Mitsuho Onimaru

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium
    Yasuhiro Ikeda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Exp Eye Res 83:1031-40. 2006
  2. doi request reprint VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B
    Mitsuho Onimaru
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Am J Physiol Heart Circ Physiol 297:H1685-96. 2009
  3. ncbi request reprint Diabetic microangiopathy in ischemic limb is a disease of disturbance of the platelet-derived growth factor-BB/protein kinase C axis but not of impaired expression of angiogenic factors
    Mitsugu Tanii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Circ Res 98:55-62. 2006
  4. ncbi request reprint Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization: critical role of the inflammatory/arteriogenic pathway
    Takaaki Fujii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 26:2483-9. 2006
  5. doi request reprint Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression
    Takaaki Fujii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Am J Physiol Heart Circ Physiol 294:H2785-91. 2008
  6. pmc Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
    Masaki Matsuura
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Am J Pathol 175:1709-21. 2009
  7. doi request reprint VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis
    Takaaki Fujii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Atherosclerosis 200:51-7. 2008
  8. doi request reprint An autocrine linkage between matrix metalloproteinase-14 and Tie-2 via ectodomain shedding modulates angiopoietin-1-dependent function in endothelial cells
    Mitsuho Onimaru
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 30:818-26. 2010
  9. ncbi request reprint Essential role of PDGFRalpha-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo: role of PDGFRalpha during angiogenesis
    Norifumi Tsutsumi
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ Res 94:1186-94. 2004
  10. ncbi request reprint Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas
    Yasunori Shikada
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 65:7241-8. 2005

