Kenoki Ohuchida

Summary

Affiliation: Kyushu University
Country: Japan

Publications

  1. doi request reprint MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA1 gene
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 19:2394-402. 2012
  2. doi request reprint The effect of CyberDome, a novel 3-dimensional dome-shaped display system, on laparoscopic procedures
    Kenoki Ohuchida
    Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    Int J Comput Assist Radiol Surg 4:125-32. 2009
  3. ncbi request reprint Over-expression of S100A2 in pancreatic cancer correlates with progression and poor prognosis
    K Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pathol 213:275-82. 2007
  4. doi request reprint CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer
    Naoki Ikenaga
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gastroenterology 139:1041-51, 1051.e1-8. 2010
  5. doi request reprint S100P is a novel marker to identify intraductal papillary mucinous neoplasms
    Kohei Nakata
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 41:824-31. 2010
  6. ncbi request reprint Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 120:1634-40. 2007
  7. doi request reprint Combination with low-dose gemcitabine and hTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer
    Manabu Onimaru
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Cancer Lett 294:178-86. 2010
  8. ncbi request reprint The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 11:7785-93. 2005
  9. ncbi request reprint The role of the DNA damage checkpoint pathway in intraductal papillary mucinous neoplasms of the pancreas
    Yoshihiro Miyasaka
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Kyushu University Hospital, Fukuoka, Japan
    Clin Cancer Res 13:4371-7. 2007
  10. doi request reprint REG4 is associated with carcinogenesis in the 'intestinal' pathway of intraductal papillary mucinous neoplasms
    Kohei Nakata
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 22:460-8. 2009

Collaborators

Detail Information

Publications78

  1. doi request reprint MicroRNA-10a is overexpressed in human pancreatic cancer and involved in its invasiveness partially via suppression of the HOXA1 gene
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 19:2394-402. 2012
    ..Despite progress in analyses of microRNAs in several types of cancers, the functional contributions of microRNAs to pancreatic cancer remain unclear...
  2. doi request reprint The effect of CyberDome, a novel 3-dimensional dome-shaped display system, on laparoscopic procedures
    Kenoki Ohuchida
    Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    Int J Comput Assist Radiol Surg 4:125-32. 2009
    ..Although a three-dimensional (3D) display was reported to be useful over two decades ago, 3D systems have not been widely used. Recently, we developed a novel 3D dome-shaped display (3DD) system, CyberDome...
  3. ncbi request reprint Over-expression of S100A2 in pancreatic cancer correlates with progression and poor prognosis
    K Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Pathol 213:275-82. 2007
    ..043). Immunohistochemical analysis was consistent with qRT-PCR. S100A2 may be a marker of tumour progression or prognosis in pancreatic carcinogenesis and pancreatic cancer...
  4. doi request reprint CD10+ pancreatic stellate cells enhance the progression of pancreatic cancer
    Naoki Ikenaga
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Gastroenterology 139:1041-51, 1051.e1-8. 2010
    ..However, the functional heterogeneity of PSCs has not been identified until now. Detailed characterization of the PSCs in human pancreatic cancer would provide a set of potential targets for stroma-directed therapy...
  5. doi request reprint S100P is a novel marker to identify intraductal papillary mucinous neoplasms
    Kohei Nakata
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 41:824-31. 2010
    ..On the other hand, MUC5AC was expressed in only 23 cases of 32 invasive components (P < .01). These data suggest that the S100P antibody may be a useful marker for detecting all types of intraductal papillary mucinous neoplasms...
  6. ncbi request reprint Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 120:1634-40. 2007
    ..009). Our results suggest that Twist is involved in tumor progression of pancreatic cancer and that measurement of Twist in pancreatic juice may be useful to differentiate pancreatic cancer from nonmalignant neoplasms such as IPMN...
  7. doi request reprint Combination with low-dose gemcitabine and hTERT-promoter-dependent conditionally replicative adenovirus enhances cytotoxicity through their crosstalk mechanisms in pancreatic cancer
    Manabu Onimaru
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Maidashi, Fukuoka, Japan
    Cancer Lett 294:178-86. 2010
    ..This combination therapy may be a promising therapeutic approach for pancreatic cancer...
