
    ..Thus, functional reconstitution of Nox systems is crucial for the study of Nox regulation. Here we describe a basic method for the reconstitution of Nox systems by expression of oxidase proteins in transfectable cells...
  27. pmc Mammalian formin fhod3 regulates actin assembly and sarcomere organization in striated muscles
    Kenichiro Taniguchi
    Department of Biochemistry, Graduate School of Medical Sciences, Fukuoka, Japan
    J Biol Chem 284:29873-81. 2009
    ..These findings suggest that actin dynamics regulated by Fhod3 are critical for sarcomere organization in striated muscle cells...
  28. ncbi request reprint Fhos2, a novel formin-related actin-organizing protein, probably associates with the nestin intermediate filament
    Hideki Kanaya
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Genes Cells 10:665-78. 2005
    ..Thus, Fhos2 not only has the actin-organizing activity but also associates with nestin, which may imply a Fhos2-mediated link between the nestin intermediate filament and actin microfilament...
  29. pmc The mammalian formin FHOD1 is activated through phosphorylation by ROCK and mediates thrombin-induced stress fibre formation in endothelial cells
    Ryu Takeya
    Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    EMBO J 27:618-28. 2008
    ....
  30. doi request reprint Enhanced expression of NADPH oxidase Nox4 in human gliomas and its roles in cell proliferation and survival
    Tadahisa Shono
    Department of Neurosurgery, Kyushu University, Graduate School of Medical Sciences, Fukuoka, Japan
    Int J Cancer 123:787-92. 2008
    ..Based on these observations, enhanced expression of Nox4 appears to be involved in cell proliferation and survival in glioma cells...
  31. doi request reprint The cell polarity protein mInsc regulates neutrophil chemotaxis via a noncanonical G protein signaling pathway
    Sachiko Kamakura
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka 812 8582, Japan
    Dev Cell 26:292-302. 2013
    ..Thus, mInsc controls directional migration via noncanonical G protein signaling, in which Gβγ-free Gαi-GDP, a product from Gαi-GTP released after receptor activation, plays a central role...
  32. pmc Expression and subcellular localization of mammalian formin Fhod3 in the embryonic and adult heart
    Meikun Kan-o
    Department of Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e34765. 2012
    ..Furthermore, the exon 25-encoded region appears to be dispensable for actin-organizing activities both in vivo and in vitro, albeit it is inserted in the catalytic FH2 domain...
  33. doi request reprint Assessment of the role for Rho family GTPases in NADPH oxidase activation
    Kei Miyano
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Methods Mol Biol 827:195-212. 2012
    ..Here, we describe methods for the assay of Rac binding to p67( phox ) and Noxa1 and for the reconstitution of Rac-dependent Nox activity in cell-free and whole-cell systems...
  34. pmc Pertussis toxin up-regulates angiotensin type 1 receptors through Toll-like receptor 4-mediated Rac activation
    Motohiro Nishida
    Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Biol Chem 285:15268-77. 2010
    ..However, ADP-ribosylation of G(i)/G(o) by PTX was not affected by inhibition of TLR4. Thus, PTX binds to two receptors; one is TLR4, which activates Rac, and another is the binding site that is required for ADP-ribosylation of G(i)/G(o)...
  35. ncbi request reprint Increased expression of gp91phox homologues of NAD(P)H oxidase in the aortic media during chronic hypertension: involvement of the renin-angiotensin system
    Takashi Akasaki
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hypertens Res 29:813-20. 2006
    ..These results suggest that blood pressure and angiotensin II type 1 receptor activation are involved in the up-regulation of Nox1 and Nox4 expression, which could contribute to vascular injury during chronic hypertension...
  36. ncbi request reprint Expression of isoforms of NADPH oxidase components in rat pancreatic islets
    Yuji Uchizono
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Life Sci 80:133-9. 2006
    ..Our results suggest that the functional significance of NADPH oxidase in insulin secretion may merit further investigation...
  37. ncbi request reprint Novel human homologues of p47phox and p67phox participate in activation of superoxide-producing NADPH oxidases
    Ryu Takeya
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 278:25234-46. 2003
    ..Thus, the novel homologues p41nox and p51nox likely function together or in combination with a classical one, thereby activating the two Nox family oxidases...