Collaborators

Detail Information

Publications33

  1. ncbi request reprint The regulation of vascular endothelial growth factors (VEGF-A, -C, and -D) expression in the retinal pigment epithelium
    Yasuhiro Ikeda
    Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Exp Eye Res 83:1031-40. 2006
    ..These findings suggest the possibility that VEGF-C and VEGF-D expression in RPE modify the ocular angiogenesis as angiogenic stimulators...
  2. doi request reprint VEGF-C regulates lymphangiogenesis and capillary stability by regulation of PDGF-B
    Mitsuho Onimaru
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Am J Physiol Heart Circ Physiol 297:H1685-96. 2009
    ....
  3. ncbi request reprint Diabetic microangiopathy in ischemic limb is a disease of disturbance of the platelet-derived growth factor-BB/protein kinase C axis but not of impaired expression of angiogenic factors
    Mitsugu Tanii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Circ Res 98:55-62. 2006
    ....
  4. ncbi request reprint Nonendothelial mesenchymal cell-derived MCP-1 is required for FGF-2-mediated therapeutic neovascularization: critical role of the inflammatory/arteriogenic pathway
    Takaaki Fujii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 26:2483-9. 2006
    ..Angiogenesis contributes to the inflammatory process; however, the molecular and cellular mechanisms of the links among the inflammatory pathway, arteriogenesis, and angiogenesis have not been well elucidated...
  5. doi request reprint Statins restore ischemic limb blood flow in diabetic microangiopathy via eNOS/NO upregulation but not via PDGF-BB expression
    Takaaki Fujii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Am J Physiol Heart Circ Physiol 294:H2785-91. 2008
    ..In conclusion, these findings indicate that statin therapy might be useful for preventing intractable diabetic foot disease in patients with diabetic angiopathy...
  6. pmc Autocrine loop between vascular endothelial growth factor (VEGF)-C and VEGF receptor-3 positively regulates tumor-associated lymphangiogenesis in oral squamoid cancer cells
    Masaki Matsuura
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Am J Pathol 175:1709-21. 2009
    ..These findings together suggested that the VEGF-C/FLT-4 autocrine loop in tumor cells was a potential enhancer system to promote cancer progression, and FLT-4 in tumor tissue might become an effective target for cancer therapy...
  7. doi request reprint VEGF function for upregulation of endogenous PlGF expression during FGF-2-mediated therapeutic angiogenesis
    Takaaki Fujii
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Atherosclerosis 200:51-7. 2008
    ..These results indicate that the FGF-2-mediated enhancement of PlGF expression was dependent on VEGF function, and the FGF-2/VEGF axis participates in FGF-2-mediated angiogenesis indirectly via PlGF as well as directly...
  8. doi request reprint An autocrine linkage between matrix metalloproteinase-14 and Tie-2 via ectodomain shedding modulates angiopoietin-1-dependent function in endothelial cells
    Mitsuho Onimaru
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 30:818-26. 2010
    ..The angiopoietin (Ang)-Tie-2 system plays a critical role during fetal and adult angiogenesis. Herein, we explored the Tie-2 shedding-related molecular mechanisms and the pathophysiological significance...
  9. ncbi request reprint Essential role of PDGFRalpha-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo: role of PDGFRalpha during angiogenesis
    Norifumi Tsutsumi
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ Res 94:1186-94. 2004
    ....
  10. ncbi request reprint Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas
    Yasunori Shikada
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 65:7241-8. 2005
    ....
  11. pmc Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration
    Yusuke Murakami
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, 812 8582, Japan
    Am J Pathol 173:1326-38. 2008
    ....
  12. pmc BioKnife, a uPA activity-dependent oncolytic Sendai virus, eliminates pleural spread of malignant mesothelioma via simultaneous stimulation of uPA expression
    Yosuke Morodomi
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Ther 20:769-77. 2012
    ..Therefore, these results suggest a proof of concept that the tumor cell-killing mechanism via BioKnife may have significant potential to treat patients with MPM that is characterized by frequent uPAR expression in a clinical setting...
  13. pmc DVC1-0101 to treat peripheral arterial disease: a Phase I/IIa open-label dose-escalation clinical trial
    Yoshikazu Yonemitsu
    Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan
    Mol Ther 21:707-14. 2013
    ..The single intramuscular administration of DVC1-0101 to PAD patients was safe and well tolerated, and resulted in significant improvements of limb function. Larger pivotal studies are warranted as a next step...
  14. ncbi request reprint A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia
    Kazuhiro Kaneko
    Div of Pathophysiological and Experimental Pathology, Dept of Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Am J Physiol Heart Circ Physiol 290:H1484-92. 2006
    ..These results suggest the distinct mechanism of MNMS from critical limb ischemia without reperfusion. Therefore, radical scavenging should be paid more attention than therapeutic angiogenesis when arterial circulation is reconstructed...
  15. doi request reprint Transfection of hypoxia-inducible factor-1 decoy oligodeoxynucleotides suppresses expression of vascular endothelial growth factor in oral squamous cell carcinoma cells
    Mie Imai
    Department of Oral and Maxillofacial Surgery, Graduate School of Dental Sciences, Kyushu University, Fukuoka, Japan
    J Oral Pathol Med 41:675-81. 2012
    ..HIF-1 decoy ODN transfection also inhibited VEGF protein synthesis. These results suggest that transfection with HIF-1 decoy ODNs is effective for regulating tumor growth by reducing VEGF...
  16. ncbi request reprint Induction of efficient antitumor immunity using dendritic cells activated by recombinant Sendai virus and its modulation by exogenous IFN-beta gene
    Satoko Shibata
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Immunol 177:3564-76. 2006
    ....
  17. doi request reprint High podoplanin expression in cancer cells predicts lower incidence of nodal metastasis in patients with lung squamous cell carcinoma
    Hanako Suzuki
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Pathol Res Pract 207:111-5. 2011
    ..These findings suggest that immunohistochemical analysis for podoplanin may serve as a marker of risk of nodal metastasis and prognosis in patients with LSCC...
  18. pmc Endogenous cardiac troponin T modulates Ca(2+)-mediated smooth muscle contraction
    Shunichi Kajioka
    Department of Urology, Kyushu University, Japan
    Sci Rep 2:979. 2012
    ..Furthermore, addition of supplemental TnI and TnC reconstructed a troponin system to enhance contraction. The results indicated that a Tn/Tn-like system on actin-filaments cooperates together with the thick-filament pathway...
