E Oki

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Phase II Study of Docetaxel and S-1 (DS) as Neoadjuvant Chemotherapy for Clinical Stage III Resectable Gastric Cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 21:2340-6. 2014
  2. pmc Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells
    Ayae Ikawa-Yoshida
    Departments of Surgery and Science Graduate School of Medical Sciences, Kyushu University Fukuoka, Japan
    Cancer Med 2:447-56. 2013
  3. pmc The impact of obesity on the use of a totally laparoscopic distal gastrectomy in patients with gastric cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Gastric Cancer 12:108-12. 2012
  4. ncbi request reprint Total laparoscopic distal gastrectomy for elderly patients with gastric cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 104:290-8. 2013
  5. doi request reprint Phase II trial of alternating mFOLFOX6 and FOLFIRI regimens in the first-line treatment for unresectable or metastatic colorectal cancer (KSCC0701)
    Eiji Oki
    Department of Surgery, Kurume University School of Medicine, Kurume, Japan
    Oncology 84:233-9. 2013
  6. doi request reprint Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Gastroenterol 47:351-8. 2012
  7. doi request reprint The difference in p53 mutations between cancers of the upper and lower gastrointestinal tract
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Digestion 79:33-9. 2009
  8. doi request reprint Surgical complications and the risk factors of totally laparoscopic distal gastrectomy
    Eiji Oki
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Nodame, Minami Ku, Japan
    Surg Laparosc Endosc Percutan Tech 21:146-50. 2011
  9. doi request reprint Huge gastric carcinoma showing an exophytic growth pattern: a case report and review of the literature
    Eiji Oki
    Department of Surgery and Science, Graduate School, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    J Gastrointest Cancer 39:42-5. 2008
  10. ncbi request reprint Genetic mutual relationship between PTEN and p53 in gastric cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Kyushu University 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Cancer Lett 227:33-8. 2005

Collaborators

Detail Information

Publications69

  1. ncbi request reprint Phase II Study of Docetaxel and S-1 (DS) as Neoadjuvant Chemotherapy for Clinical Stage III Resectable Gastric Cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 21:2340-6. 2014
    ..We conducted a phase II trial to evaluate the efficacy and safety of preoperative chemotherapy with docetaxel (DTX) plus S-1 for resectable advanced gastric cancer...
  2. pmc Contribution of BubR1 to oxidative stress-induced aneuploidy in p53-deficient cells
    Ayae Ikawa-Yoshida
    Departments of Surgery and Science Graduate School of Medical Sciences, Kyushu University Fukuoka, Japan
    Cancer Med 2:447-56. 2013
    ..0065). These observations suggest that p53 deficiency may lead to the failure of BubR1 downregulation by OS and that p53 deficiency and BubR1 accumulation could contribute to gastric carcinogenesis associated with aneuploidy...
  3. pmc The impact of obesity on the use of a totally laparoscopic distal gastrectomy in patients with gastric cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Gastric Cancer 12:108-12. 2012
    ..This study evaluated the feasibility of performing a totally laparoscopic distal gastrectomy, with intracorporeal anastomosis, in obese patients suffering from gastric cancer...
  4. ncbi request reprint Total laparoscopic distal gastrectomy for elderly patients with gastric cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 104:290-8. 2013
    ..This study evaluated the feasibility of totally laparoscopic distal gastrectomy (TLDG) in elderly patients with gastric cancer...
  5. doi request reprint Phase II trial of alternating mFOLFOX6 and FOLFIRI regimens in the first-line treatment for unresectable or metastatic colorectal cancer (KSCC0701)
    Eiji Oki
    Department of Surgery, Kurume University School of Medicine, Kurume, Japan
    Oncology 84:233-9. 2013
    ..This phase II study examined the efficacy and safety of alternating regimens of mFOLFOX6 and FOLFIRI as a first-line treatment for unresectable or metastatic colorectal cancer...
