Jun ichi Oyama

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. doi request reprint Hyperthermia by bathing in a hot spring improves cardiovascular functions and reduces the production of inflammatory cytokines in patients with chronic heart failure
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, Oita, 874 0838, Japan
    Heart Vessels 28:173-8. 2013
  2. doi request reprint Repetitive hyperthermia attenuates progression of left ventricular hypertrophy and increases telomerase activity in hypertensive rats
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital at Beppu, Japan
    Am J Physiol Heart Circ Physiol 302:H2092-101. 2012
  3. doi request reprint Continuous positive airway pressure therapy improves vascular dysfunction and decreases oxidative stress in patients with the metabolic syndrome and obstructive sleep apnea syndrome
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, Oita, Japan
    Clin Cardiol 35:231-6. 2012
  4. doi request reprint Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, Oita, Japan
    Heart Vessels 25:379-85. 2010
  5. ncbi request reprint Green tea catechins improve human forearm vascular function and have potent anti-inflammatory and anti-apoptotic effects in smokers
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital, Beppu
    Intern Med 49:2553-9. 2010
  6. ncbi request reprint Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, Japan
    Circ J 74:578-88. 2010
  7. ncbi request reprint The physical ability of elderly female Japanese patients with cerebrovascular disease correlates with telomere length in their peripheral blood leukocytes
    Toyoki Maeda
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Oita, 874 0838, Japan
    Aging Clin Exp Res 23:22-8. 2011
  8. doi request reprint Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice
    Naoki Makino
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    J Mol Cell Cardiol 50:670-7. 2011
  9. ncbi request reprint Change in the telomere length distribution with age in the Japanese population
    Jing Zhi Guan
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Kyushu University, 4546 Tsurumihara, Beppu, Oita 874 0838, Japan
    Mol Cell Biochem 304:353-60. 2007
  10. ncbi request reprint An analysis of telomere length in sarcoidosis
    Jing Zhi Guan
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Oita, Japan
    J Gerontol A Biol Sci Med Sci 62:1199-203. 2007

