Ryo Sakasai

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. pmc Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison
    Ryo Sakasai
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    J Biol Chem 285:15201-8. 2010
  2. ncbi request reprint Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks
    Ryo Sakasai
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda ku, Tokyo 101 0062, Japan
    Genes Cells 11:237-46. 2006
  3. ncbi request reprint Phosphorylation of histone H2AX at M phase in human cells without DNA damage response
    Yosuke Ichijima
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Biochem Biophys Res Commun 336:807-12. 2005
  4. pmc Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin
    Ryo Sakasai
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo, Japan
    DNA Repair (Amst) 9:76-82. 2010
  5. doi request reprint DPPA4 modulates chromatin structure via association with DNA and core histone H3 in mouse embryonic stem cells
    Hisaharu Masaki
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda ku, Tokyo 101 0062, Japan
    Genes Cells 15:327-37. 2010

Collaborators

Detail Information

Publications5

  1. pmc Transcription-dependent activation of ataxia telangiectasia mutated prevents DNA-dependent protein kinase-mediated cell death in response to topoisomerase I poison
    Ryo Sakasai
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Tokyo 101 0062, Japan
    J Biol Chem 285:15201-8. 2010
    ..Thus, ATM suppresses DNA-PK-dependent cell death in response to topoisomerase poisons, a finding with potential clinical implications...
  2. ncbi request reprint Differential involvement of phosphatidylinositol 3-kinase-related protein kinases in hyperphosphorylation of replication protein A2 in response to replication-mediated DNA double-strand breaks
    Ryo Sakasai
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda ku, Tokyo 101 0062, Japan
    Genes Cells 11:237-46. 2006
    ..These results suggest that DNA-PK is responsible for the RPA2 hyperphosphorylation following ATR-dependent RPA2 focus formation in response to replication-mediated DSBs directly induced by CPT...
  3. ncbi request reprint Phosphorylation of histone H2AX at M phase in human cells without DNA damage response
    Yosuke Ichijima
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo 101 0062, Japan
    Biochem Biophys Res Commun 336:807-12. 2005
    ..Even in the absence of DNA damage, phosphorylation of H2AX in normal cell cycle progression may contribute to maintenance of genomic integrity...
  4. pmc Proteasome inhibition suppresses DNA-dependent protein kinase activation caused by camptothecin
    Ryo Sakasai
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, 2 3 10 Kandasurugadai, Chiyoda ku, Tokyo, Japan
    DNA Repair (Amst) 9:76-82. 2010
    ..The implications of DNA-PK activation in the context of TopI poison-based therapies are discussed...
  5. doi request reprint DPPA4 modulates chromatin structure via association with DNA and core histone H3 in mouse embryonic stem cells
    Hisaharu Masaki
    Department of Pathological Biochemistry, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda ku, Tokyo 101 0062, Japan
    Genes Cells 15:327-37. 2010
    ..These results suggest that DPPA4 modulates the chromatin structure in association with DNA and histone H3 in ES cells...