  6. doi request reprint Clinical aspect and molecular mechanism of DNA aneuploidy in gastric cancers
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Gastroenterol 47:351-8. 2012
    ..Further investigations may be needed to clarify the relationship between chromosome instability and DNA ploidy...
  7. doi request reprint The difference in p53 mutations between cancers of the upper and lower gastrointestinal tract
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Digestion 79:33-9. 2009
    ..This study investigated the differences in p53 abnormalities between cancers of the upper and lower gastrointestinal tract...
  8. doi request reprint Surgical complications and the risk factors of totally laparoscopic distal gastrectomy
    Eiji Oki
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Nodame, Minami Ku, Japan
    Surg Laparosc Endosc Percutan Tech 21:146-50. 2011
    ..It has not yet been elucidated whether there are specific complications associated with totally laparoscopic distal gastrectomy (TLDG). We evaluated the complications and the risk factors associated with TLDG...
  9. doi request reprint Huge gastric carcinoma showing an exophytic growth pattern: a case report and review of the literature
    Eiji Oki
    Department of Surgery and Science, Graduate School, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    J Gastrointest Cancer 39:42-5. 2008
    ..The patient is alive and doing well without any recurrence at 5 years postoperatively...
  10. ncbi request reprint Genetic mutual relationship between PTEN and p53 in gastric cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Kyushu University 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Cancer Lett 227:33-8. 2005
    ..The result that LOH of PTEN was frequently observed in the cases with p53 gene mutations and other data in this study suggested that both PTEN and p53 have complimentary roles in gastric carcinoma development...
  11. ncbi request reprint Akt phosphorylation associates with LOH of PTEN and leads to chemoresistance for gastric cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Kyushu University, Fukuoka, Japan
    Int J Cancer 117:376-80. 2005
    ..It also indicates that AKT may therefore be a novel molecular target for therapies or chemosensitivity tests that improve the outcomes of gastric cancer patients...
  12. ncbi request reprint Impact of loss of heterozygosity of encoding phosphate and tensin homolog on the prognosis of gastric cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    J Gastroenterol Hepatol 21:814-8. 2006
    ..However, the role of LOH of PTEN and its outcome variables in gastric cancer have not been well established. In the present study, we investigated the roles of PTEN, LOH and their outcomes...
  13. doi request reprint Chemosensitivity and survival in gastric cancer patients with microsatellite instability
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 16:2510-5. 2009
    ..This study investigated the usefulness of MSI as either a prognostic indicator or predictor of distinct clinical attributes regarding the use of adjuvant chemotherapy with 5-FU and its analogues in gastric cancer...
  14. doi request reprint Transient elastography for the prediction of oxaliplatin-associated liver injury in colon cancer patients: a preliminary analysis
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    J Gastrointest Cancer 39:82-5. 2008
    ..However, oxaliplatin-induced liver injury and characterized hepatic hemostatic status can occur after chemotherapy. The assessment of this type of liver injury is often difficult...
  15. pmc Checkpoint with forkhead-associated and ring finger promoter hypermethylation correlates with microsatellite instability in gastric cancer
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    World J Gastroenterol 15:2520-5. 2009
    ..To examine the methylation status of the promoter region of the checkpoint with forkhead-associated and ring finger (CHFR) and microsatellite mutator status in 59 primary gastric cancers...
  16. ncbi request reprint Clinical significance of cytokeratin positive cells in bone marrow of gastric cancer patients
    Eiji Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Cancer Res Clin Oncol 133:995-1000. 2007
    ..Therefore it does not accurately predict the prognosis or recurrence of the disease...
  17. ncbi request reprint Salvage esophagectomy after definitive chemoradiotherapy for esophageal cancer
    E Oki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi Higashi ku, Fukuoka 812 8582, Japan
    Dis Esophagus 20:301-4. 2007
    ..Salvage esophagectomy may be indicated when the tumor can be resected completely after definitive chemotherapy. However, all cases of T4 cancer cannot be resected completely, resulting in a high risk for complications and poor survival...
