Mayumi Ono

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells
    Shunji Aoki
    Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Anticancer Drugs 17:269-78. 2006
  2. doi request reprint N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression
    Fumihito Hosoi
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 69:4983-91. 2009
  3. ncbi request reprint Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells
    Yuichi Murakami
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 396:376-81. 2010
  4. ncbi request reprint Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs
    Mayumi Ono
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 12:7242-51. 2006
  5. ncbi request reprint Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation
    Mayumi Ono
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Cancer Ther 3:465-72. 2004
  6. ncbi request reprint HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells
    Akira Hirata
    Departments of Medical Biochemistry and Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Cancer Res 65:4253-60. 2005
  7. doi request reprint Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations
    Chizuko Yamamoto
    Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 70:8715-25. 2010
  8. pmc N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells
    Yuichi Murakami
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Biol Chem 288:25025-37. 2013
  9. ncbi request reprint Synergistic effect of TNF-alpha in soluble VCAM-1-induced angiogenesis through alpha 4 integrins
    Shintaro Nakao
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 170:5704-11. 2003
  10. ncbi request reprint Alteration of dihydropyrimidine dehydrogenase expression by IFN-alpha affects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells
    Shinji Oie
    Station II for Collaborative Research, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan 812 8582
    Mol Cancer Ther 6:2310-8. 2007

Detail Information

Publications67

  1. ncbi request reprint Bastadin 6, a spongean brominated tyrosine derivative, inhibits tumor angiogenesis by inducing selective apoptosis to endothelial cells
    Shunji Aoki
    Graduate School of Pharmaceutical Sciences, Osaka University, Osaka, Japan
    Anticancer Drugs 17:269-78. 2006
    ..These results suggest that the anti-angiogenic effect of bastadin 6 is closely related to selective induction activity of apoptosis against endothelial cells...
  2. doi request reprint N-myc downstream regulated gene 1/Cap43 suppresses tumor growth and angiogenesis of pancreatic cancer through attenuation of inhibitor of kappaB kinase beta expression
    Fumihito Hosoi
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 69:4983-91. 2009
    ..This study suggests a novel mechanism by which NDRG1/Cap43 modulates tumor angiogenesis/growth and infiltration of macrophages/neutrophils through attenuation of NF-kappaB signaling...
  3. ncbi request reprint Identification of sites subjected to serine/threonine phosphorylation by SGK1 affecting N-myc downstream-regulated gene 1 (NDRG1)/Cap43-dependent suppression of angiogenic CXC chemokine expression in human pancreatic cancer cells
    Yuichi Murakami
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 396:376-81. 2010
    ..Phosphorylation of NDRG1/Cap43 at both serine330 and threonine346 is required for its suppressive action on the NF-kappaB signaling pathway and CXC chemokine expression in pancreatic cancer cells...
  4. ncbi request reprint Molecular mechanisms of epidermal growth factor receptor (EGFR) activation and response to gefitinib and other EGFR-targeting drugs
    Mayumi Ono
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 12:7242-51. 2006
    ....
  5. ncbi request reprint Sensitivity to gefitinib (Iressa, ZD1839) in non-small cell lung cancer cell lines correlates with dependence on the epidermal growth factor (EGF) receptor/extracellular signal-regulated kinase 1/2 and EGF receptor/Akt pathway for proliferation
    Mayumi Ono
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Cancer Ther 3:465-72. 2004
    ....
  6. ncbi request reprint HER2 overexpression increases sensitivity to gefitinib, an epidermal growth factor receptor tyrosine kinase inhibitor, through inhibition of HER2/HER3 heterodimer formation in lung cancer cells
    Akira Hirata
    Departments of Medical Biochemistry and Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Cancer Res 65:4253-60. 2005
    ..This study is the first to show that under basal growth conditions, HER2 sensitizes low-EGFR NSCLC cell lines to growth inhibition by gefitinib...
  7. doi request reprint Loss of PTEN expression by blocking nuclear translocation of EGR1 in gefitinib-resistant lung cancer cells harboring epidermal growth factor receptor-activating mutations
    Chizuko Yamamoto
    Department of Pharmaceutical Oncology and Laboratory of Molecular Cancer Biology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 70:8715-25. 2010
    ..Our findings reinforce the therapeutic importance of PTEN expression in the treatment of NSCLC with EGFR-targeted drugs...