  19. ncbi request reprint Cytoplasmic expression and extracellular deposition of an antiangiogenic factor, pigment epithelium-derived factor, in human atherosclerotic plaques
    Hiromitsu Baba
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Arterioscler Thromb Vasc Biol 25:1938-44. 2005
    ..To assess the expression and distribution of a neurotrophic/antiangiogenic factor, pigment epithelium-derived factor (PEDF), related to angiogenesis that is a possibly key event during atherogenesis in human atherosclerotic plaques...
  20. ncbi request reprint Angiogenic and lymphangiogenic cascades in the tumor microenvironment
    Mitsuho Onimaru
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Front Biosci (Schol Ed) 3:216-25. 2011
    ....
  21. ncbi request reprint BUBR1 Insufficiency in Mice Increases their Sensitivity to Oxidative Stress
    Daisuke Matsuda
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    In Vivo 30:769-776. 2016
    ..We previously generated mutant mice that express BUBR1 at only 20% of the normal level (BubR1L/L mice). Here, we examined the effect of low BUBR1 expression on oxidative stress-induced carcinogenesis in mice...
  22. doi request reprint BubR1 insufficiency inhibits neointimal hyperplasia through impaired vascular smooth muscle cell proliferation in mice
    Ryoichi Kyuragi
    From the Department of Surgery and Science, Graduate School of Medical Sciences R K, T M, Y M, R and D Laboratory for Innovative Biotherapeutics, Graduate School of Pharmaceutical Sciences Y H, S S, Y Y, Department of Pathology, Graduate School of Medical Sciences M O, Department of Medical Biophysics and Radiation Biology, Graduate School of Medical Sciences Y N, T T, and Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences M N, Kyushu University, Fukuoka, Japan
    Arterioscler Thromb Vasc Biol 35:341-7. 2015
    ..We generated mice in which BubR1 expression was reduced to 20% (BubR1(L/L) mice) of that in wild-type mice (BubR1(+/+)) to investigate the effects of BubR1 on arterial intimal hyperplasia...
  23. doi request reprint Chronic kidney disease is associated with neovascularization and intraplaque hemorrhage in coronary atherosclerosis in elders: results from the Hisayama Study
    Toshiaki Nakano
    Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Kidney Int 84:373-80. 2013
    ..73 m(2). Thus, elderly patients with CKD have intimal neoangiogenesis and an increased risk of intraplaque hemorrhage in coronary arteries, possibly favored by local accumulation of oxLDL and VEGF...
  24. doi request reprint Pericardial fat pad tissue produces angiogenic factors for healing the bronchial stump
    Fumihiro Shoji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Interact Cardiovasc Thorac Surg 13:271-5. 2011
    ..These results suggest that reinforcement of the bronchial stump by the pericardial fat pad is a worthwhile and justified procedure, and may prevent bronchopleural fistula after pulmonary resections...
  25. doi request reprint Antagonism of VEGF by genetically engineered dendritic cells is essential to induce antitumor immunity against malignant ascites
    Masahiko Sugiyama
    R and D Laboratory for Innovative Biotherapeutics, Graduate School of Pharmaceutical Sciences, Kyushu University, Rm 505 Collaborative Research Station II, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mol Cancer Ther 10:540-9. 2011
    ..These findings were not seen in immunodeficient mice, indicating that a VEGF-A/sFLT-1 imbalance is critical for determining the antitumor immune response by DC-vaccination therapy against MA...
  26. pmc Podoplanin in cancer cells is experimentally able to attenuate prolymphangiogenic and lymphogenous metastatic potentials of lung squamoid cancer cells
    Hanako Suzuki
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Cancer 9:287. 2010
    ..Here, we investigated the role of podoplanin expressed in lung squamoid cancer cells (LSCCs) in experimental tumor progression...
  27. pmc BubR1 Insufficiency Impairs Liver Regeneration in Aged Mice after Hepatectomy through Intercalated Disc Abnormality
    Ayae Ikawa-Yoshida
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Sci Rep 6:32399. 2016
    ..Thus, our data suggest that a reduction in BubR1 levels causes failure of liver regeneration through the DSC1 abnormality. ..
  28. doi request reprint Peritoneal Dissemination Requires an Sp1-Dependent CXCR4/CXCL12 Signaling Axis and Extracellular Matrix-Directed Spheroid Formation
    Yuta Kasagi
    R and D Laboratory for Innovative Biotherapeutics, Kyushu University Graduate School of Pharmaceutical Sciences, Fukuoka 812 8582, Japan Department of Surgery and Science, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Cancer Res 76:347-57. 2016
    ..Our findings illuminate mechanisms of peritoneal cancer dissemination and highlight the Sp1/CXCR4/CXCL12 signaling axis as a rational target for the development of therapeutics to manage this intractable form of malignancy...
  29. doi request reprint Obstruction enhances rho-kinase pathway and diminishes protein kinase C pathway in carbachol-induced calcium sensitization in contraction of α-toxin permeabilized guinea pig detrusor smooth muscle
    Nouval Shahab
    Department of Urology, Kyushu University, Fukuoka, Japan
    Neurourol Urodyn 31:593-9. 2012
    ....
  30. ncbi request reprint Fibroblast growth factor-2 gene transfer can stimulate hepatocyte growth factor expression irrespective of hypoxia-mediated downregulation in ischemic limbs
    Mitsuho Onimaru
    Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Circ Res 91:923-30. 2002
    ..The harmonized therapeutic effects of FGF-2, accompanied with the activity of endogenous HGF, may provide a beneficial effect for the treatment of limb ischemia...
  31. pmc Activation of Nod1 Signaling Induces Fetal Growth Restriction and Death through Fetal and Maternal Vasculopathy
    Hirosuke Inoue
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Immunol 196:2779-87. 2016
    ..Our data thus provided new evidence for the pathogenic role of Nod1 in the development of IUGR and IUFD at the maternal-fetal interface. ..
  32. doi request reprint Activation of an innate immune receptor, Nod1, accelerates atherogenesis in Apoe-/- mice
    Shunsuke Kanno
    Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Immunol 194:773-80. 2015
    ..Data in the present study show that the Nod1 signaling pathway in non-bone marrow-derived cells contributes to the development of atherosclerosis. ..
  33. doi request reprint Biological characterization and analysis of metastasis-related genes in cell lines derived from the primary lesion and lymph node metastasis of a squamous cell carcinoma arising in the mandibular gingiva
    Takahiro Fujinaga
    Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Int J Oncol 44:1614-24. 2014
    ..The results suggest that these molecules could be important for clarifying the mechanisms that regulate metastasis and provide new therapeutic targets for inhibiting tumor invasion...