  18. ncbi request reprint Overexpression of the MTA1 gene in gastrointestinal carcinomas: correlation with invasion and metastasis
    Y Toh
    Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Int J Cancer 74:459-63. 1997
    ....
  19. ncbi request reprint Coexistence of the loss of heterozygosity at the PTEN locus and HER2 overexpression enhances the Akt activity thus leading to a negative progesterone receptor expression in breast carcinoma
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Japan
    Breast Cancer Res Treat 101:249-57. 2007
    ..Our results suggest that simultaneous PTEN LOH and HER2 overexpression enhances Akt activation and may thus lead to a negative PR expression...
  20. doi request reprint Esophageal replacement by colon interposition with microvascular surgery for patients with thoracic esophageal cancer: the utility of superdrainage
    H Saeki
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan
    Dis Esophagus 26:50-6. 2013
    ..The 3-year and 5-year overall survival rates were both 50.6%. Colon interposition with superdrainage results in successful treatment outcomes. This technique is one option for colon interposition employing the right hemicolon...
  21. doi request reprint Salvage esophagectomy after definitive chemoradiotherapy for synchronous double cancers of the esophagus and head-and-neck
    R Yoshida
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Dis Esophagus 23:59-63. 2010
    ....
  22. ncbi request reprint Splenic volume may be a useful indicator of the protective effect of bevacizumab against oxaliplatin-induced hepatic sinusoidal obstruction syndrome
    K Imai
    Department of Gastroenterological Surgery, Graduate School of Life Sciences, Kumamoto University, Kumamoto, Japan
    Eur J Surg Oncol 40:559-66. 2014
    ....
  23. doi request reprint Feasibility of delta-shaped anastomoses in totally laparoscopic distal gastrectomy
    E Oki
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, Fukuoka, Japan okieiji surg2 med kyushu u ac jp
    Eur Surg Res 47:205-10. 2011
    ..Delta-shaped (DS) anastomosis is a new reconstruction method for totally laparoscopic distal gastrectomy (TLDG) using a linear stapler. We evaluated the feasibility of using this method for TLDG...
  24. pmc Induction of apoptosis in human tumour xenografts after oral administration of uracil and tegafur to nude mice bearing tumours
    E Oki
    Cancer Centre of Kyushu University Hospital, Fukuoka, Japan
    Br J Cancer 78:625-30. 1998
    ..Thus, tumours with a higher apoptosis induced by UFT had a higher response to UFT. Apoptosis observed in tumours might serve as a predictor of a preferable response to UFT...
  25. ncbi request reprint Overexpression of the heat shock protein HSP70 family and p53 protein and prognosis for patients with gastric cancer
    Y Maehara
    Cancer Center, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Oncology 58:144-51. 2000
    ..Our findings show that the expression of HSP70 is not associated with tumor advance-related characteristics or with the prognosis of gastric cancer. Measurements of HSP70 expression do not appear to be a useful prognostic marker...
  26. ncbi request reprint [A randomized controlled trial to evaluate the effect of adjuvant oral fluoropyrimidine derivative therapy after curative resection for stage II/III rectal cancer-adjuvant chemotherapy trial of S-1 for rectal cancer (ACTS-RC):]
    Eiji Oki
    Dept of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gan To Kagaku Ryoho 33:138-43. 2006
    ..We aim to include 400 patients in each of the treatment groups and assume that the registration period will last until 2009...
  27. doi request reprint Acute lung injury following an esophagectomy for esophageal cancer, with special reference to the clinical factors and cytokine levels of peripheral blood and pleural drainage fluid
    M Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Dis Esophagus 21:30-6. 2008
    ..Furthermore, ALI may cause not only SIRS but also other complications such as anastomotic leakage...