  38. ncbi request reprint Transient receptor potential (TRP) protein 7 acts as a G protein-activated Ca2+ channel mediating angiotensin II-induced myocardial apoptosis
    Shinji Satoh
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, 874 0838, Japan
    Mol Cell Biochem 294:205-15. 2007
    ..TRPC7 might be a key initiator linking AT1-activation to myocardial apoptosis, and thereby contributing to the process of heart failure...
  39. pmc Phosphorylation of p47phox directs phox homology domain from SH3 domain toward phosphoinositides, leading to phagocyte NADPH oxidase activation
    Tetsuro Ago
    Medical Institute of Bioregulation, Kyushu University, and Department of Molecular and Structural Biology, Kyushu University Graduate School of Medicine, Fukuoka 812 8582, Japan
    Proc Natl Acad Sci U S A 100:4474-9. 2003
    ....
  40. ncbi request reprint Molecular mechanism underlying activation of superoxide-producing NADPH oxidases: roles for their regulatory proteins
    Hideki Sumimoto
    Medical Institute of Bioregulation, Kyushu Univerisity, Fukuoka, Japan
    Jpn J Infect Dis 57:S24-5. 2004
    ..We will also describe the mechanism underlying regulation of the third oxidase Nox3, which exits in fetal kidney and inner ears...
  41. pmc TRPC3 and TRPC6 are essential for angiotensin II-induced cardiac hypertrophy
    Naoya Onohara
    Department of Pharmacology and Toxicology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka
    EMBO J 25:5305-16. 2006
    ..These data suggest that DAG-induced Ca(2+) signaling pathway through TRPC3 and TRPC6 is essential for Ang II-induced NFAT activation and cardiac hypertrophy...
  42. ncbi request reprint Catalytic residues of group VIB calcium-independent phospholipase A2 (iPLA2gamma)
    Haruki Tanaka
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 320:1284-90. 2004
    ..Since substitution of alanine for either Ser-483 or Asp-627 results in a loss of the PLA(2) activity, we propose that Ser-483 and Asp-627 of human iPLA(2)gamma constitute an active site similar to the Ser-Asp dyad in cPLA(2) and patatin...
  43. doi request reprint The insert region of the Rac GTPases is dispensable for activation of superoxide-producing NADPH oxidases
    Kei Miyano
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem J 422:373-82. 2009
    ..Thus the insert region of the Rac GTPases does not participate in regulation of the Nox family NADPH oxidases...
  44. ncbi request reprint Sulfonylurea as well as elevated glucose levels stimulate reactive oxygen species production in the pancreatic beta-cell line, MIN6-a role of NAD(P)H oxidase in beta-cells
    Hirotaka Tsubouchi
    Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 326:60-5. 2005
    ..This mechanism may be a novel therapeutic target for preventing the progression of beta-cell deterioration...
  45. pmc Mammalian formin Fhod3 plays an essential role in cardiogenesis by organizing myofibrillogenesis
    Meikun Kan-o
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biol Open 1:889-96. 2012
    ..These findings indicate that actin dynamics, regulated by Fhod3, participate in sarcomere organization during myofibrillogenesis and thus play a crucial role in heart development...
  46. ncbi request reprint Fhos, a mammalian formin, directly binds to F-actin via a region N-terminal to the FH1 domain and forms a homotypic complex via the FH2 domain to promote actin fiber formation
    Ryu Takeya
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Cell Sci 116:4567-75. 2003
    ..Thus, the mammalian formin Fhos, which directly binds to F-actin via the N-terminal region, forms a homotypic complex via the FH2 domain to organize actin cytoskeleton...
  47. ncbi request reprint Regulation of novel superoxide-producing NAD(P)H oxidases
    Ryu Takeya
    Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    Antioxid Redox Signal 8:1523-32. 2006
    ....
  48. doi request reprint Interaction of NuMA protein with the kinesin Eg5: its possible role in bipolar spindle assembly and chromosome alignment
    Yuko Iwakiri
    Department of Biochemistry, Kyushu University Graduate School of Medical Sciences, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Biochem J 451:195-204. 2013
    ..Thus dynein appears to control NuMA function in conjunction with Eg5...
  49. doi request reprint Ubiquitination of the heterotrimeric G protein α subunits Gαi2 and Gαq is prevented by the guanine nucleotide exchange factor Ric-8A
    Kanako Chishiki
    Department of Biochemistry, Kyushu University, Graduate School of Medical Sciences, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 435:414-9. 2013
    ....
  50. ncbi request reprint Role of the small GTPase Rac in p22phox-dependent NADPH oxidases
    Kei Miyano
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochimie 89:1133-44. 2007
    ..Since the enhancements are not observed with a mutant p67(phox) defective in binding to Rac, this GTPase appear to directly recruit p67(phox) to the membrane...