  8. pmc N-myc downstream-regulated gene 1 promotes tumor inflammatory angiogenesis through JNK activation and autocrine loop of interleukin-1α by human gastric cancer cells
    Yuichi Murakami
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Biol Chem 288:25025-37. 2013
    ..Together, activation of JNK/AP-1 thus seems to promote tumor angiogenesis in relationship to NDRG1-induced inflammatory stimuli by gastric cancer cells. ..
  9. ncbi request reprint Synergistic effect of TNF-alpha in soluble VCAM-1-induced angiogenesis through alpha 4 integrins
    Shintaro Nakao
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 170:5704-11. 2003
    ..These results suggest that sVCAM-1/alpha(4) integrin induces angiogenesis through p38 and FAK signaling pathways...
  10. ncbi request reprint Alteration of dihydropyrimidine dehydrogenase expression by IFN-alpha affects the antiproliferative effects of 5-fluorouracil in human hepatocellular carcinoma cells
    Shinji Oie
    Station II for Collaborative Research, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan 812 8582
    Mol Cancer Ther 6:2310-8. 2007
    ..Inhibition of DPD activity by CDHP may enhance the efficacy of IFN-alpha and 5-FU combination therapy in patients with HCC showing resistance to this therapy...
  11. doi request reprint Role of macrophages in inflammatory lymphangiogenesis: Enhanced production of vascular endothelial growth factor C and D through NF-kappaB activation
    Kosuke Watari
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Biochem Biophys Res Commun 377:826-31. 2008
    ..Furthermore, IL-1beta-induced lymphangiogenesis and angiogenesis were suppressed by NF-kappaB inhibition with marked suppression of VEGF-A, VEGF-C, and VEGF-D expression...
  12. pmc N-myc downstream regulated gene 1 (NDRG1) promotes metastasis of human scirrhous gastric cancer cells through epithelial mesenchymal transition
    Hiroki Ureshino
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Fukuoka, Japan
    PLoS ONE 7:e41312. 2012
    ..This is the first study to demonstrate that NDRG1 plays its pivotal role in the malignant progression of gastric cancer through epithelial mesenchymal transition...
  13. doi request reprint The antitumor effect of a novel angiogenesis inhibitor (an octahydronaphthalene derivative) targeting both VEGF receptor and NF-κB pathway
    Kosuke Watari
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 131:310-21. 2012
    ..AMF-26 could be a promising novel candidate drug for cancer treatments...
  14. ncbi request reprint cis-hinokiresinol, a norlignan from Anemarrhena asphodeloides, inhibits angiogenic response in vitro and in vivo
    Sei Joon Jeong
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Biol Pharm Bull 26:1721-4. 2003
    ..Moreover, CHR reduced the vessel growth induced by VEGF in the mouse corneal neovascularization model. These results suggest that CHR may prove useful for the development of a novel angiogenesis inhibitor...
  15. doi request reprint Y-box binding protein-1 contributes to both HER2/ErbB2 expression and lapatinib sensitivity in human gastric cancer cells
    Tomohiro Shibata
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Mol Cancer Ther 12:737-46. 2013
    ..The YB-1-HER2 axis may therefore be useful for the further development of personalized therapeutics against gastric cancer by HER2-targeted drugs...
  16. ncbi request reprint The up-regulation of type I interferon receptor gene plays a key role in hepatocellular carcinoma cells in the synergistic antiproliferative effect by 5-fluorouracil and interferon-alpha
    Shinji Oie
    Station II for Collaborative Research, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Int J Oncol 29:1469-78. 2006
    ..Measuring the expression levels of IFN receptors, and their ability to be up-regulated, may be a promising method for selecting HCC patients for this type of combination therapy...
  17. ncbi request reprint The basic and clinical implications of ABC transporters, Y-box-binding protein-1 (YB-1) and angiogenesis-related factors in human malignancies
    Michihiko Kuwano
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582
    Cancer Sci 94:9-14. 2003
    ..Angiogenesis is also involved in tumor growth, invasion and metastasis of various malignancies, and so angiogenesis-related molecules also offer novel molecular targets for anticancer therapeutics...