  8. ncbi request reprint The role of S100A6 in pancreatic cancer development and its clinical implication as a diagnostic marker and therapeutic target
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 11:7785-93. 2005
    ..Our present results suggest that quantitation of S100A6 mRNA is a promising tool for diagnosis of pancreatic cancer, and that S100A6 may be a promising therapeutic target for pancreatic cancer...
  9. ncbi request reprint The role of the DNA damage checkpoint pathway in intraductal papillary mucinous neoplasms of the pancreas
    Yoshihiro Miyasaka
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Kyushu University Hospital, Fukuoka, Japan
    Clin Cancer Res 13:4371-7. 2007
    ..ATM-Chk2-p53 DNA damage checkpoint activation, which is involved in prevention of the progression of several tumors, was analyzed to evaluate the role of the DNA damage checkpoint in the progression of IPMNs...
  10. doi request reprint REG4 is associated with carcinogenesis in the 'intestinal' pathway of intraductal papillary mucinous neoplasms
    Kohei Nakata
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 22:460-8. 2009
    ..Using the Ki-67 labeling index, REG4 expression was significantly correlated with proliferative activity in borderline lesions. We conclude that REG4 is involved in the 'intestinal' pathway of carcinogenesis in IPMN...
  11. pmc Prospectively isolated cancer-associated CD10(+) fibroblasts have stronger interactions with CD133(+) colon cancer cells than with CD133(-) cancer cells
    Lin Cui
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 5:e12121. 2010
    ..Therefore, these specific interactions may be promising targets for new colon cancer therapies...
  12. doi request reprint Claudin-4 expression predicts survival in pancreatic ductal adenocarcinoma
    Kosuke Tsutsumi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 19:S491-9. 2012
    ..Identification of prognostic markers would be useful in the clinical management of patients with pancreatic ductal adenocarcinoma (PDAC). The clinical relevance of claudin-4 (CLDN4), recently identified as overexpressed in PDAC, is unknown...
  13. doi request reprint Radiation enhances adenoviral gene therapy in pancreatic cancer via activation of cytomegalovirus promoter and increased adenovirus uptake
    Takuya Egami
    Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 14:1859-67. 2008
    ..However, there are no reports of definitive effects of radiation on adenovirus-mediated gene therapies. In the present study, we investigated the effect of radiation on the transduction efficiency of an adenovirus-based gene therapy...
  14. pmc LIM only 4 is overexpressed in late stage pancreas cancer
    Jun Yu
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Cancer 7:93. 2008
    ..We hypothesized that LMO4 may be related to pancreatic carcinogenesis as it is in breast carcinogenesis. If so, this could result in a better understanding of tumorigenesis in pancreatic cancer...
  15. doi request reprint Up-regulation of integrin beta3 in radioresistant pancreatic cancer impairs adenovirus-mediated gene therapy
    Takuya Egami
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 100:1902-7. 2009
    ..These results suggest that inhibition of integrin beta3 in radioresistant pancreatic cancer cells could enhance adenovirus-mediated gene therapy...
  16. ncbi request reprint Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells
    Takaharu Yasui
    Department of Surgery and Oncology, Kyushu University, Fukuoka 812 8582, Japan
    Anticancer Res 31:1279-87. 2011
    ..Nevertheless, the effect of adenoviral therapy on chemoresistant cancer cells has not been studied. In this study, we compared the efficacy of adenoviral therapy in parental and chemoresistant pancreatic cancer cells...
  17. pmc Gene expression levels as predictive markers of outcome in pancreatic cancer after gemcitabine-based adjuvant chemotherapy
    Hayato Fujita
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Neoplasia 12:807-17. 2010
    ..The aims of this study were to investigate the expression pattern of genes involved in gemcitabine sensitivity in resected PDAC tissues and to determine correlations of gene expression with treatment outcome...
  18. pmc MicroRNA expression as a predictive marker for gemcitabine response after surgical resection of pancreatic cancer
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 18:2381-7. 2011
    ..Our aim was to identify promising microRNAs as markers to predict responses to gemcitabine in patients with resected pancreatic cancer...
  19. doi request reprint Chemotherapeutic agents potentiate adenoviral gene therapy for pancreatic cancer
    Takuya Egami
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Sci 100:722-9. 2009
    ..Furthermore, they will contribute to decreases in the adenovirus doses required for gene transfer, thereby controlling the side-effects of adenovirus infection in normal tissues...
