Y Ohyagi

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. ncbi request reprint Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease
    Yasumasa Ohyagi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    FASEB J 19:255-7. 2005
  2. ncbi request reprint Intraneuronal amyloid beta42 enhanced by heating but counteracted by formic acid
    Yasumasa Ohyagi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Neurosci Methods 159:134-8. 2007
  3. ncbi request reprint Intracellular amyloid beta-protein and its associated molecules in the pathogenesis of Alzheimer's disease
    Yasumasa Ohyagi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mini Rev Med Chem 6:1075-80. 2006
  4. ncbi request reprint [Inhibition of neuronal death by promoting degradation of intracellular amyloid beta-protein]
    Yasumasa Ohyagi
    Department School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 27:57-62. 2007
  5. ncbi request reprint Intracellular amyloid beta-protein as a therapeutic target for treating Alzheimer's disease
    Y Ohyagi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Curr Alzheimer Res 5:555-61. 2008
  6. ncbi request reprint Adrenoleukodystrophy protein enhances association of very long-chain acyl-coenzyme A synthetase with the peroxisome
    T Yamada
    Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Neurology 52:614-6. 1999
  7. ncbi request reprint Glutamate enhances phosphorylation of neurofilaments in cerebellar granule cell culture
    H Asahara
    Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    J Neurol Sci 171:84-7. 1999
  8. ncbi request reprint Ceramide induces apoptosis to immature cerebellar granule cells in culture
    T Taniwaki
    Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Neurochem Res 24:685-90. 1999
  9. doi request reprint Simultaneous measurement of arterial transit time, arterial blood volume, and cerebral blood flow using arterial spin-labeling in patients with Alzheimer disease
    T Yoshiura
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    AJNR Am J Neuroradiol 30:1388-93. 2009
  10. ncbi request reprint Adult-onset hereditary sensory and autonomic neuropathy accompanied by anosmia but without skin ulceration
    N Sakae
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Acta Neurol Scand 104:316-9. 2001

Collaborators

Detail Information

Publications64

  1. ncbi request reprint Intracellular Abeta42 activates p53 promoter: a pathway to neurodegeneration in Alzheimer's disease
    Yasumasa Ohyagi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    FASEB J 19:255-7. 2005
    ....
  2. ncbi request reprint Intraneuronal amyloid beta42 enhanced by heating but counteracted by formic acid
    Yasumasa Ohyagi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    J Neurosci Methods 159:134-8. 2007
    ..Moreover, formic acid treatment counteracted such effects of autoclaving. Thus, intraneuronal Abeta42 accumulation may have been underestimated by conventional methods using formic acid only...
  3. ncbi request reprint Intracellular amyloid beta-protein and its associated molecules in the pathogenesis of Alzheimer's disease
    Yasumasa Ohyagi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Mini Rev Med Chem 6:1075-80. 2006
    ..Here, we review recent literature on intracellular Abeta, especially intranuclear Abeta, and its associated molecules. We also discuss alternative therapeutic strategies to inhibit intracellular Abeta-related pathogenesis...
  4. ncbi request reprint [Inhibition of neuronal death by promoting degradation of intracellular amyloid beta-protein]
    Yasumasa Ohyagi
    Department School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 27:57-62. 2007
    ..Apomorphine hydrochloride is now used as a dopamine agonist for Parkinson's disease or an anti-ED drug in western countries, but also may be one of the candidate drugs to inhibit neuronal death in AD...
  5. ncbi request reprint Intracellular amyloid beta-protein as a therapeutic target for treating Alzheimer's disease
    Y Ohyagi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Curr Alzheimer Res 5:555-61. 2008
    ..The focus of this article is to review the pathogenic mechanisms involving intracellular Abeta and advocate intracellular Abeta as an important therapeutic target in AD...
  6. ncbi request reprint Adrenoleukodystrophy protein enhances association of very long-chain acyl-coenzyme A synthetase with the peroxisome
    T Yamada
    Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Neurology 52:614-6. 1999
    ..To clarify the function of adrenoleukodystrophy protein (ALDP) using our ALDP-deficient mice established by gene targeting...