Collaborators

Detail Information

Publications22

  1. doi request reprint Hyperthermia by bathing in a hot spring improves cardiovascular functions and reduces the production of inflammatory cytokines in patients with chronic heart failure
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, Oita, 874 0838, Japan
    Heart Vessels 28:173-8. 2013
    ..The improvement of BNP correlates with the changes in inflammatory biomarkers. Repeated hyperthermia by bathing in a hot spring is therefore considered to improve the cardiac and inflammatory status in patients with CHF...
  2. doi request reprint Repetitive hyperthermia attenuates progression of left ventricular hypertrophy and increases telomerase activity in hypertensive rats
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital at Beppu, Japan
    Am J Physiol Heart Circ Physiol 302:H2092-101. 2012
    ..In conclusion, RHT attenuates the development of cardiac hypertrophy and fibrosis and preserves telomerase, TERT activity and the length of telomere DNA in salt-induced hypertensive rats through activation of eNOS and induction of HSPs...
  3. doi request reprint Continuous positive airway pressure therapy improves vascular dysfunction and decreases oxidative stress in patients with the metabolic syndrome and obstructive sleep apnea syndrome
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, Oita, Japan
    Clin Cardiol 35:231-6. 2012
    ..Therefore, nasal continuous positive airway pressure (CPAP) therapy may have beneficial effects in patients with the MetS and OSAS...
  4. doi request reprint Scavenging free radicals improves endothelial dysfunction in human coronary arteries in vivo
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, Oita, Japan
    Heart Vessels 25:379-85. 2010
    ..Therefore, the current results suggest that scavenging free radicals has a beneficial effect for patients with coronary endothelial dysfunction...
  5. ncbi request reprint Green tea catechins improve human forearm vascular function and have potent anti-inflammatory and anti-apoptotic effects in smokers
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory, and Geriatric Medicine, Kyushu University Hospital, Beppu
    Intern Med 49:2553-9. 2010
    ..Green tea catechins may improve peripheral endothelial dysfunction in smokers. The purpose of this study was to elucidate the beneficial effect of green tea catechins on the repair of endothelial dysfunction in smokers...
  6. ncbi request reprint Green tea catechins improve human forearm endothelial dysfunction and have antiatherosclerotic effects in smokers
    Jun ichi Oyama
    Department of Cardiovascular, Respiratory and Geriatric Medicine, Kyushu University Hospital at Beppu and Medical Institute of Bioregulation, Kyushu University, Japan
    Circ J 74:578-88. 2010
    ..Because green tea reduces cardiovascular and cerebrovascular risk, the purpose of this study aimed to elucidate the effect of green tea catechins (GTC) on endothelial dysfunction in smokers...
  7. ncbi request reprint The physical ability of elderly female Japanese patients with cerebrovascular disease correlates with telomere length in their peripheral blood leukocytes
    Toyoki Maeda
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Oita, 874 0838, Japan
    Aging Clin Exp Res 23:22-8. 2011
    ..However, correlations between telomere length in peripheral blood leukocytes and patients' physical ability are not known...
  8. doi request reprint Antioxidant therapy attenuates myocardial telomerase activity reduction in superoxide dismutase-deficient mice
    Naoki Makino
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    J Mol Cell Cardiol 50:670-7. 2011
    ..Telomerase may therefore play a pivotal role in antioxidant defense mechanisms, and may be useful as a novel therapeutic tool for treating human heart failure...
  9. ncbi request reprint Change in the telomere length distribution with age in the Japanese population
    Jing Zhi Guan
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Kyushu University, 4546 Tsurumihara, Beppu, Oita 874 0838, Japan
    Mol Cell Biochem 304:353-60. 2007
    ..This contrast implies a drastic change around the age of 50 of unknown factors that affect telomere attrition...
  10. ncbi request reprint An analysis of telomere length in sarcoidosis
    Jing Zhi Guan
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Oita, Japan
    J Gerontol A Biol Sci Med Sci 62:1199-203. 2007
    ..These findings suggest the occurrence of age-advanced changes in telomere length in patients with sarcoidosis, regardless of the patient age at the onset of sarcoidosis...
  11. doi request reprint The physical ability of Japanese female elderly with cerebrovascular disease correlates with the telomere length and subtelomeric methylation status in their peripheral blood leukocytes
    Toyoki Maeda
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Kyushu University, Oita, Japan
    Gerontology 57:137-43. 2011
    ..However, the correlation between the telomeric parameters and patients' physical ability is not known...
  12. ncbi request reprint Beneficial effects of angiotensin-converting enzyme inhibition on sarcoplasmic reticulum function in the failing heart of the Dahl rat
    Shinji Satoh
    Department of Bioclimatology and Medicine, Medical Institute of Bioregulation, Kyushu University, Japan
    Circ J 67:705-11. 2003
    ....
  13. pmc Age-related changes in subtelomeric methylation in the normal Japanese population
    Toyoki Maeda
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, Oita 874 0838, Japan
    J Gerontol A Biol Sci Med Sci 64:426-34. 2009
    ..The telomeres of somatic cells become shorter with individual aging. However, no significant change in subtelomeric methylation of somatic cells with aging has yet been reported...
  14. doi request reprint Improving insulin sensitivity via activation of PPAR-gamma increases telomerase activity in the heart of OLETF rats
    Naoki Makino
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu 874 0838, Japan
    Am J Physiol Heart Circ Physiol 297:H2188-95. 2009
    ....
  15. doi request reprint Aging-related alterations of subtelomeric methylation in sarcoidosis patients
    Toyoki Maeda
    Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Tsurumihara, Beppu, Oita, Japan
    J Gerontol A Biol Sci Med Sci 64:752-60. 2009
    ..This altered subtelomeric hypomethylation may correspond to the accelerated telomere shortening in sarcoidosis. This also means that the subtelomeric hypomethylation can be also influenced by certain disease conditions...
  16. ncbi request reprint A percentage analysis of the telomere length in Parkinson's disease patients
    Jing Zhi Guan
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    J Gerontol A Biol Sci Med Sci 63:467-73. 2008
    ..1 to 9.4 kb in the patients in their 50s and 60s. These observations suggest that telomere shortening is accelerated in PD patients in comparison to the normal population...
  17. doi request reprint The correlation between clinical laboratory data and telomeric status of male patients with metabolic disorders and no clinical history of vascular events
    Toyoki Maeda
    The Division of Molecular and Clinical Gerontology, The Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Beppu, Oita, 874 0838, Japan
    Aging Male 14:21-6. 2011
    ..Lowered serum bilirubin and creatinine phosphokinase level correlated to genomic aging represented by telomere attrition of patients with metabolic disorders...
  18. ncbi request reprint Increased productivity of tumor necrosis factor-alpha in helper T cells in patients with systolic heart failure
    Shinji Satoh
    Division of Cardiovascular and Geriatric Medicine, Kyushu University Hospital at Beppu, Beppu 874 0838, Japan
    Int J Cardiol 111:405-12. 2006
    ..We studied the productivity of TNF-alpha in peripheral lymphocytes and underlying mechanisms in patients with heart failure...
  19. ncbi request reprint Local delivery of soluble TNF-alpha receptor 1 gene reduces infarct size following ischemia/reperfusion injury in rats
    Masahiro Sugano
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Tsurumihara, Beppu, Oita, Japan
    Mol Cell Biochem 266:127-32. 2004
    ..Suppression of TNF-alpha bioactivity with the sTNFR1 plasmid reduced the infarct size in AMI following ischemia and reperfusion...
  20. ncbi request reprint Transient receptor potential (TRP) protein 7 acts as a G protein-activated Ca2+ channel mediating angiotensin II-induced myocardial apoptosis
    Shinji Satoh
    Division of Molecular and Clinical Gerontology, Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, 874 0838, Japan
    Mol Cell Biochem 294:205-15. 2007
    ..TRPC7 might be a key initiator linking AT1-activation to myocardial apoptosis, and thereby contributing to the process of heart failure...
  21. doi request reprint Aging-associated alteration of subtelomeric methylation in Parkinson's disease
    Toyoki Maeda
    Department of Molecular and Cellular Biology, Division of Molecular and Clinical Gerontology, Medical Institute of Bioregulation, Kyushu University, 4546 Tsurumihara, Beppu, Oita 874 0838, Japan
    J Gerontol A Biol Sci Med Sci 64:949-55. 2009
    ..The correlation between the telomeric attrition and the subtelomeric methylated state in PD is herein discussed...
  22. doi request reprint Oleic acid-induced ADRP expression requires both AP-1 and PPAR response elements, and is reduced by Pycnogenol through mRNA degradation in NMuLi liver cells
    Bin Fan
    Division of Clinical Immunology, Department of Immunobiology and Neuroscience, Medical Institute of Bioregulation, Kyushu University, Beppu 874 0838, Japan
    Am J Physiol Endocrinol Metab 297:E112-23. 2009
    ..PYC, a widely used dietary supplement, could be beneficial for the prevention of excessive lipid accumulation such as hepatic steatosis...