  18. ncbi request reprint Costunolide, a sesquiterpene lactone from Saussurea lappa, inhibits the VEGFR KDR/Flk-1 signaling pathway
    Sei Joon Jeong
    Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Lett 187:129-33. 2002
    ..Moreover, administration of CT reduced VEGF-induced neovascularization in a mouse corneal micropocket assay. These results suggest that CT may prove useful for the development of a novel angiogenesis inhibitor...
  19. doi request reprint Sorting nexin 2-mediated membrane trafficking of c-Met contributes to sensitivity of molecular-targeted drugs
    Sayaka Ogi
    Department of Pharmaceutical Oncology, Kyushu University, Fukuoka, Japan
    Cancer Sci 104:573-83. 2013
    ..These findings suggest that development of drugs targeting SNX2 could be useful in overcoming drug resistance to EGFR-targeted drugs in lung cancer cells harboring c-Met gene amplification...
  20. doi request reprint Nuclear Y-box binding protein-1, a predictive marker of prognosis, is correlated with expression of HER2/ErbB2 and HER3/ErbB3 in non-small cell lung cancer
    Masaki Kashihara
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    J Thorac Oncol 4:1066-74. 2009
    ..Nuclear expression of Y-box binding protein-1 (YB-1) is closely associated not only with global drug resistance and expression of several growth factor receptors in various human malignancies but also with overall patient survival...
  21. ncbi request reprint 17Beta-estradiol induces down-regulation of Cap43/NDRG1/Drg-1, a putative differentiation-related and metastasis suppressor gene, in human breast cancer cells
    Abbas Fotovati
    Center for Innovative Cancer Therapy of the 21st Century Center of Excellence Program for Medical Science and Departments of Surgery and Pathology, Kurume University, Kurume, Fukuoka, Japan
    Clin Cancer Res 12:3010-8. 2006
    ..Cap43 is known as a nickel- and calcium-inducible gene. In the present study, we examined whether 17beta-estradiol (E2) could affect the expression of Cap43 in breast cancer...
  22. ncbi request reprint Cyclooxygenase 2 is a key enzyme for inflammatory cytokine-induced angiogenesis
    Takashi Kuwano
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    FASEB J 18:300-10. 2004
    ..IL-1beta induced much less angiogenesis in cornea of COX2 knockout mice than that of wild-type mice. This is the first report that COX2 and some prostanoids play a key role in IL-1beta-induced angiogenesis...
  23. ncbi request reprint Studies on lymphangiogenesis inhibitors from Korean and Japanese crude drugs
    Dami Jeong
    Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Biol Pharm Bull 36:152-7. 2013
    ..These compounds might offer clinical benefits as lymphangiogenesis inhibitors and may be good candidates for novel anti-cancer and anti-metastatic agents...
  24. ncbi request reprint PTEN/Akt signaling through epidermal growth factor receptor is prerequisite for angiogenesis by hepatocellular carcinoma cells that is susceptible to inhibition by gefitinib
    Shu ichi Ueda
    Department of Medical Biochemistry, Graduate School of Medical Science and Station II for Collaborative Research, Kyushu University, Fukuoka, Japan
    Cancer Res 66:5346-53. 2006
    ..In conclusion, effect of gefitinib on HCC-induced angiogenesis depends on its inhibition of the production of angiogenic factors, probably involving a PTEN/Akt signaling pathway...
  25. pmc Infiltration of COX-2-expressing macrophages is a prerequisite for IL-1 beta-induced neovascularization and tumor growth
    Shintaro Nakao
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Clin Invest 115:2979-91. 2005
    ..A COX-2 inhibitor reduced tumor growth, angiogenesis, and macrophage infiltration in LLC/IL-1beta. Thus, macrophage involvement might be a prerequisite for IL-1beta-induced neovascularization and tumor progression...
  26. ncbi request reprint Preclinical and clinical studies of novel breast cancer drugs targeting molecules involved in protein kinase C signaling, the putative metastasis-suppressor gene Cap43 and the Y-box binding protein-1
    Teruhiko Fujii
    National Hospital Organization Kyushu Medical Cancer, Department of Surgery, Clinical Research Institute, Fukuoka, Japan
    Curr Med Chem 15:528-37. 2008
    ....