  7. ncbi request reprint Glutamate enhances phosphorylation of neurofilaments in cerebellar granule cell culture
    H Asahara
    Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, Japan
    J Neurol Sci 171:84-7. 1999
    ..Our findings therefore suggest that exposure to a low concentration of glutamate enhances the phosphorylation of NF-Hs, mainly via the AMPA receptor...
  8. ncbi request reprint Ceramide induces apoptosis to immature cerebellar granule cells in culture
    T Taniwaki
    Department of Neurology, Neurological Institute, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Neurochem Res 24:685-90. 1999
    ..These results thus demonstrated that C2-ceramide induces apoptosis to the CGCs at the early stage in vitro, however the CGCs were found to be less sensitive to C2-ceramide at the later stage in vitro...
  9. doi request reprint Simultaneous measurement of arterial transit time, arterial blood volume, and cerebral blood flow using arterial spin-labeling in patients with Alzheimer disease
    T Yoshiura
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    AJNR Am J Neuroradiol 30:1388-93. 2009
    ....
  10. ncbi request reprint Adult-onset hereditary sensory and autonomic neuropathy accompanied by anosmia but without skin ulceration
    N Sakae
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Acta Neurol Scand 104:316-9. 2001
    ..Both superficial and deep sensation were impaired in the most distal parts of all 4 limbs. Orthostatic hypotension was present in all patients. This is a unique subtype of HSAN distinct from the HSAN I-V described by Dyck...
  11. ncbi request reprint History of allergic disorders in common neurologic diseases in Japanese patients
    J Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Acta Neurol Scand 105:215-20. 2002
    ..To clarify the association between past and present history of allergic disorders and neurologic diseases...
  12. ncbi request reprint Infantile onset myasthenia gravis with MuSK antibodies
    H Murai
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neurology 67:174. 2006
  13. doi request reprint Phenotypic spectrum of hereditary neuralgic amyotrophy caused by the SEPT9 R88W mutation
    M Ueda
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurol Neurosurg Psychiatry 81:94-6. 2010
    ..Mutations in the septin 9 (SEPT9) gene were recently identified in some HNA patients. The phenotypic spectrum of HNA caused by SEPT9 mutations is not well known...
  14. ncbi request reprint [A case of amoxapine-induced tardive dystonia successfully treated with a low dose anti-cholinergic agent]
    Y Hayashi
    Department of Neurology, Kyushu University, Fukuoka
    Rinsho Shinkeigaku 40:367-71. 2000
    ..As a result, the long-term co-administration of biperiden, an anti-cholinergic agent, may mask the toxicity of amoxapine, which may induce tardive dystonia...
  15. ncbi request reprint Changes in the clinical phenotypes of multiple sclerosis during the past 50 years in Japan
    J Kira
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurol Sci 166:53-7. 1999
    ....
  16. ncbi request reprint Motor neuron disorder simulating ALS induced by chronic inhalation of pyrethroid insecticides
    H Doi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Neurology 67:1894-5. 2006
  17. doi request reprint Association of the HLA-DRB1 alleles with characteristic MRI features of Asian multiple sclerosis
    T Matsuoka
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Mult Scler 14:1181-90. 2008
    ..We aimed to disclose possible factors contributing to the development of such MRI features...
  18. doi request reprint CSF angiotensin II and angiotensin-converting enzyme levels in anti-aquaporin-4 autoimmunity
    T Matsushita
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neurol Sci 295:41-5. 2010
    ..Anti-aquaporin-4 (AQP4) antibody targets perivascular astrocyte foot processes, which contain abundant angiotensinogen, a precursor of angiotensin II, angiotensin-converting enzyme (ACE) and ACE2...
  19. ncbi request reprint Lovastatin does not correct the accumulation of very long-chain fatty acids in tissues of adrenoleukodystrophy protein-deficient mice
    T Yamada
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Inherit Metab Dis 23:607-14. 2000
    ..Treatment with lovastatin, however, did not correct the accumulation of VLCFA in the plasma or tissues, including the brain and spinal cord. Lovastatin does not affect the accumulation of VLCFA in ALDP-deficient tissues in mice...