  28. ncbi request reprint Detection of circulating gastric cancer cells in peripheral blood using real time quantitative RT-PCR
    Tadashi Koga
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka 812 8582, Japan
    Hepatogastroenterology 55:1131-5. 2008
    ..This study addresses the detection of circulating tumor cells in peripheral blood in patients with gastric cancer using Quantitative RT-PCR...
  29. ncbi request reprint [Chemotherapy for gastric cancer]
    Hideo Baba
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Gan To Kagaku Ryoho 30:1881-8. 2003
    ..At present, a nation-wide randomized controlled study in the postoperative adjuvant setting for gastric cancer using TS-1 (ACTS-GC) is under way that may clarify the effect of postoperative adjuvant chemotherapy in gastric cancer...
  30. doi request reprint HB-EGF orchestrates the complex signals involved in triple-negative and trastuzumab-resistant breast cancer
    Fusanori Yotsumoto
    Department of Biochemistry, School of Medicine, Fukuoka University, Jonan ku, Fukuoka, Japan
    Int J Cancer 127:2707-17. 2010
    ..In addition, it is plausible that CRM197 could be an effective anticancer agent for molecularly targeted therapies...
  31. ncbi request reprint Oxidative DNA damage in human esophageal cancer: clinicopathological analysis of 8-hydroxydeoxyguanosine and its repair enzyme
    N Kubo
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Dis Esophagus 27:285-93. 2014
    ..0065) and stage (P = 0.0019). Oxidative DNA damage, which is attributable to smoking as well as disturbances in DNA repair systems, appears to be closely related to esophageal carcinogenesis and its progression. ..
  32. ncbi request reprint [Combination chemotherapy of S-1 plus biweekly docetaxel for advanced and recurrent gastric cancer]
    Ikuo Takahashi
    Dept of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Japan
    Gan To Kagaku Ryoho 33:87-90. 2006
    ..The S-1 +biweekly DOC combination therapy can be a candidate for outpatient chemotherapy for advanced or recurrent gastric cancer...
  33. doi request reprint The impact of a high-frequency microsatellite instability phenotype on the tumor location-related genetic differences in colorectal cancer
    Yan Zhao
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Genet Cytogenet 196:133-9. 2010
    ..Therefore, instead of tumor location, microsatellite status should be a major focus for the study of colorectal cancers in the future...
  34. ncbi request reprint Adenocarcinoma of the esophagogastric junction in Japan
    Manabu Yamamoto
    Department of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University Fukuoka, Japan
    Hepatogastroenterology 55:103-7. 2008
    ..In particular, the clinical features and prognosis of adenocarcinoma of the esophagogastric junction and the differences between Siewert's type II and III tumors in Japan were evaluated...
  35. pmc Precise assessment of microsatellite instability using high resolution fluorescent microsatellite analysis
    S Oda
    Cancer Center, Kyushu University Hospital, Fukuoka 812 82, Japan
    Nucleic Acids Res 25:3415-20. 1997
    ..Analyzing many positive cases in cell lines and tissue specimens, we classified all the patterns of microsatellite alteration and set up new criteria for assessing microsatellite instability...
  36. doi request reprint Phase II study of biweekly docetaxel and S-1 combination therapy for advanced or recurrent gastric cancer
    Yoshihiro Kakeji
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Oncology 77:49-52. 2009
    ..This phase II study evaluated the toxicity and efficacy of a novel dosing schedule of docetaxel and S-1 as treatment for advanced gastric cancer...
  37. doi request reprint Repair using the pectoralis major muscle flap for anastomotic leakage after esophageal reconstruction via the subcutaneous route
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Surgery 147:212-8. 2010
    ..Anastomotic leakage with an intractable cutaneous fistula frequently develops after an esophagectomy and reconstruction via the subcutaneous route...
  38. doi request reprint Esophagectomy in patients 80 years of age and older with carcinoma of the thoracic esophagus
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Gastroenterol 43:345-51. 2008
    ..The purpose of this study was to clarify the indications for an esophagectomy in elderly patients (especially patients over 80 years of age) with esophageal cancer...
