N Sagata

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi Molecular biology. Untangling checkpoints
    Noriyuki Sagata
    Department of Biology, Kyushu University, Fukuoka 812 8581, Japan
    Science 298:1905-7. 2002
  2. ncbi What does Mos do in oocytes and somatic cells?
    N Sagata
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Bioessays 19:13-21. 1997
  3. pmc Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes
    N Nakajo
    Department of Biology, Graduate School of Science, Kyushu University, Fukuoka 812 8581, Japan
    Genes Dev 14:328-38. 2000
  4. ncbi Two structural variants of Nek2 kinase, termed Nek2A and Nek2B, are differentially expressed in Xenopus tissues and development
    K Uto
    Faculty of Science, Kyushu University, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Dev Biol 208:456-64. 1999
  5. ncbi Involvement of Chk1 kinase in prophase I arrest of Xenopus oocytes
    N Nakajo
    Faculty of Science, Kyushu University, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Dev Biol 207:432-44. 1999
  6. ncbi Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes
    T Oe
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Dev Biol 229:250-61. 2001
  7. pmc The 'second-codon rule' and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes
    M Nishizawa
    Division of Molecular Genetics, Kurume University, Fukuoka, Japan
    EMBO J 11:2433-46. 1992
  8. ncbi cDNA cloning of a novel B subunit of Xenopus protein phosphatase 2A and its biological activity in oocytes
    J Iwashita
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 232:218-22. 1997
  9. pmc The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs
    Daigo Inoue
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki, Fukuoka, Japan
    EMBO J 24:1057-67. 2005
  10. pmc Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation
    Yoshinori Katsuragi
    Department of Biology, Graduate School of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Mol Biol Cell 15:1680-9. 2004