  20. doi request reprint Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway
    Takaharu Yasui
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 102:484-91. 2011
    ..Control of such tumor-stroma interactions may lead to improvements in adenoviral gene therapy for PDAC...
  21. doi request reprint Expression of claudin-4 (CLDN4) mRNA in intraductal papillary mucinous neoplasms of the pancreas
    Kosuke Tsutsumi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 24:533-41. 2011
    ..0001). Our findings suggest that claudin-4 expression is associated with neoplastic progression of intraductal papillary mucinous neoplasms and, especially, with a distinct pathway to intestinal differentiation...
  22. doi request reprint Enhanced cell migration and invasion of CD133+ pancreatic cancer cells cocultured with pancreatic stromal cells
    Taiki Moriyama
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Kyushu University Hospital Cancer Center, Fukuoka, Japan
    Cancer 116:3357-68. 2010
    ..Recently, cancer stem cells have been reported as a new therapeutic target in pancreatic cancer as well as other cancers, but the specific role of these cells is unknown...
  23. doi request reprint Kindlin-1 expression is involved in migration and invasion of pancreatic cancer
    Prawej Mahawithitwong
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Oncol 42:1360-6. 2013
    ..001), while the proliferation abilities were not affected. The present findings suggest that kindlin-1 expression is involved in the progression of pancreatic cancer via enhancement of cell migration and invasion...
  24. pmc CD271⁺ subpopulation of pancreatic stellate cells correlates with prognosis of pancreatic cancer and is regulated by interaction with cancer cells
    Kenji Fujiwara
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e52682. 2012
    ..These findings suggest that CD271⁺ PSCs appear at the early stage of pancreatic carcinogenesis and that CD271 expression is significantly correlated with a better prognosis in patients with PDAC...
  25. doi request reprint Pirfenidone inhibits pancreatic cancer desmoplasia by regulating stellate cells
    Shingo Kozono
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 73:2345-56. 2013
    ..In conclusion, our findings indicate that pirfenidone is a promising antitumor agent for pancreatic cancer, owing to its suppression of desmoplasia through regulating PSCs...
  26. doi request reprint Invasive carcinoma derived from the nonintestinal type intraductal papillary mucinous neoplasm of the pancreas has a poorer prognosis than that derived from the intestinal type
    Yoshihiko Sadakari
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Surgery 147:812-7. 2010
    ....
  27. pmc Inhibition of p600 expression suppresses both invasiveness and anoikis resistance of gastric cancer
    Hiroshi Sakai
    Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 18:2057-65. 2011
    ..p600 (600-kDa protein), recently identified from a cervical cancer cell line, plays a role in both anoikis resistance and cell migration. In this study, we examined whether p600 is involved in the progression of gastric cancer...
  28. ncbi request reprint S100P is an early developmental marker of pancreatic carcinogenesis
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 12:5411-6. 2006
    ..Our goal was to clarify the involvement and clinical significance of S100P in pancreatic carcinogenesis...
  29. doi request reprint The risk of lymph node metastasis in mucosal gastric carcinoma: especially for a mixture of differentiated and undifferentiated adenocarcinoma
    Kohei Nakata
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hepatogastroenterology 59:1855-8. 2012
    ..Our aims were to confirm the frequency of lymph node metastasis in such cases and clarify the demarcation in indications for ESD...
  30. doi request reprint Quantitative analysis of hTERT mRNA levels in cells microdissected from cytological specimens
    Hayato Fujita
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 99:2244-51. 2008
    ..Quantitative assessment of hTERT mRNA levels in cells microdissected from cytological specimens is a potential diagnostic tool to potentiate cytological examination in diagnosing malignancy...
  31. ncbi request reprint S100A11, a putative tumor suppressor gene, is overexpressed in pancreatic carcinogenesis
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 12:5417-22. 2006
    ..Recent microarray analyses revealed that expression of S100A11 is up-regulated in pancreatic cancer. The aim of the present study was to evaluate the association of S100A11 with pancreatic carcinogenesis...
  32. ncbi request reprint S100A6 is increased in a stepwise manner during pancreatic carcinogenesis: clinical value of expression analysis in 98 pancreatic juice samples
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Cancer Epidemiol Biomarkers Prev 16:649-54. 2007
    ..Measurement of S100A6 in pancreatic juice may be useful to detect early pancreatic cancer or identify individuals with high-risk lesions that may progress to pancreatic cancer...