  20. ncbi request reprint Tc1/Tc2 and Th1/Th2 balance in Asian and Western types of multiple sclerosis, HTLV-I-associated myelopathy/tropical spastic paraparesis and hyperIgEaemic myelitis
    H Ochi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 812-8582, Fukuoka, Japan
    J Neuroimmunol 119:297-305. 2001
    ..Furthermore, our results suggest that CD8+ T cells play an adjunctive role in disease induction and the clinical course of MS...
  21. ncbi request reprint A novel autosomal dominant spinocerebellar ataxia (SCA16) linked to chromosome 8q22.1-24.1
    Y Miyoshi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neurology 57:96-100. 2001
    ..To characterize a distinct form of autosomal dominant cerebellar ataxia (ADCA) clinically and genetically...
  22. ncbi request reprint [A case of myelitis caused by visceral larva migrans due to Ascaris suum presenting only with Lhermitte's sign]
    M Kawajiri
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 41:310-3. 2001
    ..Larva migrans of Ascaris suum involving the central nervous system is considered to be extremely rare, but such cases showing mild neurologic impairment without systemic symptoms may have been overlooked...
  23. doi request reprint Increase of CD4+TNF{alpha}+IL-2-T cells in cerebrospinal fluid of multiple sclerosis patients
    N Shi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mult Scler 15:120-3. 2009
    ..The increase was more pronounced at relapse than in remission. No significant change was detected in PB. These findings suggested that CD4(+)TNFalpha(+)IL-2(-)T cells are intrathecally upregulated in MS...
  24. ncbi request reprint Cerebral white matter degeneration in frontotemporal dementia detected by diffusion-weighted magnetic resonance imaging
    Takashi Yoshiura
    Department of Clinical Radiology, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Acad Radiol 13:1373-8. 2006
    ..We studied FTD patients using DWI to determine whether microstructural changes in white matter can be detected in vivo...
  25. doi request reprint Atopic myelitis with focal amyotrophy: a possible link to Hopkins syndrome
    Jun Ichi Kira
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Sci 269:143-51. 2008
    ..This suggests a possible link between atopic myelitis and Hopkins syndrome (asthmatic amyotrophy)...
  26. ncbi request reprint Dysferlin expression in tubular aggregates: their possible relationship to endoplasmic reticulum stress
    Koji Ikezoe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University 60, 812 8582, Fukuoka, Japan
    Acta Neuropathol 105:603-9. 2003
    ..Strong expression of dysferlin in TAs suggests the possibility that it is located not only at the sarcolemma but also in the SR, at least in the pathological conditions...
  27. ncbi request reprint An improved method for Southern DNA and Northern RNA blotting using a Mupid-2 Mini-Gel electrophoresis unit
    Hirokazu Furuya
    Clinical Research Center, Japan
    J Biochem Biophys Methods 68:139-43. 2006
    ....
  28. ncbi request reprint [Molecular pathology and therapeutics in Alzheimer's disease: amyloid beta-protein as a therapeutic target]
    Yasumasa Ohyagi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Fukuoka Igaku Zasshi 97:261-8. 2006
  29. ncbi request reprint Mapping of subcortical white matter abnormality in Alzheimer's disease using diffusion-weighted magnetic resonance imaging
    Takashi Yoshiura
    Department of Clinical Radiology, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Acad Radiol 13:1460-4. 2006
    ..We studied the spatial distribution of the subcortical WM abnormality using diffusion-weighted magnetic resonance imaging (DWI)...
  30. doi request reprint Cortical damage in Alzheimer's disease estimation in medial and lateral aspects of the cerebrum using an improved mapping method based on diffusion-weighted magnetic resonance imaging
    Takashi Yoshiura
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Acad Radiol 15:193-200. 2008
    ..We improved on this method to visualize the cortical damage in Alzheimer's disease (AD) in the lateral and medial aspects of the cerebral hemispheres and to provide anatomic references...