Collaborators

Detail Information

Publications29

  1. ncbi Molecular biology. Untangling checkpoints
    Noriyuki Sagata
    Department of Biology, Kyushu University, Fukuoka 812 8581, Japan
    Science 298:1905-7. 2002
  2. ncbi What does Mos do in oocytes and somatic cells?
    N Sagata
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Bioessays 19:13-21. 1997
    ..This review discusses the cellular basis that may enable Mos to act differently in oocytes and somatic cells...
  3. pmc Absence of Wee1 ensures the meiotic cell cycle in Xenopus oocytes
    N Nakajo
    Department of Biology, Graduate School of Science, Kyushu University, Fukuoka 812 8581, Japan
    Genes Dev 14:328-38. 2000
    ..Based on these results and the data published previously in other organisms, we suggest that absence of Wee1 may be a well-conserved mechanism for omitting interphase or S phase between the two meiotic divisions...
  4. ncbi Two structural variants of Nek2 kinase, termed Nek2A and Nek2B, are differentially expressed in Xenopus tissues and development
    K Uto
    Faculty of Science, Kyushu University, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Dev Biol 208:456-64. 1999
    ..We discuss the possibility that a counterpart of Xenopus Nek2B might also exist and function in early mammalian development...
  5. ncbi Involvement of Chk1 kinase in prophase I arrest of Xenopus oocytes
    N Nakajo
    Faculty of Science, Kyushu University, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Dev Biol 207:432-44. 1999
    ..We discuss the possibility that Chk1 might function either as a G2 checkpoint kinase or as an ordinary cell cycle regulator in prophase-I-arrested oocytes...
  6. ncbi Cytoplasmic occurrence of the Chk1/Cdc25 pathway and regulation of Chk1 in Xenopus oocytes
    T Oe
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka, 812 8581, Japan
    Dev Biol 229:250-61. 2001
    ....
  7. pmc The 'second-codon rule' and autophosphorylation govern the stability and activity of Mos during the meiotic cell cycle in Xenopus oocytes
    M Nishizawa
    Division of Molecular Genetics, Kurume University, Fukuoka, Japan
    EMBO J 11:2433-46. 1992
    ..Thus, a few N-terminal amino acids are primary determinants of both the metabolic stability and physiological activity of Mos during the meiotic cell cycle...
  8. ncbi cDNA cloning of a novel B subunit of Xenopus protein phosphatase 2A and its biological activity in oocytes
    J Iwashita
    Department of Biology, Faculty of Science, Kyushu University, Fukuoka, Japan
    Biochem Biophys Res Commun 232:218-22. 1997
    ..These results suggest that the B beta' isoform can form a complex with other PP2A subunits to make a trimeric PP2A holoenzyme in Xenopus oocytes and may negatively control the initiation of oocyte maturation...
  9. pmc The Polo-like kinase Plx1 interacts with and inhibits Myt1 after fertilization of Xenopus eggs
    Daigo Inoue
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki, Fukuoka, Japan
    EMBO J 24:1057-67. 2005
    ..These results indicate a switchover in the Myt1 inhibition mechanism at fertilization of Xenopus eggs, and strongly suggest that Plx1 acts as a direct inhibitory kinase of Myt1 in the mitotic cell cycles in Xenopus...
  10. pmc Regulation of Chk1 kinase by autoinhibition and ATR-mediated phosphorylation
    Yoshinori Katsuragi
    Department of Biology, Graduate School of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Mol Biol Cell 15:1680-9. 2004
    ..These results provide significant insights into the mechanism of Chk1 activation at the DNA replication checkpoint...
  11. pmc The extracellular signal-regulated kinase-mitogen-activated protein kinase pathway phosphorylates and targets Cdc25A for SCF beta-TrCP-dependent degradation for cell cycle arrest
    Michitaka Isoda
    Department of Biology, Kyushu University, Hakozaki, Fukuoka, Japan
    Mol Biol Cell 20:2186-95. 2009
    ..These results suggest that strong ERK activation can target Cdc25A for degradation in a manner similar to, but independent of, Chk1 for cell cycle arrest...
  12. ncbi The RRASK motif in Xenopus cyclin B2 is required for the substrate recognition of Cdc25C by the cyclin B-Cdc2 complex
    Tadahiro Goda
    Department of Molecular Biology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka 812 8582, Japan
    J Biol Chem 278:19032-7. 2003
    ..These results suggest that the RRASK motif in Xenopus cyclin B2 plays an important role in defining the substrate specificity of the cyclin B-Cdc2 complex...
  13. pmc Chk1 is activated transiently and targets Cdc25A for degradation at the Xenopus midblastula transition
    Ken Shimuta
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka 812 8581, Japan
    EMBO J 21:3694-703. 2002
    ..Thus, the physiological replication checkpoint is activated transiently at the MBT by developmental cues, and activated Chk1, only together with an unknown kinase, targets Cdc25A for degradation to ensure later development...
  14. pmc The existence of two distinct Wee1 isoforms in Xenopus: implications for the developmental regulation of the cell cycle
    Kengo Okamoto
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka 812 8581, Japan
    EMBO J 21:2472-84. 2002
    ..These results suggest strongly that the differential expression of Wee1A and Wee1B is crucial for the developmental regulation of the cell cycle in Xenopus...
  15. pmc Chk1, but not Chk2, inhibits Cdc25 phosphatases by a novel common mechanism
    Katsuhiro Uto
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki, Fukuoka, Japan
    EMBO J 23:3386-96. 2004
    ..Thus, Chk1 but not Chk2 seems to inhibit virtually all Cdc25 phosphatases by a novel common mechanism...