  33. ncbi request reprint Down-regulation of deoxycytidine kinase enhances acquired resistance to gemcitabine in pancreatic cancer
    Seiji Ohhashi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Anticancer Res 28:2205-12. 2008
    ..The functional roles of deoxycytidine kinase (dCK) in acquired resistance to gemcitabine remain unknown in pancreatic cancer. Here, the functional involvement of dCK in gemcitabine-resistance of pancreatic cancer was investigated...
  34. doi request reprint Kindlin-2 expression in peritumoral stroma is associated with poor prognosis in pancreatic ductal adenocarcinoma
    Prawej Mahawithitwong
    Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan
    Pancreas 42:663-9. 2013
    ..Kindlin-2 is a novel focal adhesion protein reported to be expressed in breast, lung, and gastric cancers. This study aimed to investigate the significance of kindlin-2 expression in pancreatic ductal adenocarcinomas (PDACs)...
  35. doi request reprint MicroRNA-203 expression as a new prognostic marker of pancreatic adenocarcinoma
    Naoki Ikenaga
    Departments of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg Oncol 17:3120-8. 2010
    ..The aim of this study is to evaluate the correlation between miR-203 expression and prognosis of patients with pancreatic adenocarcinoma after curative resection...
  36. ncbi request reprint Radiation to stromal fibroblasts increases invasiveness of pancreatic cancer cells through tumor-stromal interactions
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Res 64:3215-22. 2004
    ..Our present findings further support the potential use of NK4 during radiotherapy for patients with pancreatic cancer...
  37. doi request reprint hTERT-promoter-dependent oncolytic adenovirus enhances the transduction and therapeutic efficacy of replication-defective adenovirus vectors in pancreatic cancer cells
    Manabu Onimaru
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 101:735-42. 2010
    ..This approach may be a promising combination therapy against advanced pancreatic cancer...
  38. pmc MicroRNA, hsa-miR-200c, is an independent prognostic factor in pancreatic cancer and its upregulation inhibits pancreatic cancer invasion but increases cell proliferation
    Jun Yu
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mol Cancer 9:169. 2010
    ..However, the significance of miR-200c in pancreatic cancer is unknown...
  39. doi request reprint MicroRNA-21 modulates biological functions of pancreatic cancer cells including their proliferation, invasion, and chemoresistance
    Taiki Moriyama
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Mol Cancer Ther 8:1067-74. 2009
    ..These data suggest that miR-21 expression is increased in pancreatic cancer cells and that miR-21 contributes to the cell proliferation, invasion, and chemoresistance of pancreatic cancer...
  40. doi request reprint Invasive carcinoma derived from intestinal-type intraductal papillary mucinous neoplasm is associated with minimal invasion, colloid carcinoma, and less invasive behavior, leading to a better prognosis
    Kohei Nakata
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pancreas 40:581-7. 2011
    ..The meaning of "minimal invasion" (MI) in IPMC also remains unclear. We investigated the prognosis of intraductal papillary mucinous neoplasm (IPMN) focusing on MI and subtypes...
  41. ncbi request reprint Increased expression of ADAM 9 and ADAM 15 mRNA in pancreatic cancer
    Daisuke Yamada
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Anticancer Res 27:793-9. 2007
    ..ADAM 9 and ADAM 15 are involved in cell migration and invasion. Expression of ADAM 9 and ADAM 15 was reported to be altered in several types of cancer...
  42. doi request reprint High EGFR mRNA expression is a prognostic factor for reduced survival in pancreatic cancer after gemcitabine-based adjuvant chemotherapy
    Hayato Fujita
    Department of Surgery and Oncology, Kyushu University, Fukuoka, Japan
    Int J Oncol 38:629-41. 2011
    ....
  43. doi request reprint Insig2 is overexpressed in pancreatic cancer and its expression is induced by hypoxia
    Tadashi Kayashima
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 102:1137-43. 2011
    ..The present data suggest that Insig2 is associated with the malignant potential of pancreatic cancer under hypoxic conditions...