  39. doi request reprint Advances in esophageal cancer surgery in Japan: an analysis of 1000 consecutive patients treated at a single institute
    Masaru Morita
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Surgery 143:499-508. 2008
    ..The object of this study was to evaluate advances in operative therapy for esophageal cancer in Japan...
  40. ncbi request reprint Trastuzumab and breast cancer: developments and current status
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Int J Clin Oncol 11:199-208. 2006
    ..In this review, we describe the developments and current status of trastuzumab-based treatment for breast cancer...
  41. ncbi request reprint Activation of PI3K/Akt signaling and hormone resistance in breast cancer
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Breast Cancer 13:137-44. 2006
    ..Our findings suggest that pAkt may be a useful predictor of resistance to endocrine therapy for breast cancer, while also suggesting that the inhibition of Akt may increase the efficacy of endocrine therapy...
  42. ncbi request reprint [Development of a molecular target therapy on the basis of global gene analyses of gastrointestinal carcinoma]
    Yoshihiko Maehara
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
    Fukuoka Igaku Zasshi 97:30-6. 2006
  43. ncbi request reprint Phase I study of S-1 and biweekly docetaxel combination chemotherapy for advanced and recurrent gastric cancer
    Ikuo Takahashi
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Oncol Rep 15:849-54. 2006
    ..The dose limiting toxicity of a combination of S-1 and biweekly DOC was leukopenia and neutropenia. The recommended dose for this combination in phase II study is DOC 35 mg/m2/day...
  44. ncbi request reprint Aberrant hypermethylation of the promoter region of the CHFR gene is rare in primary breast cancer
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Higashi ku, Japan
    Breast Cancer Res Treat 97:199-203. 2006
    ..We observed the hypermethylation of the CHFR promoter region in only one case (0.9%). We herein show that the aberrant hypermethylation of this region is quite a rare event in primary breast carcinoma...
  45. ncbi request reprint Akt is frequently activated in HER2/neu-positive breast cancers and associated with poor prognosis among hormone-treated patients
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 118:284-9. 2006
    ..This finding suggests that inhibition of the Akt signaling pathway may increase the efficacy of hormone therapy and improve the prognosis of patients who receive adjuvant hormone therapy...
  46. ncbi request reprint Loss of heterozygosity (LOH) in non-small cell lung cancer: difference between adenocarcinoma and squamous cell carcinoma
    Ichiro Yoshino
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Respir Med 99:308-12. 2005
    ..In non-small cell lung cancer, a loss of heterozygosity (LOH) is frequently observed; however, few studies have investigated the differences in the LOH status between adenocarcinoma and squamous cell carcinoma...
  47. ncbi request reprint Detection of disseminated cancer cells in bone marrow of gastric cancer using real time quantitative reverse transcriptase polymerase chain reaction
    Eiji Oki
    Cancer Center, Kyushu University Hospital Kyushu University Hospital, 3 1 1, Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cancer Lett 188:191-8. 2002
    ..Though long-term clinical follow up studies are needed to evaluate the clinical significance of this method, real time quantitative RT-PCR is sensitive and quantitative for detection of micrometastasis in bone marrow...
  48. ncbi request reprint Pharmacokinetics of gamma-hydroxybutylic acid (GHB) and gamma-butyrolactone (GBL), the anti-angiogenic metabolites of oral fluoropyrimidine UFT, in patients with gastric cancer
    Yasunori Emi
    Department of Surgery and Science, Graduate School of Medical Science, Kyushu University, Fukuoka, Japan
    Fukuoka Igaku Zasshi 98:418-24. 2007
    ..The concentration of GBL was much higher than its IC50 value for angiogenesis. GBL is thus suggested to contribute to the anticancer effects of UFT in addition to that of 5-FU, which is continuously metabolized from UFT...
