Sugiura T, Inoue Y, Matsuki R, Ishii K, Takahashi M, Abe M, et al. VEGF-C and VEGF-D expression is correlated with lymphatic vessel density and lymph node metastasis in oral squamous cell carcinoma: Implications for use as a prognostic marker. Int J Oncol. 2009;34:673-80 pubmed
..001). This study presents clinical evidence for the important roles of VEGF-C and VEGF-D in lymphangiogenesis and lymphatic metastasis of oral SCC, and suggests that VEGF-C or LVD can effectively predict lymphatic metastasis of oral SCC. ..
Hayashi K, Ikari T, Sugiyama G, Sugiura T, Ohyama Y, Kumamaru W, et al. Involvement of the T-box transcription factor Brachyury in early-stage embryonic mouse salivary gland. Biochem Biophys Res Commun. 2016;477:814-819 pubmed publisher
Shimoda M, Sugiura T, Imajyo I, Ishii K, Chigita S, Seki K, et al. The T-box transcription factor Brachyury regulates epithelial-mesenchymal transition in association with cancer stem-like cells in adenoid cystic carcinoma cells. BMC Cancer. 2012;12:377 pubmed publisher
..The use of a single cell line is a limitation of this study. However, parallel data from in vitro and clinical samples suggest the possibility that EMT is directly linked to CSCs and that Brachyury is a regulator of EMT and CSCs. ..