  31. ncbi request reprint High b value diffusion-weighted imaging is more sensitive to white matter degeneration in Alzheimer's disease
    Takashi Yoshiura
    Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Neuroimage 20:413-9. 2003
    ..We concluded that high b value DWI is more sensitive to AD-related white matter degeneration than is conventional DWI...
  32. ncbi request reprint A case of late-onset Segawa syndrome (autosomal dominant dopa-responsive dystonia) with a novel mutation of the GTP-cyclohydrase I (GCH1) gene
    Hirokazu Furuya
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Clin Neurol Neurosurg 108:784-6. 2006
    ..0+/-9.2 pmol/ml) in patients with HPD/DRD). The relatively conserved GCH1 activity that is expressed in stimulated peripheral blood mononuclear cells may be related to the late clinical symptoms in this patient...
  33. ncbi request reprint Some flavonoids and DHEA-S prevent the cis-effect of expanded CTG repeats in a stable PC12 cell transformant
    Hirokazu Furuya
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Biochem Pharmacol 69:503-16. 2005
    ..This system makes it easy to evaluate the toxic effects of expanded CTG repeats and therefore should be useful for screening other DM1 treatments for their efficacies...
  34. pmc Fine mapping of the alpha-T catenin gene to a quantitative trait locus on chromosome 10 in late-onset Alzheimer's disease pedigrees
    Nilufer Ertekin-Taner
    Department of Neuroscience, Mayo Clinic Jacksonville, Jacksonville, FL 32224, USA
    Hum Mol Genet 12:3133-43. 2003
    ..These findings indicate that VR22 has variant(s) which influence Abeta42 and contribute to the previously reported linkage for plasma Abeta42 in LOAD families...
  35. ncbi request reprint A case of dermato-fasciitis: amyopathic dermatomyositis associated with fasciitis
    Yuko Tsuruta
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, 812 8582, Fukuoka, Japan
    Clin Rheumatol 23:160-2. 2004
    ..With steroid therapy, her symptoms and MRI abnormality disappeared within 2 months. This case is therefore considered to be a variant of ADM, presenting as dermato-fasciitis...
  36. ncbi request reprint Electrophysiological correlates of associative visual agnosia lesioned in the ventral pathway
    Takao Yamasaki
    Department of Neurology, Graduate School of Medical Sciences, Neurological Institute, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurol Sci 221:53-60. 2004
    ..Therefore, CS-VEPs and ERPs with color and motion discrimination tasks are useful methods for assessing the functional changes of visual recognition such as visual agnosia...
  37. ncbi request reprint [A family with autosomal dominant temporal lobe epilepsy accompanied by motor and sensory neuropathy]
    Takeshi Matsuoka
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 44:43-9. 2004
    ..Based on these data, we consider that this family to be a new phenotype of autosomal dominant TLE accompanied by motor and sensory neuropathy...
  38. ncbi request reprint Age-related alterations of the functional interactions within the basal ganglia and cerebellar motor loops in vivo
    Takayuki Taniwaki
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Fukuoka, Japan
    Neuroimage 36:1263-76. 2007
    ..Aging effects on SI and ET movements are probably caused by functional alterations within BGTM and CC loops...
  39. ncbi request reprint Functional network of the basal ganglia and cerebellar motor loops in vivo: different activation patterns between self-initiated and externally triggered movements
    Takayuki Taniwaki
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Maidashi 3 1 1, Fukuoka 812 8582, Fukuoka, Japan
    Neuroimage 31:745-53. 2006
    ..Therefore, our modeling approach enabled identification of different contributions of the motor loops of basal ganglia and cerebellum to SI and ET tasks during motor execution...
  40. ncbi request reprint [An adulthood progressive case of congenital nemaline myopathy showing rimmed vacuoles in muscle biopsy and diffuse neurogenic changes on electromyography]
    Koji Ikezoe
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 44:450-3. 2004
    ..Moreover, the presence of both nemaline rods and rimmed vacuoles may have contributed to the development of diffuse neurogenic changes seen in electromyography...