  44. doi request reprint Intraductal papillary mucinous neoplasms of the pancreas with distinct pancreatic ductal adenocarcinomas are frequently of gastric subtype
    Noboru Ideno
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Ann Surg 258:141-51. 2013
    ..To identify a high-risk group of patients with pancreatic ductal adenocarcinoma (PDAC), independently arising in the pancreas with intraductal papillary mucinous neoplasm (IPMN), using histopathologic subtypes...
  45. doi request reprint MicroRNA-10b is overexpressed in pancreatic cancer, promotes its invasiveness, and correlates with a poor prognosis
    Kohei Nakata
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Surgery 150:916-22. 2011
    ..Several pancreatic cancer-specific miRNAs differed, however, in each analysis...
  46. ncbi request reprint Quantitative analysis of human telomerase reverse transcriptase in pancreatic cancer
    Kenoki Ohuchida
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Clin Cancer Res 12:2066-9. 2006
    ....
  47. doi request reprint Significance of combination therapy of zoledronic acid and gemcitabine on pancreatic cancer
    Ming Zhao
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 103:58-66. 2012
    ..These data are promising for the future application of this drug regimen in patients with pancreatic cancer...
  48. doi request reprint Characterization of CD24 expression in intraductal papillary mucinous neoplasms and ductal carcinoma of the pancreas
    Naoki Ikenaga
    Departments of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Hum Pathol 41:1466-74. 2010
    ..In conclusion, CD24 is involved in the progression of intraductal papillary mucinous neoplasms of the pancreas and in the malignant behavior of pancreatic cancers...
  49. doi request reprint MAL2 expression predicts distant metastasis and short survival in pancreatic cancer
    Daiki Eguchi
    Department of Surgery, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Surgery 154:573-82. 2013
    ..Mal, T-cell differentiation protein 2 (MAL2) has been identified as a molecule predictive of metastases; the clinical relevance of MAL2 in pancreatic cancer is unknown...
  50. doi request reprint Hypoxia enhances the interaction between pancreatic stellate cells and cancer cells via increased secretion of connective tissue growth factor
    Daiki Eguchi
    Departments of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    J Surg Res 181:225-33. 2013
    ..This study aimed to clarify the effects of hypoxic conditions on the interaction between PC cells and PSCs...
  51. doi request reprint Senescence in intraductal papillary mucinous neoplasm of the pancreas
    Yoshihiro Miyasaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Hum Pathol 42:2010-7. 2011
    ..It is suggested that senescence plays a role in preventing malignant progression of intraductal papillary mucinous neoplasm...
  52. doi request reprint S100A4 mRNA is a diagnostic and prognostic marker in pancreatic carcinoma
    Naoki Ikenaga
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    J Gastrointest Surg 13:1852-8. 2009
    ..The aim of this study is to evaluate the clinical significance of S100A4 mRNA expression in pancreatic cancer...
  53. doi request reprint Predicting the chemosensitivity of pancreatic cancer cells by quantifying the expression levels of genes associated with the metabolism of gemcitabine and 5-fluorouracil
    Nobuaki Kurata
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Int J Oncol 39:473-82. 2011
    ..05). In conclusion, pancreatic cancer cells showed no cross-resistance to GEM and 5-FU. Quantitative analyses of RRM1, TP, DPD and TS mRNA levels in pancreatic cancer cells may be useful for predicting their sensitivity to GEM and 5-FU...
  54. doi request reprint Tumor-stromal interactions with direct cell contacts enhance proliferation of human pancreatic carcinoma cells
    Hayato Fujita
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Sci 100:2309-17. 2009
    ..Direct cell contact between cancer cells and PSCs plays an important role in the control of cancer cell proliferation, and is essential to the understanding of tumor-stromal interactions...
  55. doi request reprint MicroRNA miR-17-5p is overexpressed in pancreatic cancer, associated with a poor prognosis, and involved in cancer cell proliferation and invasion
    Jun Yu
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer Biol Ther 10:748-57. 2010
    ..0001 for both). The present findings suggest that miR-17-5p plays important roles in pancreatic carcinogenesis and cancer progression, and is associated with a poor prognosis in pancreatic cancer...
  56. ncbi request reprint Overexpression of c-met in the early stage of pancreatic carcinogenesis; altered expression is not sufficient for progression from chronic pancreatitis to pancreatic cancer
    Jun Yu
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    World J Gastroenterol 12:3878-82. 2006
    ..To investigate c-met expression during early pancreatic carcinogenesis...