  16. ncbi Erp1/Emi2 is essential for the meiosis I to meiosis II transition in Xenopus oocytes
    Munemichi Ohe
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka 812 8581, Japan
    Dev Biol 303:157-64. 2007
    ..Thus, our results show the essential role for Erp1 in the meiosis I/meiosis II transition in Xenopus oocytes and can explain why normally maturing oocytes cannot arrest at Meta-I...
  17. ncbi [Regulation of the cell cycle and checkpoint by SCF(beta-TrCP)]
    Yoshinori Kanemori
    Tanpakushitsu Kakusan Koso 51:1386-90. 2006
  18. pmc Emi2 inhibition of the anaphase-promoting complex/cyclosome absolutely requires Emi2 binding via the C-terminal RL tail
    Munemichi Ohe
    Department of Biology, Graduate School of Sciences, Kyushu University, Fukuoka 812 8581, Japan
    Mol Biol Cell 21:905-13. 2010
    ..We propose that the RL tail of Emi1/Emi2 serves as a docking site for the APC/C, thereby promoting the interaction and inhibition of the APC/C by the D-box and the ZBR...
  19. pmc Mechanism of degradation of CPEB during Xenopus oocyte maturation
    Daiki Setoyama
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka 812 8581, Japan
    Proc Natl Acad Sci U S A 104:18001-6. 2007
    ..We propose that Cdc2 and Plx1 sequentially phosphorylate CPEB and target it for SCF(beta-TrCP)-dependent degradation in Xenopus oocytes. We suggest that many other proteins carrying the TSG-like motif may be targeted by SCF(beta-TrCP)...
  20. ncbi A direct link of the Mos-MAPK pathway to Erp1/Emi2 in meiotic arrest of Xenopus laevis eggs
    Daigo Inoue
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka 812 8581, Japan
    Nature 446:1100-4. 2007
    ..These results clarify the direct link of the classical Mos-MAPK pathway to Erp1 in meiotic arrest of vertebrate oocytes...
  21. pmc Mechanism for inactivation of the mitotic inhibitory kinase Wee1 at M phase
    Kengo Okamoto
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka 812 8581, Japan
    Proc Natl Acad Sci U S A 104:3753-8. 2007
    ..These results provide important insights into the mechanism of Wee1 inactivation at M phase...
  22. pmc Beta-TrCP recognizes a previously undescribed nonphosphorylated destruction motif in Cdc25A and Cdc25B phosphatases
    Yoshinori Kanemori
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka 812 8581, Japan
    Proc Natl Acad Sci U S A 102:6279-84. 2005
    ....
  23. pmc The Mos/MAP kinase pathway stabilizes c-Fos by phosphorylation and augments its transforming activity in NIH 3T3 cells
    K Okazaki
    Division of Molecular Genetics, Institute of Life Science, Kurume University, Fukuoka, Japan
    EMBO J 14:5048-59. 1995
    ..The present findings also suggest that, in general, the ERK pathway may regulate the cell fate and function by affecting the metabolic stability of c-Fos...
  24. ncbi Isolation of a cDNA encoding the X enopus homologue of mammalian Cdc25A that can induce meiotic maturation of oocytes
    K Okazaki
    Division of Molecular Genetics, Kurume University, Fukuoka, Japan
    Gene 178:111-4. 1996
    ..When its mRNA is injected into Xl oocytes, Xl Cdc25A can act as a potent M phase inducer...
  25. doi FoxM1-driven cell division is required for neuronal differentiation in early Xenopus embryos
    Hiroyuki Ueno
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka 812 8581, Japan
    Development 135:2023-30. 2008
    ..These results suggest that FoxM1 functions to link cell division and neuronal differentiation in early Xenopus embryos...
  26. ncbi Requirement for both EDEN and AUUUA motifs in translational arrest of Mos mRNA upon fertilization of Xenopus eggs
    Shuichi Ueno
    Department of Biology, Graduate School of Sciences, Kyushu University, Hakozaki 6 10 1, Fukuoka, Japan
    Dev Biol 250:156-67. 2002
    ..These results suggest that the EDEN, only together with appropriately positioned AUUUA motifs and a trans-acting factor(s), can efficiently deadenylate and hence translationally arrest Mos (as well as Eg2) mRNA after fertilization...
  27. ncbi Mr 25 000 protein, a substrate for protein serine/threonine kinases, is identified as a part of Xenopus laevis vitellogenin B1
    Satoshi Yoshitome
    Division of Pathological Biochemistry, Department of Biomedical Sciences, School of Life Sciences, Faculty of Medicine, Tottori University, 86 Nishicho, Yonago 683 8503, Japan
    Dev Growth Differ 45:283-94. 2003
    ..These results suggest that pp25 is a cytosolic non-crystallized yolk protein nutrient source, but it might also play a role in rapid development...
  28. ncbi The C-terminal seven amino acids in the cytoplasmic retention signal region of cyclin B2 are required for normal bipolar spindle formation in Xenopus oocytes and embryos
    Satoshi Yoshitome
    Department of Biomedical Sciences, School of Life Sciences, Tottori University, Yonago, Japan
    Mol Cancer Res 1:589-97. 2003
    ..These results suggest strongly that the CRS region, especially its C-terminal seven acidic residues, of cyclin B2 is required for bipolar spindle formation in both the meiotic and mitotic cell divisions...
  29. ncbi Expression of cell-cycle regulators during Xenopus oogenesis
    Nobuaki Furuno
    Division of Differentiation Mechanism, Institute for Amphibian Biology, Graduate School of Science, Hiroshima University, 1 3 1 Kagamiyama, Higashihiroshima 739 8526, Japan
    Gene Expr Patterns 3:165-8. 2003
    ..In contrast, positive regulators of MPF, MEK, MAPK and Cdc25C, were mainly synthesized late in oogenesis. Northern blotting analysis suggested that the synthesis of these cell-cycle regulators was controlled by translation...