  51. ncbi request reprint Molecular mechanism for activation of superoxide-producing NADPH oxidases
    Ryu Takeya
    Medical Institute of Bioregulation, Kyushu University, Fukuoka 812 8582, Japan
    Mol Cells 16:271-7. 2003
    ....
  52. pmc The adaptor protein p40(phox) as a positive regulator of the superoxide-producing phagocyte oxidase
    Futoshi Kuribayashi
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    EMBO J 21:6312-20. 2002
    ..Thus p40(phox) participates in activation of the phagocyte oxidase by regulating membrane recruitment of p67(phox) and p47(phox) via the PB1-PC interaction with p67(phox)...
  53. pmc Leukotriene B4 augments and restores Fc gammaRs-dependent phagocytosis in macrophages
    Fuyuki Okamoto
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    J Biol Chem 285:41113-21. 2010
    ..Surprisingly, we found that LTB(4)-BLT1 signaling restores phagocytosis in the absence of FcγRs signaling. These data indicate that LTB(4)-BLT1 signaling plays a pivotal role in macrophage phagocytosis and innate immunity...
  54. ncbi request reprint On the mechanism of cell lysis by deformation
    Hiroshi Takamatsu
    Institute for Materials Chemistry and Engineering, Kyushu University, 6 1 Kasugakoen, Kasuga, Fukuoka 816 8580, Japan
    J Biomech 38:117-24. 2005
    ..In addition, the treatment of cells with cytochalasin D results in the disappearance of cortical actin filaments and a marked drop in the viability, indicating that cell lysis is closely related to the deformation of the cytoskeleton...
  55. ncbi request reprint Involvement of TRPM7 in cell growth as a spontaneously activated Ca2+ entry pathway in human retinoblastoma cells
    Toyohisa Hanano
    Department of Pharmacology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Pharmacol Sci 95:403-19. 2004
    ..These results suggest a significant regulatory role of TRPM7 for RB cell proliferation as a spontaneously activated Ca(2+) influx pathway...
  56. ncbi request reprint Induction of cytochrome CYP4F3A in all-trans-retinoic acid-treated HL60 cells
    Yoichi Mizukami
    Department of Molecular and Cellular Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 314:104-9. 2004
    ....
  57. ncbi request reprint Protein kinase C-dependent increase in reactive oxygen species (ROS) production in vascular tissues of diabetes: role of vascular NAD(P)H oxidase
    Toyoshi Inoguchi
    Departments of Medicine and Bioregulatory Science and Molecular and Structure Biology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Am Soc Nephrol 14:S227-32. 2003
    ..Taken together, these findings strongly suggest that the PKC-dependent activation of NAD(P)H oxidase may be an essential mechanism responsible for increased oxidative stress in diabetes...
  58. ncbi request reprint PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions
    Motoyuki Kohjima
    Medical Institute of Bioregulation, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 299:641-6. 2002
    ..Nevertheless PAR3beta, expressed intrinsically or extrinsically, localizes to the tight junctions, indicating that the localization does not require the ternary complex formation...
  59. doi request reprint High cell-autonomy of the anterior endomesoderm viewed in blastomere fate shift during regulative development in the isolated right halves of four-cell stage Xenopus embryos
    Masaaki Koga
    Department of Earth System Science, Faculty of Science, Fukuoka University, Nanakuma, Fukuoka, 814 0180, Japan
    Dev Growth Differ 54:717-29. 2012
    ..The cell lineage difference in the left half GRP could result in a different utilization of maternal determinants in that area...
  60. pmc Rab27 effector Slp2-a transports the apical signaling molecule podocalyxin to the apical surface of MDCK II cells and regulates claudin-2 expression
    Takao Yasuda
    Laboratory of Membrane Trafficking Mechanisms, Department of Developmental Biology and Neurosciences, Graduate School of Life Sciences, Tohoku University, Aoba ku, Sendai, Miyagi, Japan
    Mol Biol Cell 23:3229-39. 2012
    ..Because both Slp2-a and claudin-2 are highly expressed in mouse renal proximal tubules, Slp2-a is likely to regulate claudin-2 expression through trafficking of podocalyxin to the apical surface in mouse renal tubule epithelial cells...
  61. ncbi request reprint Identification of a novel type 1 diabetes susceptibility gene, T-bet
    Yuka Sasaki
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    Hum Genet 115:177-84. 2004
    ....