  57. ncbi request reprint Suppression of metastasis of human pancreatic cancer to the liver by transportal injection of recombinant adenoviral NK4 in nude mice
    Mitsuhiko Murakami
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 117:160-5. 2005
    ..These results indicate that intraportal injection of Ad-NK4 may be a useful therapeutic modality for the clinical control of hepatic metastasis in pancreatic cancer...
  58. ncbi request reprint Quantitative assessment of telomerase activity and human telomerase reverse transcriptase messenger RNA levels in pancreatic juice samples for the diagnosis of pancreatic cancer
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Clin Cancer Res 11:2285-92. 2005
    ..Our present results suggest that the combined assessment of hTERT and telomerase activities in pancreatic juice provides a potent diagnostic method for pancreatic cancer...
  59. doi request reprint Midkine mRNA is overexpressed in pancreatic cancer
    Seiji Ohhashi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    Dig Dis Sci 54:811-5. 2009
    ..We investigated the feasibility of quantitative analysis of MK mRNA by quantitative real-time RT-PCR (qRT-PCR) as a promising tool for the diagnosis of pancreatic cancer...
  60. pmc Pancreatic cancer cells enhance the ability of collagen internalization during epithelial-mesenchymal transition
    Naoki Ikenaga
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    PLoS ONE 7:e40434. 2012
    ..The aim of this study was to characterize collagen internalization, which is the initial step of the intracellular degradation pathway in pancreatic cancer cells, in light of epithelial-mesenchymal transition (EMT)...
  61. doi request reprint Feasibility and safety of intracorporeal esophagojejunostomy after laparoscopic total gastrectomy: inverted T-shaped anastomosis using linear staplers
    Eishi Nagai
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Kyushu, Japan
    Surgery 153:732-8. 2013
    ..The purpose of this study was to evaluate perioperative and short-term outcomes of our procedure of intracorporeal gastrojejunostomy using linear staplers after LTG...
  62. doi request reprint CD44v6 expression in intraductal papillary mucinous neoplasms of the pancreas
    Yoshihiro Miyasaka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Pancreas 39:31-5. 2010
    ..The purpose of this study was to examine CD44v6 expression in intraductal papillary mucinous neoplasms (IPMNs) and clarify the role of CD44v6 in progression, invasion, metastasis, and morphogenesis of IPMNs...
  63. ncbi request reprint Strategy for prevention of local recurrence of pancreatic cancer after pancreatectomy: antitumor effect of gemcitabine mixed with fibrin glue in an orthotopic nude mouse model
    Yasuhiro Ogura
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Surgery 140:66-71. 2006
    ..The aim of this study was to evaluate the local antitumor effect of a mixture of gemcitabine (GEM) and FG on pancreatic cancer cells implanted orthotopically in nude mice...
  64. ncbi request reprint Quantitative analysis of MUC1 and MUC5AC mRNA in pancreatic juice for preoperative diagnosis of pancreatic cancer
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Int J Cancer 118:405-11. 2006
    ....
  65. ncbi request reprint MicroRNA expression analyses in preoperative pancreatic juice samples of pancreatic ductal adenocarcinoma
    Yoshihiko Sadakari
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    JOP 11:587-92. 2010
    ..MicroRNAs are small RNAs regulating various cellular processes and have recently been identified as possible markers of malignant diseases including pancreatic ductal adenocarcinoma...
  66. pmc LMO2 is a novel predictive marker for a better prognosis in pancreatic cancer
    Kohei Nakata
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Higashi ku, Fukuoka, Japan
    Neoplasia 11:712-9. 2009
    ..LIM domain only 2 (LMO2) has been identified as a novel oncogene associated with carcinogenesis and better prognosis in several malignant tumors. We investigate the involvement of LMO2 in pancreatic cancer...
  67. doi request reprint Skills assessment using a virtual reality simulator, LapSim, after training to develop fundamental skills for endoscopic surgery
    Kazuo Tanoue
    Department of Advanced Medicine and Innovative Technology, Kyushu University Hospital, Fukuoka, Japan
    Minim Invasive Ther Allied Technol 19:24-9. 2010
    ..This study demonstrates the feasibility of using a VR simulator to assess fundamental skills for endoscopic surgery after training. We found that the scores for the task were associated with the level of experience of the surgeons...