  49. ncbi request reprint p53 gene mutations in esophageal squamous cell carcinoma and their relevance to etiology and pathogenesis: results in Japan and comparisons with other countries
    Akinori Egashira
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 98:1152-6. 2007
    ..In addition, we observed a peculiar sequence of frameshift mutations. Taken together, these data suggest that this tumor suppressor gene plays a critical role in the multistep carcinogenesis process for esophageal squamous cell cancer...
  50. doi request reprint DNA repair dysfunction in gastrointestinal tract cancers
    Yoshihiko Maehara
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 99:451-8. 2008
    ..This review focuses on the function of DNA mismatch repair and oxidative DNA/nucleotide repair among various DNA repair systems in cells, both of which are essentially involved in the carcinogenesis of gastrointestinal tract cancer...
  51. ncbi request reprint The association between Akt activation and resistance to hormone therapy in metastatic breast cancer
    Eriko Tokunaga
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Higashi ku, Fukuoka 812 8582, Japan
    Eur J Cancer 42:629-35. 2006
    ....
  52. ncbi request reprint Diminished expression of ING1 mRNA and the correlation with p53 expression in breast cancers
    E Tokunaga
    Cancer Center, Kyushu University Hospital, 3 1 1, Maidashi, Higashi ku, Fukuoka, Japan
    Cancer Lett 152:15-22. 2000
    ..In these tumors, p53 may not function in case of a decreased expression of p33(ING1), and the lack of cell cycle regulation may correlate with the carcinogenesis and tumor progression...
  53. ncbi request reprint [Evaluation of positive cases with peritoneal lavage cytology in gastric cancer]
    Manabu Yamamoto
    Dept of Surgery and Sciences, Graduate School of Medical Sciences, Kyushu University
    Gan To Kagaku Ryoho 32:1389-92. 2005
    ..In addition, we describe the diagnosis of early peritoneal dissemination using peritoneal lavage tumor markers or molecular markers of peritoneal lavage...
  54. doi request reprint The triangulating stapling technique for cervical esophagogastric anastomosis after esophagectomy
    Yasushi Toh
    Department of Gastroenterological Surgery, National Kyushu Cancer Center, 3 1 1 Notame, Minami Ku, Fukuoka, 811 1395, Japan
    Surg Today 39:201-6. 2009
    ..To evaluate the safety and feasibility of the triangulating stapling technique (TST) for cervical esophagogastric anastomosis after esophagectomy (CEGA)...
  55. ncbi request reprint [Hepatic artery infusion chemotherapy to three liver metastasis cases in which systemic chemotherapy was impossible or ineffective]
    Koji Ando
    Dept of Surgery and Science, Graduate School of Medical Sciences, Kyushu University
    Gan To Kagaku Ryoho 35:2192-4. 2008
    ..We herein report three cases that were treated by HAI after initially performing systemic chemotherapy in order to treat liver metastasis from either gastric cancer or colorectal cancer...
  56. doi request reprint Proctocolectomy for colon cancer associated with ulcerative colitis a few months after living donor liver transplantation for primary sclerosing cholangitis: report of a case
    Takasuke Fukuhara
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 39:59-63. 2009
    ..Moreover, surgery, such as radical resection of the colon and rectum should be performed without delay, even shortly after LDLT. To our knowledge, this is the first report of a patient undergoing proctocolectomy after LDLT...
  57. doi request reprint High expression of BUBR1 is one of the factors for inducing DNA aneuploidy and progression in gastric cancer
    Koji Ando
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 101:639-45. 2010
    ..Collectively, our clinical and in vitro data indicate that high expression of BUBR1 may be one of causative factors for the induction of DNA aneuploidy and progression of gastric cancer...
  58. ncbi request reprint High-resolution fluorescent analysis of microsatellite instability in gastric cancer
    Masato Sakurai
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Eur J Gastroenterol Hepatol 19:701-9. 2007
    ..It has been reported that the MSI+ phenotype is relatively frequent in gastric cancer. The reported frequencies of MSI+ gastric tumors, however, are diverse...