  27. ncbi request reprint ZD1839 (Iressa) induces antiangiogenic effects through inhibition of epidermal growth factor receptor tyrosine kinase
    Akira Hirata
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Res 62:2554-60. 2002
    ....
  28. doi request reprint Structure, synthesis, and biological activity of a C-20 bisacetylenic alcohol from a marine sponge Callyspongia sp
    Takayuki Shirouzu
    Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    J Nat Prod 76:1337-42. 2013
    ....
  29. ncbi request reprint Antiangiogenic effect by SU5416 is partly attributable to inhibition of Flt-1 receptor signaling
    Takashi Itokawa
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Mol Cancer Ther 1:295-302. 2002
    ..Cell migration of vascular endothelial cells and monocytic cells through Flt-1, thus, might play a key role in VEGF-induced tumor angiogenesis in concert with KDR/Flk-1...
  30. ncbi request reprint Expression profile of class I histone deacetylases in human cancer tissues
    Masamune Nakagawa
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Oncol Rep 18:769-74. 2007
    ..Furthermore, 5-40% of cancer tissues overexpressed class I HDACs, when compared with normal epithelium. The results suggest the potential usefulness of HDAC inhibitors for the treatment of a wide variety of human cancers...
  31. ncbi request reprint Direct inhibition of EGF receptor activation in vascular endothelial cells by gefitinib ('Iressa', ZD1839)
    Akira Hirata
    Department of Medical Biochemistry, Graduate School of Medical Science, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Cancer Sci 95:614-8. 2004
    ....
  32. doi request reprint N-myc downstream regulated gene-1/Cap43 may play an important role in malignant progression of prostate cancer, in its close association with E-cadherin
    YooHyun Song
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 41:214-22. 2010
    ..0175). NDRG1/Cap43 could be a novel marker for malignant progression and poor prognosis in prostate cancer, plausibly in its close association with the down-regulation of E-cadherin expression...
  33. doi request reprint Y-box binding protein-1 (YB-1) promotes cell cycle progression through CDC6-dependent pathway in human cancer cells
    Yuji Basaki
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Cancer 46:954-65. 2010
    ..In conclusion, YB-1 plays an important role in cell cycle progression at G1/S of human cancer cells. YB-1 thus could be a potent biomarker for tumour growth and cell cycle in its close association with CDC6...
  34. doi request reprint Peroxiredoxins, thioredoxin, and Y-box-binding protein-1 are involved in the pathogenesis and progression of dialysis-associated renal cell carcinoma
    Fumiyoshi Fushimi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka, Japan
    Virchows Arch 463:553-62. 2013
    ..Once cancer has developed, antioxidant activity might have a stimulating effect on the progression of dialysis RCC. ..
  35. doi request reprint Association of the expression of mutant epidermal growth factor receptor protein as determined with mutation-specific antibodies in non-small cell lung cancer with progression-free survival after gefitinib treatment
    Koichi Azuma
    Division of Respirology, Neurology, and Rheumatology, Department of Internal Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan
    J Thorac Oncol 7:122-7. 2012
    ..Molecular markers for prediction of EGFR-TKI treatment efficacy in EGFR mutation-positive NSCLC have not been well defined...
  36. doi request reprint Molecular links between tumor angiogenesis and inflammation: inflammatory stimuli of macrophages and cancer cells as targets for therapeutic strategy
    Mayumi Ono
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 99:1501-6. 2008
    ..Thus, both inflammatory and angiogenic responses in tumor stroma could be targets for development of anticancer therapeutic drugs...
  37. pmc Loss of activating EGFR mutant gene contributes to acquired resistance to EGFR tyrosine kinase inhibitors in lung cancer cells
    Keisuke Tabara
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e41017. 2012
    ..Our study indicates that loss of addiction to mutant EGFR resulted in gain of addiction to both HER2/HER3 and PI3K/Akt signaling to acquire EGFR-TKI resistance...