  68. ncbi request reprint Fascin overexpression in intraductal papillary mucinous neoplasms (adenomas, borderline neoplasms, and carcinomas) of the pancreas, correlated with increased histological grade
    Hiroshi Yamaguchi
    Department of Anatomic Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Mod Pathol 20:552-61. 2007
    ..Our findings suggest that fascin overexpression is involved in the progression of IPMN. Fascin could become a new therapeutic target for inhibition of their progression...
  69. ncbi request reprint All-trans retinoic acid inhibits the cell proliferation but enhances the cell invasion through up-regulation of c-met in pancreatic cancer cells
    Kawin Leelawat
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan Department of Surgery, Rajavithi Hospital, Bangkok, Thailand
    Cancer Lett 224:303-10. 2005
    ..In addition, ATRA also increased the protein level of c-Met. These findings may indicate that the use of retinoic acid as an anti-cancer therapeutic drug needs some additional treatments to control cell invasion or scattering...
  70. doi request reprint Augmented reality navigation system for laparoscopic splenectomy in children based on preoperative CT image using optical tracking device
    Satoshi Ieiri
    Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Pediatr Surg Int 28:341-6. 2012
    ..We developed an augmented reality (AR) navigation system based on preoperative CT imaging. The purpose of this study is to evaluate the usefulness, feasibility, and accuracy of this system using laparoscopic splenectomy in children...
  71. doi request reprint The frontal cortex is activated during learning of endoscopic procedures
    Kenoki Ohuchida
    Department of Advanced Medical Initiatives, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    Surg Endosc 23:2296-301. 2009
    ..In the present study, we investigated cortical activation using near-infrared spectroscopy (NIRS) during endoscopic surgical tasks...
  72. ncbi request reprint SPARC mRNA expression as a prognostic marker for pancreatic adenocarcinoma patients
    Kei Miyoshi
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka 812 8582, Japan
    Anticancer Res 30:867-71. 2010
    ..However, the significance of SPARC mRNA expression in pancreatic adenocarcinoma remains unclear...
  73. doi request reprint Single-incision laparoscopy-assisted surgery for bowel obstruction: report of three cases
    Takao Ohtsuka
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka, 812 8582, Japan
    Surg Today 41:1519-23. 2011
    ..In such cases, the preoperative insertion of a long nasal tube for decompression of intestinal contents and assessment of the stenotic lesion is necessary...
  74. doi request reprint Effectiveness of basic endoscopic surgical skill training for pediatric surgeons
    Satoshi Ieiri
    Department of Pediatric Surgery, Reproductive and Developmental Medicine, Faculty of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Pediatr Surg Int 26:947-54. 2010
    ..The aim of this study was to evaluate the effectiveness of basic endoscopic surgery training for less-experienced young pediatric surgeons and then compare their skills with those of general surgeons...
  75. ncbi request reprint A highly sensitive and quantitative telomerase activity assay with pancreatic juice is useful for diagnosis of pancreatic carcinoma without problems due to polymerase chain reaction inhibitors: analysis of 100 samples of pancreatic juice from consecutive
    Kenoki Ohuchida
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan
    Cancer 101:2309-17. 2004
    ....
  76. ncbi request reprint Co-cultivation of pancreatic cancer cells with orthotopic tumor-derived fibroblasts: fibroblasts stimulate tumor cell invasion via HGF secretion whereas cancer cells exert a minor regulative effect on fibroblasts HGF production
    Li Wu Qian
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812 8582, Japan
    Cancer Lett 190:105-12. 2003
    ....
  77. pmc Laparoscopy-assisted distal gastrectomy for early gastric cancer: is it beneficial for patients of heavier weight?
    Hirokazu Noshiro
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Ann Surg 238:680-5. 2003
    ..In this retrospective review, we evaluated the advantages and disadvantages of LADG for patients of heavier weight with early gastric cancer...
  78. doi request reprint Gli1 contributes to the invasiveness of pancreatic cancer through matrix metalloproteinase-9 activation
    Shuntaro Nagai
    Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Cancer Sci 99:1377-84. 2008
    ..Taken together, these findings suggest that members of the Hh pathway, especially Gli1, play an important role in the invasiveness of pancreatic cancer cells through the regulation of MMP-9 expression...