  41. ncbi request reprint A novel mutation (L250V) in the presenilin 1 gene in a Japanese familial Alzheimer's disease with myoclonus and generalized convulsion
    Hirokazu Furuya
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812 8582, Japan
    J Neurol Sci 209:75-7. 2003
    ..This mutation was found in both patients, but not in a normal family member or normal Japanese control subjects. Thus, L250V is a novel PS1 gene mutation responsible for familial AD (FAD) in Japan...
  42. ncbi request reprint [Acute myelitis in a patient with ulcerative colitis]
    Koichi Hagiwara
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Nihon Naika Gakkai Zasshi 96:1703-5. 2007
  43. ncbi request reprint Heterogeneity and continuum of multiple sclerosis in Japanese according to magnetic resonance imaging findings
    Takeshi Matsuoka
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    J Neurol Sci 266:115-25. 2008
    ..These findings suggest that LESCLs are heterogeneous between OSMS and CMS patients, and that there are distinct subtypes of MS in Japanese, according to clinical and MRI findings...
  44. doi request reprint A unique case of fibrodysplasia ossificans progressiva with an ACVR1 mutation, G356D, other than the common mutation (R206H)
    Hirokazu Furuya
    Department of Neurology, Neuro Muscular Center, National Omuta Hospital, Fukuoka, Japan
    Am J Med Genet A 146:459-63. 2008
    ..5-Mb region spanning ACVR1 and its neighbor genes suggested that 1067G > A is a de novo mutation. These results give a clue to better understanding of FOP as well as of the mild clinical symptoms in the patient...
  45. doi request reprint Prenatal freeze lesioning produces epileptogenic focal cortical dysplasia
    Kei ichiro Takase
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Epilepsia 49:997-1010. 2008
    ..However, its epileptogenicity remains unclear. Therefore, we created a novel rat model by freeze lesioning during the late embryonic stage to verify whether FCD influences seizure activities...
  46. doi request reprint Anterior periventricular linear lesions in optic-spinal multiple sclerosis: a combined neuroimaging and neuropathological study
    Takuya Matsushita
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 8128582, Japan
    Mult Scler 14:343-53. 2008
    ..Thus, we suggested that anterior periventricular linear lesions without ovoid ones are characteristic of OSMS...
  47. ncbi request reprint Acute onset facial numbness
    Noriko Kuroki
    Department of Neurology, Neurological Institute, Kyushu University, Fukuoka, Japan
    J Clin Neurosci 15:1049, 1077. 2008
  48. ncbi request reprint [Eosinophilic fasciitis associated with Borrelia afzelii infection]
    Osamu Kikuchi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 44:299-302. 2004
    ..Eosinophilic infiltration was absent. We treated the patient with prednisolone, doxycycline and amoxicillin, which alleviated the symptoms. This is the first report to show that Borrelia afzelii was involved in eosinophilic fasciitis...
  49. ncbi request reprint [Case of eosinophilic myositis in continuum from localized nodular myositis]
    Dai Matsuse
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 48:36-42. 2008
    ..As discussed, the involvement of eosinophils in three inflammatory myopathies was indicated...
  50. ncbi request reprint Paradoxical lateralization of parasagittal spikes revealed by back averaging of EEG and MEG in a case with epilepsia partialis continua
    Ayame Oishi
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Sci 193:151-5. 2002
    ..JLA of MEG is considered to be a useful non-invasive method for localizing the epileptogenic area in EPC even when paradoxical lateralization of electroencephalographic discharges was noted...
  51. ncbi request reprint Serial diffusion-weighted MRI in a case of Wilson's disease with acute onset hemichorea
    Nobutoshi Kawamura
    J Neurol 251:1413-4. 2004
  52. ncbi request reprint [A patient with focal dystonia induced by golf and presenting a decrease in activity of cerebral motor cortex on task]
    Masahito Tanaka
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 45:304-7. 2005
    ..Therefore, dystonia of the present case appears to be similar to focal dystonia clinically but may partly have a mechanism similar to idiopathic generalized dystonia as shown in the fMRI studies...