  59. ncbi request reprint Clinical significance of heparin-binding epidermal growth factor-like growth factor and a disintegrin and metalloprotease 17 expression in human ovarian cancer
    Yoshihiro Tanaka
    Department of Obstetrics and Gynecology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 11:4783-92. 2005
    ..We aimed to investigate the clinical significance of EGFR ligands and ADAM family in the lysophosphatidic acid-induced pathogenesis of ovarian cancer...
  60. doi request reprint Successful treatment of acute esophageal necrosis caused by intrathoracic gastric volvulus: report of a case
    Noritaka Matsumoto
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 39:1068-72. 2009
    ..Although a large hiatal hernia is usually a chronic disorder, surgical treatment is recommended, considering the risk of serious complications...
  61. ncbi request reprint [Impact of single nucleotide polymorphisms in glutathione S transferase gene GSTP1 in the treatment with oxaliplatin based chemotherapy]
    Eiji Oki
    Dept of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gan To Kagaku Ryoho 35:1094-6. 2008
    ..Specific roles for the single nucleotide polymorphisms in GST-pi gene GSTP1 in the treatment with oxaliplatin based chemotherapy, have been demonstrated in recent years...
  62. ncbi request reprint Angiotensin II-induced growth of vascular smooth muscle cells is associated with modulation of cell surface area and platelet-derived growth factor receptor expression
    Sosei Kuma
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Exp Pharmacol Physiol 34:153-60. 2007
    ..4. These data obtained in vitro and in vivo imply that AngII has the potential to promote growth of VSMC and suggest that this growth promotion may be mediated by enlargement of the cell surface area...
  63. doi request reprint TEM7 (PLXDC1) in neovascular endothelial cells of fibrovascular membranes from patients with proliferative diabetic retinopathy
    Yoko Yamaji
    Department of Ophthalmology, Kyushu University Graduate School of Medical Sciences, Fukuoka, Japan
    Invest Ophthalmol Vis Sci 49:3151-7. 2008
    ..The purpose of this study was to determine whether TEM7 is associated with the formation of FVMs...
  64. ncbi request reprint [Treatment of gastric cancer: current state and future prospect]
    Yoshihiko Maehara
    Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Fukuoka Igaku Zasshi 94:285-95. 2003
  65. ncbi request reprint Validation of HB-EGF and amphiregulin as targets for human cancer therapy
    Fusanori Yotsumoto
    Department of Obstetrics and Gynecology, School of Medicine, Fukuoka University, Fukuoka, Japan
    Biochem Biophys Res Commun 365:555-61. 2008
    ..In lung cancer cells, any EGFR ligand was not recognized as a validated target for cancer therapy. These results suggest that HB-EGF and amphiregulin are promising targets for cancer therapy...
  66. pmc Two modes of microsatellite instability in human cancer: differential connection of defective DNA mismatch repair to dinucleotide repeat instability
    Shinya Oda
    Institute for Clinical Research, National Kyushu Cancer Center, Fukuoka 811 1395, Japan
    Nucleic Acids Res 33:1628-36. 2005
    ..The relationship between MSI and defective mismatch repair may be more complex than hitherto suspected...
  67. ncbi request reprint p73beta is regulated by protein kinase Cdelta catalytic fragment generated in the apoptotic response to DNA damage
    Jian Ren
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    J Biol Chem 277:33758-65. 2002
    ..These findings demonstrate that cleavage of PKCdelta to PKCdeltaCF induces apoptosis by a mechanism in part dependent on PKCdeltaCF-mediated phosphorylation of the p73beta Ser-289 site...
  68. ncbi request reprint [Molecular target therapy for colonic neoplasms]
    Eiji Oki
    Nihon Naika Gakkai Zasshi 96:289-94. 2007