  38. ncbi request reprint 1,3-dimethylisoguaninium, an antiangiogenic purine analog from the sponge Amphimedon paraviridis
    Sei Joon Jeong
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Chem Pharm Bull (Tokyo) 51:731-3. 2003
    ..Compound 1 exhibited specific inhibition of the basic fibroblast growth factor (bFGF)-induced proliferation of bovine aorta endothelial cells (BAECs). Moreover, compound 1 reduced the tube formation of BAECs in a time-dependent manner...
  39. ncbi request reprint [Screening of antiangiogenic compound]
    Mayumi Ono
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Gan To Kagaku Ryoho 31:518-21. 2004
    ..Various angiogenesis inhibitors have been developed to block tumor angiogenesis. However we need to think how and when to use angiogenesis inhibitors together with conventional chemotherapeutic agents...
  40. ncbi request reprint The EGFR inhibitor gefitinib suppresses ligand-stimulated endocytosis of EGFR via the early/late endocytic pathway in non-small cell lung cancer cell lines
    Yukio Nishimura
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Histochem Cell Biol 127:541-53. 2007
    ..Thus, impairment in some steps of the EGF-EGFR traffic out of early endosomes toward the late endosomes/lysosomes might confer gefitinib-resistance in NSCLC cell lines...
  41. doi request reprint Circadian regulation of mTOR by the ubiquitin pathway in renal cell carcinoma
    Hiroyuki Okazaki
    Authors Affiliations Departments of Pharmaceutics and Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 74:543-51. 2014
    ..Our findings demonstrate that the circadian oscillation of mTOR activity is regulated by circadian clock systems, which influence the antitumor effect of mTOR inhibitors...
  42. pmc Tumor-Derived Interleukin-1 Promotes Lymphangiogenesis and Lymph Node Metastasis through M2-Type Macrophages
    Kosuke Watari
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 9:e99568. 2014
    ..Accordingly, the IL-1R/M2-type macrophage axis may be a good therapeutic target for patients with this form of lung cancer. ..
  43. pmc Dexamethasone inhibits interleukin-1beta-induced corneal neovascularization: role of nuclear factor-kappaB-activated stromal cells in inflammatory angiogenesis
    Shintaro Nakao
    Department of Ophthalmology, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Am J Pathol 171:1058-65. 2007
    ....
  44. ncbi request reprint Prognostic implications of the nuclear localization of Y-box-binding protein-1 and CXCR4 expression in ovarian cancer: their correlation with activated Akt, LRP/MVP and P-glycoprotein expression
    Yoshinao Oda
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 98:1020-6. 2007
    ..These results indicate that YB-1 nuclear expression and CXCR4 expression are important prognostic factors in ovarian carcinoma...
  45. ncbi request reprint Downregulation of Cap43 gene by von Hippel-Lindau tumor suppressor protein in human renal cancer cells
    Katsuaki Masuda
    Department of Medical Biochemistry, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 105:803-10. 2003
    ..Although the function of the Cap43 protein remains unclear, the expression of Cap43 protein could be a molecular marker closely associated with VHL in renal cancer...
  46. doi request reprint A natural anti-inflammatory enone fatty acid inhibits angiogenesis by attenuating nuclear factor-κB signaling in vascular endothelial cells
    Ayana Furuno
    Department of Pharmaceutical Oncology, Graduate School of Pharmaceutical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Int J Oncol 38:493-501. 2011
    ....
  47. pmc Macrophage infiltration predicts a poor prognosis for human ewing sarcoma
    Toshifumi Fujiwara
    Department of Orthopaedic Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Am J Pathol 179:1157-70. 2011
    ..TAMs seem to enhance the progression of EWS by stimulating both angiogenesis and osteoclastogenesis. Further investigation of the behavior of TAMs may lead to development of biologically targeted therapies for EWS...
  48. pmc Suppression of Sproutys has a therapeutic effect for a mouse model of ischemia by enhancing angiogenesis
    Koji Taniguchi
    Division of Molecular and Cellular Immunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan
    PLoS ONE 4:e5467. 2009
    ..These data suggest that Sproutys are physiologically important negative regulators of angiogenesis in vivo and novel therapeutic targets for treating peripheral ischemic diseases...
  49. ncbi request reprint Bryoanthrathiophene, a new antiangiogenic constituent from the bryozoan Watersipora subtorquata (d'Orbigny, 1852)
    Sei Joon Jeong
    Graduate School of Pharmaceutical Sciences and Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Nat Prod 65:1344-5. 2002
    ..Among them, bryoanthrathiophene (1) exhibited the most potent antiangiogenic activity on BAEC (bovine aorta endothelial cell) proliferation...