  53. ncbi request reprint [A case of primary progressive multiple sclerosis with onset of memory impairment]
    Ken ichiro Yamashita
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 45:351-6. 2005
    ..Further neuropsychological and functional imaging studies will be necessary to achieve a better understanding of the mechanisms of cognitive impairment in PPMS...
  54. ncbi request reprint Involvement of cathepsin B in the motor neuron degeneration of amyotrophic lateral sclerosis
    Hitoshi Kikuchi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 812 8582 Fukuoka, Japan
    Acta Neuropathol 105:462-8. 2003
    ..Western blot analysis showed that the 25-kDa activated form of cathepsin B was down-regulated in ALS. Our results suggest that cathepsin B is involved in the motor neuron degeneration in ALS...
  55. ncbi request reprint [A case of cerebellar ataxia showing severe dystonia masquerading as myoclonic jerky movements on arm extension]
    Hideaki Nakagaki
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 42:7-12. 2002
    ..This is the first case to be reported of sporadic, chronic, progressive cerebellar ataxia accompanied by severe dystonic movement, especially on stretching the forearms, that mimics myoclonic movement...
  56. ncbi request reprint Intrathecal upregulation of granulocyte colony stimulating factor and its neuroprotective actions on motor neurons in amyotrophic lateral sclerosis
    Masahito Tanaka
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neuropathol Exp Neurol 65:816-25. 2006
    ..On the other hand, MCP-1 correlated with disease severity, which may aggravate motor neuron damage...
  57. ncbi request reprint The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis
    Xiaojia Sun
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neuroimmunol 180:126-34. 2006
    ..These results may provide a rationale of selective blockade of Rho-kinase by oral use of fasudil as a new therapy for multiple sclerosis...
  58. ncbi request reprint [The Japanese version of RBANS (Repeatable Battery for the Assessment of Neuropsychological Status)]
    Tetsumori Yamashima
    Department of Neurosurgery, Division of Neuroscience, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa 920 8641, Japan
    No To Shinkei 54:463-71. 2002
    ..The present data suggest that the Japanese Version RBANS is useful for both detecting and characterizing early dementia, and should be widely utilized for a neuropsychological screening battery in the clinical practice throughout Japan...
  59. ncbi request reprint Increased IL-13-producing T cells in ALS: positive correlations with disease severity and progression rate
    Nan Shi
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Neuroimmunol 182:232-5. 2007
    ....
  60. ncbi request reprint Cerebral metabolic changes in early multiple system atrophy: a PET study
    Takayuki Taniwaki
    Department of Neurology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, 812 8582, Fukuoka, Japan
    J Neurol Sci 200:79-84. 2002
    ..The hypometabolism in the brainstem was tightly linked to the autonomic dysfunction. Not the striatal dysfunction but the nigral damage may be responsible for the extrapyramidal symptoms in early MSA...
  61. ncbi request reprint [Hashimoto's encephalopathy with bilateral pallidal lesions presenting memory disturbance and executive dysfunction]
    Mami Fukunaga
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University
    Rinsho Shinkeigaku 46:568-71. 2006
    ....
  62. ncbi request reprint Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple sclerosis in Japanese
    Takeshi Matsuoka
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashiku, Fukuoka 812 8582, Japan
    Brain 130:1206-23. 2007
    ..This indicated that the mechanisms producing LESCLs are also heterogeneous in cases with optic-spinal presentation, namely AQP4 autoimmunity-related and -unrelated...
  63. ncbi request reprint Slowly progressive distal muscular atrophy of the bilateral upper limbs (O'Sullivan-McLeod syndrome) partially alleviated by intravenous immunoglobulin therapy
    Yuji Kawano
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka
    Intern Med 46:515-8. 2007
    ..These effects lasted for a few months. These observations suggest that immune-mediated neural damage partially contributes to O'Sullivan-McLeod syndrome...
  64. ncbi request reprint Therapeutic effects of normal cells on ABCD1 deficient cells in vitro and hematopoietic cell transplantation in the X-ALD mouse model
    Takeshi Yamada
    Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    J Neurol Sci 218:91-7. 2004
    ..The correction requires direct cell-to-cell contact for recovering normal cell function...