  62. ncbi request reprint Role of nicotinamide adenine dinucleotide phosphate oxidase 1 in oxidative burst response to Toll-like receptor 5 signaling in large intestinal epithelial cells
    Tsukasa Kawahara
    Department of Nutrition, School of Medicine, University of Tokushima, Tokushima, Japan
    J Immunol 172:3051-8. 2004
    ....
  63. ncbi request reprint Binding of FAD to cytochrome b558 is facilitated during activation of the phagocyte NADPH oxidase, leading to superoxide production
    Shukichi Hashida
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812
    J Biol Chem 279:26378-86. 2004
    ....
  64. ncbi request reprint Crystallization and preliminary crystallographic analysis of the autoinhibited form of the tandem SH3 domain of p47(phox)
    Satoru Yuzawa
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Acta Crystallogr D Biol Crystallogr 59:1479-80. 2003
    ..02, c = 44.94 A. The presence of one molecule per asymmetric unit gives a crystal volume per protein mass (V(M)) of 2.6 A(3) Da(-1) and a solvent content of 52% by volume...
  65. ncbi request reprint Relationship between p38 mitogen-activated protein kinase and small GTPase Rac for the activation of NADPH oxidase in bovine neutrophils
    Tohru Yamamori
    Laboratory of Radiation Biology, Department of Environmental Veterinary Sciences, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo 060 0818, Japan
    Biochem Biophys Res Commun 293:1571-8. 2002
    ..However, SB203580 showed no effect on the PI3K activity. These results suggested that PI3K/p38 MAPK/Rac pathway was present in the activation of NADPH oxidase in bovine neutrophils...
  66. ncbi request reprint Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome
    Takehiko Ueyama
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe, Japan
    J Immunol 175:2381-90. 2005
    ..In addition to this mechanism, Rac2 has a positive charge-independent mechanism in which Rac2 initially targets to endomembranes and then these endomembranes fuse to the phagosome...
  67. ncbi request reprint A molecular mechanism for autoinhibition of the tandem SH3 domains of p47phox, the regulatory subunit of the phagocyte NADPH oxidase
    Satoru Yuzawa
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    Genes Cells 9:443-56. 2004
    ....
  68. ncbi request reprint Cloning of rat p47phox and comparison with human p47phox
    Michiharu Tanabe
    Department of Medical Biochemistry and Biophysics, Division of Physiological Chemistry II, Karolinska Institutet, S 171 77, Stockholm, Sweden
    DNA Seq 16:65-8. 2005
    ..Although rat 12-lipoxygenase interacted with human p47phox in a yeast two-hybrid system, this was not the case for rat p47phox...
  69. ncbi request reprint Solution structure of atypical protein kinase C PB1 domain and its mode of interaction with ZIP/p62 and MEK5
    Yoshinori Hirano
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N 12 W 6, Kita ku, Sapporo 060 0812, Japan
    J Biol Chem 279:31883-90. 2004
    ....
  70. pmc Full-length p40phox structure suggests a basis for regulation mechanism of its membrane binding
    Kazuya Honbou
    Laboratory of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan
    EMBO J 26:1176-86. 2007
    ..The interface of the p40phox PB1 domain for the PX domain localizes on the opposite side of that for the p67phox PB1 domain, and thus the PB1-mediated PX regulation occurs without preventing the PB1-PB1 association with p67phox...
  71. ncbi request reprint [Etiological view of diseases from protein domain--activation mechanism of reactive-oxygen-species producing phagocyte NADPH oxidase important rule in host defence]
    Hideki Sumimoto
    Masui 51:S63-71. 2002
  72. ncbi request reprint Helicobacter pylori lipopolysaccharide activates Rac1 and transcription of NADPH oxidase Nox1 and its organizer NOXO1 in guinea pig gastric mucosal cells
    Tsukasa Kawahara
    Department of Nutritional Physiology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
    Am J Physiol Cell Physiol 288:C450-7. 2005
    ..Thus the H. pylori LPS-stimulated O2- production in gastric mucosal cells appears to require two distinct events: 1) transcriptional upregulation of Nox1 and NOXO1 and 2) activation of Rac1...