  50. ncbi request reprint Radiosynthesis and in vivo evaluation of 11C-labeled 1,5-diarylpyrazole derivatives for mapping cyclooxygenases
    Yoshihiko Fujisaki
    Graduate School of Pharmaceutical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Ann Nucl Med 19:617-25. 2005
    ..The results suggest that neither [11C]1 nor [11C]2 is a suitable radioligand for in vivo biomarkers of COX enzymes, mainly because of marked non-specific binding...
  51. doi request reprint Ets regulates peroxiredoxin1 and 5 expressions through their interaction with the high-mobility group protein B1
    Masaki Shiota
    Department of Molecular Biology, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan
    Cancer Sci 99:1950-9. 2008
    ..Silencing of Ets1, Ets2, Prdx1, and Prdx5 expression sensitized cells to oxidative stress. These data indicate that transcription of Prdx genes mediated by Ets/HMG proteins might protect cells from oxidative stress...
  52. ncbi request reprint High expression of insulin-like growth factor binding protein-3 is correlated with lower portal invasion and better prognosis in human hepatocellular carcinoma
    Shinichi Aishima
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 97:1182-90. 2006
    ..Low expression of IGFBP-3 was independently associated with poor survival. IGFBP-3 could be a molecular target of intrinsic importance for further development of novel therapeutic strategy against HCC...
  53. ncbi request reprint Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells--transcriptional activation and messenger RNA stabilization
    Masahiro Okamoto
    Department of Medical Biochemistry, Kyushu University, Fukuoka, Japan
    Biochim Biophys Acta 1574:24-34. 2002
    ..The up-regulation of TSP-1 by EGF and TGFbeta might play a critical role in modulation of angiogenesis and formation of matrices in tumor stroma...
  54. ncbi request reprint Suppression of thymidine phosphorylase-mediated angiogenesis and tumor growth by 2-deoxy-L-ribose
    Hiroshi Uchimiya
    Department of Cancer Chemotherapy, Institute for Cancer Research, Kagoshima University, Faculty of Medicine, Sakuragaoka 8 35 1, Kagoshima 890 8520, Japan
    Cancer Res 62:2834-9. 2002
    ..Thus, lRib is a potentially useful agent for the suppression of TP-dependent angiogenesis and tumor growth...
  55. doi request reprint Molecular basis for the induction of an angiogenesis inhibitor, thrombospondin-1, by 5-fluorouracil
    Hong ye Zhao
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka, Kagoshima, Japan
    Cancer Res 68:7035-41. 2008
    ..These findings suggest that the p38 MAPK pathway plays a crucial role in the induction of Egr-1 by 5-FU and that induced Egr-1 augments TSP-1 promoter activity, with the subsequent production of TSP-1 mRNA and protein...
  56. ncbi request reprint Potent inhibition of in vivo angiogenesis and tumor growth by a novel cyclooxygenase-2 inhibitor, enoic acanthoic acid
    Hye Jin Jung
    Department of Biotechnology, College of Engineering, Yonsei University, 134 Shinchon dong, Seodaemun gu, Seoul 120 749, Korea
    Cancer Sci 98:1943-8. 2007
    ..These results clearly demonstrate that EAA is a promising agent for the prevention and treatment of angiogenesis-related diseases including cancer...
  57. ncbi request reprint Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis
    Yusuke N Kimura
    Research Center for Innovative Cancer Therapy and Department of Surgery, Kurume University, Kurume 830 0011, Japan
    Cancer Sci 98:2009-18. 2007
    ....
  58. doi request reprint Down regulation of c-Myc and induction of an angiogenesis inhibitor, thrombospondin-1, by 5-FU in human colon cancer KM12C cells
    Hong ye Zhao
    Department of Molecular Oncology, Graduate School of Medical and Dental Sciences, Kagoshima University, Sakuragaoka 8 35 1, Kagoshima, Japan
    Cancer Lett 270:156-63. 2008
    ..Meanwhile, 5-FU dose-dependently decreased the expression of miR-17-92 cluster. These findings suggest that 5-FU decreased the expression of c-Myc and consequently miR-17-92 cluster and increased the expression of TSP-1 mRNA...
  59. doi request reprint Expression of HER2 and estrogen receptor alpha depends upon nuclear localization of Y-box binding protein-1 in human breast cancers
    Teruhiko Fujii
    Center for Innovative Cancer Therapy of the 21st Century Center of Excellence Program for Medical Science, Department of Surgery, Kurume University School of Medicine, Kurume, Japan
    Cancer Res 68:1504-12. 2008
    ..The nuclear localization of YB-1 could be an important therapeutic target against not only multidrug resistance but also tumor growth dependent on HER2 and ER alpha...
  60. ncbi request reprint Tumor growth suppression in pancreatic cancer by a putative metastasis suppressor gene Cap43/NDRG1/Drg-1 through modulation of angiogenesis
    Yuichiro Maruyama
    Department of Surgery, Research Center for Innovative Cancer Therapy, Kurume University School of Medicine, Kurume, Japan
    Cancer Res 66:6233-42. 2006
    ..0244), and overall survival rates for patients with pancreatic cancer (P = 0.0062). Thus, Cap43 could play a key role in the angiogenic on- or off-switch of tumor stroma in pancreatic ductal adenocarcinoma...
  61. ncbi request reprint VGA1155, a novel binding antagonist of VEGF, inhibits angiogenesis in vitro and in vivo
    Yasuji Ueda
    Taisho Pharmaceutical Co, Ltd, 1 403 Yoshino cho, Kita ku, Saitama, Japan
    Anticancer Res 24:3009-17. 2004
    ..VGA1155 thus exhibits promise as an antiangiogenic or anti-tumor agent with fewer side-effects...
  62. ncbi request reprint Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas
    Miguel Taron
    Catalan Institute of Oncology, Pathology Department, Hospital Germans Trias i Pujol, Badalona, Spain
    Clin Cancer Res 11:5878-85. 2005
    ..Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) confer a strong sensitivity to gefitinib, a selective tyrosine kinase inhibitor of EGFR...
  63. ncbi request reprint Cooperative cell-growth inhibition by combination treatment with ZD1839 (Iressa) and trastuzumab (Herceptin) in non-small-cell lung cancer
    Hisashi Nakamura
    Department of Surgery, Kurume University School of Medicine, 67 Asahi Machi, Kurume 830 0011, Japan
    Cancer Lett 230:33-46. 2005
    ..We therefore suggest that combination treatment with ZD1839 and trastuzumab might have improved therapeutic efficacy against NSCLC cells expressing both EGFR and HER2...
  64. ncbi request reprint Embellistatin, a microtubule polymerization inhibitor, inhibits angiogenesis both in vitro and in vivo
    Hye Jin Jung
    Chemical Genomics Laboratory, Department of Biotechnology, College of Engineering, Yonsei University, 134 Shinchon dong, Seodaemun gu, Seoul 120 749, Republic of Korea
    Biochem Biophys Res Commun 353:376-80. 2007
    ..These results demonstrate that embellistatin may serve the basis for the development of new anti-angiogenic agents...
  65. ncbi request reprint Interleukin-17 promotes angiogenesis and tumor growth
    Muneo Numasaki
    Department of Surgery, School of Medicine, University of Pittsburgh Cancer Institute, University of Pittsburgh, PA, USA
    Blood 101:2620-7. 2003
    ..Furthermore, they suggest that inhibition of biologic action of IL-17 may have therapeutic benefits when applied to angiogenesis-related disorders...
  66. doi request reprint Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages
    Koji Hiraoka
    Department of Orthopedic Surgery, Kurume University Schoool of Medicine, Kurume 830 0011, Japan
    Cancer Sci 99:1595-602. 2008
    ....
  67. ncbi request reprint [Molecular targeting drugs--present status and future development]
    Michihiko Kuwano
    Research Center for Innovative Cancer Therapy, Kurume University
    Nihon Rinsho 62:1211-5. 2004
    ..drugs could be determined in patients in evidence-based manner?; (2) What is promising molecular target for development of drug?; (3) How combination therapy of molecular targeting drug with other cytotoxic drugs should be designed?..