  73. ncbi request reprint A novel FERM domain including guanine nucleotide exchange factor is involved in Rac signaling and regulates neurite remodeling
    Tateki Kubo
    Department of Anatomy and Neuroscience, Osaka University Graduate School of Medicine, Suita, Osaka, 565 0871, Japan
    J Neurosci 22:8504-13. 2002
    ..These results suggest that FIR may regulate neurite remodeling by mediating the signaling pathways from membrane proteins to Rac...
  74. pmc Diverse recognition of non-PxxP peptide ligands by the SH3 domains from p67(phox), Grb2 and Pex13p
    Keiichiro Kami
    Department of Structural Biology, Biomolecular Engineering Research Institute, 6 2 3 Furuedai, Suita, Osaka 565 0874, Japan
    EMBO J 21:4268-76. 2002
    ....
  75. pmc A regulated adaptor function of p40phox: distinct p67phox membrane targeting by p40phox and by p47phox
    Takehiko Ueyama
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Kobe 657 8501, Japan
    Mol Biol Cell 18:441-54. 2007
    ..Thus, both p40(phox) and p47(phox) function as diverse p67(phox) "carrier proteins" regulated by the unmasking of membrane-targeting domains in distinct mechanisms...
  76. ncbi request reprint Sequence-specific resonance assignments of the tandem SH3 domains in an autoinhibitory form of p47(phox)
    Satoru Yuzawa
    J Biomol NMR 29:451-2. 2004
  77. ncbi request reprint NMR solution structure of the tandem Src homology 3 domains of p47phox complexed with a p22phox-derived proline-rich peptide
    Kenji Ogura
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N 12 W 6, Kita ku, Sapporo 060 0812, Japan
    J Biol Chem 281:3660-8. 2006
    ..Thus, the C-terminal alpha-helical region of the p22phox peptide increases the binding affinity for the tandem SH3 domains of p47phox more than 10-fold...
  78. ncbi request reprint 1H, 13C and 15N resonance assignments of the backbone and methyl groups of the 24 kDa tetratricopeptide repeat domain in p67(phox)
    Shinichi Yoshida
    J Biomol NMR 32:176. 2005
  79. ncbi request reprint OPR, PC and AID: all in the PB1 family
    Chris P Ponting
    Trends Biochem Sci 27:10. 2002
  80. ncbi request reprint Group VIB Ca2+-independent phospholipase A2gamma promotes cellular membrane hydrolysis and prostaglandin production in a manner distinct from other intracellular phospholipases A2
    Makoto Murakami
    Department of Health Chemistry, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Biol Chem 280:14028-41. 2005
    ....
  81. ncbi request reprint Characterization of teleost phagocyte NADPH oxidase: molecular cloning and expression analysis of carp (Cyprinus carpio) phagocyte NADPH oxidase
    Masayuki Mayumi
    Laboratory of Fish Pathology, Department of Veterinary Medicine, Nihon University, Kameino 1866, Fujisawa, Kanagawa 252 8510, Japan
    Mol Immunol 45:1720-31. 2008
    ..Thus, it is likely that the higher divergence of p67phox and p47phox are responsible for the difference of ROS responses between different species of teleosts...
  82. ncbi request reprint [Phagocytosis and killing of microorganisms]
    Reiko Minakami
    Tanpakushitsu Kakusan Koso 51:109-17. 2006
  83. pmc The PB1 domain and the PC motif-containing region are structurally similar protein binding modules
    Sosuke Yoshinaga
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, N12, W6, Kita ku, Sapporo 060 0812, Japan
    EMBO J 22:4888-97. 2003
    ..Based on the structural information, we group the PB1 domains and the PCCRs into a novel family, named the PB1 family. Thus, the PB1 family proteins form a specific dimer with each other...
  84. ncbi request reprint Solution structure of the tandem Src homology 3 domains of p47phox in an autoinhibited form
    Satoru Yuzawa
    Department of Structural Biology, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060 0812, Japan
    J Biol Chem 279:29752-60. 2004
    ..Once PBR/AIR is released by phosphorylation, rearrangements of the SH3 domains may occur, forming an open structure that binds to the cytoplasmic proline-rich region of membrane-bound p22(phox)...
  85. pmc Regulation of Bin1 SH3 domain binding by phosphoinositides
    Chie Kojima
    Department of Molecular Biology, Osaka Bioscience Institute, Suita, Japan
    EMBO J 23:4413-22. 2004
    ..Our results exemplify a novel mechanism of SH3 domain regulation, and suggest that the SH3-mediated protein-protein interactions of Bin1 are regulated by Exon10 so that it may only occur when Bin1 localizes to certain submembrane areas...